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| 1 | Educated consumers don't believe artificial meat is the solution to the problems with the meat industry显示文摘The production of in vitro meat by cell culture has been suggested by some scientists as one solution to address the major challenges facing our society. Firstly, consumers would like the meat industry to reduce potential discomfort of animals on modern farms, or even to avoid killing animals to eat them. Secondly, citizens would like meat producers to reduce potential environmental deterioration by livestock and finally, there is a need to reduce world hunger by increasing protein resources while the global population is predicted to grow rapidly. According to its promoters, artificial meat has a potential to make eating animals unnecessary, to reduce carbon footprint of meat production and to satisfy all the nutritional needs and desires of consumers and citizens. To check these assumptions, a total of 817 educated people(mainly scientists and students) were interviewed worldwide by internet in addition to 865 French educated people. We also interviewed 208 persons(mainly scientists) after an oral presentation regarding artificial meat. Results of the three surveys were similar, but differed between males and females. More than half of the respondents believed that 'artificial meat' was feasible and realistic. However, there was no majority to think that artificial meat will be healthy and tasty, except respondents who were in favour of artificial meat. A large majority of the respondents believed that the meat industry is facing important problems related to the protection of the environment, animal welfare or inefficient meat production to feed humanity. However, respondents did not believe that artificial meat will be the solution to solve the mentioned problems with the meat industry, especially respondents who were against artificial meat. The vast majority of consumers wished to continue to eat meat even they would accept to consume less meat in a context of increasing food needs. Only a minority of respondents(from 5 to 11%) would recommend or accept to eat in vitro meat instead of meat produced from farm animals. Despite these limitations, 38 to 47% of the respondents would continue to support research on artificial meat, but a majority of them believed that artificial meat will not be accepted by consumers in the future, except for respondents who were in favour of artificial meat. We speculated that the apparent contradictory answers to this survey expressed the fact that people trust scientists whoare supposed to continuously discover new technologies potentially useful in a long term future for the human beings, but people also expressed concern for their health and were not convinced that artificial meat will be tasty, safe and healthy enough to be accepted by consumers. | Aurélie Hocquette Carla Lambert Clémentine Sinquin Laure Peterolff Zoé Wagner Sarah P F Bonny André Lebert Jean-Franois Hocquette | 2015 | Journal of Integrative Agriculture2015，14，2： | 11 |
| 2 | ABA-Mediated Inhibition of Germination Is Related to the Inhibition of Genes Encoding Cell-Wall Biosynthetic and Architecture: Modifying Enzymes and Structural Proteins in Medicago truncatula Embryo Axis显示文摘胚根出现和储备动员是被认为控制萌芽的二个不同计划。两个节目被 abscissic 酸(骆驼毛的织物) 影响,但是这荷尔蒙怎么控制种子萌芽,仍然糟糕被知道。Phenotypic 和 Medicago truncatula 的胚胎轴的显微镜的观察在 10 在处于有丝分裂的抑制状况的萌芽期间被触发 ? M oryzalin 证明房间分割没被要求允许胚根出现。镇压减少性的杂交证明在胚胎轴的超过 10% 起来调整的基因编码了与房间墙生合成有关的蛋白质。-expansins, pectin-esterase, xylogucan-endotransglycosidase,纤维素 synthase,和 extensins 的表示在种子的胚胎轴被监视在水上发芽了,经常、临时的骆驼毛的织物。在在控制并且强烈的萌芽的结束由骆驼毛的织物禁止了以前,这些基因是 overexpressed。在种子回来在水上被转移并且继续了到萌芽以后,表示在临时处理的 ABA 被重建。这作为贡献者证明这些基因到萌芽的结束并且加强在胚胎轴在与房间扩大的关系松开并且改变的房间墙是在萌芽的一个决定因素特征的想法。我们的结果也证明那件骆驼毛的织物通过胚根出现的控制控制萌芽,也就是由禁止房间墙松开和扩大。 | Christine Gimeno-Gilles Eric Lelievre Laure Viau Mustafa Malik-Ghulam Claudie Ricoult Andreas Niebel Nathalie Leduc Anis M. Limami | 2009 | Molecular Plant2009，2，1： | 8 |
| 3 | High tacrolimus intra-patient variability is associated with graft rejection,and de novo donor-specific antibodies occurrence after liver transplantation显示文摘AIM To investigate the role of tacrolimus intra-patient variability(IPV) in adult liver-transplant recipients.METHODS We retrospectively assessed tacrolimus variability in a cohort of liver-transplant recipients and analyzed its effect on the occurrence of graft rejection and de novo donor-specific antibodies(dn DSAs), as well as graft survival during the first 2 years posttransplantation. Between 02/08 and 06/2015, 116 patients that received tacrolimus plus mycophenolate mofetil(with or without steroids) were included. RESULTS Twenty-two patients(18.5%) experienced at least one acute-rejection episode(BPAR). Predictive factors for a BPAR were a tacrolimus IPV of > 35% [OR = 3.07 95%CI(1.14-8.24), P = 0.03] or > 40% [OR = 4.16(1.38-12.50), P = 0.01), and a tacrolimus trough level of < 5 ng/mL [OR=3.68(1.3-10.4), P =0.014]. Thirteen patients(11.2%) developed at least one dn DSA during the follow-up. Tacrolimus IPV [coded as a continuous variable: OR = 1.1, 95%CI(1.0-1.12), P = 0.006] of > 35% [OR = 4.83, 95%CI(1.39-16.72), P = 0.01] and > 40% [OR = 9.73, 95%CI(2.65-35.76), P = 0.001] were identified as predictors to detect dn DSAs. IPV did not impact on patient-or graft-survival rates during the follow-up. CONCLUSION Tacrolimus-IPV could be a useful tool to identify patients with a greater risk of graft rejection and of developing a de novo DSA after liver | Arnaud Del Bello Nicolas Congy-Jolivet Marie Danjoux Fabrice Muscari Laurence Lavayssière Laure Esposito Anne-Laure Hebral Julie Bellière Nassim Kamar | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 4 | Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation显示文摘Acute humoral rejection (AHR) is uncommon after ABO-compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specif ic antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. She was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Liver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. She was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Liver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy. | Nassim Kamar Laurence Lavayssière Fabrice Muscari Janick Selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 5 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 6 | High-Resolution Crystal Structure and Redox Properties of Chloroplastic Triosephosphate Isomerase from Chlamydomonas reinhardtii显示文摘Triosephosphate isomerase (TPI ) 催化 glyceraldehyde-3-phosphate 的互变现象到 dihydroxyacetone 磷酸盐。光合的有机体通常包含位于细胞质和叶绿体的 TPI 的二 isoforms。当细胞质的 TPI 涉及 glycolysis 时, chloroplastic isoform 参予 CalvinBenson 周期,为碳固定负责的一个关键光合的过程。与它的细胞质的对应物相比, chloroplastic TPI 的功能的特征糟糕被调查了,它的三维的结构没被解决。最近,几研究包括 dithiol/disulfide 交换, glutathionylation,和 nitrosylation 作为不同氧化还原作用修正的一个潜在的目标建议了 TPI。然而,在蛋白质活动的既不效果也不位于这些氧化还原作用修正下面的分子的机制被调查了。这里,我们 recombinantly 生产了并且从单细胞的绿水藻 Chlamydomonas reinhardtii (Cr ) 净化了 TPI。酶的生物化学的性质被描出,它的结晶的结构在 1.1 的一个决定是坚定的 ? 。CrTPI 是有包含典型(/)8 桶褶层的子单元的 homodimer。尽管为 TRX 规定的证据都没被获得, CrTPI 被发现由 nitrosoglutathione 由氧化谷胱甘肽和 trans-nitrosylation 经历 glutathionylation,证实它到多重氧化还原作用修正的敏感。 | Mirko Zaffagnini Laure Michelet Chiara Sciabolini Nastasia Di Giacinto Samuel Morisse Christophe H. Marchand Paolo Trost Simona Fermani Stephane D Lemaire | 2014 | Molecular Plant2014，7，1： | 4 |
| 7 | Quality of life, physical performance and nutritional status in older patients hospitalized in a cardiology department显示文摘Objectives Quality of life(QoL) is a priority outcome in older adults suffering from cardiovascular diseases. Frailty and poor nutritional status may affect the QoL through mobility disorders and exhaustion. The objective of this study was to determine if physical frailty and nutritional status were associated with QoL, in older cardiology patients. Methods Cross sectional, observational study conducted in a cardiology department from a university hospital. Participants(n = 100) were aged 70 and older. Collected data included age, sex, cardiac diseases, New York Heart Association(NYHA) classification, comorbidities(Charlson Index) and disability. A Short Physical Performance Battery(SPPB), including walking speed assessment was performed;handgrip strength were measured as well as Fried’s frailty phenotype. Nutritional status was assessed using the Mini Nutritional Assessment(MNA) and Body Mass Index(BMI), inflammation by C-reactive protein(CRP). QoL was assessed using the EORTC–QLQ questionnaire. Univariate and multivariate analyses were performed to study the associations between all recorded parameters and QoL. Results In participants(mean age: 79.3 ± 6.7 years;male: 59%), Charlson index, arrhythmia, heart failure, NYHA class III-IV, MNA, disability, walking speed, SPPB score, frailty and CRP were significantly associated with QoL in univariate analysis. Multivariate analysis showed that NYHA class III-IV(P < 0.001), lower MNA score(P = 0.03), frailty(P < 0.0001), and higher CRP(P < 0.001) were independently associated with decreased QoL. Conclusions Frailty, nutritional status and inflammation were independently associated with poor QoL. Further studies are needed to assess the efficacy of nutritional and physical interventions on QoL in this population. | Matthieu Lilamand Mariannick Saintout Marie Vigan Astrid Bichon Laure Tourame Aurélie Brembilla Diet Bernard Iung Dominique Himbert Cédric Laouenan Agathe Raynaud-Simon | 2020 | Journal of Geriatric Cardiology2020，17，7： | 3 |
| 8 | Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent显示文摘 | Laure S. Fournier Charles Andre Cuenod Cedric Bazelaire Nathalie Siauve Christophe Rosty Phuong Lan Tran Guy Frija Olivier Clement | 2004 | European Radiology2004，，11： | 3 |
| 9 | Salmonella enterica Flagellin Is Recognized via FLS2 and Activates PAMP-Triggered Immunity in Arabidopsis thaliana显示文摘有沙门氏菌 enterica 的感染属于食物中毒和感染的水果的最突出的原因,蔬菜代表重要向量 forsalmonellosis。最近的证据显示植物认出 S。enterica 和加薪防卫回答。尽管如此,控制 S 的相互作用的分子的机制。有植物的 enterica 大部分仍然是不清楚的。这里,我们从 S 显示出那 flagellin。enterica 在 Arabidopsis thaliana 代表一个突出的联系病原体的分子的模式(PAMP ) ,它由受体 kinase FLS2 经由 flg22 领域的识别导致被触发 PAMP 的免疫(PTI ) 。Arabidopsis fls2 异种表演不过减少了没废除的 PTI 激活,显示植物也依靠另外的 S 的识别。enterica PAMP。有趣地, S。enterica 类型 III 分泌物系统(T3SS ) 异种 prgH 在 Arabidopsis 比野类型的细菌导致了更强壮的防卫基因表示,建议 T3SS 受动器涉及防卫抑制。而且,我们观察那 S。enterica 紧张在 flg22 epitope 显示出变化,它与减少的导致 PTI 活动导致蛋白质。总的来说, theseresults 表演那 S。enterica 在 Arabidopsis 激活 PTI 并且建议那,以便完成植物殖民, S。enterica 发展了策略避免或压制 PTI.Key 词: | Ana Victoria Garcia Amelie Charrier Adam Schikora Jean Bigeard Stephanie Pateyron Marie-Ludivine de Tauzia-Moreau Alexandre Evrard Axel Mithofer Marie Laure Martin-Magniette Isabelle Virlogeux-Payant Heribert Hirt | 2014 | Molecular Plant2014，7，4： | 3 |
| 10 | Protic ionic liquids/poly(vinylidene fluoride) composite membranes for fuel cell application显示文摘Poly(vinylidene fluoride), PVDF, membranes have attracted considerable attention as polymer electrolytes for fuel cells. This study explores the effect of solvent on the spherulite size and the crystallinity of the polymeric membranes. Based on Hansen solubility parameters theory, the mixture of DMC and DMSO was selected among a dozen of solvents for the preparation of PVDF membranes by thermally induced phase separation. The addition of two protic ionic liquids(PILs), bis(2-ethyl hexyl) ammonium hydrogen phosphate [EHNH_2][H_2PO_4], and imidazolium hexanoate [Im][Hex] to PVDF membranes at concentrations(10% < wP IL< 50%) has been investigated by SEM, FTIR, DSC, TGA, EIS, and DMA. The inclusion of ionic liquids into the polymer matrix influences structural parameters(degree of crystallinity and electroactive phases), thermal stability, proton conductivity and mechanical properties of the membranes. The membranes become transparent regardless type of ionic liquid employed. A small amount of ionic liquids increases the degree of crystallinity and facilitates the production of polar β and γ crystals. The proton conductivity mechanism(Grotthuss) is dependent on the ionic liquid structure(due to its selforganization in water) and the content in the PVDF membrane, as well as the membrane water uptake.Different behavior has been observed for the two ionic liquids, which stresses the challenge on selecting an appropriate cation and anion combination. The obtained composite membranes exhibited excellent mechanical performance and reduced elastic modulus, with respect to the pure polymer matrix. These results indicate that PVDF/IL composite membranes have a high potential for PEMFC applications. | Isabel Vazquez-Fernandez Mohamed Raghibi Adnane Bouzina Laure Timperman Janick Bigarre Meriem Anouti | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 11 | Modelling Regional Land Change Scenarios to Assess Land Abandonment and Reforestation Dynamics in the Pyrenees(France)显示文摘Over the last decades and centuries,European mountain landscapes have experienced substantial transformations.Natural and anthropogenic LULC changes(land use and land cover changes), especially agro-pastoral activities,have directly influenced the spatial organization and composition of European mountain landscapes.For the past sixty years, natural reforestation has been occurring due to a decline in both agricultural production activities and rural population.Stakeholders, to better anticipate future changes,need spatially and temporally explicit models to identify areas at risk of land change and possible abandonment.This paper presents an integrated approach combining forecasting scenarios and a LULC changes simulation model to assess where LULC changes may occur in the Pyrenees Mountains,based on historical LULC trends and a range of future socio-economic drivers.The proposed methodologyconsiders local specificities of the Pyrenean valleys,sub-regional climate and topographical properties,and regional economic policies.Results indicate that some regions are projected to face strong abandonment, regardless of the scenario conditions.Overall, high rates of change are associated with administrative regions where land productivity is highly dependent on socio-economic drivers and climatic and environmental conditions limit intensive(agricultural and/or pastoral) production and profitability.The combination of the results for the four scenarios allows assessments of where encroachment(e.g.colonization by shrublands) and reforestation are the most probable.This assessment intends to provide insight into the potential future development of the Pyrenees to help identify areas that are the most sensitive to change and to guide decision makers to help their management decisions. | Laure A.VACQUIE Thomas HOUET Terry L.SOHL Ryan REKER Kristi L.SAYLER | 2015 | Journal of Mountain Science2015，12，4： | 3 |
| 12 | Geochemical constraints on the origin and tectonic setting of the serpentinized peridotites from the Paleoproterozoic Nyong series,Eseka area,SW Cameroon显示文摘Serpentinized rocks closely associated with Paleoproterozoic eclogitic metabasites were recently discovered at Eseka area in the northwestern edge of the Congo craton in southern Cameroon.Here,we present new field data,petrography,and first comprehensible wholerock geochemistry data and discuss the protolith and tectonic significance of these serpentinites in the region.The studied rock samples are characterized by pseudomorphic textures,including mesh microstructure formed by serpentine intergrowths with cores of olivine,bastites after pyroxene.Antigorite constitutes almost the whole bulk of the rocks and is associated(to the less amount)with tremolite,talc,spinel,and magnetite.Whole-rock chemistry of the Eseka serpentinites led to the distinction of two types.Type 1 has high MgO(>40 wt%)content and high Mg#values(88.80)whereas Type 2 serpentinite samples display relatively low MgO concentration and Mg#values(<40 and 82.88 wt%,respectively).Both types have low Al/Si and high Mg/Si ratios than the primitive mantle,reflecting a refractory abyssal mantle peridotite protolith.Partial melting modeling indicates that these rocks were derived from melting of spinel peridotite before serpentinization.Bulk rock high-Ti content is similar to the values of subducted serpentinites(>50 ppm).This similarity,associated with the high Cr contents,spinel-peridotite protolith compositions and Mg/Si and Al/Si ratios imply that the studied serpentinites were formed in a subductionrelated environment.The U-shaped chondrite normalizedREE patterns of serpentinized peridotites,coupled with similar enrichments in LREE and HFSE,suggest the refertilized nature due to melt/rock interaction prior to serpentinization.Based on the results,we suggest that the Eseka serpentinized peridotites are mantle residues that suffered a high degree of partial melting in a subductionrelated environment,especially in Supra Subduction Zone setting.These new findings suggest that the Nyong series in Cameroon represents an uncontested Paleoproterozoic suture zone between the Congo craton and the Sao Francisco craton in Brazil. | Philomene Nga Essomba Tsoungui Sylvestre Ganno Evine Laure Tanko Njiosseu Jean Lavenir Ndema Mbongue Brice Kamguia Woguia Landry Soh Tamehe Jonas Didero Takodjou Wambo Jean Paul Nzenti | 2020 | Acta Geochimica2020，39，3： | 3 |
| 13 | Operculina and Neoassilina:A Revision of Recent Nummulitid Genera Based on Molecular and Morphological Data Reveals a New Genus显示文摘The genus Operculina,a large symbiont-bearing benthic foraminifer,is characterized by high morphological variability showing thick involute to intermediate semi-involute to flat evolute tests.Different morphotypes are either considered as ecophenotypes or distinct species.In order to test the hypothesis of ecophenotypes versus different species,a single cell high throughput sequencing approach was applied to assess the interspecific diversity of Operculina.This results in two groups of ribotypes,one corresponding to Operculina ammonoides/Operculina discoidalis,the other containing Operculina complanata/Operculina elegans.These groups can also be separated morphologically.Therefore,O.complanata and O.elegans represent a single species and the latter can be regarded as a junior synonym of O.complanata.Operculina ammonoides and O.discoidalis also form a single species,which makes the latter a junior synonym of O.ammonoides.Because generic differences in Operculina species are manifested in morphology and molecular genetics,the genus Neoassilina with the designated species Neoassilina ammonoides is installed.Additional analysis of ribosomal SSU rDNA data of eight recent nummulitid genera confirms the obtained high troughput sequencing results and further shows that Palaeonummulites venosus builds a clade with O.complanata that branches at the base of other Nummulitidae containing Planostegina,Planoperculina,Cycloclypeus,Heterostegina,Operculinella and Neoassilina. | Maria Holzmann Johann Hohenegger Laure Apothéloz-Perret-Gentil Raphael Morard Sigal Abramovich Danna Titelboim Jan Pawlowski | 2022 | Journal of Earth Science2022，33，6： | 2 |
| 14 | Ranibizumab versus Bevacizumab for neovascular age-related macular degeneration. Results from the GEFAL noninferiority randomized trial显示文摘 | Laurent Kodjikian Eric H. Souied Gérard Mimoun Martine Mauget-Fa?sse Francine Behar-Cohen Evelyne Decullier Laure Huot Gilles Aulagner | 2013 | Ophthalmology2013，，： | 2 |
| 15 | CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice显示文摘 | Medina-Contreras Oscar Geem Duke Laur Oskar Williams Ifor R Lira Sergio A Nusrat Asma Parkos Charles A Denning Timothy L | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 16 | Human Blood CXCR5 + CD4 + T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion显示文摘 | Rimpei Morita Nathalie Schmitt Salah-Eddine Bentebibel Rajaram Ranganathan Laure Bourdery Gerard Zurawski Emile Foucat Melissa Dullaers SangKon Oh Natalie Sabzghabaei Elizabeth M. Lavecchio Marilynn Punaro Virginia Pascual Jacques Banchereau Hideki Ueno | 2011 | Immunity2011，，1： | 2 |
| 17 | Advances in processing of ferroelectrie thin films 显示文摘 | Laure M Sheppard | 1992 | Ceramic Bulletin1992，71，1： | 1 |
| 18 | Multilocus Sequence Typing of Laaobacillus casei Reveals a Clonal Population Structure with Low Levels of Homologous Re- combination 显示文摘 | LAURE DIANCOUtLT VItLIGINIE PASSET Christian Chervaux | 2007 | Applied and Environmental Microbiology2007，73，20： | 1 |
| 19 | Kinetics and mechanism of the reaction between maleic anhydride and fatty acid esters and the structure of the products 显示文摘 | Florina S Laure C Carlos V | 2008 | Eur J Lipid Sci Technol2008，110，： | 1 |
| 20 | Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms显示文摘 | Laure Sarda Patrice Colin Franck Boccara Doumit Daou Rachida Lebtahi Marc Faraggi Charles Nguyen Ariel Cohen Michel S Slama Philippe G Steg Dominique Le Guludec | 2001 | Journal of the American College of Cardiology2001，，3： | 1 |
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