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| 1 | Mass-forming pancreatitis: Value of contrast-enhanced ultrasonography显示文摘瞄准:在在集体形成的胰腺炎和胰腺的癌之间的鉴别诊断与第二代的造影剂估计提高对比的 ultrasonography (CEUS ) 的用途。方法:从我们的收音机病理数据库,我们检索了经历了 CEUS 的集体形成的胰腺炎或胰腺的癌影响的所有病人。我们由识别“ parenchymographic ”就在集体形成的胰腺炎和胰腺的肿瘤之间的鉴别诊断的可能性而言在 173 胰腺的群众的学习评估了 CEUS 的结果改进在 CEUS 的动态阶段期间,它为集体形成的胰腺炎被认为诊断。结果:在 CEUS, 94% 集体形成的胰腺炎显示出 intralesional parenchymography。CEUS 有 88.6% 的敏感的集体形成的胰腺炎的允许的诊断, 97.8% 的特性, 91.2% 的积极预兆的价值, 97.1% 的否定预兆的价值,和外套 96% 的精确性。CEUS 显著地在在集体形成的胰腺炎和胰腺的癌之间的鉴别诊断增加了诊断信心,与操作从 0.557 的特性曲线区域的接收装置(P = 0.1608 ) 为到 0.956 的基线美国(P <
0.0001 ) 为 CEUS。结论:CEUS 与 96% 的诊断精确性允许集体形成的胰腺炎的诊断。CEUS 显著地在从胰腺的瘤认出集体形成的胰腺炎关于基础美国增加诊断信心。 | Mirko D'Onofrio Giulia Zamboni Alessia Tognolini Roberto Malagò Niccolò Faccioli Luca Frulloni Roberto Pozzi Mucelli | 2006 | World Journal of Gastroenterology2006，12，26： | 28 |
| 2 | Exocrine pancreatic insufficiency in adults:A shared position statement of the Italian association for the study of the pancreas显示文摘This is a medical position statement developed by the Exocrine Pancreatic Insufficiency collaborative group which is a part of the Italian Association for the Study of the Pancreas(AISP).We covered the main diseases associated with exocrine pancreatic insufficiency(EPI)which are of common interest to internists/gastroenterologists,oncologists and surgeons,fully aware that EPI may also occur together with many other diseases,but less frequently.A preliminary manuscript based on an extended literature search(Medline/PubMed,Cochrane Library and Google Scholar)of published reports was prepared,and key recommendations were proposed.The evidence was discussed at a dedicated meeting in Bologna during the National Meeting of the Association in October 2012.Each of the proposed recommendations and algorithms was discussed and an initial consensus was reached.The final draft of the manuscript was then sent to the AISP Council for approval and/or modification.All concerned parties approved the final version of the manuscript in June 2013. | Raffaele Pezzilli Angelo Andriulli Claudio Bassi Gianpaolo Balzano Maurizio Cantore Gianfranco Delle Fave Massimo Falconi Luca Frulloni the Exocrine Pancreatic Insufficiency collaborative(EPIc) Group | 2013 | World Journal of Gastroenterology2013，19，44： | 16 |
| 3 | ERCP in acute pancreatitis:What takes place in routine clinical practice?显示文摘AIM:To evaluate the data from a survey carried out in Italy regarding the endoscopic approach to acute pancreatitis in order to obtain a picture of what takes place after the release of an educational project on acute pancreatitis sponsored by the Italian Association for the Study of the Pancreas.METHODS:Of the 1 173 patients enrolled in our survey,the most frequent etiological category was biliary forms(69.3%) and most patients had mild pancreatitis(85.8%).RESULTS:344/1 173(29.3%) underwent endoscopic retrograde cholangiopancreatography(ERCP).The mean interval between the onset of symptoms and ERCP was 6.7 ± 5.0 d;only 89 examinations(25.9%) were performed within 72 h from the onset of symptoms.The main indications for ERCP were suspicion of common bile duct stones(90.3%),jaundice(44.5%),clini cal worsening of acute pancreatitis(14.2%) and cho langitis(6.1%).Biliary and pancreatic ducts were visua lized in 305 patients(88.7%) and in 93 patients(27.0%) respectively.The success rate in obtaining a cholangio gram was statistically higher(P = 0.003) in patients with mild acute pancreatitis(90.6%) than in patients with severe disease(72.2%).Biliary endoscopic sphinc terotomy was performed in 295 of the 305 patients(96.7%) with no difference between mild and severe disease(P = 0.985).ERCP morbidity was 6.1% and mortality was 1.7%;the mortality was due to the complications of acute pancreatitis and not the endoscopic procedure.CONCLUSION:The results of this survey,as with those carried out in other countries,indicate a lack of compliance with the guidelines for the indications for interventional endoscopy. | Armando Gabbrielli Raffaele Pezzilli Generoso Uomo Alessandro Zerbi Luca Frulloni Paolo De Rai Laura Castoldi Guido Costamagna Claudio Bassi Valerio Di Carlo | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，9： | 14 |
| 4 | A practical approach to the diagnosis of autoimmune pancreatitis显示文摘Autoimmune pancreatitis is a disease characterized by specific pathological features,different from those of other forms of pancreatitis,that responds dramatically to steroid therapy.The pancreatic parenchyma may be diffusely or focally involved with the possibility of a low-density mass being present at imaging,mimicking pancreatic cancer.Clinically,the most relevant problems lie in the diagnosis of autoimmune pancreatitis and in distinguishing autoimmune pancreatitis from pancreatic cancer.Since in the presence of a pancreatic mass the probability of tumour is much higher than that of pancreatitis,the physician should be aware that in focal autoimmune pancreatitis the first step before using steroids is to exclude pancreatic adenocarcinoma.In this review,we briefly analyse the strategies to be followed for a correct diagnosis of autoimmune pancreatitis. | Luca Frulloni Antonio Amodio Anna Maria Katsotourchi Italo Vantini | 2011 | World Journal of Gastroenterology2011，17，16： | 8 |
| 5 | Diagnostic yield of EUS-FNA of small(≤15 mm) solid pancreatic lesions using a 25-gauge needle显示文摘Background: Early detection of small solid pancreatic lesions is increasingly common. To date, few and contradictory data have been published about the relationship between lesion size and endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) diagnostic yield. The aim of this study was to assess the relation between the size of solid pancreatic lesions and the diagnostic yield of EUS-FNA using a 25-gauge needle in a center without available rapid on-site evaluation.Methods: In the retrospective cohort study, we selected patients who underwent EUS-FNA for solid pancreatic lesions with a 25-gauge needle from October 2014 to October 2015. Patients were divided into three groups(≤15 mm, 16–25 mm and >25 mm), and the outcomes were compared.Results: We analyzed 163 patients. Overall adequacy, sensitivity, specificity and accuracy were 85.2%,81.8%, 93.7%, and 80.4%, respectively. When stratified by size, the sensitivity and accuracy correlated with size(P = 0.016 and P = 0.042, respectively). Multivariate analysis showed that lesion size was the only independent factor(P = 0.019, OR = 4.76) affecting accuracy. The role of size as an independent factor affecting accuracy was confirmed in a separate multivariate analysis, where size was included in the model as a covariate(P = 0.018, OR = 1.08).Conclusion: Our study demonstrates that, in the absence of rapid on-site evaluation, mass size affects the accuracy of EUS-FNA of solid pancreatic lesions. | Stefano Francesco Crinò Maria Cristina Conti Bellocchi Laura Bernardoni Erminia Manfrin Alice Parisi Antonio Amodio Nicolò De Pretis Luca Frulloni Armando Gabbrielli | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 4 |
| 6 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 7 | Cystic fibrosis transmembrane conductance regulator functional evaluations in a G542X+/-IVS8Tn:T7/9 patient with acute recurrent pancreatitis显示文摘BACKGROUND Acute recurrent pancreatitis(ARP)is characterized by episodes of acute pancreatitis in an otherwise normal gland.When no cause of ARP is identifiable,the diagnosis of'idiopathic'ARP is given.Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR)gene increase the risk of ARP by 3-to 4-times compared to the general population,while cystic fibrosis(CF)patients present with a 40-to 80-times higher risk of developing pancreatitis.CASE SUMMARY In non-classical CF or CFTR-related disorders,CFTR functional tests can help to ensure a proper diagnosis.We applied an individualized combination of standardized and new CFTR functional bioassays for a patient referred to the Verona CF Center for evaluation after several episodes of acute pancreatitis.The CFTR genotype was G542X+/-with IVS8Tn:T7/9 polymorphism.The sweat(Cl-)values were borderline.Intestinal current measurements were performed according to the European Cystic Fibrosis Society Standardized Operating Procedure.Recent nasal surgery for deviated septum did not allow for nasal potential difference measurements.Lung function and sputum cultures were normal;azoospermia was excluded.Pancreas divisum was excluded by imaging but hypoplasia of the left hepatic lobe was detected.Innovative tests applied in this case include sweat rate measurement by image analysis,CFTR function in monocytes evaluated using a membrane potential-sensitive fluorescent probe,and the intestinal organoids forskolin-induced swelling assay.CONCLUSION Combination of innovative CFTR functional assays might support a controversial diagnosis when CFTR-related disorders and/or non-classical CF are suspected. | Sara Caldrer Gabriella Bergamini Angela Sandri Silvia Vercellone Luca Rodella Angelo Cerofolini Francesco Tomba Filippo Catalano Luca Frulloni Mario Buffelli Gloria Tridello Hugo de Jonge Baroukh Maurice Assael Claudio Sorio Paola Melotti | 2019 | World Journal of Clinical Cases2019，7，22： | 2 |
| 8 | Comparison of two dosing regimens of gabexate in the prophylaxis of post-ERCP pancreatitis显示文摘 | Enzo Masci Giorgio Cavallini Alberto Mariani Luca Frulloni Pier Alberto Testoni Simona Curioni Alberto Tittobello Generoso Uomo Guido Costamagna Sandro Zambelli Gianpiero Macarri Paolo Innocenti Carola Dragonetti | 2003 | The American Journal of Gastroenterology2003，，10： | 2 |
| 9 | Incidence of cancer in the course of chronic pancreatitis显示文摘 | Giorgio Talamini Massimo Falconi Claudio Bassi Nora Sartori Roberto Salvia Erminia Caldiron Luca Frulloni Vincenzo Di Francesco Bruna Vaona Paolo Bovo Italo Vantini Paolo Pederzoli Giorgio Cavallini | 1999 | The American Journal of Gastroenterology1999，，5： | 2 |
| 10 | International Consensus Diagnostic Criteria for Autoimmune Panereatitis : Guidelines of the International Association of Pancreatology 显示文摘 | Shimosegawa T Chari S T Frulloni L | 2011 | Pancreas2011，40，3： | 1 |
| 11 | International consensus diagnostic criteria for autoimmune panereatitis : guidelines of the International Association of Pancreatology 显示文摘 | Shimosegawa T Chaff ST Frulloni L | 2011 | Pancreas2011，40，： | 1 |
| 12 | Internationalconsensus diagnostic criteria for autoimmune pancreatitis:guidelines of the International Association of Pancreatology显示文摘 | Shimosegawa T Chari ST Frulloni L | 2011 | Pancreas2011，40，3： | 1 |
| 13 | Autoinmmne pancreatitis:a challenging diagnostic puzzle for clinicians显示文摘 | Buscarini E Frulloni L De Lisi S | 2010 | Dig Liver Dis2010，42，： | 1 |
| 14 | Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens显示文摘 | Giuseppe Zamboni Jutta Lüttges Paola Capelli Luca Frulloni Giorgio Cavallini Paolo Pederzoli Alexander Leins Daniel Longnecker Günter Kl?ppel | 2004 | Virchows Archiv2004，，6： | 1 |
| 15 | Diagnosis and treatment of acute pancreatitis: The position statement of the Italian Association for the study of the pancreas显示文摘 | R. Pezzilli G. Uomo A. Zerbi A. Gabbrielli L. Frulloni P. De Rai G. Delle Fave V. Di Carlo | 2008 | Digestive and Liver Disease2008，，10： | 1 |
| 16 | International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology 显示文摘 | Shimosegawa T Chari ST Frulloni L | 2011 | Pancreas2011，40，3： | 1 |
| 17 | Analysis of the entire coding region of the cystic fibrosis transmembrane regulator gene in idiopathic pancreatitis 显示文摘 | Castellani C Lira MG Frulloni L | 2001 | Hum Murat2001，18，2： | 1 |
| 18 | Diagnostic assessment and outcome of acute pancreatitis in Italy: Results of a prospective multicentre study显示文摘 | G. Uomo R. Pezzilli A. Gabbrielli L. Castoldi A. Zerbi L. Frulloni P. De Rai G. Cavallini V. Di Carlo | 2007 | Digestive and Liver Disease2007，，9： | 1 |
| 19 | Autoimmune panereatitis: Pancreatic andextrapancreatic MR imaging-MR eholangiopanereatography findings at diagnosis, aftersteroid therapy, and at recurrence显示文摘 | Manfredi R Frulloni L Mantovani W | 2011 | Radiology2011，260，2： | 1 |
| 20 | Long-term follow-up of patients with chronic pancreatitis in Italy显示文摘 | Cavallini G Frulloni L Pederzoli P | 1998 | Scand J Gastroenterol1998，33，8： | 1 |
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