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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Neurophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism显示文摘 | Zhou FQ Walzer M Wu YH | 2006 | J Cell Science2006，119，13： | 1 |
| 3 | Neuropsychological and psychopathologic changes following cardiac procedures显示文摘 | Walzer TA Herrmann M | 1998 | Fortschr Neurol Psychiatr1998，66，2： | 1 |
| 4 | Interaction of pneumocystis carinii with host lungs : an ultrastrnctural study 显示文摘 | Yoneda K Walzer PD | 1980 | Infect Immun1980，29，2： | 1 |
| 5 | Disilanylenearylene oligomers and polymers from dehydropolymerization of 1,4 - RH2SiCsH&iH2R (R = Methyl, Ethyl, and Hexyl) 显示文摘 | IMORI T WOO H G WALZER J F | 1993 | Chem Mater1993，5，： | 1 |
| 6 | Insulin glargine added to them- py with oral antidiabetic agents improves glycemic control and reduces long - term complications in patients with type 2 diabetes - a simulation with the Diabetes Mellitus Model (DMM) 显示文摘 | Janka HU Hessel F Walzer S | 2007 | Int J Clin Phannacol Ther2007，45，12： | 1 |
| 7 | Growth characteristics and pathogenesis of experimental Pneumocystis carinii pneumonia显示文摘 | Walzer PD Powell RD | 1980 | Infect Immun1980，27，： | 1 |
| 8 | Pneurnocystis pneumonia associated with human immunodeficiency virus 显示文摘 | Miller RF Huang L Walzer PD | 2013 | Clin Chest Med2013，34，2： | 1 |
| 9 | Experimental pneumocystis carinii pneumonia in different strains of cortisonized mice显示文摘 | Walzer P D Powell R D Jr Yoneda K | 1979 | Infect Immtm1979，24，： | 1 |
| 10 | STM and STS investigation ofultrathin tin phthalocyanine layers adsorbed on HOPG(0001 ) and Au (111) 显示文摘 | Walzer K Hietschold M | 2001 | Surface Science2001，471，： | 1 |
| 11 | Edueation, Democratic Citizenship and Multiculturalism显示文摘 | Walzer | 1995 | Journal of Philosophy1995，，2： | 1 |
| 12 | Natural-killer cells and dendritic ceils: I'union fait la force 显示文摘 | Walzer T Dalod M Robbins SH | 2005 | Blood2005，106，： | 1 |
| 13 | Pneumocystis carinii pneumonia in the United States:epidemiologic, clinical and diagnosis features 显示文摘 | Perl D P Krogstad D J | 1974 | Ann Intern Med1974，80，： | 1 |
| 14 | Partial antagonism of tiletamine-zolaze pam in cheetah显示文摘 | Walzer C Huber C | 2002 | Journal of Wildlife Diseases2002，38，2： | 1 |
| 15 | Thermolysin treatment: a new method for dermo-epidermal separation显示文摘 | Benathan M Frenk E | 1989 | J Invest Dermatol1989，92，1： | 1 |
| 16 | Identification,activation, and selective in vivo ablation of mouse NKcells via NKp46 显示文摘 | Walzer T Blery M Chaix J | 2007 | Proc Natl Acad Sci USA2007，104，9： | 1 |
| 17 | Cellular response to a 55-kilodalton recombinant Pneumocystis carinii antigen显示文摘 | Theus SA Sullivan DW Walzer PD | 1994 | Infect I mmun1994，62，： | 1 |
| 18 | Dendritic cell function in mice lacking Plexin C1显示文摘 | Walzer T Galibert L De Smedt T | 2005 | Int Immunol2005，17，7： | 1 |
| 19 | New alterations of serum glycoproteins in alcoholic and cirrhotic patients revealed by high resolution two-dimensional gel electrophoresis显示文摘 | GRAVEL P WALZER C AUBRY C | 1996 | Biochem Biophys Res Commun1996，220，1： | 1 |
| 20 | Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration显示文摘 | Walzer T Galibert L Comeau M R | 2005 | J Immunol2005，174，1： | 1 |
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