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| 1 | The Metabolic Response of Arabidopsis Roots to Oxidative Stress is Distinct from that of Heterotrophic Cells in Culture and Highlights a Complex Relationship between the Levels of Transcripts, Metabolites, and Flux显示文摘新陈代谢的调整是一重要,但是糟糕理解,到氧化应力的植物的反应的部分。在以前的研究(巴斯斯特等, 2007 ) ,在到由甲蔡醌的氧化应力的正式就职的文化的 Arabidopsis 房间的新陈代谢的反应被描绘。紧急情况幸存策略在 anabolism 的主要新陈代谢大部分在哪个是下面调整的赞成被揭开分解代谢并且抗氧化剂新陈代谢。在整个植物纸巾的反应可能是不同的,我们因此调查了 Arabidopsis 根的反应到甲蔡醌处理,分析有主要以及第二等的新陈代谢的焦点的 transcriptome, metabolome 和关键新陈代谢的流动。用氧化还原作用敏感的 GFP,甲蔡醌引起氧化还原作用不安,这也被显示出,不是就在线粒体,而且在根的 cytosol 和质体。在里面开始的 30 ? 处理的 min,反应类似于房间文化:在 TCA 周期和氨基酸生合成的代谢物有减少, transcriptomic 反应被 DNA 规章的蛋白质的起来规定统治。在 2 和 6 以后 ? 处理的 h,根的反应对房间文化不同。代谢物层次没仍然保持沮丧,但是相反恢复并且在 pyruvate 的情况中,一些氨基酸和脂肪族的 glucosinolates 在控制层次上面显示出稳定的增加。然而,在中央碳新陈代谢的流动的主要变化都没被观察,新陈代谢的抄本主要独立于相应代谢物变化了。一起,结果建议根纸巾能在氧化抑制以后恢复新陈代谢的活动并且为 glycolysis 和氧化戊糖磷酸盐小径加亮潜在地重要的角色。 | Martin Lehmann Markus Schwarzlander Toshihiro Obata Supaart Sirikantaramas Meike Burow Carl Erik Olsen Takayuki Tohge Mark D. Fricker Birger Lindberg Moiler Alisdair R. Fernie Lee J. Sweetlove Miriam Laxa | 2009 | Molecular Plant2009，2，3： | 8 |
| 2 | A self-made, low-cost infrared system for evaluating the sciatic functional index in mice显示文摘The sciatic functional index(SFI) is a popular parameter for peripheral nerve evaluation that relies on footprints obtained with ink and paper. Drawbacks include smearing artefacts and a lack of dynamic information during measurement. Modern applications use digitized systems that can deliver results with less analytical effort and fewer mice. However, the systems are expensive(€40,000). This study aimed to evaluate the applicability and precision of a self-made, low-cost infrared system for evaluating SFI in mice. Mice were subjected to unilateral sciatic nerve crush injury(crush group; n = 7) and sham operation(sham group; n = 4). They were evaluated on the day before surgery, the 2^(nd), 4^(th) and 6^(th) days after injury, and then every day up to the 23^(rd) day after injury. We compared two SFI evaluation methods, i.e., conventional inkand-paper SFI(C-SFI) and our infrared system(I-SFI). Our apparatus visualized footprints with totally internally reflected infrared light(950 nm) and a camera that can only detect this wavelength. Additionally we performed an analysis with the ladder beam walking test(LBWT) as a reference test. I-SFI assessment reduced the standard deviation by about 33 percent, from 11.6 to 7.8, and cut the variance around the baseline to 21 percent. The system thus requires fewer measurement repetitions and fewer animals, and cuts the cost of keeping the animals. The apparatus cost €321 to build. Our results show that the process of obtaining the SFI can be made more precise via digitization with a self-made, low-cost infrared system. | Lukas Fricker Vincenzo Penna Florian Lampert G.Bjoern Stark Christian Witzel Georgios Koulaxouzidis | 2016 | Neural Regeneration Research2016，11，5： | 4 |
| 3 | Leptin in Anorexia and Cachexia Syndrome显示文摘 | Diana R. Engineer Jose M. Garcia Lloyd D. Fricker | 2012 | International Journal of Peptides2012，，： | 2 |
| 4 | Impact of throid dysfunction on serum cystatin C显示文摘 | Fricker M Wiesli P Brandle M | 2003 | Kidney Int2003，63，5： | 1 |
| 5 | Biomechanics of iliotibial band friction syndrome in runners显示文摘 | Orchard JW Fricker PA Abud AT | 1996 | Am J Sports Med1996，24，3： | 1 |
| 6 | Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier:fimctional similarities between pig and human PXR显示文摘 | Oft M Fricker G Bauer B | 2009 | J Pharmacol Exp Ther2009，329，1： | 1 |
| 7 | The Role of Calcium in Blue-lightdependent Chloroplast Movement in Lemna trisulca L 显示文摘 | TLALKA M FRICKER M | 1999 | Plant J1999，20，： | 1 |
| 8 | A vaccine approach to healthy lipoprotein levels显示文摘 | Fricker J | 1999 | Mol Med Today1999，5，7： | 1 |
| 9 | A new self-curing resin-modified glass ionomer cement for the direct bonding of orthodontic brackets in vivo显示文摘 | Fricker JP | 1998 | Am J Ortho Dentofacial Orthop1998，113，4： | 1 |
| 10 | High spatial resolution trace element analysis by LA-ICP-MS using a novel ablation cell for multiple or large samples 显示文摘 | Fricker M B Kutscher D Aeschlimann B Frommer J Dietiker R Bettmer J Gtinther D | 2011 | International Journal of Mass Spectrometry2011，307，： | 1 |
| 11 | Identification of emetic toxin producing Bacillus cereus strains by a novel molecular assay显示文摘 | SCHULZ M E FRICKER M SCHERER S | 2004 | FEMS Microbiology Letters2004，232，2： | 1 |
| 12 | Site-specific migration and neural differentiation of human neural progenitor cells after transplantation in the adult rat brain显示文摘 | Fricker RA Carpenter MK Winkler C | 1999 | J Neurosci1999，19，： | 1 |
| 13 | Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4 显示文摘 | Fricker SP Anastassov V Cox J | 2006 | Biochem Pharmacol2006，72，5： | 1 |
| 14 | Letrozole better than tamoxifen in postmenopausal women显示文摘 | Fricker J | 2005 | Lancet Oncol2005，6，3： | 1 |
| 15 | Generation and transplantation of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice显示文摘 | Carpenter MK Winkler C Fricker R | | 0，，01： | 1 |
| 16 | Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination显示文摘 | Fricker FR Antunes-Martins A Galino J | 2013 | Brain2013，136，： | 1 |
| 17 | An institutional review of the value of computed tomography angiography in the diagnosis of congenital cardiac malformations显示文摘 | Chandran A Fricker FJ Schowengerdt KO | 2005 | Cardiol Young2005，15，1： | 1 |
| 18 | Characterization of the molecular pharmacology of AMD3100:a specific antagonist of the G-protein coupled chemokine receptor,CXCR4显示文摘 | Fricker SP Anastassov V Cox J | | 0，，05： | 1 |
| 19 | pH gradients are not associated with tip growth in pollen tubes of Lilium lon- giflorum 显示文摘 | Fricker M D White N S Obermeyer G | 1997 | Journal of Cell Science1997，110，： | 1 |
| 20 | Microstructural status of ipsilesional and contralesional corticospinal tract corre- lates with motor skill in chronic stroke patients显示文摘 | Schaechter JD Fricker ZP Perdue KL | 2009 | Hum Brain Mapp2009，30，11： | 1 |
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