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| 1 | 经鼻持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征患者睡眠结构近远期的影响显示文摘目的 观察经鼻持续气道正压 (nCPAP)通气对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠结构近远期的影响。方法 17例对照者行多导睡眠图 (PSG)监测 ,对 30例经PSG诊断的OSAHS患者行nCPAP治疗 ,治疗第 1夜行PSG监测 ,连续家庭nCPAP治疗 6个月后行第 2次PSG监测 ,分析比较睡眠结构的变化。结果 OSAHS患者治疗前睡眠转换次数、1期、2期睡眠比例较对照组增加 (P <0 0 5 ) ,慢波睡眠期、快动眼 (REM )期比例较对照组低 (P <0 0 5 ) ;nCPAP治疗第 1夜睡眠转换次数、1期、2期睡眠比例较治疗前降低 (P <0 0 5 ) ,慢波睡眠期、REM期比例较治疗前升高 (P <0 0 5 ) ;nCPAP治疗 6个月后睡眠转换次数、1期、2期、慢波睡眠期比例与治疗第 1夜比较差异均无显著性 (P >0 0 5 ) ,而REM期比例较治疗第 1夜降低 (P <0 0 5 )。结论 OSAHS患者睡眠转换次数明显增多 ,1期睡眠增加而REM期睡眠减少 ,睡眠结构紊乱。nCPAP治疗第 1夜及6个月后睡眠结构得到有效纠正 ,是OSAHS长期有效的治疗方法之一。 | 肖永龙 Frank Richter Fulk Brunner Birgid Lerche 张德平 郑培德 | 2004 | 中华内科杂志2004，43，9： | 8 |
| 2 | Models of Acute and Chronic Pancreatitis显示文摘 | Markus M. Lerch Fred S. Gorelick | 2013 | Gastroenterology2013，，6： | 5 |
| 3 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 4 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 5 | Experimental animal model of acute pancreatitis显示文摘 | Lerch MM Adler G | 1994 | Inter J Pancreat1994，15，： | 2 |
| 6 | Pancreatic cancer–Palliative therapy: stenting显示文摘Pancreatic cancer remains a common and very lethal malignancy with a median survival of approximately 6 months. Surgical resection offers the only potentially curative approach but many patients (80% or more) are ineligible for this kind of therapy, because of age, comorbidities, or locally advanced or metastatic disease that does not benefit from resection. Thus, for many patients with pancreatic cancer treatment remains palliative and endoscopic therapy to relieve bile duct or gastric outlet obstruction becomes of special importance. Although both surgical and non surgical palliative procedures can relieve biliary and duodenal obstruction particularly endoscopic treatment with plastic prostheses or self expanding metal stents was shown to be not only highly effective but also to be burdened with only few complications. The present article summarizes the palliative endoscopic treatment in patients with non resectable pancreatic cancer. | U. Wahnschaffe M. Kraft S. Turi M. M. Lerch | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，2： | 2 |
| 7 | 形成水合物的基本条件显示文摘每种水合物都有特殊的温度压力稳定场.一般存在某一标配压力(通常取水合物在0℃条件下存在的临界压力),可根据该压力估计存在特殊气体水合物所需的地质条件。在0℃条件下,纯甲烷水合物存在需要的临界压力约26MPa(相当于约260m的淡水柱,对于海水要减少约3.5%),而纯乙烷水合物存在需要的临界压力约5.2MPa(相当于约52m的淡水柱和约50m的海水柱)。温度高于0℃时,要使特定气体水合物存在,上覆液柱压力必须大于临界值; | Lan Lerche Elchin Bagirov 谢力 | 2004 | 石油勘探与开发2004，31，5： | 2 |
| 8 | Inversion of multiple thermal indicators: Quantitative methods of determining paleoheat flux and geological parameters. I. Theoretical development for paleoheat flux显示文摘 | I. Lerche | 1988 | Mathematical Geology1988，，1： | 2 |
| 9 | Selecting Chemical Substances for the UN-ECE POP Protocol显示文摘 | LERCHE D VAN DE PLASSCHE E SCHWEGLER A | 2002 | Chemosphere2002，47，6： | 1 |
| 10 | Effects of heat treatment on theballistic impact properties of Inconel 718for jet engine fancontainment applications显示文摘 | PEREIRA J M LERCH B A | 2001 | International Journal of ImpactEngineering2001，25，： | 1 |
| 11 | Early trypsinogen activation in acute pancreatitis 显示文摘 | Lerch MM Gorelick FS | 2000 | Med Clin North Am2000，84，3： | 1 |
| 12 | Systemically induced allergic exanthem from mercury显示文摘 | LERCH M BIRCHER AJ | 2004 | Contact Dermatitis2004，50，6： | 1 |
| 13 | Basin evaluation using burial history calculations: an overview显示文摘 | Guidish T M Kendall C G Lerche I | 1985 | AAPG Bulletin1985，69，1： | 1 |
| 14 | An inverse method for determining parameters or folded structures显示文摘 | | 1996 | Quarterly of Applied Mathematics1996，54，： | 1 |
| 15 | Optical lightpipe as a high -band width fusion diagnostic显示文摘 | Moran M J Lerche R A G Mant | 2006 | Rev Sci Inslrum2006，77，10： | 1 |
| 16 | Determination of paleoheat flux from vitrinite reflectance data显示文摘 | Lerche I Yarzab R F Kendall C G | 1984 | AAPG Bull1984，68，： | 1 |
| 17 | Cortical thickness in congenital amusia: when bess is better than more 显示文摘 | Hyde KL Lerch JP Zatorre R J | 2007 | Journal of Neuroscience2007，，13： | 1 |
| 18 | Comparison of conventional ver- sus minimally invasive extraperitoneal approach for anterior lumbar inter- body fusion 显示文摘 | Saraph V Lerch C Walochnik N | 2004 | Eur Spine J2004，13，5： | 1 |
| 19 | Genetics of idiopathic epilepsies显示文摘 | Weber YG Lerche H | 2013 | Nervenarzt2013，84，2： | 1 |
| 20 | Basin analysis and hydrocarbongeneration of the South Mozambique Graben using extensionaImodels of heat flo w 显示文摘 | lliffe J E Lerche I DeBuyl M | 1991 | Marine and Petroleum Geology1991，8，2： | 1 |
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