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| 1 | Treatment of colorectal cancer in the elderly显示文摘Colorectal cancer has a high incidence, and approxi-mately 60% of colorectal cancer patients are older than 70, with this incidence likely increasing in the near future. Elderly patients(> 70-75 years of age) are a very heterogeneous group, ranging from the very fit to the very frail. Traditionally, these patients have often been under-treated and recruited less frequently to clinical trials than younger patients, and thus are underrepresented in publications about cancer treatment. Recent studies suggest that fit elderly patients can be treated in the same way as their younger counterparts, but the treatment of frail patients with comorbidities is still a matter of controversy. Many factors should be taken into account, including fitness for treatment, the wishes of the patient and family, and quality of life. This review will focus on the existing evidence for surgical, oncologic, and palliative treatment in patients over 70 years old with colorectal cancer. Careful patient assessment is necessary in order to individualize treatment approach, and this should rely on a multidisciplinary process. More well-designed controlled trials are needed in this patient population. | Monica Millan Sandra Merino Aleidis Caro Francesc Feliu Jordi Escuder Tani Francesch | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 9 |
| 2 | Transanal endoscopic surgery in rectal cancer显示文摘Total mesorectal excision(TME) is the standard treatment for rectal cancer, but complications are frequent and rates of morbidity, mortality and genitourinary alterations are high. Transanal endoscopic microsurgery(TEM) allows preservation of the anal sphincters and, via its vision system through a rectoscope, allows access to rectal tumors located as far as 20 cm from the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lymph node invasion. This means that correct preoperative staging of the rectal tumor is necessary. Currently, local surgery is indicated for rectal adenomas and adenocarcinomas invading the submucosa, but not beyond(T1). Here we describe the standard technique for TEM, the different types of equipment used, and the technical limitations of this approach. TEM to remove rectal adenoma should be performed in the same way as if the lesion were an adenocarcinoma, due to the high percentageof infiltrating adenocarcinomas in these lesions. In spite of the generally good results with T1, some authors have published surprisingly high recurrence rates; this is due to the existence of two types of lesions, tumors with good and poor prognosis, divided according to histological and surgical factors. The standard treatment for rectal adenocarcinoma T2N0M0 is TME without adjuvant therapy. In this type of adenocarcinoma, local surgery obtains the best results when complete pathological response has been achieved with previous chemoradiotherapy. The results with chemoradiotherapy and TEM are encouraging, but the scientific evidence remains limited at present. | Xavier Serra-Aracil Laura Mora-Lopez Manel Alcantara-Moral Aleidis Caro-Tarrago Carlos Javier Gomez-Diaz Salvador Navarro-Soto | 2014 | World Journal of Gastroenterology2014，20，33： | 8 |
| 3 | Transanal endoscopic microsurgery with 3-D (TEM) or high-definition 2-D transanal endoscopic operation (TEO) for rectal tumors. A prospective, randomized clinical trial显示文摘 | Xavier Serra-Aracil Laura Mora-Lopez Manel Alcantara-Moral Aleidis Caro-Tarrago Salvador Navarro-Soto | 2014 | International Journal of Colorectal Disease2014，，5： | 2 |
| 4 | In vitro anticomplementary activity of constituents from Morinda morindoides显示文摘 | Tess DB Aleidis L | 1995 | J Nat Prod1995，58，3： | 1 |
| 5 | In vitro anticomplemen- tary activity of constituents from Morinda morindoides 显示文摘 | Kanyanga C Tess D B Aleidis L | 1995 | J Nat Prod1995，58，3： | 1 |
| 6 | In vitro anticomplemen- tary activity of constituents from Morinda morindoides显示文摘 | Kanyanga C Tess DB Aleidis L | 1995 | J Nat Prod1995，58，3： | 1 |
| 7 | In vitro biological activities of alkaloids from Cryptolepis sangninolenta显示文摘 | tess DB Aleidis L | 1996 | Planta Med1996，62，： | 1 |
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