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| 1 | 极高强度他汀治疗对冠状动脉粥样硬化消退的影响——ASTEROID试验显示文摘背景:以前的血管内超声(intravascular ultrasound,IVUS)试验证实,他汀治疗可减缓或阻止动脉粥样硬化的进展,但是迄今尚无应用动脉粥样斑块体积百分比(percent atheroma volume,PAV)证实粥样硬化消退的确切证据。PAV是最严格的评价病变进展和消退的IVUS测量指标。
目标:评价极高强度他汀治疗是否能逆转IVUS确定的冠状动脉粥样硬化。
设计和地点:于美国、加拿大、欧洲和澳大利亚53个社区和3级保健中心进行前瞻性开标盲法终点试验(A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden,ASTEROID)。应用马达驱动回撤IVUS评价基线和治疗24个月时冠状动脉粥样斑块负荷。每对基线和随访IVUS测量结果均进行盲法分析。
病例:从2002年11月到2003年10月,507例患者有基线IVUS检查结果,并接受至少1个剂量的研究药物。在24个月后,349例患者具有可用于评估的系列IVUS检查结果。
干预:所有患者均接受瑞舒伐他汀40ms/d强化治疗。
主要观测指标:预先设定了两个一级疗效指标:PAV变化和基线最严重病变10min节段动脉粥样斑块体积变化。二级疗效指标为整个动脉标准化总斑块体积的变化。结果:平均(SD)LDL—C水平由基线时的130.4(34.3)ms/dL降至60.8(20.0)ms/扎,平均下降了53.2%(P〈0.001)。平均(SD)HDL-C水平从基线时的43.1(11.1)ms/dL升至49.0(12.6)ms/dL,平均增加了14.7%(P〈0.001)。整个血管PAV平均(SD)变化为-0.98%(3.15%),中位数为-0.79%(97.5%CI,-1.21%~-0.53%)(与基线比较,P〈0.001)。最严重病变10min节段斑块体积平均(SD)变化为-6.1(10.1)mm^3,中位数为-5.6mm^3(97.5%CI,-6.8~-4.0mm^3)(与基线比较,P〈0.001)。总斑块体积变化中位数降低了6.8%,平均减少了-14.7(25.7)mm^3,中位数为-12.5mm^3(95%CI,-15.1~-10.5mm^3)(与基线比较,P〈0.001)。不良事件少见,与其他他汀试验相似。
结论:应用瑞舒伐他汀40ms/d进行极高强度他汀治疗可使LDL-C平均水平达到60.8ms/dL,使HDL—C增加14.7%。这导致所有3个预先设定的IVUS斑块负荷指标均显示动脉粥样硬化消退。因此,将LDL-C降至低于目前指南规定的水平,同时显著提高HDL-C,可以使冠心病患者动脉粥样硬化斑块消退。这些变化对临床预后的影响尚需进一步研究确定。 | Steven E. Nissen Stephen J. Nicholls Ilks Sipahi Peter Libby Joel S. Raichlen Christie M. Ballantyne Jean Davignon Raimund Erbel Jean Charles Fruchart Jean-Claude Tardif Paul Schoenhagen Tim Crowe Valerie Cain Kathy Wolski Marlene Coormastic E. Murat Tuzcu 仝其广(译) 王淑敏(译) 胡大一(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 341 |
| 2 | 冠状动脉血流储备的经胸多普勒超声心动图与冠状动脉内多普勒血流测量的对照研究显示文摘目的 ①探讨经胸声学造影二次谐波多普勒超声心动图 (TTDE)探测冠状动脉左前降支(LAD)远端血流的可行性 ;②与冠状动脉内多普勒 (ICD)相对照 ,分析研究LAD冠状动脉血流储备(CFR)。方法 利用TTDE连续检测 110例患者LAD血流。冠状动脉血流速度储备 (CFVR)为注射腺苷后的最大平均血流速度与静息状态平均血流速度的比值。结果 CFVR探测的成功率为 96%。TTDE所探测的CFVR(2 .83± 0 .68)与ICD所探测的结果 (2 .91± 0 .74)密切相关 (r =0 .83 ,Y =0 .76X + 0 .61,P <0 .0 0 1)。结论 TTDE结合声学造影及二次谐波技术是一项可行、可信的无创性探测CFVR的方法 ,可用于冠状动脉病变的探测及冠脉介入治疗的随访。 | 杨娅 Thomas Bartel 王新房 Raimund Erbel | 2002 | 中华超声影像学杂志2002，11，6： | 23 |
| 3 | HPLC-ICP-MS快速、准确测定鱼肉组织中的砷甜菜碱(AsB)显示文摘采用高效液相色谱与电感耦合等离子体质谱法联用测定鱼肉样品中的砷甜菜碱,样品前处理采用快速溶剂萃取,分析方法快速、准确。通过测定鱼肉中砷甜菜碱的标准参考物质以及在欧洲实验室间对盲样进行比对实验,进一步验证了该方法的有效性。采用等度洗脱一次可分离分析多达6种不同形态的砷,仅需10分钟。通过优化方法,最大程度地简化了费时的样品前处理步骤并实现了对大批量样品进行自动萃取与分析。该实验分别比较了标准加入法与外标法的测定结果,结果显示两者并无显著差异,表明HPLC_ICP_MS法受基体影响极小。萃取过程中可自动处理多达24个样品,所建立的HPLC_ICP_MS分析方法稳定、可靠,能连续进样50针以上,相当于总运行时间在12小时以上。因此,该方法适用于毒物甄别研究中快速、准确地判断砷总含量较高的鱼肉样品中无毒砷甜菜碱的比例。 | Raimund Wahlen | 2004 | 中国环境监测2004，20，6： | 16 |
| 4 | 新型无创性冠状动脉血流储备检测经胸壁声学造影二次谐波多普勒技术显示文摘目的 研究经胸壁声学造影二次谐波多普勒超声心动图探测左前降支 (LAD)冠状动脉血流储备 (CFVR)的可行性、安全性及可靠性。方法 46例患者经静脉注射利声显 ,利用二次谐波观察LAD血流 ,对多普勒血流图像质量进行分级。CFVR为注射腺苷后的最大平均血流速度与静息状态平均血流速度的比值。结果 CFVR探测的成功率为 98%。注射腺苷后 ,心率加快 ,血压减低。60 %患者有轻微副反应。CFVR为 2 84± 0 65 ,与冠状动脉内多普勒探测的结果密切相关 (r=0 87,P <0 0 0 1 )。结论 经胸壁声学造影二次谐波多普勒超声心动图可明显提高冠状动脉血流探测的成功率 ,是安全、可行。 | 杨娅 王新房 Thomas Bartel Holger Eggebrecht Loredana Latina Raimund Erbel | 2003 | 中华心血管病杂志2003，31，2： | 11 |
| 5 | 冠状动脉造影正常者冠状动脉血流储备的经胸多普勒超声研究显示文摘目的 研究经胸多普勒超声心动图 (TTDE)探测冠状动脉 (冠脉 )造影正常者左前降支(LAD)远端血流的准确性 ;与冠脉内超声 (IVUS)相对照 ,分析影响冠脉造影正常者冠脉血流储备 (CFVR)的病理因素。方法 利用TTDE检测 40例冠脉造影正常者的LAD血流。CFVR为注射腺苷后的最大平均血流速率与静息状态平均血流速率的比值。结果 37例患者成功地进行了CFVR的测量。TTDE所检测的CFVR与冠脉内多普勒 (ICD)所检测的结果密切相关 (Y =0 .65X +0 .92 ,r =0 .88,P <0 .0 0 0 1 )。合并高血压的患者CFVR减低。 34例患者行IVUS检查 ,1 7例LAD内有粥样硬化斑块形成。结论 TTDE是一项可行、可信的无创性检测CFVR的方法。冠脉造影正常者LAD内可有斑块形成 。 | 杨娅 Thomas Bartel 王新房 李治安 Raimund Erbel | 2003 | 中华超声影像学杂志2003，12，8： | 9 |
| 6 | Transjugular intrahepatic portosystemic shunt in liver transplant recipients显示文摘AIM:To evaluate the efficacy of transjugular intrahepatic portosystemic shunts (TIPSs) after liver transplantation (LT). METHODS: Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection (n=4), ductopenic rejection (n=5) or portal vein thrombosis (n=1) were included in this analysis. Eleven TIPSs (one patient underwent two TIPS procedures) were placed for management of therapy-refractory ascites (n=7), hydrothorax (n=2) or bleeding from colonic varices (n=1). The median time interval between LT and TIPS placement was 15 (4-158) mo. RESULTS: TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 (range 0.4-20) mo. The majority of patients died from sepsis with multiorgan failure.CONCLUSION: Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression. | Armin Finkenstedt Ivo W Graziadei Karin Nachbaur Werner Jaschke Walter Mark Raimund Margreiter Wolfgang Vogel | 2009 | World Journal of Gastroenterology2009，15，16： | 8 |
| 7 | Improvement of center segregation in high-carbon steel billets using soft reduction显示文摘Center segregation is the main reason for cup fracture of high-carbon wire rod during drawing. Therefore, to continuously produce cast billets with very low center segregation is an important objective. The soft reduction technology is considered to be an effective method to minimize center segregation. To elucidate the effect of soft reduction on the internal quality of high-carbon steel billets, soft reduction was applied with different solid fractions in the core area of billets in a laboratory casting machine. A coupled temperature/displacement finite element model was developed to calculate the solid fraction using the commercial software ABAQUS.Center segregation, center porosity, homogeneity of elements, and equiaxed crystal zone were obviously improved by applying soft reduction, especially when the solid fraction was less than 1.0. The optimal results were obtained when the solid fraction was approximately 0.9. | Wenjun Wang Xionggang Hu Linxin Ning Raimund Bülte Wolfgang Bleck | 2006 | Journal of University of Science and Technology Beijing2006，13，6： | 5 |
| 8 | Identification of syndrome X using intravascular ultrasound imaging and Doppler flow mapping显示文摘Background The purpose of this study was to assess the morphological changes and physiological function of coronary arteries in patients presenting with chest pain but having normal coronary angiograms, using intravascular ultrasound imaging (IVUS) and intracoronary Doppler (ICD) flow measurements, in order to elucidate the mechanism of syndrome X. Methods A total of 126 patients [67 males, 59 females, mean age (53.1±13.0) years] who experienced chest pain but had normal coronary angiograms were included in this study. ICD flow measurements of the left anterior descending coronary artery (LAD) were performed using a Cardiometrics FloMap Ⅱ system. Coronary flow velocity reserve (CFVR) was defined as the ratio of the average peak velocity during hyperemia to that at baseline, induced by an intracoronary bolus injection of 18 μg adenosine. A 3.2F or 2.9F 30 MHz mechanical rotating ultrasound catheter (CVIS, Boston Scientific) or a 3.0F 20MHz electronic ultrasound catheter (Endosonics) was used for IVUS. Results The mean CFVR value of the LAD was 2.71±0.74. Reduction of CFVR (<3.0) was found in 82 of 126 (65.1%) patients. IVUS images of the LAD were available for 109 patients. Plaque formation was detected in 76/109 (69.7%) patients. Based on the presence or absence of plaque formation as well as the reduction or non-reduction of CFVR, patients were divided into four groups: Group Ⅰ (n=10), normal IVUS findings and normal CFVR; Group Ⅱ (n=23), normal IVUS findings with reduction in CFVR; Group Ⅲ (n=29), IVUS evidence of plaque formation but normal CFVR; and Group Ⅳ (n=47), IVUS evidence of plaque formation with reduction in CFVR. Conclusion This study shows the important clinical value of a combination of IVUS and ICD in diagnosing patients with angiographically normal coronary arteries. Only 10% of patients studied (Group Ⅰ) were found to be truly free of coronary disease, while 20% of patients (Group Ⅱ) would be diagnosed as suffering from syndrome X. | 钱菊英 葛均波 樊冰 王齐兵 陈灏珠 Dietrich Baumgart Michael Haude Raimund Erbel | 2004 | Chinese Medical Journal2004，，4： | 4 |
| 9 | 神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐显示文摘目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。 | Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti Pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-Martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon Jean-Francois Payen Anders Perner Martin Smith Jose Suarez Walter Videtta Elisa R. Zanier Giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) | 2019 | 国际脑血管病杂志2019，27，2： | 4 |
| 10 | Assessment of Coronary Flow Velocity Reserve by Noninvasive Transthoracic Doppler Echocardiography in Patients with Angiographically Normal Coronary Arteries显示文摘The measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE) with invasive intracoronary Doppler flow wire technique (ICD) was validated and the pathological factors which influence CFVR in patients with angiographically normal coronary arteries were analyzed. CFVR was determined successfully in left anterior descending artery (LAD) in 37 of 40 patients with angiographically normal coronary arteries (men 22, women 15, age 20-75 years, mean age 54±12 years). Coronary flow velocity was measured in the distal LAD by TTDE with contrast enhancement at baseline and during intravenous adenosine infusion of 140 μg/kg per min within 48 h after ICD technique. Average peak velocity at baseline (APVb), average peak velocity during hyperemia (APVh) and CFVR determined from TTDE were correlated closely with those from ICD measurements (APVb: y=0.64x+5.04, r=0.86, P<0.001; APVh: y=0.63x+14.36, r=0.82, P<0.001; CFVR: y=0.65x+0.92, r=0.88, P<0.001). For CFVR measurements, the mean differences between TTDE and ICD methods were 0.12± 0.39. CFVR in patients with history of hypertension was significantly lower than that in patients without history of hypertension (P<0.05). Intravascular ultrasound (IVUS ) was performed in 34 patients. Plaque formation was found in LAD by IVUS in 17 (50 %) patients. No significant difference in CFVR was found between the patients without plaque formation (3.11±0.49) and those with plaque formation (2.76±0.53, P=0.056). It is suggested that TTDE with contrast enhancement provides reliable measurement of APV and CFVR in the distal LAD. The early stage of atherosclerosis could be detected by IVUS, which may be normal in angiography. CFVR is impaired in patients with history of hypertension compared with that in patients without history of hypertension. | 杨娅 Thomas BARTEL 李治安 Raimund ERBEL | 2005 | Journal of Huazhong University of Science and Technology(Medical Sciences)2005，25，5： | 3 |
| 11 | Accuracy of myocardial viability imaging by cardiac MRI and PET depending on left ventricular function显示文摘AIM To compare myocardial viability assessment accuracy of cardiac magnetic resonance imaging(CMR)compared to[^(18)F]-fluorodeoxyglucose(FDG)-positron emission tomography(PET)depending on left ventricular(LV)function.METHODS One-hundred-five patients with known obstructive coronary artery disease(CAD)and anticipated coronary revascularization were included in the study and examined by CMR on a 1.5T scanner.The CMR protocol consisted of cine-sequences for function analysis and late gadolinium enhancement(LGE)imaging for viability assessment in 8 mm long and contiguous short axis slices.All patients underwent PET using[^(18)F]-FDG.Myocardial scars were rated in both CMR and PET on a segmental basis by a 4-point-scale:Score 1=no LGE,normal FDG-uptake;score 2=LGE enhancement<50% of wall thickness,reduced FDG-uptake(≥50% of maximum);score 3=LGE≥50% ,reduced FDG-uptake(<50% of maximum);score 4=transmural LGE,no FDG-uptake.Segments with score 1 and 2 were categorized'viable',scores 3 and 4 were categorized as'non-viable'.Patients were divided into three groups based on LV function as determined by CMR:Ejection fraction(EF),<30% :n=45;EF:30% -50% :n=44;EF>50% :n=16).On a segmental basis,the accuracy of CMR in detecting myocardial scar was compared to PET in the total collective and in the three different patient groups.RESULTS CMR and PET data of all 105 patients were sufficient for evaluation and 5508 segments were compared in total.In all patients,CMR detected significantly more scars(score 2-4)than PET:45% vs 40% of all segments(P<0.0001).In the different LV function groups,CMR found more scar segments than PET in subjects with EF<30% (55% vs 46% ;P<0.0001)and EF 30% -50% (44% vs 40% ;P<0.005).However,CMR revealed less scars than PET in patients with EF>50% (15% vs 23% ;P<0.0001).In terms of functional improvement estimation,i.e.,expected improvement after revascularization,CMR identified'viable'segments(score 1 and 2)in 72% of segments across all groups,PET in 80% (P<0.0001).Also in all LV function subgroups,CMR judged less segments viable than PET:EF<30% ,66% vs 75% ;EF=30% -50% ,72% vs 80% ;EF>50% ,91% vs 94% .CONCLUSION CMR and PET reveal different diagnostic accuracy in myocardial viability assessment depending on LV function state.CMR,in general,is less optimistic in functional recovery prediction. | Peter Hunold Heinz Jakob Raimund Erbel Jorg Barkhausen Christina Heilmaier | 2018 | World Journal of Cardiology2018，10，9： | 3 |
| 12 | 冠脉造影正常者的冠脉血流储备分析:经胸多普勒冠脉血流显像与冠脉内超声和多普勒的对照分析显示文摘目的 经胸多普勒超声心动图与冠状动脉内超声 (IVUS)相结合 ,探讨冠脉造影正常者的冠状动脉形态及血流动力学变化。方法 探测 47例冠脉造影正常者前降支 (LAD)IVUS及血流速度并计算冠脉血流储备 (CFVR)。结果 47例患者中 ,14例 (3 0 % )LAD内无斑块 ,CFVR正常 ;16例 (3 4% )无斑块 ,CFVR减低 ;9例 (19% )有斑块 ,CFVR正常 ;8例 (17% )有斑块 ,CFVR减低。结论 冠脉造影正常者中仅 3 0 %为真正的正常 ,其余患者冠脉内或有斑块形成和 /或CFVR受损。 | 杨娅 Thomas Bartel 李治安 Raimund Erbel | 2004 | 中国医学影像技术2004，20，9： | 3 |
| 13 | Protecting kidneys in liver transplant patients:A pathway to preventive interventions显示文摘Acute kidney injury(AKI) is a frequent postoperative complication after liver transplantation. The etiology is multifactorial,including perioperative renal status,surgery related events,and postoperative immunosuppression therapy. The role of renal hypoperfusion and hepatic ischemia-reperfusion injury as causes of early AKI are now being increasingly recognized. Further studies should focus on therapies that would attenuate this injury. | Lena Sibulesky Scott W Biggins Raimund Pichler | 2018 | World Journal of Hepatology2018，10，9： | 2 |
| 14 | Neopterin, a prognostic marker in human malignancies显示文摘 | Robert Sucher Katharina Schroecksnadel Guenter Weiss Raimund Margreiter Dietmar Fuchs Gerald Brandacher | 2009 | Cancer Letters2009，，1： | 2 |
| 15 | 成功联用HPLC-ICP-MS用于食品中的汞形态分析显示文摘汞是对生物体毒性最大的元素之一,因此对其进行可靠的定量分析极其重要。汞在环境中的浓度相对较低,但它可通过食物链放大.在某些食品中的最终浓度可能相当高。另外,其毒性与总浓度和化学形态息息相关.因此食品分析中的汞形态分析对于全面评估这一元素对人类的潜在毒性很有必要。Agilent 7700x ICP—MS可用于快速、简便的汞形态分析. | Sébastien Sannac Yu-Hong Chen Raimund Wahlen Ed McCurdy | 2012 | 食品安全导刊2012，，12： | 2 |
| 16 | NeoGemOx: Gemcitabine and oxaliplatin as neoadjuvant treatment for locally advanced, nonmetastasized pancreatic cancer显示文摘 | Klaus Sahora Irene Kuehrer Axel Eisenhut Belgin Akan Claus Koellblinger Peter Goetzinger Bela Teleky Raimund Jakesz Markus Peck-Radosavljevic Ahmed Ba’ssalamah Christoph Zielinski Michael Gnant | 2011 | Surgery2011，，3： | 2 |
| 17 | Complete reversal of paraplegia after thoracic endovascular aortic repair in a patient with complicated acute aortic dissection using immediate cerebrospinal fluid drainage显示文摘 | Holger Eggebrecht Dirk B?se Thomas Gasser Jaroslav Benedik Petra Mummel Oliver Müller Philipp Kahlert Konstantinos Tsagakis Heinz G. Jakob Raimund Erbel | 2009 | Clinical Research in Cardiology2009，，12： | 1 |
| 18 | Influence of Department Volume on Survival for Ovarian Cancer: Results From a Prospective Quality Assurance Program of the Austrian Association for Gynecologic Oncology显示文摘 | Christian Marth Sonja Hiebl Willi Oberaigner Raimund Winter Sepp Leodolter Paul Sevelda | 2009 | International Journal of Gynecological Cancer2009，，1： | 1 |
| 19 | Contralateral Breast Cancer: Molecular Differentiation Between Metastasis and Second Primary Cancer显示文摘 | Elisabeth Janschek Daniela Kandioler-Eckersberger Carmen Ludwig Sonja Kappel Brigitte Wolf Susanne Taucher Margaretha Rudas Michael Gnant Raimund Jakesz | 2001 | Breast Cancer Research and Treatment2001，，1： | 1 |
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