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| 1 | Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice显示文摘Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.Methods: Liver weight of 506 mice generated from 39 different Collaborative Cross(CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high-density single nucleotide polymorphic markers.Results: Statistical analysis revealed a significant(P < 0.05) variation of liver weight between the CC lines, with broad sense heritability(H^2) of 0.32 and genetic coefficient of variation(CV_G) of 0.28. Subsequently, quantitative trait locus(QTL) mapping was performed, and results showed a significant QTL only for females on chromosome 8 at genomic interval 88.61-93.38 Mb(4.77 Mb). Three suggestive QTL were mapped at chromosomes 4, 12 and 13. The four QTL were designated as LWL1-LWL4 referring to liver weight loci 1-4 on chromosomes 8, 4, 12 and 13,respectively.Conclusion: To our knowledge, this report presents, for the first time, the utilization of the CC for mapping QTL associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes. | Hanifa J.Abu-Toamih Atamni Maya Botzman Richard Mott Irit Gat-Viks Fuad A.Iraqi | 2018 | Animal Models and Experimental Medicine2018，1，3： | 3 |
| 2 | Acute lymphocytic leukemia: role of hematopoioetic stem cell transplantation in current management 显示文摘 | Irit A Jacob MR | 2003 | Curr Opin Hemato12003，10，： | 1 |
| 3 | Vascular endothelial growth factor (VEGF) fails to improve blood flow and to promote collateralization in a diabetic mouse ischemic hindlimb model显示文摘 | Ariel RO Samy NI Irit RU | 2003 | Cardiovasc Diabetol2003，2，18： | 1 |
| 4 | The Effects of Fluoxetine Treatment in a Chronic Mild Stress Rat Model on Depression - Related Behavior, Brain Neurotrophins and ERK Expi'ession 显示文摘 | Maya First Irit Gil - Ad Michal Taler | 2011 | J Mol Neurosci2011，45，： | 1 |
| 5 | Use of the Polymerase chain reaction for the diagnesis of natural infection of chick-ens and tarkeys with Marek's disease virus and reticuloendotheliosis virus显示文摘 | Irit Davidson I Borovskays A Perl s | 1995 | Avian Pathology1995，24，： | 1 |
| 6 | Luteinizing hormone-induced connexin 43 down-regulation:Inhibition of translation显示文摘 | Yael K Irit G Dalia G | 2004 | Endocrinology2004，145，4： | 1 |
| 7 | Treatment and evaluation indices of auditory processing disorders显示文摘 | Hanna PK Limor Adi Ben S Irit F | 2002 | Seminars in hearing2002，23，： | 1 |
| 8 | Phosphated crosslinked guar for colon-specific drug delivery I: Preparation and physicochemical characterization 显示文摘 | IRIT G K BORIS Y ADEL P | 2000 | Journal of Controlled Release2000，63，1： | 1 |
| 9 | Phosphated erosslinked guar for colon-specific drug delivery II: In vitro and in vivo evaluation in the rat显示文摘 | IRIT G K BORIS Y ADEL P | 2000 | Journal of Controlled Release2000，63，2： | 1 |
| 10 | Low molecular weight heparin (LMWH) for primary thrombo-prophylaxis in patients with solid malignancies – systematic review and meta-analysis显示文摘 | Irit Ben-Aharon Salomon M. Stemmer Leonard Leibovici Ofer Shpilberg Aaron Sulkes Anat Gafter-Gvili | 2014 | Acta Oncologica2014，，： | 1 |
| 11 | Approximating SVP ∞ to within almost-polynomial factors is NP-hard显示文摘 | Irit Dinur | 2002 | Theoretical Computer Science2002，，1： | 1 |
| 12 | A randomized study comparing yttrium‐90 ibritumomab tiuxetan (Zevalin) and high‐dose BEAM chemotherapy versus BEAM alone as the conditioning regimen before autologous stem cell transplantation in patients with aggressive lymphoma显示文摘 | Avichai Shimoni Irit Avivi Jacob M. Rowe Moshe Yeshurun Itai Levi Reuven Or Paulina Patachenko Abraham Avigdor Tzila Zwas Arnon Nagler | 2012 | Cancer2012，，19： | 1 |
| 13 | Cancer Cachexia: Mechanisms and Clinical Implications显示文摘 | Claire L. Donohoe Aoife M. Ryan John V. Reynolds Irit Chermesh | 2011 | Gastroenterology Research and Practice2011，，： | 1 |
| 14 | Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination显示文摘 | Irit S Andreas L Chaya K | 2007 | Development2007，134，3： | 1 |
| 15 | Interrelationship between phosphorus toxicity and sugar metabolism in Verticordia plumosa L显示文摘 | Avner Silber Jaacov Ben-Jaacov Alexander Ackerman Asher Bar-Tal Irit Levkovitch Tania Matsevitz-Yosef Dvora Swartzberg Josef Riov David Granot | 2002 | Plant and Soil2002，，2： | 1 |
| 16 | Open space planning models:a review of approaches and methods显示文摘 | TSEIRA M IRIT A C | 2007 | Landscape and Urban Planning2007，81，12： | 1 |
| 17 | Detection of Wildand Vaccine-Type Avian Infectious Laryngotracheitis Virus in Clinical Samples and Feather Shafts of Commercial Chickens显示文摘 | IRIT DAVIDSON SAGIT NAGAR ISRAEL RIBSHTEIN | | 0，，04： | 1 |
| 18 | A structured forensic interview protocol improves the quality and informativeness of investigative interviews with children: A review of research using the NICHD Investigative Interview Protocol显示文摘 | Michael E. Lamb Yael Orbach Irit Hershkowitz Phillip W. Esplin Dvora Horowitz | 2007 | Child Abuse & Neglect2007，，11： | 1 |
| 19 | Enhanced Oxidative Stress and Leucocyte Activation in Neoplastic Tissues of the Colon显示文摘 | Tova Rainis Irit Maor Amos Lanir Sergay Shnizer Alexandra Lavy | 2007 | Digestive Diseases and Sciences2007，，2： | 1 |
| 20 | Intraductal papillary mucinous neoplasm of the pancreas: Associated cancers, family history, genetic predisposition?显示文摘 | Nir Lubezky Menahem Ben-Haim Guy Lahat Sylvia Marmor Irit Solar Eli Brazowski Richard Nackache Joseph M. Klausner | 2012 | Surgery2012，，1： | 1 |
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