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| 1 | Breath and string test: A diagnostic package for the identification of treatment failure and antibiotic resistance of Helicobacter pylori without the necessity of upper gastrointestinal endoscopy显示文摘AIM: Helicobacter pylori ( H pylofi) resistance after failed eradication has a major impact on the outcome of a further treatment regimen. The aim of this study was to assess the validity of a non-invasive strategy using the 13C-urea breath test (UBT) and the gastric string test in identifying post-treatment resistance of Hpylori.METHODS: The UBT was routinely performed 4 to 6 wk after H pylorieradication therapy. Forty-two patients (24 females, 18 males, mean age 48 years) with a positive UBT were included in the study. A gastric string test using a capsule containing a 90 cm-long nylon fiber was performed.Before the capsule was swallowed, the free end of the string was taped to the cheek. After one hour in the stomach, the string was withdrawn. The distal 20 cm of the string was inoculated onto an agar plate and processed under microaerophilic conditions. Following the string test, upper gastrointestinal endoscopy was performed to obtain gastric biopsies for conventional culture.RESULTS: H pyloriwas successfully cultured from the gastric string in 34 patients (81%), but not in 5 patients due to contamination with oropharyngeal flora. Hpyloriwas cultured from the gastric biopsies obtained at endoscopy in 39 patients (93%).CONCLUSION: The UBT followed by the gastric string test in the case of treatment failure is a valid diagnostic strategy with the aim of determining the post-therapeutic antibiotic resistance of Hpyloriwith little inconvenience to the patient.Upper GI-endoscopy can be avoided in several cases by applying consequently this diagnostic package. | Andreas Leodolter Kathlen Wolle Ulrike von Arnim Stefan Kahl Gerhard Treiber Matthias P.Ebert Ulrich Peitz Peter Malfertheiner | 2005 | World Journal of Gastroenterology2005，11，4： | 10 |
| 2 | Prevalence of H pylori associated 'high risk gastritis' for development of gastric cancer in patients with normal endoscopic findings显示文摘AIM: To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any signifi cant abnormal fi ndings during upper- GI endoscopy. METHODS: Gastric biopsies from 3548 patients were obtained during upper GI-endoscopy in a 4-year period. Two biopsies from antrum and corpus were histologically assessed according to the updated Sydney-System. Eight hundred and forty-fi ve patients (mean age 54.8 ± 2.8 years) with H pylori infection and no peptic ulcer or abnormal gross fi ndings in the stomach were identifi ed and analyzed according to gastritis phenotypes using different scoring systems. RESULTS: The prevalence of severe H pylori associated changes like pangastritis, CPG, IM, and severe atrophy increased with age, reaching a level of 20% in patients of the age group over 45 years. No differences in frequencies between genders were observed. The prevalence of IM had the highest increase, being 4-fold higher at the age of 65 years versus in individuals less than 45 years. CONCLUSION: The prevalence of gastritis featuring at risk for cancer development increases with age. These findings reinforce the necessity for the histological assessment, even in subjects with normal endoscopic appearance. The age-dependent increase in prevalence of severe histopathological changes in gastric mucosa, however, does not allow estimating the individual risk forgastric cancer development-only a proper follow-up can provide this information. | Andreas Leodolter Matthias P Ebert Ulrich Peitz Kathlen Wolle Stefan Kahl Michael Vieth Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | A citric acid solution is an optimal test drink in the 13C-urea breath test for the diagnosis of Helicobacterpylori infection显示文摘 | Dominguez-Munoz JE Leodolter A Sauerbruch T | 1997 | Gut1997，40，： | 2 |
| 4 | Validity of a modified 13C-urea breath test for pre- and posttreatment diagnosis of Helicobacterpylori infection in the routine clinical setting显示文摘 | Leodolter A Dominguez Munoz JE von Amim U | 1999 | Am J Gastroenterol1999，94，： | 2 |
| 5 | Influence of Department Volume on Survival for Ovarian Cancer: Results From a Prospective Quality Assurance Program of the Austrian Association for Gynecologic Oncology显示文摘 | Christian Marth Sonja Hiebl Willi Oberaigner Raimund Winter Sepp Leodolter Paul Sevelda | 2009 | International Journal of Gynecological Cancer2009，，1： | 1 |
| 6 | Vascular endothelial growth factor splice variants and their prognostic value in breast and ovarian cancer显示文摘 | Stimpfl M Tong D Fasching B Schuster E Obermair A Leodolter S | 2002 | Clin Cancer Res2002，8，： | 1 |
| 7 | Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage显示文摘 | Koichi Suzuki Ikuko Suzuki Andreas Leodolter Sergio Alonso Shina Horiuchi Kentaro Yamashita Manuel Perucho | 2006 | Cancer Cell2006，，： | 1 |
| 8 | Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2′-deoxycytidine显示文摘 | Jie Chen Christoph R?cken Ludger Klein-Hitpass Tobias G?tze Andreas Leodolter Peter Malfertheiner Matthias P.A. Ebert | 2004 | Clinical & Experimental Metastasis2004，，5： | 1 |
| 9 | The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells显示文摘 | Bernd C. Schmid Günther A. Rezniczek Gerhild Fabjani Toshiyuki Yoneda Sepp Leodolter Robert Zeillinger | 2007 | Breast Cancer Research and Treatment2007，，3： | 1 |
| 10 | The use of colour-coded and spectral Doppler ultrasound in the differentiation of benign and malignant breast lesions显示文摘 | Peters-Engl C Medl M Leodolter S | 1995 | Br J Cancer1995，71，1： | 1 |
| 11 | Tumor flow in malignant breast tumors measured by Doppler ultrosound:an independent predictor of survival显示文摘 | Peter C Frank W Leodolter S | 1999 | Breast Cancer Res Treat1999，54，1： | 1 |
| 12 | The use of colour - coded and Spectral Doppler ultrasound in the differentiation of benign and malignant breast lesions 显示文摘 | PETERS- ENGL C MEDL M LEODOLTER S | 1995 | Br J Cancer1995，71，： | 1 |
| 13 | Current standards in the diagnosis of Helicobacter pylori infection显示文摘 | LEODOLTER A WOLLE K MALFERTHEINER P | 2001 | Dig Dis2001，19，2： | 1 |
| 14 | The use of color and Doppler ultrasound in the differentiation of brnign and malignant breast lesion显示文摘 | Peters-Engl C Medi M Leodolter S | 1995 | Br J Can1995，71，： | 1 |
| 15 | Long-term clinical course of extra-oesophageal manifestations in patients with gastro-oesophageal reflux disease显示文摘 | D. Jaspersen J. Labenz S.N. Willich M. Kulig M. Nocon A. Leodolter T. Lind W. Meyer-Sabellek M. Vieth M. Stolte P. Malfertheiner | 2005 | Digestive and Liver Disease2005，，4： | 1 |
| 16 | 显示文摘 | Leodolter A Kahl S Dominguez-Munoz JE | 2000 | Eur J Gastroenterol Hepatol2000，12，12： | 1 |
| 17 | EUS in the diagnosis of early chronic pancreatitis:a prospective follow- up study显示文摘 | KAHL S GLASBRENNER B LEODOLTER A | 2002 | Gastrointest Endosc2002，55，4： | 1 |
| 18 | Endoscopic ul trasonography in the diagnosis of early chronic pancreatitis: a prospective follow-up study显示文摘 | Kahl S Glasbrenner B Leodolter A | 2002 | Gastrointest Endosc2002，55，4： | 1 |
| 19 | The use of color Doppler ultrasound in the diffierentiation of benign and malignant breast leisions显示文摘 | Peters EC Medi M Leodolter S | 1995 | British J Can1995，71，1： | 1 |
| 20 | Global DNA demethylationin gastrointestinal cancer is age dependent and precedes genomicdamage显示文摘 | Suzuki K Suzuki I Leodolter A | 2006 | Cancer Cell2006，9，3： | 1 |
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