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| 1 | Prevalence and determinants of delayed gastric emptying in hospitalised Type 2 diabetic patients显示文摘AIM: To determine the prevalence of delayed gastric emptying (GE) in older patients with Type 2 diabetes mellitus. METHODS: One hundred and forty seven patients with Type 2 diabetes, of whom 140 had been hospitalised, mean age 62.3 ± 8.0 years, HbA1c 9.1% ± 1.9%, treated with either oral hypoglycemic drugs or insulin were studied. GE of a solid meal (scintigraphy), autonomic nerve function, upper gastrointestinal symptoms, acute and chronic glycemic control were evaluated. Gastric emptying results were compared to a control range of hospitalised patients who did not have diabetes. RESULTS: Gastric emptying was delayed (T50 > 85 min) in 17.7% patients. Mean gastric emptying was slower in females (T50 72.1 ± 72.1 min vs 56.9 ± 68.1 min, P = 0.02) and in those reporting nausea (112.3 ± 67.3 vs 62.7 ± 70.0 min, P < 0.01) and early satiety (114.0 ± 135.2 vs 61.1 ± 62.6 min, P = 0.02). There was no correlation between GE with age, body weight, duration of diabetes, neuropathy, current glycemia or the total score for upper gastrointestinal symptoms. CONCLUSION: Prolonged GE occurs in about 20% of hospitalised elderly patients with Type 2 diabetes when compared to hospitalised patients who do not have diabetes. Female gender, nausea and early satiety areassociated with higher probability of delayed GE. | Vladimir Kojecky Jaromir Bernatek Michael Horowitz Stanislav Zemek Jiri Bakala Ales Hep | 2008 | World Journal of Gastroenterology2008，14，10： | 8 |
| 2 | Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson's disease显示文摘AIM: To determine gastric emptying, blood pressure, mesenteric artery blood flow, and blood glucose responses to oral glucose in Parkinson's disease. METHODS: Twenty-one subjects(13 M, 8 F; age 64.2 ± 1.6 years) with mild to moderate Parkinson's disease(Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g glucose drink, labelled with 20 MBq 99mTc-calcium phytate. Gastric emptying was quantified with scintigraphy, blood pressure and heart rate with an automated device, superior mesenteric artery blood flow by Doppler ultrasonography and blood glucose byglucometer for 180 min. Autonomic nerve function was evaluated with cardiovascular reflex tests and upper gastrointestinal symptoms by questionnaire. RESULTS: The mean gastric half-emptying time was 106 ± 9.1 min, gastric emptying was abnormally delayed in 3 subjects(14%). Systolic and diastolic blood pressure fell(P < 0.001) and mesenteric blood flow and blood glucose(P < 0.001 for both) increased, following the drink. Three subjects(14%) had definite autonomic neuropathy and 8(38%) had postprandial hypotension. There were no significant relationships between changes in blood pressure, heart rate or mesenteric artery blood flow with gastric emptying. Gastric emptying was related to the score for autonomic nerve function(R = 0.55, P < 0.01). There was an inverse relationship between the blood glucose at t = 30 min(R =-0.52, P < 0.05), while the blood glucose at t = 180 min was related directly(R = 0.49, P < 0.05), with gastric emptying. CONCLUSION: In mild to moderate Parkinson's disease, gastric emptying is related to autonomic dysfunction and a determinant of the glycaemic response to oral glucose. | Laurence G Trahair Thomas E Kimber Katerina Flabouris Michael Horowitz Karen L Jones | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 3 | Whey protein: The “whey” forward for treatment of type 2 diabetes?显示文摘A cost-effective nutritional approach to improve postprandial glycaemia is attractive considering the rising burden of diabetes throughout the world. Whey protein, a by-product of the cheese-making process, can be used to manipulate gut function in order to slow gastric emptying and stimulate incretin hormone secretion, thereby attenuating postprandial glycaemic excursions. The function of the gastrointestinal tract plays a pivotal role in glucose homeostasis, particularly during the postprandial period, and this review will discuss the mechanisms by which whey protein slows gastric emptying and stimulates release of gut peptides, including the incretins. Whey protein is also a rich source of amino acids, and these can directly stimulate beta cells to secrete insulin, which contributes to the reduction in postprandial glycaemia. Appetite is suppressed with consumption of whey, due to its effects on the gut-brain axis and the hypothalamus. These properties of whey protein suggest its potential in the management of type 2 diabetes. However, the optimal dose and timing of whey protein ingestion are yet to be defined, and studies are required to examine the long-term benefits of whey consumption for overall glycaemic control. | Linda E Mignone Tongzhi Wu Michael Horowitz Christopher K Rayner | 2015 | World Journal of Diabetes2015，6，14： | 2 |
| 4 | GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications显示文摘 | Peter Bytzer Nicholas J Talley Johann Hammer Lisa J Young Michael P Jones Michael Horowitz | 2002 | The American Journal of Gastroenterology2002，，3： | 2 |
| 5 | Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia显示文摘 | Adam M. Deane Nam Q. Nguyen Julie E. Stevens Robert J. L. Fraser Richard H. Holloway Laura K. Besanko Carly Burgstad Karen L. Jones Marianne J. Chapman Chris K. Rayner Michael Horowitz | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，1： | 1 |
| 6 | Hyperglycemia Affects Gastric Electrical Rhythm and Nausea During Intraduodenal Triglyceride Infusion显示文摘 | Geoffrey S. Hebbard Melvin Samsom Jane M. Andrews David Carman Ben Tansell Wei Ming Sun John Dent Michael Horowitz | 1997 | Digestive Diseases and Sciences1997，，3： | 1 |
| 7 | Gastric Emptying, Diabetes, and Aging显示文摘 | Paul Kuo Christopher K. Rayner Michael Horowitz | 2007 | Clinics in Geriatric Medicine2007，，4： | 1 |
| 8 | A structured forensic interview protocol improves the quality and informativeness of investigative interviews with children: A review of research using the NICHD Investigative Interview Protocol显示文摘 | Michael E. Lamb Yael Orbach Irit Hershkowitz Phillip W. Esplin Dvora Horowitz | 2007 | Child Abuse & Neglect2007，，11： | 1 |
| 9 | Volatile organic compound emissions from green waste composting: Characterization and ozone formation显示文摘 | Anuj Kumar Christopher P. Alaimo Robert Horowitz Frank M. Mitloehner Michael J. Kleeman Peter G. Green | 2011 | Atmospheric Environment2011，，10： | 1 |
| 10 | Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite显示文摘 | Abdul R Maher Sayqa Arif Melanie Madhani Khalid Abozguia Ibrar Ahmed Bernadette O Fernandez Martin Feelisch AG O’Sullivan Arthur Christopoulos Aaron L Sverdlov Doan Ngo Rustem Dautov Philip E James John D Horowitz Michael P Frenneaux | 2013 | Br J Pharmacol2013，，3： | 1 |
| 11 | Upper gastrointestinal function and glycemic control in diabetes mellitus显示文摘Recent evidence has highlighted the impact of glycemic control on the incidence and progression of diabetic micro- and macrovascular complications, and on cardiovascular risk in the non-diabetic population. Postprandial blood glucose concentrations make a major contribution to overall glycemic control, and are determined in part by upper gastrointestinal function. Conversely, poor glycemic control has an acute, reversible effect on gastrointestinal motility. Insights into the mechanisms by which the gut contributes to glycemia have given rise to a number of novel dietary and pharmacological strategies designed to lower postprandial blood glucose concentrations. | Reawika Chaikomin Christopher K Rayner Karen L Jones Michael Horowitz | 2006 | World Journal of Gastroenterology2006，12，35： | 1 |
| 12 | Elevated Cardiac Troponin I and Relationship to Persistence of Electrocardiographic and Echocardiographic Abnormalities After Aneurysmal Subarachnoid Hemorrhage显示文摘 | Marilyn Hravnak J Michael Frangiskakis Elizabeth A. Crago Yuefang Chang Masaki Tanabe John Gorcsan Michael B. Horowitz | 2009 | Stroke2009，，11： | 1 |
| 13 | Transluminal stent-assisted angioplasty of the intracranial vertebrobasilar system for medically refractory,posterior circulation ischemia:early results显示文摘 | LEVY ELAD I HOROWITZ MICHAEL B KOEBBE CHRISTOPHER J | 2001 | Neurosurgery2001，48，6： | 1 |
| 14 | Relation of Elevation in Cardiac Troponin I to Clinical Severity, Cardiac Dysfunction, and Pulmonary Congestion in Patients With Subarachnoid Hemorrhage显示文摘 | Masaki Tanabe Elizabeth A. Crago Matthew S. Suffoletto Marilyn Hravnak J. Michael Frangiskakis Amin B. Kassam Michael B. Horowitz John Gorcsan | 2008 | The American Journal of Cardiology2008，，11： | 1 |
| 15 | Relationships between oesophageal transit and solid and liquid gastric emptying in diabetes mellitus显示文摘 | Michael Horowitz Anne F. Maddox Judith M. Wishart Philip E. Harding Barry E. Chatterton David J. C. Shearman | 1991 | European Journal of Nuclear Medicine1991，，4： | 1 |
| 16 | Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life显示文摘 | Nicholas J Talley Lisa Young Peter Bytzer Johann Hammer Melanie Leemon Michael Jones Michael Horowitz | 2001 | The American Journal of Gastroenterology2001，，1： | 1 |
| 17 | Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life显示文摘 | Nicholas J Talley Lisa Young Peter Bytzer Johann Hammer Melanie Leemon Michael Jones Michael Horowitz | 2001 | The American Journal of Gastroenterology2001，，1： | 1 |
| 18 | Stent-assisted Intracranial Recanalization for acute stroke:early results显示文摘 | Ecker Robert D Horowitz Michael B | 2006 | Neurosurgery2006，58，： | 1 |
| 19 | Reduced Pretreatment Ipsilateral Middle Cerebral Artery Cerebral Blood Flow Is Predictive of Symptomatic Hemorrhage Post–Intra-Arterial Thrombolysis in Patients With Middle Cerebral Artery Occlusion显示文摘 | Rishi Gupta Howard Yonas James Gebel Steven Goldstein Michael Horowitz Stephen Z. Grahovac Lawrence R. Wechsler Maxim D. Hammer Ken Uchino Tudor G. Jovin | 2006 | Stroke2006，，10： | 1 |
| 20 | New Intolerance between Crescent and Cross显示文摘 | Michael Horowitz | 1995 | Wall Street Journal1995，5，： | 1 |
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