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| 1 | Highly accurate colorectal cancer prediction model based on Raman spectroscopy using patient serum显示文摘BACKGROUND Colorectal cancer(CRC) is an important disease worldwide, accounting for the second highest number of cancer-related deaths and the third highest number of new cancer cases. The blood test is a simple and minimally invasive diagnostic test. However, there is currently no blood test that can accurately diagnose CRC.AIM To develop a comprehensive, spontaneous, minimally invasive, label-free, bloodbased CRC screening technique based on Raman spectroscopy.METHODS We used Raman spectra recorded using 184 serum samples obtained from patients undergoing colonoscopies. Patients with malignant tumor histories as well as those with cancers in organs other than the large intestine were excluded. Consequently, the specific diseases of 184 patients were CRC(12), rectal neuroendocrine tumor(2), colorectal adenoma(68), colorectal hyperplastic polyp(18), and others(84). We used the 1064-nm wavelength laser for excitation. The power of the laser was set to 200 mW.RESULTS Use of the recorded Raman spectra as training data allowed the construction of a boosted tree CRC prediction model based on machine learning. Therefore, the generalized R^2 values for CRC, adenomas, hyperplastic polyps, and neuroendocrine tumors were 0.9982, 0.9630, 0.9962, and 0.9986, respectively.CONCLUSION For machine learning using Raman spectral data, a highly accurate CRC prediction model with a high R^2 value was constructed. We are currently planning studies to demonstrate the accuracy of this model with a large amount of additional data. | Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki William Yang Kenji Issha Kai Matsuo Satoshi Kimura Yuji Arai Hiromasa Tokunaga Saiko Okada Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Takashi Fukagai Yumi Kamijo | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 2 |
| 2 | Resveratrol and its analogs:defense against cancer,coronary disease and neurodegenerative maladies or just a fad显示文摘 | SAIKO P SZAKMARY A JAEGER W | 2008 | Mutat Res2008，658，12： | 1 |
| 3 | Comparison of Autologous Hematopoietic Cell Transplantation and Chemotherapy as Postremission Treatment in Non-M3 Acute Myeloid Leukemia in First Complete Remission显示文摘 | Kensuke Usuki Saiko Kurosawa Naoyuki Uchida Kazuaki Yakushiji Fusako Waki Eijo Matsuishi Kumiko Kagawa Tatsuo Furukawa Yoshinobu Maeda Manabu Shimoyama Hiroatsu Ago Yujiro Yamano Shingo Yano Naohito Fujishima Yasushi Takamatsu Tetsuya Eto Michihiro Hidaka | 2012 | Clinical Lymphoma Myeloma and Leukemia2012，，6： | 1 |
| 4 | Excess α‐tocopherol decreases extrahepatic phylloquinone in phylloquinone‐fed rats but not menaquinone‐4 in menaquinone‐4‐fed rats显示文摘 | Fumiaki Hanzawa Eri Sakuma Saki Nomura Tomono Uchida Hiroaki Oda Saiko Ikeda | 2014 | Mol. Nutr. Food Res2014，，： | 1 |
| 5 | Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL -60 pro- myelocytic leukemia cells 显示文摘 | Saiko P Ozsvar - Kozma M Bernhaus A | 2007 | Cancer Letters2007，250，2： | 1 |
| 6 | Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes显示文摘 | Naoki Nishio Masaaki Teranishi Yasue Uchida Saiko Sugiura Fujiko Ando Hiroshi Shimokata Michihiko Sone Hironao Otake Ken Kato Tadao Yoshida Mitsuhiko Tagaya Tatsuya Hibi Tsutomu Nakashima | 2012 | Gene2012，，1： | 1 |
| 7 | Neurotrophic function of conditioned medium from human amniotic epithelial cells 显示文摘 | Yukiko I Makiko K | 2000 | Neurosci Res2000，62，4： | 1 |
| 8 | Miyoshi myopathy patients with novel 5'splicing donor site mutations showed different dysferlin immunostaining at the sarcolemma显示文摘 | Higuchi I Nakagawa M | 2002 | Acta Neuropathol2002，104，6： | 1 |
| 9 | Synergistic action of resveratrol,an ingredient of wine,with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells显示文摘 | HORVATH Z SAIKO P ILLMER C | 2005 | Exp Hematol2005，33，3： | 1 |
| 10 | Resveratrol and its analogs:defense against cancer,coronary disease and neurodegenerative maladies or just a fad显示文摘 | Saiko P Szakmary A Jaeger W | | 0，，1： | 1 |
| 11 | Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells显示文摘 | Philipp Saiko Geraldine Graser Benedikt Giessrigl Marie-Thérèse Steinmann Heike Schuster Andreas Lackner Michael Grusch Georg Krupitza Walter Jaeger Venkateswarlu Somepalli Trimurtulu Golakoti Monika Fritzer-Szekeres Thomas Szekeres | 2013 | Investigational New Drugs2013，，5： | 1 |
| 12 | A bHLH com- plex controls embryonic vascular tissue establishment and in- determinate growth in Arabidopsis显示文摘 | BERT DE R BARBARA M SAIKO Y | 2013 | Developmental Cell2013，24，4： | 1 |
| 13 | Analysis of mechanisms contributing to AraC-mediated chemoresistance and re-establishment of drug sensitivity by the novel heterodinucleoside phosphate 5- FdUrd-araC 显示文摘 | Maier S Strasser S Saiko P | 2006 | Apoptosis2006，11，3： | 1 |
| 14 | Effect of sesaminol on plasma and tissue α-tocopherol and α- tocotrienol concentrations in rats fed a citamin E concentrate rich in tocotrienols显示文摘 | Kanae Yamashita Saiko Ikeda Yoshie Iizuka | 2002 | Lipids2002，37，4： | 1 |
| 15 | Epigallocatechin gal- late, ellagic acid, and rosmarinie acid perturb dNTP pools and inhib- it de novo DNA synthesis and proliferation of human HL-60 prorny- eloeytic leukemia cells: Synergism with arabinofuranosylcytosine 显示文摘 | Saiko P Steinmann MT Schuster H | 2015 | Phytomedieine2015，22，1： | 1 |
| 16 | Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss显示文摘 | Terukazu M Saiko S Hiroshi K | 2009 | Eur Arch Otorhinolaryngol2009，266，3： | 1 |
| 17 | Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells显示文摘 | Bernhaus A Ozsvar Kozma M Saiko P | 2009 | Invest New Drugs2009，27，5： | 1 |
| 18 | Influence of lubricant additive and surface texture on the sliding friction characteristics of steel under varying speeds ranging from ultra low to moderate 显示文摘 | Masabumi Masuko Saiko Aoki Akihito Suzuki | 2005 | Tribology Transaction2005，48，： | 1 |
| 19 | Dietary Sesame Seed and Its Lignan, Sesamin, Increase Tocopherol and Phylloquinone Concentrations in Male Rats1-3显示文摘 | Hanzawa Fumiaki Nomura Saki Sakuma Eri Uchida Tomono Ikeda Saiko | 2013 | The Journal of Nutrition2013，，： | 1 |
| 20 | Ave- mar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in hu- man HL-60 promyelocytic leukemia cells显示文摘 | Saiko P Ozsvar- Kozma M Madlener S | 2007 | Cancer Letters2007，25，2： | 1 |
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