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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Correlation of p53 over-expression and alteration in p53 gene detected by polymerase chain reaction-single strand conformation polymorphism in adenocarcinoma of gastric cancer patients from India显示文摘AIM:To study the alterations in p53 gene among Indian gastric cancer patients and to correlate them with the various clinicopathological parameters. METHODS:A total of 103 gastric cancer patients were included in this study.The p53 alterations were studied by both immunohistochemical method as well as polymerase chain reaction(PCR)-single strand conformation polymorphism(SSCP)analysis.We only studied four(exon 5,6,7,and 8)of the 11 p53 exons.The alterations in p53 were also correlated with respect to various clinicopathological parameters. RESULTS:Among 103 cases,p53 over-expression and alteration were detected in 37(35.92%)and 19(18.44%)cases,respectively.Most of the p53 alterations were found at exon 5(31.54%),followed by exon 6(26.31%),exon 7(21.04%)and exon 8(21.04%).A significant correlation of p53 over- expression was found with p53 alteration(P=0.000). Concordance between p53 alteration(as detected by SSCP)and over-expression[as detected by immunohistochemistry(IHC)]was found in 75%cases. We found that IHC-positive/SSCP-negative cases accounted for 21%of cases and IHC-negative/SSCP- positive cases accounted for remaining 4%cases. CONCLUSION:Our results show that p53 genemutations are significantly correlated with p53 protein overxpression,with 75%concordance in overexpression and alteration in the p53 gene,but 25% disconcordance also cautions against the assumption that p53 over-expression is always associated with a gene mutation.There may be other mechanisms responsible for stabilization and accumulation of p53 protein with no evidence of gene mutation that reflect an accumulation of a non-mutated protein,or a false negative SSCP result. | Sajjad Karim Arif Ali | 2009 | World Journal of Gastroenterology2009，15，11： | 28 |
| 3 | 洱海流域不同施肥模式对稻田氮磷径流流失的影响显示文摘为探究洱海流域水稻种植的合理施肥模式,减少稻田氮磷径流流失,通过田间小区试验,研究不同施肥模式对稻田氮磷径流流失和水稻产量的影响。结果表明:与常规施肥处理(CF)相比,化肥减量20%处理(T1)总氮径流流失量无显著差异,有机肥替代处理(T2~T5)总氮径流流失量降低31.6%~40.4%,缓控释肥处理(T6)总氮径流流失量降低15.7%;与CF处理相比,T1、T2和T6处理总磷径流流失量无显著差异,T3和T5处理总磷径流流失量分别降低23.3%和17.4%,T4处理总磷流失量增加57.0%。与CF处理相比,T6处理和T1处理籽粒产量无显著差异,T2~T5处理籽粒产量降低11.8%~42.9%;与T1处理相比,T5和T3处理籽粒产量无显著差异。与CF处理相比,T1、T6和T4处理秸秆产量无显著差异,T2、T3和T5处理秸秆产量分别降低15.5%、16.0%和36.0%。综合考虑不同施肥处理的稻田径流流失量和水稻产量等因素,化肥减量(T1)、有机无机配施(T3和T5)和缓控释肥(T6)处理是可供选择的环境友好型施肥模式。 | 姜海斌 沈仕洲 谷艳茹 于双 邹洪涛 Arif Husain 张磊 张克强 | 2021 | 农业环境科学学报2021，40，6： | 17 |
| 4 | Internal biliary fistula due to cholelithiasis:A single-centre experience显示文摘AIM: To discuss about the perioperative problems encountered in patients with internal biliary fistula (IBF) caused by cholelithiasis. METHODS: In our hospital, 4 130 cholecystectomies were carried out for symptomatic cholelithiasis from January 2000 to March 2004 and only 12 patients were diagnosed with IBF. The perioperative data of these 12 IBF patients were analyzed retrospectively. RESULTS: The incidence of IBF due to cholelithiasis was nearly 0.3%. The mean age was 57 years. Most of the patients presented with non-specific complaints. Only two patients were considered to have IBF when gallstone ileus was observed during the investigations. Nine patients underwent emergency laparotomy with a pre-operative diagnosis of acute abdomen. In the remaining three patients, elective laparoscopic cholecystectomy was converted to open surgery after identification of IBF. Ten patients had cholecystoduodenal fistula and two patients had cholecystocholedochal fistula. The mean hospital stay was 13 d. Two wound infections, three bile leakages and three mortalities were observed. CONCLUSION: Cholecystectomy has to be performed in early stage in the patients who were diagnosed as cholelithiasis to prevent the complications like IBF which is seen rarely. Suspicion of IBF should be kept in mind, especially in the case of difficult dissection during cholecystectomy and attention should be paid in order to prevent iatrogenic injuries. | Arife Polat Duzgun Mehmet Mahir Ozmen Mehmet Vasfi Ozer Faruk Coskun | 2007 | World Journal of Gastroenterology2007，13，34： | 15 |
| 5 | 旋转状态下风机叶片雷击接闪特性的实验研究显示文摘风机雷击事故频发,严重威胁风电场正常运行。现场观测数据表明,旋转风机更易遭受雷击。对此该文设计1:30缩比可旋转3MW风机模型,模拟真实风机旋转叶尖线速度,使用正负极性标准操作波,利用长间隙放电模拟真实雷电,开展旋转状态下风机叶片防雷装置接闪特性研究。实验结果表明,旋转会对接闪过程中叶片接闪点分布与接闪后放电通道产生影响,放电具有明显的极性效应。旋转使得正极性放电下叶片接闪器拦截效率下降;对负极性影响较小。正极性放电更易击中远离叶尖部位。成功接闪后,接闪点附近放电通道因叶片旋转发生偏移,产生"拉弧"现象,造成叶片损伤,并与实际风机受损情况相对应。所得结果为风机叶片防雷优化设计提供参考。 | 郭子炘 李庆民 于万水 张黎 王国政 马宇飞 WAQAS Arif SIEW Wah Hoon | 2018 | 中国电机工程学报2018，38，16： | 15 |
| 6 | Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis:A systematic review and meta-analysis显示文摘AIM:To conduct a systemic review and meta-analysis to investigate the role of early precut technique.Multiple randomized controlled trails(RCTs)have reported conflicting results of the early precut sphincterotomy.METHODS:MEDLINE/PubMed,EMBASE,Cochrane Central Register of Controlled Trials and Database of Systematic Reviews,and recent abstracts from major conference proceedings were searched(June 2013).Randomized and non-randomized studies comparing early precut technique with prolonged standard methods were included.Pooled estimates of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP),cannulation and adverse events were analyzed by using odds ratio(OR).Random and fixed effects models were used as appropriate.Publication bias was assessed by funnel plots.Heterogeneity among studies was assessed by calculating I2 measure of inconsistency.RESULTS:Seven randomized and seven non-randomized trials met inclusion criteria.Meta-analysis of RCTs showed a decrease trend for PEP with early precut sphincterotomy but was not statistically significant(OR=0.58;95%CI:0.32-1.05;P=0.07).No heterogeneity was noted among the studies with I2 of 0%.CONCLUSION:Early precut technique for common bile duct cannulation decreases the trend of post-ERCP pancreatitis. | Abhishek Choudhary Jessica Winn Sameer Siddique Murtaza Arif Zainab Arif Ghassan M Hammoud Srinivas R Puli Jamal A Ibdah Matthew L Bechtold | 2014 | World Journal of Gastroenterology2014，20，14： | 13 |
| 7 | Survey on synchrophasor data quality and cybersecurity challenges, and evaluation of their interdependencies显示文摘Synchrophasor devices guarantee situation awareness for real-time monitoring and operational visibility of smart grid. With their widespread implementation,significant challenges have emerged, especially in communication, data quality and cybersecurity. The existing literature treats these challenges as separate problems,when in reality, they have a complex interplay. This paper conducts a comprehensive review of quality and cybersecurity challenges for synchrophasors, and identifies the interdependencies between them. It also summarizes different methods used to evaluate the dependency and surveys how quality checking methods can be used to detect potential cyberattacks. | Aditya SUNDARARAJAN Tanwir KHAN Amir MOGHADASI Arif I.SARWAT | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 12 |
| 8 | Rotator cuff tears: An evidence based approach显示文摘Lesions of the rotator cuff(RC) are a common occurrence affecting millions of people across all parts of the globe. RC tears are also rampantly prevalent with an agedependent increase in numbers. Other associated factors include a history of trauma, limb dominance, contralateral shoulder, smoking-status, hypercholesterolemia, posture and occupational dispositions. The challenge lies in early diagnosis since a high proportion of patients are asymptomatic. Pain and decreasing shoulder power and function should alert the heedful practitioner in recognizing promptly the onset or aggravation of existing RC tears. Partial-thickness tears(PTT) can be bursalsided or articular-sided tears. Over the course of time, PTT enlarge and propagate into full-thickness tears(FTT) and develop distinct chronic pathological changes due to muscle retraction, fatty infiltration and muscle atrophy. These lead to a reduction in tendon elasticity and viability. Eventually, the glenohumeral joint experiences a series of degenerative alterations- cuff tear arthropathy. To avert this, a vigilant clinician must utilize and corroborate clinical skill and radiological findings to identify tear progression. Modern radio-diagnostic means of ultrasonography and magnetic resonance imaging provide excellent visualization of structural details and are crucial in determining further course of action for these patients. Physical therapy along with activity modifications, antiinflammatory and analgesic medications form the pillars of nonoperative treatment. Elderly patients with minimal functional demands can be managed conservatively and reassessed at frequent intervals. Regular monitoring helps in isolating patients who require surgical interventions. Early surgery should be considered in younger, active and symptomatic, healthy patients. In addition to being costeffective, this helps in providing a functional shoulder witha stable cuff. An easily reproducible technique of maximal strength and sturdiness should by chosen among the armamentarium of the shoulder surgeon. Grade 1 PTTs do well with debridement while more severe lesions mandate repair either by trans-tendon technique or repair following conversion into FTT. Early repair of repairable FTT can avoid appearance and progression of disability and weakness. The choice of surgery varies from surgeon-to-surgeon with arthroscopy taking the lead in the current scenario. The double-row repairs have an edge over the single-row technique in some patients especially those with massive tears. Stronger, costeffective and improved functional scores can be obtained by the former. Both early and delayed postoperative rehabilitation programmes have led to comparable outcomes. Guarded results may be anticipated in patients in extremes of age, presence of comorbidities and severe tear patters. Overall, satisfactory results are obtained with timely diagnosis and execution of the appropriate treatment modality. | Senthil Nathan Sambandam Vishesh Khanna Arif Gul Varatharaj Mounasamy | 2015 | World Journal of Orthopedics2015，6，11： | 11 |
| 9 | Numerical simulation to evaluate gas diffusion of turbulent flow in mine ventilation system显示文摘Tracer gas technique is a method to analyze the airflow path, measure the airflow quantity, and detect any recirculation or leakages in underground mine. In addition, it is also possible to evaluate the axial gas diffusion of gas in turbulent bulk flow by utilizing the tracer gas data. This paper discussed about the measurement using tracer gas technique in Cibaliung Underground Mine, Indonesia and the evaluation of effective axial diffusion coefficient, E, by numerical simulation. In addition, a scheme to treat network flow in mine ventilation system was also proposed. The effective axial diffusion coefficient for each airway was evaluated based on Taylor's theoretical equation. It is found that the evaluated diffusion coefficient agrees well with Taylor's equation by considering that the wall friction factor, f, is higher than those for smooth pipe flow. It also shows that the value of effective diffusion coefficient can be inherently determined and the value is constant when matching with other measurements. Furthermore, there are possibilities to utilize the tracer gas measurement data to evaluate the airway friction factors. | Arif Widiatmojo Kyuro Sasaki Nuhindro Priagung Widodo Yuichi Sugai Johannes Sinaga Haris Yusuf | 2013 | International Journal of Mining Science and Technology2013，23，3： | 8 |
| 10 | Deciphering codon usage patterns and evolutionary forces in chloroplast genes of Camellia sinensis var. assamica and Camellia sinensis var. sinensis in comparison to Camellia pubicosta显示文摘Codon usage bias(CUB) is a unique property of genome which refers to non-random usage of synonymous codons in coding sequences. The present study makes an attempt to find out the pattern of CUB in chloroplast(cp) genes among three tea species, i.e., Camellia sinensis var. assamica(Assam tea), Camellia sinensis var. sinensis(Chinese tea) and Camellia pubicosta(wild tea species) as no work on CUB was reported earlier. To understand the patterns of codon usage among the cp genes of three tea groups, we used bioinformatic tools to investigate the protein coding sequences of cp genes. In our present study, the mean nucleobase T was the highest whereas C was the lowest in all the three tea groups. The overall AT content was more than GC content, i.e., genes were AT rich. The scaled chi-square(SCS) value indicated that the CUB of cp genes was low. The codon CGT(Arg) was over-represented in C. sinensis var. sinensis whereas GGA(Pro) was over-represented in C. pubicosta species. Heatmap study revealed that most of the GC ending codons showed positive correlations between codon usage and GC3 while AT ending codons exhibited negative correlations. From neutrality plot analysis, it was evident that natural selection had played a major role, while mutation pressure exerted a minor effect in the CUB of cp genes in three tea groups. Highly significant(P<0.01) positive correlation was found between SCS and synonymous codon usage order(SCUO) of cp genes which suggested that high expression of cp genes was associated with high degree of CUB. | Sophiarani Yengkhom Arif Uddin Supriyo Chakraborty | 2019 | Journal of Integrative Agriculture2019，18，12： | 7 |
| 11 | PSO Based Controlled Six-phase Grid Connected Induction Generator for Wind Energy Generation显示文摘This paper deals a detailed performance investigation of asymmetrical six-phase grid connected induction generator(GCIG)in two proposed configurations in variable speed operation.During the system development,regulation of DC-link voltage has been proposed using particle swarm optimization(PSO)based PI controller,ensuring the power flow to utility grid through back to back converters.The closed loop operation of asymmetrical six-phase GCIG using indirect field oriented control in different configurations has been carried out in Matlab/Simulink environment.Analytical results have been verified using real time test results on virtual platform of Typhoon HIL supported with some experimental validation. | Arif Iqbal Girish Kumar Singh | 2021 | CES Transactions on Electrical Machines and Systems2021，5，1： | 7 |
| 12 | Toward artificial intelligent self-cooling electronic skins:Large electrocaloric effect in all-inorganic flexible thin films at room temperature显示文摘Intelligent robots have assisted mankind in achieving and operating thousands of functions,especially with the arrival of the artificial intelligent.However,heat dissipation and thermal management in the intelligent robots remain big challenges,which limit their miniaturization and performance.Electrocaloric(EC)materials,which exhibit temperature change in response to the application or withdrawal of an electric field,open a new strategy for cooling technology and have gained a flurry of research interest in recent years.Toward artificial intelligent self-cooling electronic skins,large-scale flexible materials with high EC effect near room temperature are in demand.Here,we report a large room temperature EC effect in flexible Pb_(0.82)Ba_(0.08)La_(0.1)Zr0.9Ti_(0.1)O_(3)(PBLZT)inorganic thin films via a transfer-free cost-effective sol-gel process,assisted by unique two-dimensional mica substrates.The maximum adiabatic temperature change and isothermal entropy change of the flexible PBLZT thin films reach to 22.5 K and 25.9 J K^(-1) kg^(-1) at room temperature.In particular,the flexible PBLZT thin films exhibit a stable EC effect both under bending state and after bending for 20000 times.Our flexible EC materials offer an alternative strategy to the development of cooling technologies for both artificial intelligent robots and personal wearable cooling devices. | Ding Wang Xin Chen Guoliang Yuan Yanmin Jia Yiping Wang Arif Mumtaz Yaojin Wang Jun-Ming Liu | 2019 | Journal of Materiomics2019，5，1： | 7 |
| 13 | Synchronous and metachronous occurrence of gastric adenocarcinoma and gastric lymphoma: A review of the literature显示文摘在一样的病人的主要胃的淋巴瘤和胃的腺癌的出现是一个稀罕实体。在治疗形式的恶意和变化的同步或异时的出现的可能的原因的因素用英语语言根据出版盒子被考察医药文学。 | Erhan Hamaloglu Serdar Topaloglu Arif Ozdemir Ahmet Ozenc | 2006 | World Journal of Gastroenterology2006，12，22： | 7 |
| 14 | Greenhouse Gas Emissions from Agro-Ecosystems and Their Contribution to Environmental Change in the Indus Basin of Pakistan显示文摘正在种在空气增加温室气体的集中负责在放射平衡和温度上的通过他们的效果的全球温暖的担心。排出物和不同来源的相对重要性的大小广泛地,地区性并且局部地变化。巴基斯坦的印度河盆是这个国家的食物篮子,农业活动对由于 GHG 的加速的排出物的全球温暖的效果脆弱。许多开发在新冒险为投资在政府和私人部门的鼓励的变化角色的背景在最近的十年发生在巴基斯坦的农业部门。这些干预有可观的 GHG 排放潜力。不幸地,没有出版信息在在印度河盆的 GHG 集中上当前是可得到的估计他们的大小和排放趋势。现在的学习是一次尝试估计 GHG (公司 2, CH 4 和 N 2 O ) 排出物从印度河盆的不同 agro 生态系统产生。GHG 从出版文学主要用 IPCC 指南和数据被估计。结果证明 CH 4 排出物是最高(4.126 Tg 年 −1) 由 N 2 O (0.265 Tg 年 −1) 和公司 2(52.6 Tg 年 −1) 。CH 4 的来源是伤寒发酵,米饭耕作和另外的庄稼的耕作。N 2 O 被在休闲土壤上在收割土壤上或由本国的有机物的矿化作用从应用 fertilizer-N 生产的没有 3 的微生物引起的 denitrification 形成。公司 2 被烧植物残余并且由土壤呼吸由于土壤有机物的分解形成。 | M. Mohsin IQBAL M. Arif GOHEER | 2008 | Advances in Atmospheric Sciences2008，25，6： | 7 |
| 15 | 基于模糊语言变量的动态目标无线网络选择技术(英文)显示文摘Even though various wireless Network Access Technologies(NATs)with different specifications and applications have been developed in the recent years,no single wireless technology alone can satisfy the anytime,anywhere,and any service wireless-access needs of mobile users.A real seamless wireless mobile environment is only realized by considering vertical and horizontal handoffs together.One of the major design issues in heterogeneous wireless networks is the support of Vertical Handoff(VHO).VHO occurs when a multi-interface enabled mobile terminal changes its Point of Attachment(PoA)from one type of wireless access technology to another,while maintaining an active session.In this paper we present a novel multi-criteria VHO algorithm,which chooses the target NAT based on several factors such as user preferences,system parameters,and traffic-types with varying Quality of Service(QoS)requirements.Two modules i.e.,VHO Necessity Estimation(VHONE)module and target NAT selection module,are designed.Both modules utilize several'weighted'users’and system’s parameters.To improve the robustness of the proposed algorithm,the weighting system is designed based on the concept of fuzzy linguistic variables. | Faisal Kaleem Abolfazl Mehbodniya Arif Islam Kang K.Yen Fumiyuki Adachi | 2013 | China Communications2013，10，1： | 6 |
| 16 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 17 | Watermarking of Digital Images in Frequency Domain显示文摘Invisible watermarking methods have been applied in frequency domains, trying to embed a small image inside a large original image. The original bitmap image will be converted into frequency domain to obtain the discrete cosine transform (DCT) matrices from its blocks. The bits of the logo image are embedded in random color components of the original image, as well as in random positions in each selected block. These positions are alternating current (AC) coefficients of the DCT matrix. The randomness is obtained from RC4 pseudorandom bit generator that determines in which color component this logo image bits will be embedded. The embedded bits have been hidden in random blocks in the image, which are chosen according to a (semi-random) function proposed in this work. | Sami E. I. Baba Lala Z. Krikor Thawar Arif Zyad Shaaban | 2010 | International Journal of Automation and computing2010，7，1： | 6 |
| 18 | Effects of the myeloperoxidase 463 gene polymorphisms on development of atrophy in H pylori infected or noninfected gastroduodenal disease显示文摘AIM: To investigate the relationship between myelo- peroxidase polymorphisms as a host-related factor and atrophy caused by H pylori. METHODS: Our study enrolled 77 patients. Biopsy materials obtained during gastrointestinal endoscopies were evaluated for the presence of H pylori. Polymerase chain reaction-restriction fragment length polymorphism assay was used to characterize myeloperoxidase genotypes. RESULTS: Forty four patients (57.1%) were Hp (+) and 33 (42.9%) were Hp (-). Sixty six (85.7%) had GG genotype, 10 (12.9%) had GA genotype and 1 (1.29%) had AA genotype. The change in atrophy in relation to neutrophil infiltration was significant in Hp (+) patients (P = 0.0001). The change in atrophy in relation to neutrophil infiltration in patients with GG genotype was significant (P = 0.002). However, the change in atrophy in relation to neutrophil infiltration was not significiant in patients with Hp (+) GG genotype (r = 0.066, P = 0.63). CONCLUSION: Myeloperoxidase genotype is critical for development of atrophy in relation to the severity of inflammation. However, it is interesting to note that, H pylori does not show any additive effect on development of atrophy. | mer Yilmaz Hakan Dursun Nesrin Gürsan ibrahim Pirim Arif Yilmaz Nihat Okcu | 2007 | World Journal of Gastroenterology2007，13，8： | 6 |
| 19 | Handheld high-throughput plasmonic biosensor using computational on-chip imaging显示文摘We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings.This lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures.Employing a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm.Integrating large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations.In this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings. | Arif E Cetin Ahmet F Coskun Betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug | 2014 | Light(Science & Applications)2014，3，1： | 6 |
| 20 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
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