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| 1 | Psychological controversies in gastroparesis: A systematic review显示文摘AIM To systematically review literature addressing three key psychologically-oriented controversies associated with gastroparesis. METHODS A comprehensive search of Pub Med, CINAHL, and PsycI NFO databases was performed to identify literature addressing the relationship between gastroparesis and psychological factors. Two researchers independently screened all references. Inclusion criteria were: an adult sample of gastroparesis patients, a quantitative methodology, and at least one of the following:(1) evaluation of the prevalence of psychopathology;(2) an outcome measure of anxiety, depression, or quality of life; and(3) evidence of a psychological intervention. Case studies, review articles, and publications in languages other than English were excluded from the current review. RESULTS Prevalence of psychopathology was evaluated by three studies(n = 378), which found that combined anxiety/depression was present in 24% of the gastroparesis cohort, severe anxiety in 12.4%, depression in 21.8%-23%, and somatization in 50%. Level of anxiety and depression was included as an outcome measure in six studies(n = 1408), and while limited research made it difficult to determine the level of anxiety and depression in the cohort, a clear positive relationship with gastroparesis symptom severity was evident.Quality of life was included as an outcome measure in 11 studies(n = 2076), with gastroparesis patients reporting lower quality of life than population norms, and a negative relationship between quality of life and symptom severity. One study assessed the use of a psychological intervention for gastroparesis patients(n = 120) and found that depression and gastric function were improved in patients who received psychological intervention, however the study had considerable methodological limitations. CONCLUSION Gastroparesis is associated with significant psychological distress and poor quality of life. Recommendations for future studies and the development of psychological interventions are provided. | Sally Woodhouse Geoff Hebbard Simon R Knowles | 2017 | World Journal of Gastroenterology2017，23，7： | 12 |
| 2 | Role of Adiponectin and Its Receptors in Cancer显示文摘Adiponectin(APN),a novel hormone/cytokine derived from adipocyte tissue,is involved in various physiological functions. Genetics,nutrition,and adiposity are factors contributing to circulating plasma concentrations of APN.Clinical correlation studies have shown that lower levels of serum APN are associated with increased malignancy of various cancers,such as breast and colon cancers,suggesting that APN has a role in tumorigenesis.APN affects insulin resistance,thus further influencing cancer development. Tumor cells may express receptors for APN.Cellular signaling is the mechanism by which APN exerts its host-protective responses. These factors suggest that serum APN levels and downstream signaling targets of APN may serve as potential diagnostic markers for malignancies.Further research is necessary to clarify the exact role of APN in cancer diagnosis and therapy. | Stephanie Obeid Lionel Hebbard | 2012 | Clinical oncology and cancer resexreh2012，9，4： | 7 |
| 3 | Hepatocellular carcinoma and non-alcoholic steatohepatitis:The state of play显示文摘Hepatocellular carcinoma(HCC) is now the fifth cancer of greatest frequency and the second leading cause of cancer related deaths worldwide. Chief amongst the risks of HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The latter can promote non-alcoholic fatty liver disease(NAFLD), that can lead to the inflammatory form non-alcoholic steatohepatitis(NASH), and can in turn promote HCC. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give a summary of the recent findings that describe and associate NAFLD and NASH with the subsequent HCC progression. We will focus our discussion on clinical and genomic associations that describe new risks for NAFLD and NASH promoted HCC. In addition, we will consider novel murine models that clarify some of the mechanisms that drive NASH HCC formation. | Bérénice Charrez Liang Qiao Lionel Hebbard | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 4 | Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development显示文摘Hepatocellular carcinoma(HCC) is increasing in prevalence and is one of the most common cancers in the world. Chief amongst the risks of attaining HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The later has been shown to promote non alcoholic fatty liver disease, which can lead to the inflammatory form non alcoholic steatohepatitis(NASH). NASH is a complex metabolic disorder that can impact greatly on hepatic function. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give an overview of the recent novel mechanisms published that have been associated with NASH and subsequent HCC progression. We will focus our discussion on inflammation and gut derived inflammation and how they contribute to NASH driven HCC. | Chun-Meng Jiang Chun-Wen Pu Ya-Hui Hou Zhe Chen Mohammed Alanazy Lionel Hebbard | 2014 | World Journal of Gastroenterology2014，20，44： | 5 |
| 5 | Determination of spread of injectate after ultrasound-guided transversus abdominis plane block:a cadaveric study显示文摘 | Tran T M Ivanusic J J Hebbard P | 2009 | Br J Anaesth2009，102，1： | 1 |
| 6 | Hyperglycemia Affects Gastric Electrical Rhythm and Nausea During Intraduodenal Triglyceride Infusion显示文摘 | Geoffrey S. Hebbard Melvin Samsom Jane M. Andrews David Carman Ben Tansell Wei Ming Sun John Dent Michael Horowitz | 1997 | Digestive Diseases and Sciences1997，，3： | 1 |
| 7 | Subcostal transversus abdominis plane block under ultrasound guidance显示文摘 | Hebbard P | 2008 | Anesth Analg2008，106，2： | 1 |
| 8 | Ultrasound-guided continuous oblique subcostal transversus abdominis plane blockade:description of anatomy and clinical technique显示文摘 | Hebbard P D Barrington M J Vasey C | 2010 | Reg Anesth Pain Med2010，35，5： | 1 |
| 9 | Proximal gastric compliance and perception of distension in type I diabetes mellitus:effects of hyperglycemia显示文摘 | Rayner CK Verhagen MA Hebbard GS | | 0，，05： | 1 |
| 10 | Proximal gastric compliance and perception of distension in type Ⅰ diabetes mellitus: effects of hyperglycemia显示文摘 | Rayner CK Verbagen MA Hebbard GS | 2000 | Am J Gastrocnterol2000，95，5： | 1 |
| 11 | Classical and innovative insulin sensitizing drugs for the prevention and treatment of NAFLD显示文摘 | Carulli L Maurantonio M Hebbard L | | 0，，： | 1 |
| 12 | CD44 expression and regulation during mammary gland development and function显示文摘 | Hebbard L Steffen A Zawadzki V Fieber C | 2000 | J Cell Sci2000，113，： | 1 |
| 13 | T cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model显示文摘 | Hebbard LW Garlatti M Young LJ | 2008 | Cancer Res2008，68，5： | 1 |
| 14 | High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry显示文摘 | Fox M Hebbard G Janiak P | | 0，，： | 1 |
| 15 | Non-viral causes of liver cancer: does obesity led inflammation play a role 显示文摘 | Alzahrani B Iseli TJ Hebbard LW | 2014 | Cancer Lett2014，345，2： | 1 |
| 16 | Augmentin- induced jaundice with a fatal outcome显示文摘 | Hebbard GS Smith KG Gibson PR | 1992 | Med J Aust1992，156，4： | 1 |
| 17 | Ultrasound- guided transversus abdominis plane (TAP) block 显示文摘 | Hebbard P Fujiwara Y Shibata Y | 2007 | Anaesth Intensive Care2007，35，4： | 1 |
| 18 | Activation of mu opi- oid receptors in the striatum differentially augments metham- phetamine-inducedgene expression and enhances stereotypic behavior显示文摘 | Homer K A Hebbard J C Logan A S | 2012 | J Neurochem2012，120，5： | 1 |
| 19 | Subcostal transversus abdominis plane block under ultrasound guidance 显示文摘 | Hebbard P | 2008 | Anesth Analg2008，106，2： | 1 |
| 20 | Control of mammary tumor differentiation by SKI- 606 (bosutinib) 显示文摘 | HEBBARD L CECENA G GOLAS J etal | 2011 | Oncogene2011，30，3： | 1 |
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