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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | 齿轮-轴承系统非线性振动混沌吸引子周期轨道控制显示文摘考虑轴承支撑齿轮传动系统建立了含多间隙的系统非线性动力学模型,模型中考虑了时变啮合刚度和综合传动误差等因素。基于OGY混沌控制改进策略对高维非双曲齿轮系统实施了多周期混沌控制,采用Newton-Raphson迭代法搜寻了P1、P2、P4和P8等多组不稳定周期轨道(Unstable Periodic Orbits,UPO)不动点,求解了各UPO解对应的Jacobi矩阵特征值和局部参数敏感度矢量,结合Poincaré截面等工具解析了混沌吸引子向P10周期轨道转换时的轨道间隔及迁移特性。在2 000周期步下对混沌吸引子实施了P1、P2、P4、P8和P10等多种周期组合式控制,结果表明在状态转换阶段,尤其30周期步内控制参数摄动量发生激增,此后恢复稳定且保持与目标控制轨道相同周期的状态演化;多周期轨道持续控制时周期状态越高,控制难度越大,所需参数摄动量相应增加。研究结果在理论上有助于齿轮系统混沌响应减振控制。 | 林何 屈文宽 MATTHIAS R tsch 王三民 | 2020 | 振动与冲击2020，39，13： | 6 |
| 3 | 基于G-P算法关联维数齿轮系统相空间吸引子数值特性显示文摘为有效刻画齿轮系统相空间吸引子结构的数值特性,建立了直齿轮系统含间隙与综合传动误差的非线性动力学模型,基于G-P算法推导了等间隔的齿轮系统吸引子关联维数计算公式。对周期运动和混沌运动吸引子,采用Lyapunov指数与关联维数等手段定量表征其数值特性,利用Poin caré截面法定性分析了混沌吸引子的演化和迁移进程。通过关联维数对阻尼比和综合传动误差变化下的混沌吸引子演化行为进行了追踪刻画,结果表明,吸引子结构越复杂则关联维数越大,系统振动越敏感,混沌吸引子关联维数值介于整数1和2之间,具有分数维特征。 | 林何 Matthias R?tsch 王三民 胥光申 | 2019 | 机械传动2019，43，7： | 5 |
| 4 | 基于卷积神经网络的人脸图像美感分类显示文摘针对复杂环境下人脸图像美感分类准确率低的问题,给出一种适用于人脸图像美感分类的网络模型F-Net。该模型以LeNet-5为基础网络,使用卷积层提取复杂背景下的人脸图像特征,优化网络模型中的参数,改变模型中卷积层和全连接层特征元的数量。结果表明,本文给出的F-Net网络模型在复杂环境背景下的人脸图像分类准确率达到73%,较其他经典的卷积神经网络分类模型相比性能更佳。 | 吴菲 朱欣娟 吴晓军 MATTHIAS R?tsch | 2019 | 西安工程大学学报2019，33，6： | 5 |
| 5 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 6 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 7 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 8 | Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study显示文摘 | Bengt Winblad Niels Andreasen Lennart Minthon Annette Floesser Georges Imbert Thomas Dumortier R Paul Maguire Kaj Blennow Joens Lundmark Matthias Staufenbiel Jean-Marc Orgogozo Ana Graf | 2012 | Lancet Neurology2012，，7： | 3 |
| 9 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 10 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 11 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 12 | Pancreatic cancer cells surviving gemcitabine treatment express markersof stem cell differentiation and epithelial-mesenchymal transition显示文摘 | Karl Quint Manuel Tonigold Pietro Di Fazio Roberta Montalbano Susanne Lingelbach Felix Rückert Beate Alinger Matthias Ocker Daniel Neureiter | 2012 | International Journal of Oncology2012，，6： | 2 |
| 13 | Postoperative pain after transvaginal cholecystectomy: single-center, double-blind, randomized controlled trial显示文摘 | Dietmar H. Borchert Matthias Federlein Frauke Fritze-Büttner Jens Burghardt Britta Liersch-L?hn Yüksel Atas Verena Müller Oskar Rückbeil Stefan Wagenpfeil Stefan Gr?ber Klaus Gellert | 2014 | Surgical Endoscopy2014，，6： | 2 |
| 14 | The network of psychological variables in patients with diabetes and their importance for quality oflife and metabolic control显示文摘 | Thea S Herbert F | 2002 | Diabetes Care2002，25，1： | 1 |
| 15 | what does it mean to identify a protein in proteomics显示文摘 | Juri R Matthias P | 2002 | Trends in Biochemical Sciences2002，27，2： | 1 |
| 16 | Wall material and capping effects on microlysimeter temperatures and evaporation显示文摘 | Evett S R Warrick A W Matthias A D | 1995 | Soil Science Society of America Journal1995，59，2： | 1 |
| 17 | A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease显示文摘 | Matthias R Lidija K Patricia F | | 0，，： | 1 |
| 18 | Molecular screening of gastric cancer by proteome analysis显示文摘 | Matthias P.A. Ebert Christoph R?cken | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 1 |
| 19 | Bare soil evaporation near a surface point-source emitter显示文摘 | Matthias A D Salehi R Warrick A W | 1986 | Agricultural Water Management1986，11，34： | 1 |
| 20 | Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2′-deoxycytidine显示文摘 | Jie Chen Christoph R?cken Ludger Klein-Hitpass Tobias G?tze Andreas Leodolter Peter Malfertheiner Matthias P.A. Ebert | 2004 | Clinical & Experimental Metastasis2004，，5： | 1 |
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