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| 1 | Kallistatin,a new and reliable biomarker for the diagnosis of liver cirrhosis显示文摘Kallistatin,which protects organs and cells against inflammation,fibrosis and oxidative stress,is mainly synthesized and secreted in liver.However,its relationship to human liver disease remains unclear.The purpose of this study was to explore the relationship between serum kallistatin and clinical evidence of both cirrhosis and hepatocellular carcinoma(HCC),and to determine if serum kallistatin levels could be used as a diagnostic indicator of hepatic health status,especially human liver cirrhosis(LC).Our cohort consisted of 115 patients with clinically proven liver fibrosis(LF),LC,or HCC by liver biopsies,and 31 healthy controls(CON).Serum kallistatin levels were quantified by ELISA.Results of the present study demonstrated that irrespective of the underlying etiology,serum kallistatin levels were significantly lower in the LF/LC group when compared with the CON group.A decrease in serum kallistatin levels appeared to reflect the extent of cirrhosis,with the lowest levels associated with higher grades of cirrhosis.Patients with LC had a noticeable correlation between serum kallistatin levels and other serum biochemical indicators.The area under the curve(AUC) for LC,viral liver cirrhosis(VLC)and alcoholic liver cirrhosis(ALC) was 0.845,0.757 and 0.931,respectively.In conclusion,our findingsdemonstrated that kallistatin,a plasma protein produced by the liver,can be a useful and reliable diagnostic indicator of hepatic health status,especially for LC. | Zhiyun Cheng Yinghui Lv Suqiu Pang Ruyu Bai Mingxi Wang Shuyu Lin Tianwen Xu Duncan Spalding Nagy Habib Ruian Xu | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 7 |
| 2 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 3 | Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic. | Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 4 | 老年病筛查与预防显示文摘我国正逐渐步入老龄化社会,老年病的筛查与预防日益受到重视。尤其是我国农村老年人口占老年人口总数的65.82%,这也是医疗卫生改革形势下社区卫生保健和新型农村合作医疗发展所面临的新挑战。本文对美国的老年病筛查与预防标准做了相关介绍,以期为我国的老年病筛查和预防提供借鉴。 | Spalding MC Sebesta SC 周淑新 牛娇娇 | 2009 | 中国全科医学2009，12，2： | 4 |
| 5 | 佛罗里达涉禽羽毛的汞浓度显示文摘1987~1990年,在美国佛罗里达州奥基乔比湖及其南边的湿地收集了92只涉禽(涉水鸟)的初级飞羽或尾羽。雏鸟羽毛中汞平均浓度检定结果:玫瑰琵鹭(Ajaia ajaja)为 2.0ppm,大蓝鹭(Ardea herodias)为 3.5ppm,大白鹭(Ardea herodias occidentalis)为4.7ppm,巨白鹭(Casmerodius albus)为7.1ppm。大白鹭羽毛中汞的浓度随年龄增长而升高,雏鸟为4.7ppm,幼鸟为6.7ppm,成鸟为8.2ppm。猎食大鱼的鸟类汞浓度最高。林鹳(Mycteriaamericana)羽毛中汞平均浓度为3.3ppm。佛罗里达南部涉禽羽毛中汞浓度比所报道的亚洲涉禽羽毛中的要高。已知25只涉禽肝脏和羽毛中汞浓度。肝脏(湿重)汞浓度(Y)与羽毛汞浓度(X)的回归方程是:log(Y)=1.52log(X)-0.722,相关系数为0.84。如果成鸟羽毛中平均汞浓度达9ppm,就会出现生殖失调,正如从一项已发表的绿头鸭(Anas platyrhynchos)实验室研究成果可以推断的那样,那么,佛罗里达南部汞浓度就高得足以减少涉禽种群的繁殖力。然而,在有把握地指定羽毛中最低中毒浓度以前,需要另外进行对照研究。 | W.Nelson Beyer Marilyn Spalding Doug Morrison 寒江 | 1997 | 人类环境杂志1997，26，2： | 4 |
| 6 | Combined administration of platelet rich plasma and autologous bone marrow aspirate concentrate for spinal cord injury: a descriptive case series显示文摘Administration of platelet rich plasma(PRP) and bone marrow aspirate concentrate(BMAC) has shown some promise in the treatment of neurological conditions;however, there is limited information on combined administration. As such, the purpose of this study was to assess safety and functional outcomes for patients administered combined autologous PRP and BMAC for spinal cord injury(SCI). This retrospective case series included seven patients who received combined treatment of autologous PRP and BMAC via intravenous and intrathecal administration as salvage therapy for SCI. Patients were reviewed for adverse reactions and clinical outcomes using the Oswestry Disability Index(ODI) for up to 1 year, as permitted by availability of follow-up data. Injury levels ranged from C3 through T11, and elapsed time between injury and salvage therapy ranged from 2.4 months to 6.2 years. Post-procedure complications were mild and rare, consisting only of self-limited headache and subjective memory impairment in one patient. Four patients experienced severe disability prior to PRP combined with BMAC injection, as evidenced by high(> 48/100) Oswestry Disability Index scores. Longitudinal Oswestry Disability Index scores for two patients with incomplete SCI at C6 and C7, both of whom had cervical spine injuries, demonstrated a decrease of 28–40% following salvage therapy, representing an improvement from severe to minimal disability. In conclusion, intrathecal/intravenous co-administration of PRP and BMAC resulted in no significant complications and may have had some clinical benefits. Larger clinical studies are needed to further test this method of treatment for patients with SCI who otherwise have limited meaningful treatment options. This study was reviewed and approved by the Ohio Health Institutional Review Board(IRB No. 1204946) on May 16, 2018. | Joseph A.Shehadi Steven M.Elzein Paul Beery M.Chance Spalding Michelle Pershing | 2021 | Neural Regeneration Research2021，16，2： | 3 |
| 7 | The numerical computation of turbulent flows显示文摘 | LAUNDER B E SPALDING D B | 1974 | Computer Mehhods in Applied Mechanics and Engineering1974，3，： | 2 |
| 8 | Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system显示文摘 | Spalding KL Tan MM Hendry IA | 2002 | Molecular & Cellular Neurosciences2002，19，4： | 2 |
| 9 | A calculation procedure for heat, mass, and momentum transfer in three-dimensional flows 显示文摘 | PATANKAR S V SPALDING D A | 1972 | Int J Heat Mass Transfer1972，15，： | 2 |
| 10 | A role for the AKT1 potassium channel in plant nutrition显示文摘 | Hirsch R E Lewis B D Spalding E P | 1998 | Science1998，280，： | 1 |
| 11 | New estimates of global and regional coral reef areas 显示文摘 | Spalding M D Grenfell A M | 1997 | Coral Reefs1997，16，： | 1 |
| 12 | A novel finite difference formulation for differential expressions involving both first and second derivatives显示文摘 | Spalding D B | 1972 | International Journal of Numerical Method in Engineering1972，4，4： | 1 |
| 13 | The Numerical Compu tation of Turbulent Flows显示文摘 | Launder B E Spalding D B | 1974 | Computer Methods in Applied Mechanics and Engineering1974，，3： | 1 |
| 14 | Candida albicans and non-albicans blood-stream infections in adult and Pediatric Patients: comparison of mortality and costs显示文摘 | Moran C Grussemeyer CA Spalding JR | 2009 | Pediatr Infect Dis J2009，28，5： | 1 |
| 15 | A convenient micro- biological assay employing cell-free extracts for the rapid characterization of gram-negative carbapenemase produc- ers显示文摘 | Marchiaro P Ballerini V Spalding T | 2008 | Antimicrob Chemother2008，62，2： | 1 |
| 16 | A theory of inflammability limits and flame-quenching 显示文摘 | SPALDING D | 1957 | Proceedings of the Royal Society of London: Series A--Mathematical and Physical Sciences1957，240，1220： | 1 |
| 17 | Dynamics of hippocampal neurogenesis in adult humans显示文摘 | Spalding KL Bergmann O Alkass K | 2013 | Cell2013，153，： | 1 |
| 18 | Occurrence of Nitrate in Groundwa- ter: A Review 显示文摘 | SPALDING R F EXNER M E | 1993 | Journal of Environmental Quality1993，22，： | 1 |
| 19 | A calculation procedure for heat,mass and momentum transfer in three-dimensional parabolic flows显示文摘 | Patankar S V Spalding D B | 1972 | Int J Heat Mass Transfer1972，15，11： | 1 |
| 20 | The nature and formation of the spermatophore and sperm plug in Carcinus maenas 显示文摘 | Spalding J F | 1942 | Quarterly Journal of Microscopical Science1942，83，： | 1 |
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