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| 1 | Genomic era diagnosis and management of hereditary and sporadic colon cancer显示文摘The morbidity and mortality attributable to heritable and sporadic carcinomas of the colon are substantial and affect children and adults alike. Despite current colonoscopy screening recommendations colorectal adenocarcinoma(CRC) still accounts for almost 140000 cancer cases yearly. Familial adenomatous polyposis(FAP) is a colon cancer predisposition due to alterations in the adenomatous polyposis coli gene, which is mutated in most CRC. Since the beginning of the genomic era next-generation sequencing analyses of CRC continue to improve our understanding of the genetics of tumorigenesis and promise to expand our ability to identify and treat this disease. Advances in genome sequence analysis have facilitated the molecular diagnosis of individuals with FAP, which enables initiation of appropriate monitoring and timely intervention. Genome sequencing also has potential clinical impact for individuals with sporadic forms of CRC, providing means for molecular diagnosis of CRC tumor type, data guiding selection of tumor targeted therapies, and pharmacogenomic profiles specifying patient specific drug tolerances. There is even a potential role for genomic sequencing in surveillance for recurrence, and early de-tection, of CRC. We review strategies for diagnostic assessment and management of FAP and sporadic CRC in the current genomic era, with emphasis on the current, and potential for future, impact of genome sequencing on the clinical care of these conditions. | Edward David Esplin Michael Paul Snyder | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Alterations of the PPP2R1B gene in human lung and colon cancer显示文摘 | Wang SS Esplin ED Li JL | 1998 | Science1998，282，5387： | 1 |
| 3 | Paternal and maternalcomponents of the predisposition to preeclampsia显示文摘 | Esplin MS Tausett MB Trasor A | 2001 | NewEngJ Med2001，344，： | 1 |
| 4 | Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra- amniotic infection显示文摘 | Esplin MS Romero R Chaiworapongsa T | 2005 | J Matern Fetal Neonatal Med2005，17，6： | 1 |
| 5 | SABER instrument overview显示文摘 | ESPLIN R BATTY C JENSEN M | 2000 | SPIE2000，2268，： | 1 |
| 6 | Alterations of the PPP2R1B gene in human lung and colon cancer显示文摘 | Wang SS Esplin ED Li JL | 1998 | Science1998，282，5387： | 1 |
| 7 | Related non-Hodgkin's lymphoma:abdominal CT findings in 112 patients显示文摘 | Radin DR Esplin JA Levine AM | 1993 | AJR1993，160，5： | 1 |
| 8 | Paternal and maternal components of the predisposition to preeclampsia显示文摘 | Esplin MS MB Fauset A Fraser R | 2001 | NEngl J Med2001，344，： | 1 |
| 9 | Alterations of the PPP2R1B gene in human lung and colon cancer显示文摘 | WANG S S ESPLIN E D LI J L | 1998 | Science1998，282，5387： | 1 |
| 10 | Monocyte chemotactic protein-1is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intraamniotic infection显示文摘 | Esplin MS Romero R Edwin S | 2005 | J Matern Fetal and Med2005，17，6： | 1 |
| 11 | Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and pretern Labor显示文摘 | Esplin MS Peliter MR Hamblin S | 2005 | Placenta2005，26，89： | 1 |
| 12 | The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor显示文摘 | Esplin M S Fausett M B Pelfier M R | 2005 | Am J Obstet Gynecol2005，193，2： | 1 |
| 13 | Monocyte chemo- tactic protein-1 is increased in the amniotic fluid of women who de- liver preterm in the presence or absence of intra-amniotic infection 显示文摘 | Esplin MS Romero R Chaiworapongsa T | 2005 | J Matern Fetal Neonatal Med2005，17，6： | 1 |
| 14 | A structured forensic interview protocol improves the quality and informativeness of investigative interviews with children: A review of research using the NICHD Investigative Interview Protocol显示文摘 | Michael E. Lamb Yael Orbach Irit Hershkowitz Phillip W. Esplin Dvora Horowitz | 2007 | Child Abuse & Neglect2007，，11： | 1 |
| 15 | Alterations of the PPP2R1B genein human lung and colon cancer 显示文摘 | Wang SS Esplin ED Li JL e( al | 1998 | Science1998，282，5387： | 1 |
| 16 | The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function显示文摘 | RAMOS P MARTINEZ B | 2006 | Genes Chromosomes Cancer2006，45，2： | 1 |
| 17 | Hyperkeratotic form of porokeratosis of Mibelli显示文摘 | Jacyk WK Esplin L | 1993 | Int J Dermatol1993，32，12： | 1 |
| 18 | Paternal and ma- ternal components of the predisposition to pre-eclampsia 显示文摘 | Esplin MS Fausett MB Fraser A | 2001 | N Engl J Med2001，344，： | 1 |
| 19 | A method for radiologic-assisted gastrostomy when percutaneous endoscopic gastrostomy is contraindicated显示文摘 | Rosenzweig TB Palestrant AM Esplin CA | 1994 | Am J Surg1994，168，6： | 1 |
| 20 | Gaucher disease:recommendations on diagnosis evaluation and monito- ring显示文摘 | CHARROW J ESPLIN J A GRIBBLE T J | 1998 | Arch Intern Med1998，158，： | 1 |
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