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| 1 | Adjunctive acupuncture for pain and symptom management in the inpatient setting: protocol for a pilot hybrid effectiveness-implementation study显示文摘BACKGROUND: Effective pain management among hospitalized patients is an important aspect of providing quality care and achieving optimal clinical outcomes and patient satisfaction. Common pharmacologic approaches for pain, though effective, have serious side effects and are not appropriate for all inpatients. Findings from randomized controlled trials(RCTs) support the efficacy of acupuncture for many symptoms relevant to inpatients including postoperative pain, cancer-related pain, nausea and vomiting, and withdrawal from narcotic use. However, the extent to which findings from RCTs translate to real-world implementation of acupuncture in typical hospital settings is unknown. METHODS/DESIGN: In partnership with the launch of a clinical program offering acupuncture services to inpatients at the University of California San Francisco's Mount Zion Hospital, we are conducting a pilot study using a hybrid effectiveness-implementation design to:(1) assess the effectiveness of acupuncture to manage pain and other symptoms and improve patient satisfaction; and(2) evaluate the barriers and facilitators to implementing an on-going acupuncture service for inpatients. During a twomonth pre-randomization phase, we evaluated and adapted clinical scheduling and treatment protocols with acupuncturists and hospital providers and pretested study procedures including enrollment, consent, and data collection. During a six-month randomization phase, we used a two-tiered consent process in which inpatients were first consented into a study of symptom management, randomized to be offered acupuncture, and consented for acupuncture if they accepted. We are also conducting in-depth interviews and focus groups to assess evidence, context, and facilitators of key provider and hospital administration stakeholders.DISCUSSION: Effectiveness research in 'real-world' practice settings is needed to inform clinical decision-making and guide implementation of evidence-based acupuncture practices. To successfully provide clinical acupuncture services and maintain a rigorous research design, practice-based trials of acupuncture require careful planning and attention to setting-specific, contextual factors.TRIAL REGISTRATION: This trial has been registered in Clinical Trials.gov. The identifier is NCT01988194, registered on November 5, 2013. | Maria T.Chao Alexandra Chang Sanjay Reddy James D.Harrison Joseph Acquah Miria Toveg Trilce Santana Frederick M.Hecht | 2016 | Journal of Integrative Medicine2016，14，3： | 5 |
| 2 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients显示文摘 | Noyan Gokce Joseph A. Vita Marie McDonnell Armour R. Forse Nawfal Istfan Maria Stoeckl Izabella Lipinska John F. Keaney Caroline M. Apovian | 2005 | The American Journal of Cardiology2005，，2： | 4 |
| 4 | Chemotherapy plus percutaneous radiofrequency ablation in patients with inoperable colorectal liver metastases显示文摘AIM:To access the efficacy of chemotherapy plus radiofrequency ablation(RFA)as one line of treatment in inoperable colorectal liver metastases.METHODS:Eligible patients were included in three PhaseⅡstudies.In the first study percutaneous RFA was used first followed by 6 cycles of 5-fluorouracil,leucovorin and irinotecan combination(FOLFIRI)(adjunctive chemotherapy trial).In the other two,chemotherapy(FOLFIRI or 5-fluorouracil,leucovorin and oxaliplatin combination)up to 12 cycles was used first with percutaneous RFA offered to responding patients (primary chemotherapy trials).RESULTS:Thirteen patients were included in the adjunctive chemotherapy trial and 17 in the other two.At inclusion they had 1-4 liver metastases(up to 6.5 cm in size).Two patients died during chemotherapy.All patients in the adjunctive chemotherapy trial and 44%in the primary chemotherapy studies had their metastases ablated.Median PFS and overall survival in the adjunctive study were 13 and 24 mo respectively while in the primary chemotherapy studies they were 10 and 21 mo respectively.Eighty one percent of the patients had tumour relapse in at least one previously ablated lesion.CONCLUSION:Chemotherapy plus RFA in patients with low volume inoperable colorectal liver metastases seems safe and relatively effective.The high local recurrence rate is of concern. | Joseph Sgouros James Cast Krishna K Garadi Maria Belechri David J Breen John RT Monson Anthony Maraveyas | 2011 | World Journal of Gastrointestinal Oncology2011，3，4： | 4 |
| 5 | Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome显示文摘 | Delphine M. Saulnier Kevin Riehle Toni–Ann Mistretta Maria–Alejandra Diaz Debasmita Mandal Sabeen Raza Erica M. Weidler Xiang Qin Cristian Coarfa Aleksandar Milosavljevic Joseph F. Petrosino Sarah Highlander Richard Gibbs Susan V. Lynch Robert J. Shulman | 2011 | Gastroenterology2011，，5： | 4 |
| 6 | Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review显示文摘 | Ewan McNicol Nathalie Horowicz-Mehler Ruth A Fisk Kyle Bennett Maria Gialeli-Goudas Priscilla W Chew Joseph Lau Daniel Carr | 2003 | Journal of Pain2003，，5： | 3 |
| 7 | Perspective on ultramicroporous carbon as sulphur host for Li-S batteries显示文摘Lithium-sulphur(Li-S)batteries are currently considered as next-generation battery technology.Sulphur is an attractive positive electrode for lithium metal batteries,mainly due to its high capacity(1675 m Ah g^(-1))and high specific energy(2600 Wh kg^(-1)).The electrochemical reaction of lithium with sulphur in non-aqueous electrolytes results in the formation of electrolyte soluble intermediate lithium-polysulphides.The dissolved polysulphides shuttle to the anode and get reduced at the anode resulting in Li metal corrosion.The solubility of polysulphide gradually reduces the amount of sulphur in the cathode,thereby limiting the cycle life of Li-S batteries.Several strategies have been proposed to improve the cycling stability of Li-S batteries.A unique approach to eliminate the polysulphide shuttle is to use ultramicroporous carbon(UMC)as a host for sulphur.The pore size of UMC which is below 7A,is the bottleneck for carbonate solvents to access sulphur/polysulphides confined in the pores,thereby preventing the polysulphide dissolution.This perspective article will emphasise the role of UMC host in directing the lithiation mechanism of sulphur and in inhibiting polysulphide dissolution,including the resulting parasitic reaction on the lithium anode.Further,the challenges that need to be addressed by UMC-S based Li-S batteries,and the strategies to realise high power density,high Coulombic efficiency,and resilient Li-S batteries will be discussed. | Helen Maria Joseph Maximilian Fichtner Anji Reddy Munnangi | 2021 | Journal of Energy Chemistry2021，30，8： | 2 |
| 8 | A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function显示文摘 | Maria I. Vazquez–Roque Michael Camilleri Thomas Smyrk Joseph A. Murray Eric Marietta Jessica O’Neill Paula Carlson Jesse Lamsam Denise Janzow Deborah Eckert Duane Burton Alan R. Zinsmeister | 2013 | Gastroenterology2013，，5： | 2 |
| 9 | The Epidemiology of Cancer Pain显示文摘 | Leonidas C. Goudas Rina Bloch Maria Gialeli-Goudas Joseph Lau Daniel B. Carr | 2005 | Cancer Investigation2005，，2： | 2 |
| 10 | The antimicrobial activity of microencapsulated thymol and carvacrol显示文摘 | Abel Guarda Javiera F. Rubilar Joseph Miltz Maria Jose Galotto | 2011 | International Journal of Food Microbiology2011，，2： | 2 |
| 11 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases . 2013 (supp)2013，，： | 1 |
| 12 | Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients显示文摘 | Noyan Gokce Joseph A. Vita Marie McDonnell Armour R. Forse Nawfal Istfan Maria Stoeckl Izabella Lipinska John F. Keaney Caroline M. Apovian | 2005 | The American Journal of Cardiology2005，，2： | 1 |
| 13 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases (suppl )2013，，2： | 1 |
| 14 | Current status quo on COVID-19 including chest imaging显示文摘With each day the number coronavirus disease 2019(COVID-19)cases continue to rise rapidly and our imaging knowledge of this disease is expeditiously evolving.The role of chest computed tomography(CT)in the screening or diagnosis of COVID-19 remains the subject of much debate.Despite several months having passed since identifying the disease,and numerous studies related to it,controversy and concern still exists regarding the widespread use of chest CT in the evaluation and management of COVID-19 suspect patients.Several institutes and organizations around the world have released guidelines,recommendations and statements against the use of CT for diagnosing or screening COVID-19 infection and advocating its use only for those cases with a strong clinical suspicion of complication or an alternate diagnosis.However,these guidelines and recommendations are in disagreement with majority of the widely available literature,which strongly favour CT as a pivotal tool in the early diagnosis,management and even follow-up of COVID-19 infection.This article besides comprehensively reviewing the current status quo on COVID-19 disease in general,also writes upon the current consensus statements/recommendations on the use of diagnostic imaging in COVID-19 as well as highlighting the precautions and various disinfection procedures being employed world-wide at the workplace to prevent the spread of infection. | Rishi Philip Mathew Merin Jose Vinayak Jayaram Paul Joy Danny George Maria Joseph TeenaSleeba Ajith Toms | 2020 | World Journal of Radiology2020，12，12： | 1 |
| 15 | The Use of Simulation in Planning the Transportation of Patients to Hospitals Following a Disaster显示文摘 | Joseph Christie P Maria Levary Reuven R | 1998 | Journal of Medical Systems1998，22，5： | 1 |
| 16 | Expression and characterization of Geotrichum candidum lipase Ⅰ gene comparison of specificity profile with lipase Ⅱ显示文摘 | Joseph D S Miroslaw C | 1995 | Eur J Biochem1995，228，： | 1 |
| 17 | MAC protocols used by wireless sensor networks and a general method of performance evaluation显示文摘 | JOSEPH K MARIA C | 2012 | International Journal of Distributed Sensor Networks2012，，2： | 1 |
| 18 | Controlling Transgene Escape in GM Creeping Bentgrass显示文摘 | Hong Luo Albert P. Kausch Qian Hu Kimberly Nelson Joseph K. Wipff Crystal C. R. Fricker T. Page Owen Maria A. Moreno Jang-Yong Lee Thomas K. Hodges | 2005 | Molecular Breeding2005，，2： | 1 |
| 19 | Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review显示文摘 | Ewan McNicol Nathalie Horowicz-Mehler Ruth A Fisk Kyle Bennett Maria Gialeli-Goudas Priscilla W Chew Joseph Lau Daniel Carr | 2003 | Journal of Pain2003，，5： | 1 |
| 20 | Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients显示文摘 | Noyan Gokce Joseph A. Vita Marie McDonnell Armour R. Forse Nawfal Istfan Maria Stoeckl Izabella Lipinska John F. Keaney Caroline M. Apovian | 2005 | The American Journal of Cardiology2005，，2： | 1 |
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