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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Comparative Evaluation of 29 Commercial H elicobacter pylori Serological Kits显示文摘 | Christophe Burucoa Jean‐Charles Delchier Anne Courillon‐Mallet Jean‐Dominique Korwin Francis Mégraud Frank Zerbib Josette Raymond Jean‐Louis Fauchère | 2013 | Helicobacter2013，，3： | 3 |
| 3 | Evidence of mast cell activation in a subset of patients with eosinphilic chronic obstructive pulmonary disease显示文摘 | Louis RE Cataldo D | 2002 | Eur Respir J2002，20，： | 1 |
| 4 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 5 | Evidence of mast cell activation in a subset of patients with eosinphilic chronic obstructive pulmonary dsease显示文摘 | Louis RE Cataldo D Buckley MG | 2002 | Eur Rcspir J2002，20，： | 1 |
| 6 | Antireflux Transoral Incisionless Fundoplication Using EsophyX: 12-Month Results of a Prospective Multicenter Study显示文摘 | Guy-Bernard Cadière Michel Buset Vinciane Muls Amin Rajan Thomas R?sch Alexander J. Eckardt Joseph Weerts Boris Bastens Guido Costamagna Michele Marchese Hubert Louis Fazia Mana Filip Sermon Anna K. Gawlicka Michael A. Daniel Jacques Devière | 2008 | World Journal of Surgery2008，，8： | 1 |
| 7 | Simplified identification of Lynch syndrome: A prospective, multicenter study显示文摘 | Delphine Bonnet Janick Selves Christine Toulas Marie Danjoux Jean Pierre Duffas Guillaume Portier Sylvain Kirzin Laurent Ghouti Nicolas Carrère Bertrand Suc Laurent Alric Karl Barange Louis Buscail Thierry Chaubard Kamran Imani Rosine Guimbaud | 2012 | Digestive and Liver Disease2012，，6： | 1 |
| 8 | Evidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease显示文摘 | Louis RE Cataldo D Buckley MG | 2002 | Eur Respir2002，20，2： | 1 |
| 9 | Cerebral blood flow is symmertrically reduced in patients with intracerebral hemorrhage显示文摘 | Michael N Louis D Admas RE | 1998 | Neurology1998，50，： | 1 |
| 10 | Detection of positional airway obstruction in neonates by acoustic reflection显示文摘 | Jarreau PH Louis B Desfrère L | | 0，，5： | 1 |
| 11 | Multiphasic Approach for the Identification of the Different Classification Levels Of Pseudomonas savastanoi Pv. Phaseolicola显示文摘 | Abi S. dos A. Marques Roselyne Corbière Louis Gardan Catherine Tourte Charles Manceau John D. Taylor Régine Samson | 2000 | European Journal of Plant Pathology2000，，： | 1 |
| 12 | Cerebral blood flow is symmetrically reduced in patients with intracerebral hemorrhage显示文摘 | Dringer MN Louis ST Adarnas RE | 1998 | Neurology1998，50，： | 1 |
| 13 | Differentiation of Human Induced Pluripotent Stem Cells into Brown and White Adipocytes: Role of Pax3显示文摘 | Tala Mohsen‐Kanson Anne‐Laure Hafner Brigitte Wdziekonski Yasuhiro Takashima Phi Villageois Audrey Carrière Maria Svensson Claude Bagnis Bérengère Chignon‐Sicard Per‐Arne Svensson Louis Casteilla Austin Smith Christian Dani | 2014 | Stem Cells2014，，： | 1 |
| 14 | Antireflux Transoral Incisionless Fundoplication Using EsophyX: 12-Month Results of a Prospective Multicenter Study显示文摘 | Guy-Bernard Cadière Michel Buset Vinciane Muls Amin Rajan Thomas R?sch Alexander J. Eckardt Joseph Weerts Boris Bastens Guido Costamagna Michele Marchese Hubert Louis Fazia Mana Filip Sermon Anna K. Gawlicka Michael A. Daniel Jacques Devière | 2008 | World Journal of Surgery2008，，： | 1 |
| 15 | Differentiation of Human Induced Pluripotent Stem Cells into Brown and White Adipocytes: Role of Pax3显示文摘 | Tala Mohsen‐Kanson Anne‐Laure Hafner Brigitte Wdziekonski Yasuhiro Takashima Phi Villageois Audrey Carrière Maria Svensson Claude Bagnis Bérengère Chignon‐Sicard Per‐Arne Svensson Louis Casteilla Austin Smith Christian Dani | 2014 | Stem Cells2014，，6： | 1 |
| 16 | New diagnostic criteria for diabetes and coronary artery disease: insights from an angiographic study显示文摘 | Fran?ois Ledru Pierre Ducimetière Salvatore Battaglia Dominique Courbon Fabrice Beverelli Louis Guize Jean-Léon Guermonprez Beno??t Diébold | 2001 | Journal of the American College of Cardiology2001，，6： | 1 |
| 17 | The Ch'ou-Jen Chuan of YüanYüan显示文摘 | Père Louis Van Hée | 1926 | ISIS1926，8，1： | 1 |
| 18 | Predicting Late Myocardial Recovery and Outcomes in the Early Hours of ST-Segment Elevation Myocardial Infarction显示文摘 | Eric Larose Josep Rodés-Cabau Philippe Pibarot Stéphane Rinfret Guy Proulx Can M. Nguyen Jean-Pierre Déry Onil Gleeton Louis Roy Bernard No?l Gérald Barbeau Jacques Rouleau Jean-Rock Boudreault Marc Amyot Robert De Larochellière Olivier F. Bertrand | 2010 | Journal of the American College of Cardiology2010，，22： | 1 |
| 19 | Cerebral blood flow is symmetrically reduced in patients with intracerebral hemorrhage显示文摘 | Dringer MN Louis ST Adarnas RE | 1988 | Neurology1988，50，： | 1 |
| 20 | Outcomes of nonresected main-duct intraductal papillary mucinous neoplasms of the pancreas显示文摘AIM:To compare characteristics and outcomes of resected and nonresected main-duct and mixed intraductal papillary mucinous neoplasms of the pancreas(IPMN).METHODS:Over a 14-year period,50 patients who did not undergo surgery for resectable main-duct or mixed IPMN,for reasons of precluding comorbidities,age and/or refusal,were compared with 74 patients who underwent resection to assess differences in rates of survival,recurrence/occurrence of malignancy,and prognostic factors.All study participants had dilatation of the main pancreatic duct by ≥ 5 mm,with or without dilatation of the branch ducts.Some of the nonsurgical patients showed evidence of mucus upon perendoscopic retrograde cholangiopancreatography or endoscopic ultrasound and/or after fine needle aspiration.For the surgical patients,pathologic analysis of resected specimens confirmed a diagnosis of IPMN with involvement of the main pancreatic duct or of both branch ducts as well as the main pancreatic duct.Clinical and biologic follow-ups were conducted for all patients at least annually,through hospitalization or consultation every six months during the first year of follow-up,together with abdominal imaging analysis(magnetic resonance cholangiopancreatography or computed tomography) and,if necessary,endoscopic ultrasound with or without fine needle aspiration.RESULTS:The overall five-year survival rate of patients who underwent resection was significantly greater than that for the nonsurgical patients(74% vs 58%; P =0.019).The parameters of age(< 70 years) and absence of a nodule were associated with better survival(P < 0.05); however,the parameters of main pancreatic duct diameter > 10 mm,branch ductdiameter > 30 mm,or presence of extra pancreatic cancers did not significantly influence the prognosis.In the nonsurgical patients,pancreatic malignancy occurred in 36% of cases within a mean time of 33 mo(median:29 mo; range:8-141 mo).Comparison of the nonsurgical patients who experienced disease progression with those who did not progress showed no significant differences in age,sex,symptoms,subtype of IPMN,or follow-up period; only the size of the main pancreatic duct was significantly different between these two sub-groups,with the nonsurgical patients who experienced progression showing a greater diameter at the time of diagnosis(> 10 mm).CONCLUSION:Patients unfit for surgery have a 36% greater risk of developing pancreatic malignancy of the main-duct or mixed IPMN within a median of 2.5 years. | Mathieu Daudé Fabrice Muscari Camille Buscail Nicolas Carrère Philippe Otal Janick Selves Louis Buscail Barbara Bournet | 2015 | World Journal of Gastroenterology2015，21，9： | 0 |
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