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| 1 | Hepatic venous outflow obstruction:Three similar syndromes显示文摘Our goal is to provide a detailed review of veno- occlusive disease (VOD), Budd-Chiari syndrome (BCS), and congestive hepatopathy (CH), all of which results in hepatic venous outflow obstruction. This is the first article in which all three syndromes have been reviewed, enabling the reader to compare the characteristics of these disorders. The histological findings in VOD, BCS, and CH are almost identical: sinusoidal congestion and cell necrosis mostly in perivenular areas of hepatic acini which eventually leads to bridging fibrosis between adjacent central veins. Tender hepatomegaly with jaundice and ascites is common to all three conditions. However, the clinical presentation depends mostly on the extent and rapidity of the outflow obstruction. Although the etiology and treatment are completely different in VOD, BCS, and CH; the similarities in clinical manifestations and liver histology may suggest a common mechanism of hepatic injury and adaptation in response to increased sinusoidal pressure. | Ulas Darda Bayraktar Soley Seren Yusuf Bayraktar | 2007 | World Journal of Gastroenterology2007，13，13： | 28 |
| 2 | Molecular basis and management of gastrointestinal stromal tumors显示文摘Molecularly targeted agents have dramatically impacted the management of several cancers. Targeting KIT has led to a new treatment paradigm in gastrointestinal stromal tumors (GISTs). KIT is a cell surface receptor with tyrosine kinases that, upon binding of its ligand, stem cell factor, activates various signaling pathways. Imatinib and sunitinib, both tyrosine kinase inhibitors directed to KIT, were approved for firstand secondline treatment of metastatic and unresectable GISTs. In this article, we will review the molecular pathogenesis of GISTs followed by a discussion of imatinib and sunitinib’s role in the treatment of GISTs. Finally, we will introduce novel therapeutic options for imatiniband sunitinib-resistant GISTs. | Ulas D Bayraktar Soley Bayraktar Caio M Rocha-Lima | 2010 | World Journal of Gastroenterology2010，16，22： | 23 |
| 3 | Treatment of iron deficiency anemia associated with gastrointestinal tract diseases显示文摘The gastrointestinal (GI) tract is a common site of bleeding that may lead to iron deficiency anemia (IDA). Treatment of IDA depends on severity and acuity of patients’ signs and symptoms. While red blood cell transfusions may be required in hemodynamically unstable patients, transfusions should be avoided in chronically anemic patients due to their potential side effects and cost. Iron studies need to be performed after episodes of GI bleeding and stores need to be replenished before anemia develops. Oral iron preparations are efficacious but poorly tolerated due to non-absorbed iron-mediated GI side effects. However, oral iron dose may be reduced with no effect on its efficacy while decreasing side effects and patient discontinuation rates. Parenteral iron therapy replenishes iron stores quicker and is better tolerated than oral therapy. Serious hypersensitive reactions are very rare with new intravenous preparations. While data on worsening of inflammatory bowel disease (IBD) activity by oral iron therapy are not conclusive, parenteral iron therapy still seems to be advantageous in the treatment of IDA in patients with IBD, because oral iron may not be sufficient to overcome the chronic blood loss and GI side effects of oral iron which may mimic IBD exacerbation. Finally, we believe the choice of oral vs parenteral iron therapy in patients with IBD should primarily depend on acuity and severity of patients’ signs and symptoms. | Ulas D Bayraktar Soley Bayraktar | 2010 | World Journal of Gastroenterology2010，16，22： | 13 |
| 4 | Recent developments in palliative chemotherapy for locally advanced and metastatic pancreas cancer显示文摘In spite of advances made in the management of the other more common cancers of the gastrointestinal tract,significant progress in the treatment of pancreatic cancer remains elusive.Nearly as many deaths occur from pancreatic cancer as are diagnosed each year reflecting the poor prognosis typically associated with this disease.Until recently,the only treatment with an impact on survival was surgery.In the palliative setting,gemcitabine(Gem) has been a standard treatment for advanced pancreatic cancer since it was shown a decade ago to result in a superior clinical benefit response and survival compared with bolus 5-fluorouracil.Since then,clinical trials have explored the pharmacokinetic modulation of Gem by fixed dose administration and the combination of Gem with other cytotoxic or the biologically'targeted'agents.However,promising trial results in small phaseⅡtrials have not translated into survival improvements in larger phaseⅢrandomized trials in the advanced disease setting.Two trials have recently reported modest survival improvements with the use of combination treatment with Gem and capecitabine(United Kingdom National Cancer Research GEMCAP trial) or erlotinib(National Cancer Institute of CanadaClinical Trials Group PA.3 trial) .This review will focus on the use of systemic therapy for advanced and metastatic pancreatic cancer,summarizing the results of several recent clinical trials and discuss their implications for clinical practice.We will also discuss briefly the second-line chemotherapy options for advanced pancreatic cancer. | Soley Bayraktar Ulas Darda Bayraktar Caio Max Rocha-Lima | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 5 | Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion显示文摘AIM: To evaluate central macular thickness(CMT) and mean choroidal thickness(MCT) in eyes with branch retinal vein occlusion(BRVO), before and after ranibizumab treatment using spectral domain-optical coherence tomography(SD-OCT).·METHODS: Forty-two patients with unilateral BRVO and macular edema were included in this study. There were 25 men and 17 women. Using SD-OCT, choroidal thickness was measured at 500 μm intervals up to 1500μm temporal and nasal to the fovea. MCT was calculated based on the average of the 7 locations. All the eyes with BRVO were treated with intravitreal ranibizumab(0.5 mg/0.05 m L). Comparisons between the BRVO and fellow eyes were analyzed using Mann-Whitney U test. Preinjection and post-injection measurements were analyzed using Wilcoxon test and repeated measure analysis.· RESULTS: At baseline, there was a significant difference between the BRVO and fellow eyes in MCT[BRVO eyes 245(165-330) μm, fellow eyes 229(157-327) μm]and CMT [BRVO eyes 463(266-899) μm, fellow eyes 235(148-378) μm(P =0.041, 0.0001, respectively)]. Following treatment, CMT [295(141-558) μm] and MCT [229(157-329) μm] decreased significantly compared to the baseline measurements(P =0.001, 0.006, respectively).Also BCVA(log MAR) improved significantly(P=0.0001) in the BRVO eyes following treatment. After treatment CMT[BRVO eyes 295(141-558) μm, fellow eyes 234(157-351) μm]and MCT [BRVO eyes 229(157-329) μm, fellow eyes 233(162-286) μm] values did not reveal any significant difference in BRVO eyes and fellow eyes(P=0.051, 0.824,respectively).· CONCLUSION: In eyes with BRVO, CMT and MCT values are greater than the fellow eyes, and decrease significantly following ranibizumab injection. | Muge Coban-Karatas Rana Altan-Yaycioglu Burak Ulas Selcuk Sizmaz Handan Canan Cagla Sariturk | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 6 |
| 6 | 新光线下的艺术--谈博物馆与美术馆照明显示文摘博物馆和美术馆的照明是影响观众展览体验的重要因素。在使用LED等节能灯具的同时,合理有效的利用日光是当代博物馆照明的重要趋势,尽管日光的动态变化能给观众连接外部世界的体验并增加舒适度,但博物馆中日光的使用一直是充满挑战的任务,要关注照明节能,要提高观众的体验,同时保护展品免受光损伤。 | Emrah Baki Ulas Mirjam Roos | 2014 | 中国博物馆2014，，4： | 3 |
| 7 | Comparison of the inhibitory effect of different doses of subconjunctival bevacizumab application in an experimental model of corneal neovascularization显示文摘● AIM: To evaluate the inhibitory effect of subconjunctival bevacizumab as single-and multiple-dose application, and compare their effects on corneal neovascularization in a rat model.● METHODS: Thirty adult Sprague-Dawley rats were used in this experimental study. The central cornea of the rats was cauterized chemically. The rats were randomly enrolled into three groups. All groups received subconjunctival injections. In Group 1(control group, n=10), 0.05 m L 0.9% Na Cl solution was injected on the first day. In Group 2(single-dose group, n=10), 0.05 m L bevacizumab(1.25 mg) was injected on the first day. In Group 3(multiple-dose group, n=10), four doses of 0.05 m L bevacizumab(1.25 mg) were injected on the first, third, fifth and seventh day. Slit-lamp examination of all rats was performed at the third and ninth day. Digital images of the corneas were taken and analyzed using image analysis software to calculate corneal neovascularization area. All rats were sacrificed on the tenth day. In corneal sections, the number of blood vessels, state of inflammation and collagen formation was evaluated histopathologically.● RESULTS: In Group 3, corneal edema grades were significantly lower than Group 1 and Group 2(P=0.02, and P=0.035, respectively). The mean percentage of neovascularized corneal area in Group 3 was significantly lower than Group 2(P=0.005). On histopathological examination, Group 2 and Group 3 showed significantly less number of blood vessels than Group 1(P=0.005, and P=0.001, respectively). Additionally, Group 3 showed significantly less number of blood vessels compared to Group 2(P=0.019). Inflammation and edema grades were significantly lower in Group 3 compared to Group 1(P=0.001).● CONCLUSION: Subconjunctival bevacizumab injection is effective in inhibition of newly formed corneal neovascularization. The multiple-dose bevacizumab treatment seems to be more effective compared to single-dose treatment. | Burak Ulas Rana Altan-Yaycioglu Nebil Bal | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 3 |
| 8 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria显示文摘 | Ivaylo I. Ivanov Koji Atarashi Nicolas Manel Eoin L. Brodie Tatsuichiro Shima Ulas Karaoz Dongguang Wei Katherine C. Goldfarb Clark A. Santee Susan V. Lynch Takeshi Tanoue Akemi Imaoka Kikuji Itoh Kiyoshi Takeda Yoshinori Umesaki Kenya Honda Dan R. Littma | 2009 | Cell2009，，3： | 3 |
| 9 | Sorption of quaternary ammonium compounds to municipal sludge显示文摘 | Zainab Z. Ismail Ulas Tezel Spyros G. Pavlostathis | 2009 | Water Research2009，，7： | 2 |
| 10 | Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates显示文摘AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication. | Rana Altan-Yaycioglu Nedime Sahinoglu-Keskek Handan Canan Muge Coban-Karatas Burak Ulas | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 2 |
| 11 | Prediction of wear loss quantities of ferro-alloy coating using different machine learning algorithms显示文摘In this study,experimental wear losses under different loads and sliding distances of AISI 1020 steel surfaces coated with(wt.%)50FeCrC‐20FeW‐30FeB and 70FeCrC‐30FeB powder mixtures by plasma transfer arc welding were determined.The dataset comprised 99 different wear amount measurements obtained experimentally in the laboratory.The linear regression(LR),support vector machine(SVM),and Gaussian process regression(GPR)algorithms are used for predicting wear quantities.A success rate of 0.93 was obtained from the LR algorithm and 0.96 from the SVM and GPR algorithms. | Osman ALTAY Turan GURGENC Mustafa ULAS Cihan OZEL | 2020 | Friction2020，8，1： | 2 |
| 12 | A new approach for prediction of the wear loss of PTA surface coatings using artificial neural network and basic,kernel-based,and weighted extreme learning machine显示文摘Wear tests are essential in the design of parts intended to work in environments that subject a part to high wear.Wear tests involve high cost and lengthy experiments,and require special test equipment.The use of machine learning algorithms for wear loss quantity predictions is a potentially effective means to eliminate the disadvantages of experimental methods such as cost,labor,and time.In this study,wear loss data of AISI 1020 steel coated by using a plasma transfer arc welding(PTAW)method with FeCrC,FeW,and FeB powders mixed in different ratios were obtained experimentally by some of the researchers in our group.The mechanical properties of the coating layers were detected by microhardness measurements and dry sliding wear tests.The wear tests were performed at three different loads(19.62,39.24,and 58.86 N)over a sliding distance of 900 m.In this study,models have been developed by using four different machine learning algorithms(an artificial neural network(ANN),extreme learning machine(ELM),kernel-based extreme learning machine(KELM),and weighted extreme learning machine(WELM))on the data set obtained from the wear test experiments.The R2 value was calculated as 0.9729 in the model designed with WELM,which obtained the best performance among the models evaluated. | Mustafa ULAS Osman ALTAY Turan GURGENC Cihan OZEL | 2020 | Friction2020，8，6： | 2 |
| 13 | Adapting to Climate Change: What Might Be Needed?显示文摘Increasingly,experts agree that the planet is poised to warm beyond the mitigation targets established by the Intergovernmental Panel on Climate Change(IPCC).In their 2018 special report,“Global Warming of 1.5℃,”the 1PCC warned that keeping temperatures within 1.5℃ of warming above preindustrial levels is critical to avoiding some of the worst impacts of climate change[1].According to the 2019 United Nations(UN)Emissions Gap Report,global emissions would need to decline by 7.6%every year between 2020 and 2030 to avoid this temperature threshold. | Ula Chrobak | 2020 | Engineering2020，6，11： | 2 |
| 14 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 15 | Effects of octreotide acetate and amniotic membrane on wound healing in experimental glaucoma surgery显示文摘 | Tamer Demir Burak Turgut Ulku Celiker Ibrahim Ozercan Fatih Ulas Nuray Akyol | 2003 | Documenta Ophthalmologica2003，，2： | 2 |
| 16 | Acupuncture Enhances Chances of Pregnancy in Unexplained Infertile Patients Who Undergo A Blastocyst Transfer in A Fresh-Cycle显示文摘Objective: To analyze the effects of acupuncture on in vitro fertilization patients with unexplained infertility.Methods: We retrospectively analyzed the charts of a total of 302 cycles performed in 273 patients attending Assisted Reproductive Technology(ART) Centre from August 2013 to August 2016.During the study period,embryo transfer with acupuncture(Acupuncture group,46 cases) and without acupuncture(Control group,42 cases) were applied.Prior to embryo transfer,the following points were used in the acupuncture group: Neiguan(CX 6),Diji(SP 8),Taichong(Liv 3),Baihui(Gv 20),and Guilai(S 29).These sessions were carried out two times before and after embryo transfer in a single day.In addition,auricular acupuncture was also performed at ear points,including ear point 55(Shenmen),ear point 58(Zhigong),ear point 22(Neifenmi)and ear point 34(Naodian).The biochemical pregnancy rate and clinical pregnancy rate after transplantation were compared between two groups.Results: The clinical pregnancy rate in the acupuncture group was higher than that in the control group [60.9%(28/46) vs.33.3%(14/42),respectively,P<0.05].Likewise,the live birth rate in the acupuncture group was also higher than that in the control group [71.7%(33/46) vs.31.0%(12/42),P<0.01).Conclusion: Administration of acupuncture on the day of embryo transfer dramatically improved fertility results in women who underwent in vitro fertilization/intra-cytoplasm sperm injection for reproduction. | Hakan ?oksüer Mert Ula Barut Murat BozkurT Elif Agacayak Sibel Sak Mustafa Demir Eray Cal?skan | 2019 | Chinese Journal of Integrative Medicine2019，25，4： | 2 |
| 17 | Elevated NMDA receptors in parkinsonian striatum显示文摘 | Weihmuller FB Ulas J Nguyen L | 1992 | Neuroreport1992，3，11： | 1 |
| 18 | Sponteneousrupture of hepatoeellular carcinoma: a wstern experience显示文摘 | BATI'ULA N MADANUR M PRIEST O | 2009 | Am J Surg2009，197，： | 1 |
| 19 | Evaluation of factor V G1691A,prothrombin G20210A,factor Ⅹ Ⅲ V34L,MTHFR A1298C,MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD)panel in south-east region of Turkey显示文摘 | Oztuzcu S Ergun S Ulas M | 2014 | Mol Biol Rep2014，41，6： | 1 |
| 20 | Estimation of Tree Size Diversity Using Object Oriented Texture Analysis and AsterImagery显示文摘 | Ozdemir I Norton D A Ulas Ozkan Y | 2008 | Sensors2008，，8： | 1 |
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