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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | The Origin and Evolution of Mutations in Acute Myeloid Leukemia显示文摘 | John S. Welch Timothy J. Ley Daniel C. Link Christopher A. Miller David E. Larson Daniel C. Koboldt Lukas D. Wartman Tamara L. Lamprecht Fulu Liu Jun Xia Cyriac Kandoth Robert S. Fulton Michael D. McLellan David J. Dooling John W. Wallis Ken Chen Christop | 2012 | Cell2012，，2： | 3 |
| 3 | The sensitivity method in finite element model updating: A tutorial显示文摘 | John E. Mottershead Michael Link Michael I. Friswell | 2010 | Mechanical Systems and Signal Processing2010，，7： | 2 |
| 4 | The Origin and Evolution of Mutations in Acute Myeloid Leukemia显示文摘 | John S. Welch Timothy J. Ley Daniel C. Link Christopher A. Miller David E. Larson Daniel C. Koboldt Lukas D. Wartman Tamara L. Lamprecht Fulu Liu Jun Xia Cyriac Kandoth Robert S. Fulton Michael D. McLellan David J. Dooling John W. Wallis Ken Chen Christop | 2012 | Cell2012，，2： | 1 |
| 5 | 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy显示文摘 | Bernard J. Gersh Barry J. Maron Robert O. Bonow Joseph A. Dearani Michael A. Fifer Mark S. Link Srihari S. Naidu Rick A. Nishimura Steve R. Ommen Harry Rakowski Christine E. Seidman Jeffrey A. Towbin James E. Udelson Clyde W. Yancy | 2011 | Journal of the American College of Cardiology2011，，25： | 1 |
| 6 | Antecedents and sex/gender differences in youth suicidal behavior显示文摘Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in males than females, while the converse is true for suicide attempts. We review this 'gender paradox' in youth, and in particular, the age-dependency of these sex/gender differences and the developmental mechanisms that may explain them. Epidemiologic, genetic,neurodevelopmental and psychopathological research have identified suicidal behaviour risks arising from genetic vulnerabilities and sex/gender differences in early adverse environments, neurodevelopment, mental disorder and their complex interconnections. Further, evolving sex-/gender-defined social expectations and norms have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conforming to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the importance of interventions that alter early environment(s)(e.g., childhood maltreatment) and/or one's ability to adapt to them. Further, such interventions may have more enduring protective effects, for the individual and for future generations, if implemented in youth. | Anne E Rhodes Michael H Boyle Jeffrey A Bridge Mark Sinyor Paul S Links Lil Tonmyr Robin Skinner Jennifer M Bethell Corine Carlisle Sarah Goodday Travis Salway Hottes Amanda Newton Kathryn Bennett Purnima Sundar Amy H Cheung Peter Szatmari | 2014 | World Journal of Psychiatry2014，4，4： | 1 |
| 7 | EU COST Action 628:life cycle assessment (LCA) of textile products,eco-efficiency and definition of beet awilahle technology (BAT) of textile processing显示文摘 | EIJA Nieminen MICHAEL Linke MARION Tobler | 2007 | Journal of Cleaner Production2007，15，1314： | 1 |
| 8 | Chinese enterprises in Germany: Establishment modes and strategies to mitigate the liability of foreignness显示文摘 | Andreas Klossek Bernd Michael Linke Michael Nippa | 2010 | Journal of World Business2010，，1： | 1 |
| 9 | Quantification of lower leg arterial calcifications by high-resolution peripheral quantitative computed tomography显示文摘 | Janina M. Patsch Martin A. Zulliger Nicolas Vilayphou Elizabeth J. Samelson Daniel Cejka Danielle Diarra Gundula Berzaczy Andrew J. Burghardt Thomas M. Link Michael Weber Christian Loewe | 2014 | Bone2014，，： | 1 |
| 10 | Five months’ follow-up of patients with and without iodine-positive lymph node metastases of thyroid carcinoma as disclosed by 131 I-SPECT/CT at the first radioablation显示文摘 | Daniela Schmidt Rainer Linke Michael Uder Torsten Kuwert | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，： | 1 |
| 11 | EU COST Action 628 : life cycle assessment (LCA) of textile products, ecoefficiency and definition of best available technology (BAT) of textile processing 显示文摘 | Eija Nieminen Michael Linke Marion Tobler | 2007 | Journal of Cleaner Production2007，15，1314： | 1 |
| 12 | Microbial community analysis of a biogas-preducing completely stirred tank reactor fed con- tinuously with fodder beet silage as mono-substrate 显示文摘 | Michael Klockea Pia Mahnert Kerstin Mundt Khadidja Souidi Bemd Linke | 2007 | Systematic and Applied Microbiology2007，30，2： | 1 |
| 13 | 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Executive Summary显示文摘 | Bernard J. Gersh Barry J. Maron Robert O. Bonow Joseph A. Dearani Michael A. Fifer Mark S. Link Srihari S. Naidu Rick A. Nishimura Steve R. Ommen Harry Rakowski Christine E. Seidman Jeffrey A. Towbin James E. Udelson Clyde W. Yancy | 2011 | Journal of the American College of Cardiology2011，，25： | 1 |
| 14 | Part 8: Adult Advanced Cardiovascular Life Support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care显示文摘 | Robert W. Neumar Charles W. Otto Mark S. Link Steven L. Kronick Michael Shuster Clifton W. Callaway Peter J. Kudenchuk Joseph P. Ornato Bryan McNally Scott M. Silvers Rod S. Passman Roger D. White Erik P. Hess Wanchun Tang Daniel Davis Elizabeth Sinz Laur | 2010 | Circulation ( Suppl )2010，，18： | 1 |
| 15 | The sensitivity method in finite model updating:A tutorial 显示文摘 | John E Mottershead Michael Link Michael I Friswell | 2011 | Mechanical systems and signal processing2011，25，： | 1 |
| 16 | Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response显示文摘 | Sue A. Theus A.George Smulian Paul Steele Michael J. Linke Peter D. Walzer | 1998 | Vaccine1998，，11： | 1 |
| 17 | Mechanical Comparison in Cadaver Specimens of Three Different 90-Degree Double-Plate Osteosyntheses for Simulated C2-Type Distal Humerus Fractures With Varying Bone Densities显示文摘 | Ivo Schuster Jan Korner Michael Arzdorf Karsten Schwieger Gerd Diederichs Berend Linke | 2008 | Journal of Orthopaedic Trauma2008，，2： | 1 |
| 18 | 2012 ACCF/AHA/HRS Focused Update of the 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities显示文摘 | Cynthia M. Tracy Andrew E. Epstein Dawood Darbar John P. DiMarco Sandra B. Dunbar N.A. Mark Estes T. Bruce Ferguson Stephen C. Hammill Pamela E. Karasik Mark S. Link Joseph E. Marine Mark H. Schoenfeld Amit J. Shanker Michael J. Silka Lynne Warner Stevens | 2012 | Journal of the American College of Cardiology2012，，14： | 1 |
| 19 | A new data fusion model for high spatial- and temporal-resolution mapping of forest disturbance based on Landsat and MODIS显示文摘 | Thomas Hilker Michael A. Wulder Nicholas C. Coops Julia Linke Greg McDermid Jeffrey G. Masek Feng Gao Joanne C. White | 2009 | Remote Sensing of Environment2009，，8： | 1 |
| 20 | Practice Patterns and Outcomes of Retrievable Vena Cava Filters in Trauma Patients: An AAST Multicenter Study显示文摘 | Riyad Karmy-Jones Gregory J. Jurkovich George C. Velmahos Thomas Burdick Konstantinos Spaniolas Samuel R. Todd Michael McNally Robert C. Jacoby Daniel Link Randy J. Janczyk Felicia A. Ivascu Michael McCann Farouck Obeid William S. Hoff Nathaniel McQuay Br | 2007 | The Journal of Trauma: Injury Infection and Critical Care2007，，1： | 1 |
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