维普中文期刊产品整合服务
12篇 您的检索式:作者名="Coarfa"
    题名 作者 年代 出处 被引量
1An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley 2014Cell Research2014,24,7:10
2Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome显示文摘Delphine M. Saulnier Kevin Riehle Toni–Ann Mistretta Maria–Alejandra Diaz Debasmita Mandal Sabeen Raza Erica M. Weidler Xiang Qin Cristian Coarfa Aleksandar Milosavljevic Joseph F. Petrosino Sarah Highlander Richard Gibbs Susan V. Lynch Robert J. Shulman 2011Gastroenterology2011,,5:4
3CDKN2D-WD- FY2 is a cancer-specific fusion gene recurrent in high- grade serous ovarian carcinoma 显示文摘Kannan K Coarfa C Rajapakshe K 2014PLoS Genet2014,10,10:1
4A SNP discovery method to assess variant allele probability from next-generation resequencing data显示文摘Shen Yufeng Wan Zhengzheng Coarfa Cristian 2010Genome Res2010,20,6:1
5miRNA data analysis: next-gen sequencing显示文摘Gunaratne P H Coarfa C Soibam B 2012Methods in Molecular Biology2012,822,:1
6Comparison of sequencing- based methods to profile DNA methylation and identification of monoallelic epigenetic modifications 显示文摘Harris RA Wang T Coarfa C 2010Nat Biotechnol2010,28,10:1
7A genome-wide search for promotes that respond to increased MYCN reweals both new onco- genic and tumor suppressor microRNAs associated with aggressive neuroblastoma显示文摘Shohet JM Ghosh R Coarfa C 2011Cancer Res2011,71,11:1
8Analysis of microRNAexpression in the prepubertal testis 显示文摘Buchold GM Coarfa C Kim J 2010PLoS One2010,5,12:1
9ReadDepth: a parallel R package for detecting copy number alterations from short sequencing reads 显示文摘MILLER C A HAMPTON O COARFA C 2011PLoS ONE2011,6,16:1
10The Repertoire and Features of Human Platelet microRNAs显示文摘PLH LANDRY P BENHAM A COARFA C 2012PLoS One2012,7,50:1
11A Genome-wide Search for MYCN binding sites reveals both new oncogenic and tumor suppressor MicroRNAs associated with aggressive neuroblastoma显示文摘Shohet JM Ghosh R Coarfa C 2011Cancer Res2011,71,11:1
12A SNP discovery method to assess variant allele probability from next-generation re- sequencing data显示文摘Shen Y Wan Z Coarfa C 2010Genome Research2010,20,2:1
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费