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| 1 | Safety of anti-tumor necrosis factor therapy during pregnancy in patients with inflammatory bowel disease显示文摘Treatment of inflammatory bowel disease has significantly improved since the introduction of biological agents, such as infliximab, adalimumab, certolizumab pegol, and golimumab. The Food and Drug Administration has classified these factors in category B, which means that they do not demonstrate a fetal risk. However, during pregnancy fetuses are exposed to high anti-tumor necrosis factor(TNF) levels that are measurable in their plasma after birth. Since antibodies can transfer through the placenta at the end of the second and during the third trimesters, it is important to know the safety profile of these drugs, particularly for the fetus, and whether maintaining relapse of the disease compensates for the potential risks of fetal exposure. The limited data available for the anti-TNF drugs to date have not demonstrated any significant adverse outcomes in the pregnant women who continued their therapy from conception to the first trimester of gestation. However, data suggest that antiTNFs should be discontinued during the third trimester, as they may affect the immunological system of the newborn baby. Each decision should be individualized, based on the distinct characteristics of the patient and her disease. Considering all the above, there is a need for more clinical studies regarding the effect of antiTNF therapeutic agents on pregnancy outcomes. | Ioannis Androulakis Christos Zavos Panagiotis Christopoulos George Mastorakos Maria Gazouli | 2015 | World Journal of Gastroenterology2015，21，47： | 3 |
| 2 | Posttensioned Energy Dissipating Connections for Moment-Resisting Steel Frames显示文摘 | Constantin Christopoulos Andre Filiatrault Chia-Ming Uang Bryan Folz | 2002 | Journal of Structural Engineering2002，，9： | 2 |
| 3 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 4 | Financial development and economic growth: evidence from panel unit root and cointegration tests显示文摘 | Dimitris K Christopoulos Efthymios G Tsionas | 2003 | Journal of Development Economics2003，，1： | 2 |
| 5 | Discrete transform technique for sol- ving coupled integro- differential equations in digital computers 显示文摘 | S Y R HUI C Christopoulos | 1991 | IEEE PROCEEDINGS - A1991，138，5： | 1 |
| 6 | Analytical formulation for the shielding effectiveness of enclosures with apertures显示文摘 | Robinson M P Benson T M Christopoulos C | 1998 | IEEE Trans on Electromagn Compat1998，40，3： | 1 |
| 7 | Financial devel- opment and economic growth: evidence from panel unit root and eointegration tests 显示文摘 | Christopoulos D K Tsionas E G | 2004 | Journal of Development Econom- ics2004，73，1： | 1 |
| 8 | Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma显示文摘 | Christopoulos TA Papageorgakopoulou N Ravazoula P | 2007 | Oncol Rep2007，18，4： | 1 |
| 9 | The JPEG2000 Still Image Coding System:An Overview显示文摘 | A Skodras | 2003 | IEEE Transactions on Consumer E-lectronics2003，46，4： | 1 |
| 10 | Testing for Granger (non)-Causality in a time varying coefficient VAR model显示文摘 | Christopoulos D Le6n-Ledesma M | 2008 | Journal of Forecasting2008，27，4： | 1 |
| 11 | Plasmablastic lymphoma of visceral cranium,cervix and thorax in an HIV-negative woman显示文摘 | Masgala A Christopoulos C Giannakou N | 2007 | Ann Hematol2007，86，： | 1 |
| 12 | Drug-eluting balloon: new tool in the box显示文摘 | Sharma S Kukreja N Christopoulos C | 2010 | Expert Rev Med Devices2010，7，3： | 1 |
| 13 | paihogenesis of venous ulceration in relation to the calt muscle pump function显示文摘 | Christopoulos D Nicolaioles AN cook A | 1989 | sugery1989，，： | 1 |
| 14 | Analytical formulation for the shielding effectiveness of enclosures with apertures显示文摘 | Robinson M P Benson T M Christopoulos C | 1998 | IEEE Transactions on Electromagnetic Compatibility1998，40，3： | 1 |
| 15 | Effects of package atmosphere and temperature on phenolics,total antioxidant capacity and colour in kernels of'Franquette'walnuts during 8-month storage显示文摘 | Christopoulos M V Tsantili E Papageorgiou V | 2010 | Acta Horticulturae2010，，585： | 1 |
| 16 | G-protein-coupled receptor allosterism : the promise and the problem (s) 显示文摘 | Christopoulos A May LT Avlani VA | 2004 | Biochem Soc Trans2004，32，5： | 1 |
| 17 | PERFORMANCE-BASED SEISMIC RESPONSE OF FRAME STRUCTURES INCLUDING RESIDUAL DEFORMATIONS. PART II: MULTI-DEGREE OF FREEDOM SYSTEMS显示文摘 | Stefano Pampanin Constantin Christopoulos M. J. Nigel Priestley | 2003 | Journal of Earthquake Engineering2003，，1： | 1 |
| 18 | Efficient methods for encoding region of interest in the upcoming JPEG2000 still image coding standard 显示文摘 | Christopoulos C Askelof J Larsson M | 2000 | IEEE Signal Processing Letters2000，7，9： | 1 |
| 19 | Experi- mental validation of replaceable shear links for eccen- trically braced steel frames 显示文摘 | Mansour N Christopoulos C Tremblay R | 2011 | Journal of Structural Engineering2011，137，10： | 1 |
| 20 | Efficient Methods for Encoding Region of Interest in the Upcoming JPEG2000 Still Image Coding Standard显示文摘 | Christopoulos C Askelf J Larsson M | 2000 | IEEE Signal Processing Letters2000，7，9： | 1 |
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