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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Measurements of static and dynamic mooring line damping and their importance for floating WEC devices显示文摘 | Lars Johanning George H. Smith Julian Wolfram | 2007 | Ocean Engineering2007，，14： | 2 |
| 3 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 4 | Measurements of static and dynamic mooring line damping and their importance for floating WEC devices 显示文摘 | Lars Johanning George H Smith Julian Wolfram | 2007 | Ocean Engineering2007，，34： | 1 |
| 5 | The impact of 3-dimensional reconstructions on operation planning in liver surgery显示文摘 | Wolfram L Gerald G Lars F | 2000 | Arch Surg2000，135，11： | 1 |
| 6 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 7 | ETVARD (endoscopic transanal vacuum-assisted rectal drainage) leads to complete but delayed closure of extraperitoneal rectal anastomotic leakage cavities following neoadjuvant radiochemotherapy显示文摘 | Wolfram Bernstorff Anne Glitsch André Schreiber Lars Ivo Partecke Claus Dieter Heidecke | 2009 | International Journal of Colorectal Disease2009，，7： | 1 |
| 8 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 9 | Measurements of static and dynamic mooring line damping and their importance for floating WEC devices显示文摘 | Lars Johanning G H Smith J Wolfram | 2007 | Ocean Engineering2007，34，： | 1 |
| 10 | Postpancreatot- omy hemorrhage; diagnosisand treatment - an analysis in 1669 consecutive pancreati resections显示文摘 | Emre F Yekebas MD Lars Wolfram | 2007 | Ann Surg2007，246，2： | 1 |
| 11 | Measurements of static and dynamic mooring line damping and their importance for floating WEC devices 显示文摘 | Lars Joharming George H Smith Julian Wolfram | 2007 | Ocean Engineering2007，34，1415： | 1 |
| 12 | The lymphotoxin-β receptor is critical for control of murine Citrobacter rodentium –induced colitis显示文摘 | Thomas W. Spahn Christian Maaser Lars Eckmann Jan Heidemann Andreas Lügering Rodney Newberry Wolfram Domschke Hermann Herbst Torsten Kucharzik | 2004 | Gastroenterology2004，，： | 1 |
| 13 | Postpancreatectomy Hemorrhage: Diagnosis and Treatment: An Analysis in 1669 Consecutive Pancreatic Resections显示文摘 | Emre F. Yekebas Lars Wolfram Guellue Cataldegirmen Christian R. Habermann Dean Bogoevski Alexandra M. Koenig Jussuf Kaifi Paulus G. Schurr Michael Bubenheim Claus Nolte-Ernsting Gerhard Adam Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 14 | Moor- ing systems for wave energy converters: A review of design issues and choices显示文摘 | HARRIS Robert E JOHANNING Lars WOLFRAM Julian | 2006 | Journal of Engineering for the Maritime Environ- ment2006，22，12： | 1 |
| 15 | 麦当劳慈善之家显示文摘罗纳德·麦当劳之家是一个入住设施齐全的慈善机构,专为远程前来医院就医的病童及其家人提供一个距离医院只有数分钟路程的"家以外的家"(Home Away from Home)的生活空间。
整座建筑呈现一个独特的弯钩造型,坐落在德国圣奥斯汀一个小山坡的坡顶上。隐藏式的入口设计,直到走近后才会在一旁发现"Ronald McDonald Haus(麦当劳叔叔之家)"的门牌字样。 | Wolfram Putz Thomas Willemeit Lars Krueckeberg Raphael Hemmer Stefanie Gotz Rita Schmidt Sebastian Gernhardt Denis Hegic Izabela Pavel Alexandra Tobescu Tobias Hein(摄) 姜敏华(编译) | 2016 | 现代装饰2016，0，3： | 0 |
| 16 | 新与旧的相互移植打造独一无二的空间体验——塞尔维亚贝尔格莱德老磨坊酒店显示文摘地点:塞尔维亚,贝尔格莱德客户:Soravia Group完成时间:2014年设计理念在贝尔格莱德这座白色之城市里,GRAFT将位于萨瓦河边的一座历史性建筑"老磨坊"改造成了一家新酒店。室内设计的理念是用新材料,色彩和形状来改造现存的历史性建筑,激发这栋文化古建筑的原始品质,并因此创造出独一无二的视觉体验,这座地标性的酒店建筑拥有236间客房和位于顶层的14间带阳台的套间,同时还在顶层建造了一个有四间会议室的会议中心,一个巨大的宴会厅,和一个高级商务休息室。 | Lars Kruckeberg Wolfram Putz Thomas Willemeit Andrea Goldel Sascha Kruckeberg Sebastian Gernhardt Stephen Molloy Denis Leo Hegic Sonia Wedemeyer Alice Mayer Antonio Luque Tade Godbersen Tobias Hein | 2015 | 设计家2015，，3： | 0 |
| 17 | 贝尔格莱德老磨坊酒店显示文摘项目地址塞尔维亚竣工时间2014建筑设计单位Sanjin Grbic&Jovan Jovanovic室内设计单位GRAFT建筑事务所在贝尔格莱德这座白色之城的萨瓦河畔,来自GRAFT建筑事务所的设计团队将一座具有历史意义的老磨坊建筑改造成了一个四星级酒店。这是一个雄心勃勃的室内设计概念,设计师将新型的材料、颜色和形状运用于旧建筑中,激发了旧建筑的本质光芒,也因此创造出独一无二的视觉体验。 | Wolfram Putz Thomas Willemeit Lars Krueckeberg Tobias Hein 姜敏华 | 2015 | 现代装饰2015，0，6： | 0 |
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