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| 1 | Effect of intra-abdominal pressure on respiratory function in patients undergoing ventral hernia repair显示文摘AIM: To determine the influence of intra-abdominal pressure(IAP) on respiratory function after surgical repair of ventral hernia and to compare two different methods of IAP measurement during the perioperative period. METHODS: Thirty adult patients after elective repair of ventral hernia were enrolled into this prospective study.IAP monitoring was performed via both a balloontipped nasogastric probe [intragastric pressure(IGP), Ci MON, Pulsion Medical Systems, Munich, Germany] and a urinary catheter [intrabladder pressure(IBP), Uno Meter Abdo-Pressure Kit, Uno Medical, Denmark] on five consecutive stages:(1) after tracheal intubation(AI);(2) after ventral hernia repair;(3) at the end of surgery;(4) during spontaneous breathing trial through the endotracheal tube; and(5) at 1 h after tracheal extubation. The patients were in the complete supine position during all study stages.RESULTS: The IAP(measured via both techniques) increased on average by 12% during surgery compared to AI(P < 0.02) and by 43% during spontaneous breathing through the endotracheal tube(P < 0.01). In parallel, the gradient between РаСО2 and Et CO2 [Р(а-et)CO2] rose significantly, reaching a maximum during the spontaneous breathing trial. The PаO2/Fi O2 decreased by 30% one hour after tracheal extubation(P = 0.02). The dynamic compliance of respiratory system reduced intraoperatively by 15%-20%(P < 0.025). At all stages, we observed a significant correlation between IGP and IBP(r = 0.65-0.81, P < 0.01) with a mean bias varying from-0.19 mm Hg(2SD 7.25 mm Hg) to-1.06 mm Hg(2SD 8.04 mm Hg) depending on the study stage. Taking all paired measurements together(n = 133), the median IGP was 8.0(5.5-11.0) mm Hg and the median IBP was 8.8(5.8-13.1) mm Hg. The overall r2 value( n = 30) was 0.76(P < 0.0001). Bland and Altman analysis showed an overall bias for the mean values per patient of 0.6 mm Hg(2SD 4.2 mm Hg) with percentage error of 45.6%. Looking at changes in IAP between the different study stages, we found an excellent concordance coefficient of 94.9% comparing IBP and IGP( n = 117).CONCLUSION: During ventral hernia repair, the IAP rise is accompanied by changes in Р(а-et)CO2 and PаO2/Fi O2-ratio. Estimation of IAP via IGP or IBP demonstrated excellent concordance. | Konstantin M Gaidukov Elena N Raibuzhis Ayyaz Hussain Alexey Y Teterin Alexey A Smetkin Vsevolod V Kuzkov Manu LNG Malbrain Mikhail Y Kirov | 2013 | World Journal of Critical Care Medicine2013，2，2： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Effect of cross linking on the physicochemical properties of Cola starch显示文摘 | OMOJOLA M O MANU N THOMAS S A | 2012 | African Journal of Food Science2012，6，4： | 1 |
| 4 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 5 | First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway显示文摘 | MANU K A SHANMUGAM M K RAMACHANDRAN L | 2012 | 2012，，08： | 1 |
| 6 | Gene silencing in mammals by small interfering RNAs 显示文摘 | MANUS M T SHARP P A | 2002 | Nature Reviews Genetics2002，3，10： | 1 |
| 7 | Effect of nickel-rich layer on improvement of hot-dip zinc coating 显示文摘 | Shibi S M A Manu R Dilimon V S | 2005 | Applied Surface Science2005，245，： | 1 |
| 8 | Fundamental investigations of differences in bonding mechanisms in iron ore sinter formed from magnetite concentrates and hematite ores 显示文摘 | J Clout M F Manue J R | 2003 | Powder Technology2003，130，： | 1 |
| 9 | The conversion from cellulose I to cellulose II in NaOH mercerization performed in alcohol-water systems: An X-ray powder diffraction study显示文摘 | Paavo M Manu L Kari R | 2007 | Carbohydr Polym2007，68，1： | 1 |
| 10 | Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle显示文摘 | Picard M Gentil BJ Mc Manus MJ | 2013 | J Appl Physiol2013，115，10： | 1 |
| 11 | Protein characteristics and peroxidase activities of different In- dian wheat varieties and their relationship to chapati- making quality显示文摘 | Hemalatha M S Manu B T Bhagwat S G | 2007 | European Food Research and Tech- nolog2007，225，： | 1 |
| 12 | Automatic surface inspection of steel显示文摘 | MANUS M GEORGE J | 1999 | Iron and Steel Engineer1999，23，3： | 1 |
| 13 | Development of biofuels for the UK automotive market显示文摘 | Hammond G P Kallu S Manus M C | 2008 | Applied Energy2008，85，6： | 1 |
| 14 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 15 | Effect of nickel- rich barrier layer on improvement of hot-dip zinc coat- ing显示文摘 | Shibli S M A Manu R Dilimon V S | 2005 | Applied Surface Science2005，245，14： | 1 |
| 16 | Effect of Nickel-rich Barrier Layer on Improvement of Hot-dip Zinc Coating显示文摘 | SHIBIS M A MANU R DILIMON V S | 2005 | Applied Surface Science2005，245，1： | 1 |
| 17 | Protein characteristics and peroxidase activities of different Indian wheat varieties and their relationship to chapati- making quality显示文摘 | Hemalatha M S Manu B T | 2007 | European Food Research and Teclmology2007，225，34： | 1 |
| 18 | Thermomechanical and morphological characteristics of crosslinked GAP and GAP-HTPB networks with different diisocyanates 显示文摘 | Suresh M Manu S K Varghese T L | 2008 | Propellants Explosives Pyrotechnics2008，33，2： | 1 |
| 19 | First evidence that ',/ - tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF - KB pathway 显示文摘 | MANU K A SHANMUGAM M K RAMACHANDRAN L | 2012 | Clin Cancer Res2012，18，8： | 1 |
| 20 | Effect of nickel-rich layer on improvement of hot-dip zinc coating 显示文摘 | Shibi S M A Manu R Dilimon V S | 2005 | Appl Surf Sci2005，245，： | 1 |
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