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| 1 | Voltage-gated sodium channel Nav1.5 promotes proliferation, migration and invasion of oral squamous cell carcinoma显示文摘The protein voltage-gated sodium channel Nav1.5 is highly upregulated in various types of cancer and, in general, promotes cancer cell invasiveness and metastatic progression. A previous study found that Nav1.5 was highly expressed in poorly differentiated oral squamous cell carci noma (OSCC). However, whether Nav1.5 enhances invasiveness and metastasis of OSCC are still unknown. In this study, we found that Nav1.5 was highly expressed in OSCC cell lines compared with normal oral keratinocyte HOK cell line by using western blot analysis. CCK-8 assay results revealed that downregulation of Nav1.5 expression by its specific siRNA reduced proliferation of OSCC HSC-3 cells. Moreover, transwell assay results showed Nav1.5 knockdown significantly inhibited migration and invasion of HSC-3 cells. Meanwhile, qRT-PCR and western blot analysis results showed that epidermal growth factor (EGF) induced Nav1.5 expression in a time-and dosedependent manner. In addition, EGF promoted proliferation, migration and invasion of HSC-3 cells. Importantly, the Nav1.5 inhibitor tetrodotoxin significantly inhibited the proliferation of HSC-3 cells and impeded the migration and invasion of HSC-3 cells. Furthermore, it was found that siRNAmediated knockdown of Nav1.5 also lessened the proliferation of HSC-3 cells and blocked the migration and invasion of HSC-3 cells. Taken together, these results indicate that Nav1.5 is involved in the progression of OSCC and Nav1.5 promotes the proliferation, migration and invasion of OSCC cells. | Jie Zhang Weijia Mao Ybngzheng Dai Chengwei Qian Yang Dong Zhangming Chen Lei Meng Zhe Jiang Ting Huang Jie Hu Panquan Luo Heinrich Korner Yong Jiang Songcheng Ying | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 3 |
| 2 | Absolute and relative contraindications to pegylated‐interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV ‐infected, evaluated patients显示文摘 | A. H. Talal J. LaFleur R. Hoop P. Pandya P. Martin I. Jacobson J. Han E. J. Korner | 2013 | Aliment Pharmacol Ther2013，，4： | 2 |
| 3 | Proximal humeral fractures: how stiff should an implant be?显示文摘 | H. Lill P. Hepp J. Korner J.-P. Kassi A. P. Verheyden C. Josten G. N. Duda | 2003 | Archives of Orthopaedic and Trauma Surgery (-)2003，，2： | 2 |
| 4 | Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line显示文摘 | Lohmann V Korner F Koch J | | 0，，5424： | 2 |
| 5 | Reproducibility and simplification of the preparation procedure for carbon stripper foils by laser plasma ablation deposition显示文摘 | Maier-Komor P Dollinger G Korner H J | 1999 | Nuclear Instruments and Methods in Physics Research A1999，438，1： | 1 |
| 6 | Effects of genetic variation in the visfatin gene(PBEF1) on obesity,glucose metabolism,and blood pressure in children显示文摘 | KORNER A BOTTCHER Y ENIGK B | 2007 | Metabolism2007，56，6： | 1 |
| 7 | Growth responses of an alpine grassland to elevated CO2 显示文摘 | Schappi B Korner C | 1996 | Oecologia1996，105，： | 1 |
| 8 | Structured triglycerides to postoperative patients: A safety and tolerance study 显示文摘 | Sandtrom R Hyltander A Korner U | 1993 | JPEN1993，17，2： | 1 |
| 9 | Proximal humeral fractures:how stiff shoul danim plantbe?Acom parative mechanical study with newimplantin humans pecimens显示文摘 | Lill H Hepp P Korner J et al | 2003 | Arch Orthop Trauma Surg2003，123，23： | 1 |
| 10 | Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line显示文摘 | LOHMANN V KORNER F KOCH J | 1999 | Science1999，285，5424： | 1 |
| 11 | Persistent hallucinosis in borderline personality disorder显示文摘 | Yee L Korner A J McSwiggan S | 2005 | Compr Psychiatry2005，46，2： | 1 |
| 12 | The biosynthesis of mammalian melanin 显示文摘 | Pawelek JM Korner AM | 1982 | Am Sci1982，70，2： | 1 |
| 13 | Daily temperature integration:a simulation study to quantify energy consumption显示文摘 | Korner O Bakker M J Heuvelink E | 2004 | Biosystems Engineering2004，87，3： | 1 |
| 14 | 显示文摘 | Korner C Arnold M Subger R F | 2005 | Materials Science and Engineering A2005，396，12： | 1 |
| 15 | Bile du~-'l cysts in adults 显示文摘 | Soreide K Korner H Havnen J | 2004 | Br J Surg2004，91，12： | 1 |
| 16 | The effect of pH variation at the ammonium/ammonia equilibrium in wastewater and its toxicity to Lemnagibba 显示文摘 | Korner S Das S K Veensta S | 2001 | Aquatic Botany2001，71，1： | 1 |
| 17 | One-to-one peer support in cancer care: a review of scholarship published between 2007 and 2014显示文摘 | Meyer A Coroiu A Korner A | 2015 | Cur J Cancer Care (Engl)2015，24，3： | 1 |
| 18 | The effect of pH variation at the ammonium/ammonia equilibrium in wastewater and its toxicity to Lemna gibba 显示文摘 | Das S K Veenstra S Vermaat J E | 2001 | Aquatic Botany2001，71，： | 1 |
| 19 | Regulation of hypothalamic proopiomelanocortin by Leptin in leanand obese rats 显示文摘 | Korner J Chua S C Williams J A | 1999 | Neuroendocrinology1999，70，6： | 1 |
| 20 | Reworkable Epoxies:Thermosets with thermally cleavable groups for controlled network breakdown显示文摘 | Yang S Chen J Korner H | 1998 | Chem Mater1998，10，： | 1 |
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