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| 1 | Intra-habitat heterogeneity of microbial food web structure under the regime of eutrophication and sediment resuspension in the large subtropical shallow Lake Taihu, China显示文摘 | Wu QLL Chen YW Xu KD Liu ZW Hahn MW | 2007 | 中国生物学文摘2007，21，8： | 26 |
| 2 | Insulin glargine versus NPH insulin therapy in Asian Type 2 diabetes patients显示文摘 | Pan, CY Sinnassamy, P Chung, KD Kim, KW | 2007 | 中国生物学文摘2007，21，11： | 17 |
| 3 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 4 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 5 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 6 | 世界第一座近海风电场显示文摘 | Jepe.,KD 王世槐 | 1992 | 新能源1992，14，9： | 4 |
| 7 | 累积性液体正平衡与急性呼吸窘迫综合征合并急性肾损伤患儿病死率相关显示文摘目的:急性肾损伤(acute kidney injury,AKI)和累积液体平衡(cumulative fluidbalance,CFB)升高常同时发生在ARDS患儿中,本文旨在识别其发生的危险因素并评估其与病死率的独立关系。本文假设CFB升高与炎症指标相关,CFB升高并发AKI患儿预后较其他患儿更差。设计前瞻性观察性研究,采用pRIFLE AKI分级。场所5家学术型PICUs。对象2008至2014年间符合ARDS柏林标准的260例1月至18岁患儿。干预措施无。结果PICU病死率为13%(34/260),病死患儿与存活患儿相比在ARDS第3天CFB较高(+90.1 ml/kg,IQR 26.6~161.7比+44.9 ml/ kg,IQR 10.0~111.3,P=0.008),且AKI发生率更高(50%比23%,P=0.001)。分层分析显示并发AKI患儿中,ARDS第3天CFB较高与病死率有关(病死者+111.5 ml/kg,IQR 82.6~236.8比存活者+58.5 ml/kg,IQR 0.9~176.2,P=0.041),而在不伴有AKI的ARDS患儿中无此相关性(P=0.308)。ARDS第3天并发AKI与正CFB患儿病死率相关(29.1%比10.4%,P=0.001),而在液体平衡或负平衡患儿中无此相关性(P=0.430)。ARDS第1天的血浆IL-6水平与第3天正CFB,AKI及PICU病死率相关,第1天IL-6与PICU病死率升高之间的关系由第3天正CFB和AKI部分介导(P<0.001)。结论儿童ARDS第3天正CFB与病死率相关,尤其在并发AKI患儿。血浆IL-6水平与正CFB及AKI发生相关,提示炎症可能是导致病死率增加的机制。 | Zinter MS Spicer AC Liu KD 方伯梁(译者) 钱素云(审校者) | 2019 | 中国小儿急救医学2019，26，4： | 3 |
| 8 | Composite polymer networks of polyacrylamide and modified amino resin-polyurethane for oil field water shutoff显示文摘SINCE water emitting in oil wells is a general problem in developing oil fields, the workers inthe world put quite an emphasis on water shutoff. In recent years, the study on develop-ing a novel and highly effective water plugging agent has become an important technical mea-sure for controlling water emitting in the middle and later periods of an oil field. A highly ef-fective water plugging agent can form gel, gradually swell in water and shut off water, but oilcan get through. It also has suitable resistance to pressure and high temperature and a longservice life. Only when the water shutoff agent can form a composite polymer network (CPN) | Liu, QP Hou, SJ Ha, RH Yao, KD | 1997 | Chinese Science Bulletin1997，42，15： | 3 |
| 9 | Primary biliary cirrhosis显示文摘 | Lindor KD Gershwin ME Poupon R | | Hepatology0，，： | 2 |
| 10 | A multicenter retrospective cohort study of ketogenic diet therapy in 481 children with infantile spasms显示文摘Background:Ketogenic diet(KD)therapy is one of the main treatments for drug-resistant epilepsy.However,the KD therapy has been applied in only a small number of infantile spasm cases.In this large multicenter study,we investigated the efficacy of KD therapy in the treatment of infantile spasms.Methods:In this retrospective,multicenter cohort study,clinical data from main epilepsy centers were analyzed.Patients were classified into different groups according to age,type of drug and whether glucocorticoid was used before initiation of KD.Results:From October 2014 to March 2020,481 patients(308 males and 173 females)with infantile spasms were treated with the KD therapy.The age of the patients ranged from 2 months to 20 years,with a mean age of 1 year and 10 months.The number of anti-seizure medications(ASMs)used before KD initiation ranged 0-6,with a median of 3.In different time from initiation(1,3,6,and 12 months),the rates of seizure freedom after KD were 6.9,11.6;16.0 and 16.8%,respectively(x^(2)=27.1772,P<0.0001).There was a significant difference in the rate of seizure freedom between 3 months and 1 month(x^(2)=6.5498,P=0.0105)groups,and 6 months and 3 months(x^(2)=3.8478,P=0.0498)groups,but not between 12 months and 6 months(x^(2)=0.1212,P=0.7278)groups.The rates of effectiveness were 44.7;62.8,49.1 and 32.0%(x^(2)=93.2674,P<0.0001),respectively.The retention rates were 94.0,82.5,55.7 and 33.1%(x^(2)=483.7551,P<0.0001),correspondingly.The rate of effectiveness and the retention rate of KD were significantly different among the 1,3,6 and 12 months.KD treatment was the first choice in 25 patients(5.2%),55 patients(11.4%)started KD after the failure of the first ASM,158 patients(32.8%)started KD after the failure of the second ASM,157 patients(32.6%)started KD after the failure of the third drug,and 86 patients(17.9%)started KD after the failure of the fourth and more.The KD effect was not related to the number of ASMs used before KD startup(P>0.05).Two hundred and eighteen patients(45.3%)failed to respond to corticotropin or glucocorticoid before initiation.There was no significant difference in the effectiveness rate at different time points between the group of KD therapy after glucocorticoid failure and the group after non-hormone failure (x^(2)=0.8613,P=0.8348).The rate of adverse events of KD in 1,3,6,and 12 months after KD initiation were 22.3,21.7,16.8 and 6.9%,respectively.The adverse events mainly occurred during the first 3 months of KD,and the main adverse events were gastrointestinal disturbance and constipation.Conclusions:The efficacy of the KD treatment for infantile spasms was not affected by age,medication,and glucocorticoid use before initiation.KD is one of the effective treatments for infantile spasms. | Yuanzhen Ye Dan Sun Hua Li Jianmin Zhong Rong Luo Baomin Li Dengna Zhu Dan Li Shaoping Huang Yuwu Jiang Nong Xiao Yucai Chen Yuqin Zhang Mei Yu Xiaoyun Shen Li Gao Guo Zheng Congmin Zhao Baoqiang Yuan Jianxiang Liao Jiong Qin CAAE KD group | 2022 | Acta Epileptologica2022，5，1： | 2 |
| 11 | 熔融态玻璃电阻率的测定与钠,钾硅酸盐玻璃熔体的混合碱效应显示文摘 | Kim.,KD 胡明 | 1995 | 国外建材译丛1995，7，4： | 2 |
| 12 | Panceraicoduodenetomy for cancer of the head of the pancreas: 201 patients 显示文摘 | YEO CJ CAMERON JL LILLEMOE KD | 1995 | Ann Surg1995，221，6： | 2 |
| 13 | A Sliding Mode Observer for Uncertain Nonlinear Systems Based on Multiple Models Approach显示文摘This paper presents a method of state estimation for uncertain nonlinear systems described by multiple models approach.The uncertainties, supposed as norm bounded type, are caused by some parameters variations of the nonlinear system. Linear matrix inequalities(LMIs) have been established in order to ensure the stability conditions of the multiple observer which lead to determine the estimation gains. A sliding mode gain has been added in order to compensate the uncertainties. Numerical simulations through a state space model of a real process have been realized to show the robustness of the synthesized observer. | Kd s Hfa edh Karim Dahech Tarak Damak | 2017 | International Journal of Automation and computing2017，14，2： | 2 |
| 14 | Bone marrow as a potential source of hepatic oval cells 显示文摘 | Petersen BE Bowen WC Patrene KD | 1999 | Science1999，284，5417： | 2 |
| 15 | Composition and glycosaminog-lycan metabolism of articular cartilage from habitually loaded and habitually unloaded sites 显示文摘 | Slowman SD Brandt KD | 1986 | Arthritis Rheum1986，29，： | 2 |
| 16 | Vasostatin,a calreticulin fragment,inhibits angiogenesis and suppresses tumor growth显示文摘 | Pike SE Yao L Jones KD | 1998 | J Exp Med1998，188，12： | 2 |
| 17 | Resveratrol in wine 显示文摘 | McMurtrey KD | 1997 | Acs Sympos Series1997，661，： | 2 |
| 18 | Lupus tumidus显示文摘 | Dekle CL Mannes KD Davis LS | 1999 | J Am Acad Dermatal1999，41，21： | 2 |
| 19 | 老年女性蔬菜硝酸盐的摄入与颈动脉粥样硬化和缺血性脑血管病的相关性显示文摘膳食硝酸盐的短期增加可通过形成一氧化氮和其他氮氧化物来改善血管健康。其是否可降低长期血管疾病风险尚未得到验证,为了明确这一点,Bondonno教授团队调查了植物来源的硝酸盐摄入与老年女性颈总动脉内膜中层厚度(common carotid artery intimamedia thickness,CCA-IMT)、斑块严重程度和缺血性脑血管疾病事件的关系(n=1226),方法:纳入研究对象,确定基线时(1998年)的蔬菜硝酸盐摄入量、生活方式因素和心血管病危险因素。 | 刘莉 叶鹏 Bondonno CP Blekkenhorst LC Prince RL Ivey KL Lewis JR Devine A Woodman RJ Lundberg JO Croft KD Thompson PL Hodgson JM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 20 | Laparoscopic partial adrenalectomy for aldosterone-producing adenomas with needlescopic instruments显示文摘 | Liao CH Chueh SC Wu KD | 2006 | Urology2006，，03： | 2 |
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