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| 1 | 乙型肝炎病毒基因型和血清亚型在我国部分地区的分布及其特点显示文摘目的 研究乙型肝炎病毒 (hepatitisBvirus ,HBV)基因型和血清亚型的分布特点及其基因的相关性。方法 湖南、广西、河南和河北 4省 (区 ) 2 5个县 (市 ) 2 80例慢性HBV携带者 ,应用聚合酶链反应 (PCR)扩增和脱氧核糖核酸 (DNA)序列分析 ,确定HBV基因型和血清亚型。结果 HBV基因型B、C和D均有分布 ,分别占 2 9.3%、6 7.9%和 2 .9% ,其中B和C为优势基因型。adr、adw2、ayr、ayw1、ayw2和ayw3等 6种血清亚型均有分布 ,其中adr和adw2为优势血清亚型 ,分别占6 4.3%和 31.4%。基因型B与adw2血清亚型 ,基因型C与adr血清亚型有非常密切的基因相关性。 2 80例HBV携带者表面抗原基因序列每 10 0个核苷酸的平均置换频数为 2 .94。基因型B(adw2血清亚型 )毒株核苷酸置换频数为 5 .6 3(5 .48) ,而基因型C(adr血清亚型 )仅为 1.6 (1.5 1)。结论 HBV基因型和血清亚型的分布均有明显的地区性 ;基因型B及相对应的adw2血清亚型毒株的基因可变性明显高于基因型C及相应的adr血清亚型。 | 夏国良 Omana V Nainan 贾志远 刘洪斌 罗述斌 李荣成 曹慧霖 刘崇柏 HaroldS Margolis | 2001 | 中华流行病学杂志2001，22，5： | 131 |
| 2 | 太阳能发电技术的应用与发展显示文摘随着全球能源需求的不断增长,能源、环境和气候变暖等问题日益突出。倡导低碳经济运行,提高资源利用率,加大利用可再生能源力度,进一步减少化石能源消耗,保护生态环境,共同推进人类社会和谐可持续发展,已成为全社会的共识和责任。文章介绍了太阳能光发电与太阳能热发电的基本方式和发电技术,阐述了随着能源市场份额的不断增长,需要重点关注和解决独立运行与并网运行的安全、可靠及系统兼容问题,并指出将太阳能发电与智能电网、大容量热储存系统进行整合,是今后太阳能发电的方向。 | Benjamin Kroposki Robert Margolis Dan Ton 邓琳(编译) 杜建军(校) | 2009 | 上海电力2009，，4： | 7 |
| 3 | 未控制高血压患者进行家庭血压监测与药剂师管理后的心血管事件及费用显示文摘未控制高血压是心血管病的主要病因。在16家初级保健诊所进行的整群随机试验结果表明:12个月的远程家庭血压监测与药剂师管理可较常规治疗24个月降压幅度更大。该文报道心血管事件(非致死性心肌梗死、非致死性脑卒中、心力衰竭住院、冠状动脉再血管化及心血管病死亡)与随访5年的花费。在远程干预组(TI组,n=228),10例患者发生15次心血管事件(5次心肌梗死、4次脑卒中、5次心力衰竭、1次心血管病死亡)。 | 赵狄(摘译) 刘莉(审校) Margolis KL Dehmer SP Sperl-Hillen J O’Connor PJ Asche SE Bergdall AR Green BB Nyboer RA Pawloski PA Trower NK Maciosek MV | 2020 | 中华高血压杂志2020，28，11： | 3 |
| 4 | 体质量状态变化与高血压发生的相关性显示文摘在美国近1/3的儿童和青少年是肥胖或超重的。虽然最近该比值保持稳定,但在过去40年中则呈快速上升的趋势。儿童肥胖与高血压显著相关。主要在初中和高中学生中进行的流行病学调查研究报道,高血压的发病率在0.8%~3.2%,而在肥胖学生中高血压发病率则〉10%。在大型的医疗保健系统门诊和小学儿童中进行的一项研究报道显示,正常体质量的儿童高血压总发病率为0.3%~0.9%,肥胖儿童为1.0%~9.2%。 | Parker ED Sinaiko AR Kharbanda EO Margolis KL Daley MF Trower NK Sherwood NE Greenspan LC Lo JC Magid DJ o'connor pj | 2016 | 中华高血压杂志2016，24，6： | 3 |
| 5 | Yin and Yang of mesenchymal stem cells and aplastic anemia显示文摘Acquired aplastic anemia(AA) is a bone marrow failure syndrome characterized by peripheral cytopenias and bone marrow hypoplasia. It is ultimately fatal without treatment, most commonly from infection or hemorrhage. Current treatments focus on suppressing immune-mediated destruction of bone marrow stem cells or replacing hematopoietic stem cells(HSCs) by transplantation. Our incomplete understanding of the pathogenesis of AA has limited development of targeted treatment options. Mesenchymal stem cells(MSCs) play a vital role in HSC proliferation; they also modulate immune responses and maintain an environment supportive of hematopoiesis. Some of the observed clinical manifestations of AA can be explained by mesenchymal dysfunction. MSC infusions have been shown to be safe and may offer new approaches for the treatment of this disorder. Indeed, infusions of MSCs may help suppress auto-reactive, T-cell mediated HSC destruction and help restore an environment that supports hematopoiesis. Small pilot studies using MSCs as monotherapy or as adjuncts to HSC transplantation have been attempted as treatments for AA. Here we review the current understanding of the pathogenesis of AA and the function of MSCs, and suggest that MSCs should be a target for further research and clinical trials in this disorder. | Larisa Broglie David Margolis Jeffrey A Medin | 2017 | World Journal of Stem Cells2017，9，12： | 3 |
| 6 | Hair shaft elongation,follicle growth,and spontaneous regression in long-term,gelatin sponge-supported histoculture of human scalp skin显示文摘 | Li L Margolis L B Paus R | 1992 | Proc Natl Acad Sci USA1992，89，18： | 2 |
| 7 | Skin toxicity determined in vitro by three- dimensional,native-state histoculture显示文摘 | Li L N Margolis L B Hoffman R M | 1991 | Proc Natl Acad Sci USA1991，88，： | 2 |
| 8 | Review of application of mass spectrometry for analyses of anterior eye proteome显示文摘Proteins have important functional roles in the body, which can be altered in disease states. The eye is a complex organ rich in proteins; in particular, the anterior eye is very sophisticated in function and is most commonly involved in ophthalmic diseases. Proteomics, the large scale study of proteins, has greatly impacted our knowledge and understanding of gene function in the post-genomic period. The most significant breakthrough in proteomics has been mass spectrometric identification of proteins, which extends analysis far beyond the mere display of proteins that classical techniques provide. Mass spectrometry functions as a 'mass analyzer' which simplifies the identification and quantification of proteins extracted from biological tissue. Mass spectrometric analysis of the anterior eye proteome provides a differential display for protein comparison of normal and diseased tissue. In this article wepresent the key proteomic findings in the recent literature related to the cornea, aqueous humor, trabecular meshwork, iris, ciliary body and lens. Through this we identified unique proteins specific to diseases related to the anterior eye. | Sherif Elsobky Ashley M Crane Michael Margolis Teresia A Carreon Sanjoy K Bhattacharya | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 9 | Robust relativism显示文摘 | Margolis Joseph | 1976 | Journal of Aesthetics and Art Criticism1976，，35： | 1 |
| 10 | The spinocerebellar ataxias: order emerges from chaos显示文摘 | Margolis RL | 2002 | Curr Neurol Neurosci Rep2002，2，： | 1 |
| 11 | Resistance of Streptococcus pneumoniae to deformylase inhibitor is due to mutations in defB显示文摘 | Margolis P Hackbarch C Trias J | 2001 | Antimicrob Agents Chemother2001，45，9： | 1 |
| 12 | Composition of human plaque fluid显示文摘 | MORENO E C MARGOLIS H C | 1988 | J Dent Res1988，67，9： | 1 |
| 13 | Videoassisted Thoracic Surgery Lohectomy for Stage I Lung Cancer Ann显示文摘 | Farid Gharagozloo Barbara Tempesta Marc Margolis | 2003 | Thorac Surg2003，76，4： | 1 |
| 14 | Multifequency tympanometry:current clinical application显示文摘 | Hunter LL Margolis RH | 1992 | Am J Audiol1992，1，： | 1 |
| 15 | Tympanometry in newborn infants 1 kHz norms显示文摘 | MARGOLIS R H BASS-RINGDAHL S HANKS W D | 2003 | J Am Acad Audiol2003，14，： | 1 |
| 16 | Impact of pul- monary artery pressure on exercise function in severe COPD显示文摘 | Sims MW Margolis DJ Loealio AR | 2009 | Chest2009，136，2： | 1 |
| 17 | Effect of calcium and vitamin D supplementation on blood pressure:the Women's Health Initiative RandomizedTrial显示文摘 | Margolis KL Ray RM Van Horn L | | 0，，5： | 1 |
| 18 | Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines ( 2nd edition ) 显示文摘 | Silvestri GA Gould MK Margolis ML | 2007 | Chest2007，132，3： | 1 |
| 19 | Safe minimum standards in dynamic resource problems:conditions for living on the edge of risk显示文摘 | MARGOLIS M N VDAL E | 2008 | Environmental&resource economics2008，40，3： | 1 |
| 20 | Peripar tun, changes in the bovine placenta related to fetal membrane retention显示文摘 | Williams W F Margolis M J Manspeaker J E etal | 1987 | Theriogenology1987，，28： | 1 |
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