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| 1 | MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer:Current insights and future perspectives显示文摘Non-invasive diagnostic biomarkers may contribute to an early identification of gastric cancer(GC) and improve the clinical management.Unfortunately,no sensitive and specific screening biomarkers are available yet and the currently available approaches are limited by the nature of the disease.GC is a heterogenic disease with various distinct genetic and epigenetic events that occur during the multifactorial cascade of carcinogenesis.Micro RNAs(mi RNAs) are commonly deregulated in gastric mucosa during the Helicobacter pylori infection and in stepwise manner from chronic gastritis,through preneoplastic conditions such as atrophic gastritis and intestinal metaplasia,to early dysplasia and invasive cancer.Identification of mi RNAs in blood in 2008 led to a great interest on mi RNA-based diagnostic,prognostic biomarkers in GC.In this review,we provide the most recent systematic review on the existing studies related to mi RNAs as diagnostic biomarkers for GC.Here,we systematically evaluate 75 studies related to differential expression of circulating mi RNAs in GC patients and provide novel view on various heterogenic aspects of the existing data and summarize the methodological differences.Finally,we highlight several important aspects crucial to improve the future translational and clinical research in the field. | Alexander Link Juozas Kupcinskas | 2018 | World Journal of Gastroenterology2018，24，30： | 32 |
| 2 | Review on monolayer CBN superabrasive wheels for grinding metallic materials显示文摘A state-of-the-art review on monolayer electroplated and brazed cubic boron nitride(CBN) superabrasive wheels for grinding metallic materials has been provided in this article. The fabrication techniques and mechanisms of the monolayer CBN wheels are discussed. Grain distribution, wheel dressing, wear behavior, and wheel performance are analyzed in detail. Sample applications of monolayer CBN wheel for grinding steels, titanium alloys, and nickel-based superalloys are also provided. Finally, this article highlights opportunities for further investigation of monolayer CBN grinding wheels. | Ding Wenfeng Barbara Linke Zhu Yejun Li Zheng Fu Yucan Su Honghua Xu Jiuhua | 2017 | Chinese Journal of Aeronautics2017，30，1： | 24 |
| 3 | Current biomarkers for hepatocellular carcinoma: Surveillance, diagnosis and prediction of prognosis显示文摘Biomarkers for surveillance, diagnosis and prediction of prognosis in patients with hepatocellular carcinoma(HCC) are currently not ready for introduction into clinical practice because of limited sensitivity and specificity. Especially for the early detection of small HCC novel biomarkers are needed to improve the current effectiveness of screening performed byultrasound. The use of high-throughput technologies in hepatocellular research allows to identify molecules involved in the complex pathways in hepatocarcinogenesis. Several invasive and non-invasive biomarkers have been identified already and have been evaluated in different clinical settings. Gene signatures with prognostic potential have been identified by gene expression profiling from tumor tissue. However, a single 'all-in-one' biomarker that fits all-surveillance, diagnosis, prediction of prognosis-has not been found so far. The future of biomarkers most probably lies in a combination of non-invasive biomarkers, imaging and clinical parameters in a surveillance setting. Molecular profiling of tumorous and non-tumorous liver tissue may allow a prediction of prognosis for the individual patient and hopefully clear the way for individual treatment approaches. This article gives an overview on current developments in biomarker research in HCC with a focus on currently available and novel biomarkers, in particular on micro RNA. | Kerstin Schütte Christian Schulz Alexander Link Peter Malfertheiner | 2015 | World Journal of Hepatology2015，7，2： | 18 |
| 4 | Photodegradation of fluoroquinolone antibiotic gatifloxacin in aqueous solutions显示文摘Fluoroquinolone antibiotics (FQs) are frequently detected as emerging pollutants in aqueous environments.In this study,kinetics,influencing factors and mechanisms on the photodegradation of gatifloxacin,a representative FQ,were investigated.The photodegradation follows the pseudo-first-order kinetics.Gatifloxacin photodegrades with a quantum yield of (5.94 ± 0.95) × 10 3 in pure water and undergoes direct photolysis as well as self-sensitized photodegradation.The FQ photodegrades slower in freshwater and seawater than in pure water,which is attributed to the integrative effects of pH and the aqueous dissolved matter (e.g.,humic acids and NO 3-) on the photodegradation.A toxicity test using Vibrio fischeri revealed the formation of hazardous photoproducts. | GE LinKe CHEN JingWen ZHANG SiYu CAI XiYun WANG Zhuang WANG ChunLing | 2010 | Chinese Science Bulletin2010，55，15： | 17 |
| 5 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 6 | Marginal revenue of land and total factor productivity in Chinese agriculture: Evidence from spatial analysis显示文摘这份报纸试图探索土地,全部的因素生产率(TFP ) 变化和它的三个部件的边缘的收入的时间、空间的性质:技术变化(TC ) ,技术效率变化(侦探) 和规模效率变化(秒) 是从 1995 ~ 1999 在中国农业生产看。基于县级的数据,学习利用了随机的边疆和印射的分析方法。在最获得发生在东方沿海的地区的地方,结果证明在土地的边缘的收入的生长越过各种各样的区域是多样的,当损失在西北和诺思中国时。中国与可观的地区性的变化在年度 TFP 变化(0.26%) 经历了中等减少。明确地,在谷物生产的行政干预和农业技术散开系统的恶化在年度 TFP 变化导致了中等落下。县级的印射分析在 TFP 和它的部件考虑了 interregional 变化。关于 TFP 的部件,侦探差别在 TFP 解释地区性的分散的多数。作为在中国的发达区域, Huang-Huai-Hai 区域和 Beijing-Tianjin-Tangshan 经济地区在都市化的过程中面对陆地变换和谷物安全的挑战。 | HOU Linke ZHANG Yanjie ZHAN Jinyan Thomas GLAUBEN | 2012 | Journal of Geographical Sciences2012，22，1： | 12 |
| 7 | Characteristics of developing scour-holes at a sand-embedded cylinder显示文摘Characteristics of developing scour-holes at a sand-embedded 0.2 m diameter circular cylinder are presented. Non-intrusive, high-resolution topographic measurements of developing scour-holes were made with an experimental installation using a laser distance sensor (LDS) and precision step-motors. A clear-water experiment was conducted with bed shear stress equal to 95% of the critical bed shear stress for the initiation of sediment motion at the undisturbed plane sand bed with a d50 of 0.26 mm. During the running experiment of 21 hours duration, measurements were taken by the LDS in different azimuthal half-planes with θ = 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165 and 180o in order to study the spatio-temporal variation of geometric properties in developing scour-holes. After 21 hours, the equilibrium condition was approached, with a scour rate less than d50 per hour. Measurement of maximum scour depth in different azimuthal half-planes at different points in time during the experiment show that scour started at the cylinder side and surrounded the cylinder after about 20% of experiment time. Slopes of developing scour-holes presented three regions with different inclinations, which were attributed to vortex action. Both maximum scour depth and maximum scour radius at different azimuthal half-planes are well correlated with the maximum scour depth at plane with θ = 0o. When providing maximum scour depth at the cylinder front, the presented correlations are useful for simple calculation of scour-hole topography. This work provides an experimental database for advanced numerical simulation for loose sediment hydraulics. | Oscar LINK Florian PFLEGER Ulrich ZANKE | 2008 | International Journal of Sediment Research2008，23，3： | 12 |
| 8 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 9 | Distribution and characteristic of PAHs in snow of Fildes Peninsula显示文摘Polycyclic aromatic hydrocarbons (PAHs) investigation in different matrices has been reported largely,whereas reports on snow samples were limited.Snow,as the main matrix in the polar region,has an important study meaning.PAHs in snow samples were analyzed to investigate the distribution and contamination status of them in the Antarctic,as well as to provide some references for global migration of PAHs.Snow samples collected in Fildes Peninsula were enriched and separated by solid-phase membrane disks and eluted by methylene dichloride,then quantified by gas chromatography/mass spectrometry.All types of PAHs were detected except for Benzo(a)pyrene.Principal component analysis method was applied to characterize them.Three factors (Naphthalene,Fluorene and Phenanthrene) accounted for 60.57%,21.61% and 9.80%,respectively.The results showed that the major PAHs sources maybe the atmospheric transportation,and the combustion of fuel in Fildes Peninsula.The comparison of concentration and types of PAHs between accumulated snow and fresh snow showed that the main compound concentrations in accumulated snow samples were higher than those in fresh ones.The risk assessment indicated that the amount of PAHs in the snow samples would not lead to ecological risk. | Guangshui Na Chunyang Liu Zhen Wang Linke Ge Xindong Ma Ziwei Yao | 2011 | Journal of Environmental Sciences2011，23，9： | 8 |
| 10 | System security of hybrid AC-HVDC-systems challenges and new approaches for combined security assessment,preventive optimization and curative actions显示文摘The intense application of Voltage Source Converter based HVDC interconnections and grids will result in a hybrid AC-HVDC-system. The operation of such a system becomes complex regarding system security and system operation. This paper describes major challenges and proposes potential solutions, including a combined security assessment, preventive optimization and curative actions. A coordination of both systems enables an efficient application of existing transport capacity. | Florian Sass Tom Sennewald Franz Linke Dirk Westermann | 2018 | Global Energy Interconnection2018，1，5： | 7 |
| 11 | Phenotypic plasticity in response to soil moisture availability in the clonal plant Eremosparton songoricum (Litv.) Vass.显示文摘Eremosparton songoricum(Litv.) Vass is a dwarf clonal shrubby legume developed on the windward slopes of mobile or semi-fixed sand dunes of Central Asia. It is assumed that E. songoricum must possess a high degree of phenotypic plasticity for such a heterogeneous habitat. The variations of E. songoricum plants growing in two typical microhabitats(the upper slope and the lower slope of semi-mobile dune) were investigated. The morphological characteristics and the biomass allocation patterns were measured and compared at the clonal fragment level. Compared with the clonal fragment on the lower slope of dune,the clonal fragment on the upper slope of the dune(a) declined in total biomass and ramet height,(b) increased the length of rhizomes and the number of roots,(c) increased the degree of asym-metry,and(d) heightened allocation to the belowground biomass. Our results confirmed the hypothesis of high phenotypic adjustment capacity of E. songoricum to habitat moisture availability. Phenotypic plasticity of E. songoricum contributed to reduce the damage risk,led to an environmentally induced specialization in function of resources exploitation,resulted in its persistence in heterogeneous environments and was adaptive in sand dune environment. | JianCheng WANG Xiang SHI DaoYuan ZHANG LinKe YIN | 2011 | Journal of Arid Land2011，3，1： | 6 |
| 12 | 常规胸腹部多层CT矢状重组影像在检测骨质疏松骨折和脊椎异常诊断中的价值显示文摘本研究的目的是评价骨质疏松椎骨骨折和其他椎骨损伤在常规多层CT(MDCT)胸腹部扫描获得的矢状重组影像上的表现,以及在检出这些病变时矢状重组影像与横断位影像的差异,并研究这些病变在放射科报告中漏报的频度。112例绝经后妇女接受标准参数的常规腹部或胸腹部MDCT检查。横断位和矢状重组影像由2位放射科医师分别进行分析比较,并达成一致意见.以评价这些异常被检出的频度。此外还评价了放射科的报告,明确有多少异常得以诊断。112例绝经妇女中,101例显示脊椎异常。 | D. Müller J.S. Bauer M. Zeile E.J. Rummeny T.M. Link 白荣杰(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 6 |
| 13 | Induction of the AOX1D Isoform of Alternative Oxidase in A. thaliana T-DNA Insertion Lines Lacking Isoform AOX1A Is Insufficient to Optimize Photosynthesis when Treated with Antimycin A显示文摘植物呼吸被二条小径为电子转移描绘到 O2,也就是被连接到 ATP 生产的细胞色素小径(CP ) ,和其他的小径(AP ) ,没有伴随物 ATP,从 ubiquinol 的电子在哪儿,直接经由其他的 oxidase (AOX ) 转到 O2 生产。这条后者小径很好被适合在光过量电子处理,导致优化光合的性能。我们描绘了不表示主要 isoform 的 Arabidopsis thaliana 的 T-DNA-insertion 变异的线, AOX1A。处于标准生长条件,这些植物没由抗霉素 A 通过 CP 显示出电子流动的任何显型,而是限制,它导致 AOX1A 表示在野类型,在 aox1a 大美人异种的叶子导致了 AOX1D 的增加的表情。尽管有在异种的 AOX1D isoform 的增加的存在,抗霉素 A 引起了光合作用的抑制,增加了 ROS,并且当时,最终导致了放大的膜漏和坏死与相比野类型,它被禁止者仅仅在边际地影响。经由 CP 的电子流动什么时候被限制,因此出现 AOX1D 是不能的充分补偿 AOX1A 的损失。抑制的联合学习,联合了到代谢物介绍并且指向了 glycine decarboxylase 建筑群(GDC ) 的 P 蛋白质的表示分析,建议 aox1a 异种试图为 photorespiration 增加他们的能力。然而,给他们的缺乏,在当与抗霉素 A 对待时,任何一个 AOX1D 都不能充分补偿让 AOX1A 的缺乏优化光合作用的表示增加,是吸引人的。我们建议 aox1a 异种能进一步被用来有关对光合的性能和基因表示的 mitochondrial 氧化还原作用的影响证实当前的模型。 | Inga Strodtkotter Kollipara Padmasree Challabathula Dinakar Birgit Speth Pamela S. Niazi Joanna Wojtera Ingo Voss Phuc Thi Do Adriano Nunes-Nesi Alisdair R. Fernie Vera Linke Agepati S. Raghavendra Renate Scheibe | 2009 | Molecular Plant2009，2，2： | 5 |
| 14 | Subcycle control of terahertz waveform polarization using all-optically induced transient metamaterials显示文摘Coherent radiation with frequencies ranging from 0.3 to 30 THz has recently become accessible using femtosecond laser technology.These terahertz(THz)waves have already been applied in spectroscopy and imaging and can be manipulated using static optical elements such as lenses,polarizers and filters.However,ultrafast modulation of THz radiation is required as well,for instance,in short-range wireless communication or for preparing shaped THz transients for the coherent control of numerous material excitations.Here,we demonstrate an all-optically created transient metamaterial that allows us to manipulate the polarization of THz waveforms with subcycle switch-on times.The polarization-modulated pulses are potentially interesting for controlling elementary motions such as the vibration of crystal lattices,the rotation of molecules and the precession of spins. | N Kamaraju Andrea Rubano Linke Jian Surajit Saha T Venkatesan Jan Notzold R Kramer Campen Martin Wolf Tobias Kampfrath | 2014 | Light(Science & Applications)2014，3，1： | 5 |
| 15 | 修正结构有限元模型的一种方法显示文摘本文讨论了一个寻找结构有限元模型的误差源和对它进行修正的方法.为了减少待修正模型的未知参数数目,将质量、刚度矩阵描述为设计变量的函数.在此基础上,先用少量测得的静位移数据修正刚变矩阵;然后用少数几阶实验的固有频率、固有振型数据修正质量矩阵.为了避免测量旋转自由度的静位移和固有振型分量的困难,还讨论了聚缩模型的修正问题.最后,文中附有算例及结果. | 周传荣 Link M. | 1989 | 振动工程学报1989，2，4： | 5 |
| 16 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 17 | DDGS和酵母培养物对奶牛生产性能和乳成分的影响显示文摘选择16头泌乳天数为127±52d经产荷斯坦泌乳牛用于评价酵母培养物(达农威益康XP)和玉米酒糟及其可溶物(DDGS)在试验日粮中含有限草料纤维数量(草料中的中性洗涤纤维含量为19.3%,干物质基础)之情况下对产奶量和乳成分的影响及其它们之间的互作效应。本次试验采用4重复4×4拉丁方设计,试验时间为4个星期。处理组均按照2×2因子排列而设定,其中:1)日粮中不含酵母培养物和DDGS(对照组);2)日粮中含有20%DDGS,无酵母培养物(DDGS组);3)日粮中含有60g/d的酵母培养物益康XP(XP组);4)日粮中含有20%DDGS和60g/d的益康XP(XP+DDGS组)。本次试验结果表明:各处理组之间对奶牛体重和体况评分无显著的影响。日粮的处理并不影响干物质采食量(DMI),在使用草料纤维含量较低且添加20%DDGS的日粮情况下乳脂率会降低。添加益康XP的确能够提高产奶量及乳蛋白产量,但却不能够完全阻止因DDGS所造成的乳脂率下降的趋势。无论日粮中是否含有DDGS,益康XP都能够提高奶牛的生产性能。 | AR Hippen DJ Schingoethe KF Kalscheur P Linke K Gross DR Rennich IIkye Yoon 徐明 | 2010 | 中国奶牛2010，，8： | 4 |
| 18 | 宽幅打印机按需喷墨打印头的墨滴运动显示文摘本文主要研究宽幅打印机中墨滴的流动状况。按需式压电打印头的油墨喷射多采用光学技术进行测量,根据激光多普勒速度测量仪测得的速度和图像可视化系统获得的图像数据,对打印头的性能进行全面了解。在模拟操作条件的情况下观察压电式打印头的工作状况,从而确定印刷密度的最优参数。结果表明印品质量不精确的主要原因是由卫星式液滴造成的。对压电推拉式(thePiezoelectricPush-mode)按需喷墨印刷头进行计算机仿真,主要进行墨滴喷射和墨滴向印刷介质转移过程的仿真。仿真结果与实验结果基本一致,表明施加在压电晶体上的电压脉冲与最终压力之间存在联系。 | N. Link R. Semiat | 2009 | 中国印刷与包装研究2009，1，1： | 4 |
| 19 | Alzheimer型痴呆的髓鞘素蛋白自身应答性T细胞免疫反应显示文摘通过计数分泌细胞因子γ-干扰素(IFN-γ)、辅助性T细胞(Th1),检查AD患者外周血和脑脊液(CSF)中T细胞免疫应答。方法:将单个核细胞(MNC)暴露于中枢神经系统(CNS)髓鞘素抗原髓鞘碱性蛋白(MBP)和含脂质蛋白(PLP)中进行体外短时间培养,用酶联免疫斑点试验(Elispot)检测IFN-γ分泌性Th1细胞链,同时检测急性脑血管病(CVD)和其他神经疾病(OND)患者作为对照。结果显示AD患者外周血中呈高水平MBP应答性Th1细胞链,而其CSF中尤为明显,外周血中PLP应答性Th1细胞亦显著高于OND对照组。结论认为AD患者存在高水平的髓鞘素蛋白自身应答性T细胞反应,且在与CNS紧邻的CSF中表现得尤为显著,其在AD发病机制中的作用还有待进一步深入探讨。 | 王维治 肖保国 Link H | 1996 | 中华神经科杂志1996，29，3： | 4 |
| 20 | The Plastid-Localized NAD-Dependent Malate Dehydrogenase Is Crucial for Energy Homeostasis in Developing Arabidopsis thaliana Seeds显示文摘当光合作用不在时, ATP 被 ATP/ADP transporters 进口进叶绿体和非绿的质体或在 glycolysis 期间形成了,要求 NAD+ 的连续新生的后者,由 NADMDH 的 plastidial isoform 供应了。在在 Arabidopsis 的 plNADMDH 基因为 T-DNA 插入异种屏蔽期间,仅仅异质接合的植物能被孤立,同型结合的猛烈异种仅仅在互补以后成长了。这些异质接合的植物显示出其他的改革 NAD+ 酶的更高的抄本层次, NADHGOGAT,并且,显著地,当铵是唯一的 N 来源时,改进了生长。在 situ,杂交并且 GUS 组织化学的染色表明 plNADMDH 特别地充满男、女的配偶体。猛烈 plNADMDH 花粉展览在 vitro 损害了试管生长,它能被增加 NADHGOGAT 的底层克服。在 vivo,猛烈花粉能使肥沃卵房间。异质接合的植物包含的 selfed 的年轻 siliques 相应于 wild-type/heterozygous (绿色) 和同型结合的猛烈异种(白色) 在的绿、白的种子一(1:2 ): 1 比率。同型结合的猛烈种子的胚胎仅仅到达了球状的阶段,绿,并且发展了到微小的起皱的种子。有在本国的倡导者下面的基因的互补救了作为野类型开发的这个缺点,和所有种子。这建议在 plNADMDH 异种的一个堵住的主要生理的过程停止胚胎和内乳开发,因此避免在损害后代吸收投资。 | Jennifer Selinski Nicolas Konig Benedikt Wellmeyer Guy T. Hanke Vera Linke H. Ekkehard Neuhaus Renate Scheibe | 2014 | Molecular Plant2014，7，1： | 4 |
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