|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Radon in indoor spaces 显示文摘 | Schmid K Kuwert T DreMer H | 2010 | Dtseh Arztebl Int2010，7，11： | 1 |
| 2 | A review on the clinical uses of SPECT/CT显示文摘 | Mariani G Bruselli L Kuwert T | 2010 | Eur J Nucl Med Mol Imaging2010，37，10： | 1 |
| 3 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 4 | A review on the clinical uses of SPECT/CT显示文摘 | Mariani G Bruselli L Kuwert T | 2010 | European Journal Nuclear Medicine & Molecular Imaging2010，37，10： | 1 |
| 5 | Radon in indoors spaces显示文摘 | Schmid K Kuwert T DreMer H | 2010 | Dtseh Arztebl Int2010，7，11： | 1 |
| 6 | Impact of ^sup 131^I SPECT/Spiral CT on Nodal Staging of Differentiated Thyroid Carcinoma at the First Radioablation显示文摘 | Schmidt Daniela Szikszai Attila Linke Rainer Bautz Werner Kuwert Torsten | 2009 | The Journal of Nuclear Medicine2009，，： | 1 |
| 7 | The specifity of leukocyte antibodies in histocompatibility testing of serum from prim- and muhiparas 显示文摘 | BERTRAMS J KUWERT E LOHMEYER H H | 1971 | Bibl Haematol1971，37，： | 1 |
| 8 | Purification of rabies virus grown in tissue culture 显示文摘 | Sokol F Kuwert E Wiktor T J | 1968 | J Virol1968，2，8： | 1 |
| 9 | A review on the clinical uses of SPECT/CT显示文摘 | Mariani G Bruselli L Kuwert T | 2010 | Eur J Nucl Med Mol Imaging2010，37，： | 1 |
| 10 | Regional lymph node in- volvement in T papillary thyroid carcinoma: a bicentric prospec- tive SPECT/CT study显示文摘 | Mustafa M Kuwert T Weber K | 2012 | Eur J Nucl Med Mol Imaging2012，37，8： | 1 |
| 11 | A review on the clinical uses of SPECT-CT 显示文摘 | Mariani G Bruselli L Kuwert T | 2010 | Eur J Nucl Med Mol Imaging2010，37，10： | 1 |
| 12 | Five months’ follow-up of patients with and without iodine-positive lymph node metastases of thyroid carcinoma as disclosed by 131 I-SPECT/CT at the first radioablation显示文摘 | Daniela Schmidt Rainer Linke Michael Uder Torsten Kuwert | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，： | 1 |
| 13 | A review on the clinical uses of SPECT/CT显示文摘 | Marian G Bruselli L Kuwert T | 2010 | Eur J Nucl Med Mol Imaging2010，37，10： | 1 |
| 14 | A review on the clinical uses of SPECT/CT显示文摘 | Giuliano Mariani Laura Bruselli Torsten Kuwert Edmund E. Kim Albert Flotats Ora Israel Maurizio Dondi Naoyuki Watanabe | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，： | 1 |
| 15 | Regional lymph node involvement in T1 papillary thyroid carcinoma: a bicentric prospective SPECT/CT study显示文摘 | Mona Mustafa Torsten Kuwert Kathrin Weber Peter Knesewitsch Thomas Negele Alexander Haug Rainer Linke Peter Bartenstein Daniela Schmidt | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，： | 1 |
| 16 | Positron emission tomography with F-18-deoxyglucose in patients with differentiated thyroid carcinoma, elevated thyroglobulin levels, and negative iodine scans显示文摘 | G. Altenvoerde H. Lerch T. Kuwert P. Matheja M. Sch?fers O. Schober | 1998 | Langenbecks Archiv für Chirurgie1998，，2： | 1 |
| 17 | A review on the clinical uses of SPECT/CT显示文摘 | Mariani G Bmsdli L Kuwert T | 2010 | Eur J Nucl Med Mol Imaging2010，37，10： | 1 |
| 18 | A review on the clinical uses of SPECT/CT显示文摘 | Mariani G Bruselli L Kuwert T | | 0，，10： | 1 |
| 19 | 131I SPECT/CT in the Follow-Up of Patients With Differentiated Thyroid Carcinoma显示文摘 | Mareen Menges Michael Uder Torsten Kuwert Daniela Schmidt | 2012 | Clinical Nuclear Medicine2012，，： | 1 |
| 20 | A review on the clinical uses of SPECT/显示文摘 | Mariani G Brusdli L Kuwert T | 2010 | Eur J Nucl IVied 1Vbl Imaging2010，37，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员