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| 1 | Predicting functional outcome of ischemic stroke patients in Romania based on plasma CRP, sTNFR-1, D-Dimers, NGAL and NSE measured using a biochip array显示文摘在服的局部缺血,涉及各种各样的病理学的小径的多重 biomarkers 的评估是在甚至从疾病的早阶段估计病人的结果的一个有用工具。在这研究,我们在局部缺血的尖锐阶段调查了煽动性的地位, neuronal 破坏和第二等的纤维蛋白溶解作用的 5 外部 biomarkers 的一块面板的用途,并且在 ischemic 击以后在功能的结果上评估了这些 biomarkers 的影响。5 biomarkers (血浆 CRP, D-Dimers, sTNFR-1, NGAL 和 NSE ) 用一种生物晶片数组技术被测量。在罗马尼亚的八十九个病人用在 ischemic 击以后在 3 个月评估的修改 Rankin 规模被划分成 2 亚群;相反的功能的结果上的分析 biomarkers 的可能的影响被二项式的逻辑回归测试。有相反的结果的亚群有 CRP, NGAL, sTNFR-1 和 D-dimers 的更高的集中,但是 CRP 和 NGAL 价值不在二亚群之间是统计上不同的。univariate 血浆 biomarkers 的逻辑回归分析揭示了那 CRP, D-Dimers, NGAL, sTNFR-1 是相反的临床的结果的重要预言者。在 D-Dimers 和 sTNFR-1 的情况中,我们注意了一个增加的辨别能力(对基线临床的模型) 向统计含义与一个趋势分类差的功能的结果。在 ischemic 击的尖锐阶段期间, CRP, D-Dimers 和 sTNFR-1 的血浆集中在相反的结果病人被提高。D-Dimers 和 sTNFR-1 是在在 ischemic 击以后的 3 个月的差的结果的独立预言者。生物晶片数组技术提供可能性同时测量涉及多重 pathophysiological 小径的几个参数,在小样品卷。 | Adina HUTANU Mihaela IANCU Rodica BALASA Smaranda MAIER Minodora DOBREANU | 2018 | Acta Pharmacologica Sinica2018，39，7： | 25 |
| 2 | Wound-Induced Shoot-to-Root Relocation of JA-Ile Precursors Coordinates Arabidopsis Growth显示文摘Multicellular organisms rely on the movement of signaling molecules across cells,tissues,and organs to communicate among distal sites.In plants,localized leaf damage activates jasmonic acid(JA)-dependent transcriptional reprogramming in both harmed and unharmed tissues.Although it has been indicated that JA species can translocate from damaged into distal sites,the identity of the mobile compound(s),the tissues through which they translocate,and the effect of their relocation remain unknown.Here,we found that following shoot wounding,the relocation of endogenous jasmonates through the phloem is essential to initiate JA signaling and stunt growth in unharmed roots of Arabidopsis thaliana.By employing grafting experiments and hormone profiling,we uncovered that the hormone precursor cis-12-oxo-phytodienoic acid(OPDA)and its derivatives,but not the bioactive JA-Ile conjugate,translocate from wounded shoots into undamaged roots.Upon root relocation,the mobile precursors cooperatively regulated JA responses through their conversion into JA-Ile and JA signaling activation.Collectively,our findings demonstrate the existence of long-distance translocation of endogenous OPDA and its derivatives,which serve as mobile molecules to coordinate shoot-to-root responses,and highlight the importance of a controlled redistribution of hormone precursors among organs during plant stress acclimation. | Adina Schulze Marlene Zimmer Stefan Mielke Hagen Stellmach Charles WMelnyk Bettina Hause Debora Gasperini | 2019 | Molecular Plant2019，12，10： | 7 |
| 3 | High levels of homocysteine downregulate apolipoprotein E expression via nuclear factor kappa B显示文摘AIM: To investigate the effect of high homocysteine(Hcy) levels on apolipoprotein E(apoE) expression and the signaling pathways involved in this gene regulation.METHODS: Reverse transcriptase polymerase chain reaction(RT-PCR) and Western blot were used to assess apo E expression in cells treated with various concentrations(50-500 μmol/L) of Hcy. Calcium phosphatetransient transfections were performed in HEK-293 and RAW 264.7 cells to evaluate the effect of Hcy on apoE regulatory elements [promoter and distal multienhancer 2(ME2)]. To this aim, plasmids containing the proximal apoE promoter [(-500/+73)apoE construct] alone or in the presence of ME2 [ME2/(-500/+73)apoE construct] to drive the expression of the reporter luciferase gene were used. Co-transfection experiments were carried out to investigate the downstream effectors of Hcymediated regulation of apoE promoter by using specific inhibitors or a dominant negative form of IKβ. In other co-transfections, the luciferase reporter was under the control of synthetic promoters containing multiple specific binding sites for nuclear factor kappa B(NF-κB), activator protein-1(AP-1) or nuclear factor of activated T cells(NFAT). Chromatin immunoprecipitation(ChI P)assay was accomplished to detect the binding of NF-κB p65 subunit to the apoE promoter in HEK-293 treated with 500 μmol/L Hcy. As control, cells were incubated with similar concentration of cysteine. NF-κB p65 proteins bound to DNA were immunoprecipitated with anti-p65 antibodies and DNA was identified by PCR using primers amplifying the region-100/+4 of the apoE gene. RESULTS: RT-PCR revealed that high levels of Hcy(250-750 μmol/L) induced a 2-3 fold decrease in apoE m RNA levels in HEK-293 cells, while apo E gene expression was not significantly affected by treatment with lower concentrations of Hcy(100 μmol/L). Immunoblotting data provided additional evidence for the negative role of Hcy in apoE expression. Hcy decreased apoE promoter activity, in the presence or absence of ME2, in a dose dependent manner, in both RAW 264.7 and HEK-293 cells, as revealed by transient transfection experiments. The downstream effectors of the signaling pathways of Hcy were also investigated. The inhibitory effect of Hcy on the apo E promoter activity was counteracted by MAPK/ERK kinase 1/2(MEK1/2) inhibitor U0126, suggesting that MEK1/2 is involved in the downregulation of apoE promoter activity by Hcy. Our data demonstrated that Hcy-induced inhibition of apoE took place through activation of NF-κB. Moreover, we demonstrated that Hcy activated a synthetic promoter containing three NF-κB binding sites, but did not affect promoters containing AP-1 or NFAT binding sites. ChI P experiments revealed that NF-κB p65 subunit is recruited to the apoE promoter following Hcy treatment of cells.CONCLUSION: Hcy-induced stress negatively modulates apoE expression via MEK1/2 and NF-κB activation. The decreased apo E expression in peripheral tissues may aggravate atherosclerosis, neurodegenerative diseases and renal dysfunctions. | Violeta G Trusca Adina D Mihai Elena V Fuior Ioana M Fenyo Anca V Gafencu | 2016 | World Journal of Biological Chemistry2016，7，1： | 6 |
| 4 | Correlation of proealcitonin and C -reactive protein to inflammation,complications,and outcome during the intensive care unit course of multiple -trauma patients 显示文摘 | Meisner M Adina H Schmidt J | 2006 | Crit Care2006，10，1： | 1 |
| 5 | Synthesis and degradation of poly (2-hydroxyethyl methacrylate)-graft-poly (ε-caprolactone) copolymers显示文摘 | Adina Cretu Richard Gattin Laurent Brachais | 2004 | Polym Degrad Stab2004，833，： | 1 |
| 6 | Diffusion abnormality maps in demyelinating disease: Correlations with clinical scores显示文摘 | Mihaela Onu Adina Roceanu Uta Sboto-Frankenstein Robert Bendic Eugen Tarta Florentin Preoteasa Ovidiu Bajenaru | 2011 | European Journal of Radiology2011，，3： | 1 |
| 7 | Service Quality Evaluation Models Determined by Online Consumer Perception and Satisfacion显示文摘 | Maria-Cristiana Munthiu Bogdan C fin Velicu Mihaela Tu Adina lulia Zara | 2014 | Procedia - Social and Behavioral Sciences2014，，12： | 1 |
| 8 | ADINA theory and modeling guide显示文摘 | Adina R&D Inc | 2001 | Watertown MA2001，，： | 1 |
| 9 | Lowcomplexity unambiguous acquisition methods for BOC- modulated CDMA signals显示文摘 | Lohan Elena Simona Burian Adina Renfors Markku | 2008 | International Journal of Satellite Communications and Networking2008，26，6： | 1 |
| 10 | Correlation of procalcitonin andC-reactive protein to inflammation,complications, and outcome during the intensive care unit course of multiple-trauma patients 显示文摘 | Meisner M Adina H Schmidt J | 2006 | Crit Care2006，10，1： | 1 |
| 11 | A comparative study of surgery and endoscopy for the treatment of bile duct stricture in patients with chronic pancreatitis显示文摘 | Jean-Marc Regimbeau David Fuks Eric Bartoli Mathurin Fumery Adina Hanes Thierry Yzet Richard Delcenserie | 2012 | Surgical Endoscopy2012，，10： | 1 |
| 12 | Gallbladder dysfunction in diabetes mellitus显示文摘 | Sylvia J. Shaw MD Ferenc Hajnal MD Yoron Lebovitz BSc Philip Ralls MD Madeline Bauer PhD Dr. Jorge Valenzuela MD Adina Zeidler MD | 1993 | Digestive Diseases and Sciences1993，，3： | 1 |
| 13 | ADINA Theory and Modeling guide显示文摘 | ADINA R & D Inc | 2005 | Volumel:ADINA Solid & Structures2005，，： | 1 |
| 14 | Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90显示文摘 | Keren Aviezer-Hagai Julia Skovorodnikova Mario Galigniana Odelia Farchi-Pisanty Erez Maayan Shmuel Bocovza Yael Efrat Pascal Koskull-D?ring Nir Ohad Adina Breiman | 2007 | Plant Molecular Biology2007，，2： | 1 |
| 15 | Kinetics of thermal inactivation of catalase in the presence of additives显示文摘 | Anca Ruxandra Cantemir Adina Raducan Mihaela Puiu | | 0，，3： | 1 |
| 16 | Correlation of procalcitonin and C -reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiole - trauma patients 显示文摘 | Meisner M Adina H Schmidt J | 2006 | Crit Care2006，10，1： | 1 |
| 17 | CD4 + T cells activated in the rues- enteric lymph node mediate gastrointestinal food allergy in mice 显示文摘 | Adina KK Ana BB Zhang S | 2007 | Am J Physiol Gastrointestinal Liver Physio12007，293，： | 1 |
| 18 | CD4^+ T cells activated in the mesenteric lymph node mediate gastrointestinal food allergy in mice 显示文摘 | Adina KK Ana BB Zhang S | 2007 | Am J Physiol Gastrointestinal Liver Physiol2007，293，： | 1 |
| 19 | Metal organic frameworks for electrochemical applications 显示文摘 | Adina M Frederic J | 2012 | Energy & environmental science2012，5，11： | 1 |
| 20 | Low- complexity unambiguous acquisition methods for BOC-modu- lated CDMA signals显示文摘 | Elena Simona Lohan Adina Burian Markku Renfors | 2008 | International Journal of Satellite Communications2008，26，： | 1 |
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