|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 2 | The use of virtual surgical planning and navigation in the treatment of orbital trauma显示文摘 | Alan Scott Herford Meagan Miller Floriana Lauritano Gabriele Cervino Fabrizio Signorino Carlo Maiorana | 2017 | Chinese Journal of Traumatology2017，20，1： | 19 |
| 3 | Paediatric cholestatic liver disease:Diagnosis,assessment of disease progression and mechanisms of fibrogenesis显示文摘Cholestatic liver disease causes significant morbidity and mortality in children.The diagnosis and management of these diseases can be complicated by an inability to detect early stages of fibrosis and a lack of adequate interventional therapy.There is no single gold standard test that accurately reflects the presence of liver disease,or that can be used to monitor fibrosis progression,particularly in conditions such as cystic fibrosis.This has lead to controversy over how suspected liver disease in children is detected and diagnosed.This review discusses the challenges in using commonly available methods to diagnose hepatic fibrosis and monitor disease progression in children with cholestatic liver disease.In addition,the review examines the mechanisms hypothesised to be involved in the development of hepatic fibrogenesis in paediatric cholestatic liver injury which may ultimately aid in identifying new modalities to assist in both disease detection and therapeutic intervention. | Tamara N Pereira Meagan J Walsh Peter J Lewindon Grant A Ramm | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 7 |
| 4 | Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs显示文摘Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic medium.Results from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-MSCs.Interestingly,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis methods.Lastly,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and senolytics.The results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in cartilage.The P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans. | Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang Lin | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 5 | Serotonin and Its Role in Colonic Function and in Gastrointestinal Disorders显示文摘 | Meagan M. Costedio M.D. Neil Hyman M.D. Gary M. Mawe Ph.D | 2007 | Diseases of the Colon & Rectum2007，，3： | 1 |
| 6 | Self-Perceived Gender Typicality, Gender-Typed Attributes, and Gender Stereotype Endorsement in Elementary-School-Aged Children 显示文摘 | Meagan M Patterson | 2012 | Sex Roles2012，，7： | 1 |
| 7 | Management of Bladder Function after Outpatient Surgery显示文摘 | Janet D. Pavlin Edward G. Pavlin Dermot R. Fitzgibbon Meagan E. Koerschgen Terryn M. Plitt | 1999 | Anesthesiology1999，，1： | 1 |
| 8 | Moving agroforestry into the mainstream显示文摘 | Dean A. Current Kenneth N. Brooks Peter F. Ffolliott Meagan Keefe | 2009 | Agroforestry Systems2009，，1： | 1 |
| 9 | Prevalence of anal human papillomavirus infection and anal HPV-related disorders in women: a systematic review显示文摘 | Elizabeth A. Stier Meagan C. Sebring Audrey E. Mendez Fatimata S. Ba Debra D. Trimble Elizabeth Y. Chiao | 2015 | American Journal of Obstetrics and Gynecology2015，，3： | 1 |
| 10 | Variable-sized bar targets for characterizing three-dimensional resolution in OCT 显示文摘 | GU Ruoyu Lurie Kristen L Pipes Meagan | 2012 | Biomedical Optics Express(S2156-7085)2012，3，9： | 1 |
| 11 | Vereckei criteria as a diagnostic tool amongst emergency medicine residents to distinguish between ventricular tachycardia and supra-ventricular tachycardia with aberrancy显示文摘 | Rupen P. Baxi Kimberly W. Hart András Vereckei John Miller Sora Chung Wendy Chang Brent Gottesman Meagan Hunt Ginger Culyer Thomas Trimarco Christopher Willoughby Guillermo Suarez Christopher J. Lindsell Sean P. Collins | 2012 | Journal of Cardiology2012，，3： | 1 |
| 12 | Solution concentration influences voluntary consumption of nicotine under multiple bottle conditions 显示文摘 | Biondolillo Kris Pearce Amy R Louder Meagan C | 2009 | Pharmacology Biochemistry and Behavior2009，92，2： | 1 |
| 13 | Racial differences in the distribution of a low density lipoprotein receptor-related protein(LRP) polymorphism and its association with serum lipiprotein, lipid and apolipoprotein levels 显示文摘 | Meagan RH Clareann HB Richard FH | 1998 | Atherosclerosis1998，138，： | 1 |
| 14 | Skeletal muscle LIM protein 1 (SLIM 1/FHL 1) induces α5β1-integrin-dependent myocyte elongation显示文摘 | Meagan J McGrath Christina A | 2003 | Am J Physiol Cell Physiol2003，285，： | 1 |
| 15 | The value of rock mass classification systems for weak rock masses:a case example from Huntly,New Zealand显示文摘 | Vichi M Geoff R Meagan S | 2001 | Engineering Geology2001，61，1： | 1 |
| 16 | Skeletal muscle LIM p-rotein 1(SLIM1/FHL1)inducesα5β1-integrin-dependent myocyte elongation显示文摘 | MEAGAN J MCGRATH CHRISTINA A | 2003 | Am J Physiol Cell Physiol2003，285，： | 1 |
| 17 | Skeletal muscle lim pro- tein 1 ( SLIM1/FHL1 ) induces ot5131 - integrin - dependent myo- cyte elongation 显示文摘 | Meagan J McgTath M Christina A | 2003 | American Journal Physiol Cell Physiol2003，285，： | 1 |
| 18 | Vibrio mimicus Infection Associated with Crayfish Consumption, Spokane, Washington, 2010显示文摘 | Kay Meagan K Cartwright Emily J MacEachern Dorothy McCullough Joel Barzilay Ezra Mintz Eric Duchin Jeffrey S MacDonald Kathryn Turnsek Maryann Tarr Cheryl Talkington Deborah Newton Anna Marfin Anthony A | 2012 | EN2012，，4： | 1 |
| 19 | Characterizing sources of groundwater to a tropical coastal lagoon in a karstic area using radium isotopes and water chemistry显示文摘 | Megan B. Young Meagan Eagle Gonneea Derek A. Fong Willard S. Moore Jorge Herrera-Silveira Adina Paytan | 2007 | Marine Chemistry2007，，3： | 1 |
| 20 | Investigating the Efficacy of Embedment: Experiments in Information Literacy Integration 显示文摘 | Meagan Bowler Kori Street | 2008 | Reference Services Review2008，36，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员