|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The past, current and future trends in DNA vaccine immunisations显示文摘This review focuses on DNA vaccines, denoting the last two decades since the early substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In spite of being safely administered and easily engineered and manufactured DNA vaccine, it holds the future prospects of immunization by inducing potent cellular immune responses against infectious and non-infectious diseases. It is well documented that injection of DNA plasmid encoding a desired gene of interest can result in the subsequent expression of its products and lead to the induction of an immune response within a host. This is pertinent to prophylactic and therapeutic vaccination approach when the peculiar gene produces a protective epitope from a pathogen. The recent studies demonstrated by a number of research centers showed that these immune responses evoke protective immunity against several infectious diseases and cancers, which provides adequate support for the use of this approach. We attempt in this review to provide an informative and unbiased overview of the general principles and concept of DNA vaccines technology with a summary of a novel approach to the DNA vaccine, present investigations that describe the mechanism(s) of protective immunity provoked by DNA immunization and to highlight the advantages and disadvantages of DNA immunisation. | Sidgi Syed Anwer Abdo Hasson Juma Khalifa Zayid Al-Busaidi Talal Abdulmalek Sallam | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，5： | 7 |
| 2 | Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16" monocyte population via the IL-10/STAT3 axis显示文摘 | Claire Lastrucci Alan Benard Luciana Balboa Karine Pingris Shanti Sourian Renaud Poincloux Talal A Saati Voahangy Rasolofo Pablo Gonzfilez-Montaner Sandra Inwentarz Eduardo Jose Morafia Ivanela Kondova Frank AW Verreck Maria del Carmen Sasiain Olivier Neyrolles Isabelle Maridonneau-Parini Geanncarlo Lugo-Villarino Ce1ine Cougoule | 2015 | Cell Research2015，25，12： | 7 |
| 3 | The role of recrystallization and grain growth in optimizing the sheet texture of magnesium alloys with calcium addition during annealing显示文摘The contribution of recrystallization and grain growth to the texture evolution in AZ31 alloy and a modified version AZ31+0.5 wt.%Ca was investigated utilizing a multi-step annealing process.The results showed that the addition of Ca triggered a considerable texture modification by increasing the texture spread and decreasing the overall texture intensity.This effect was found to be temperature dependent.When the annealing temperature remained lower than 450℃,a weak double peak texture with large basal pole tilt towards the RD was formed.This is correlated to microstructure observations of a large number of Ca-containing nano-sized particles that seemed to suppress grain growth below 450℃,which stabilized the weak recrystallization texture.This favorable texture was lost upon annealing at higher temperatures.In AZ31,recrystallization nuclei were found to preserve the orientation of their deformed parents,which offered limited potential to optimize the texture via annealing treatments.Grain growth of recrystallized grains resulted in a distinct sheet texture transition from a double-peak to a single-peak basal texture.Aspects of grain boundary energy and grain topology are discussed to explain the growth advantage of the sharp basal component over other orientations. | Fei Guo Risheng Pei Luyao Jiang Dingfei Zhang Sandra Korte-Kerzel Talal Al-Samman | 2020 | Journal of Magnesium and Alloys2020，8，1： | 4 |
| 4 | Transjugular intrahepatic porto 全身的分流在老: 为门高血压的复杂并发症的减轻显示文摘 AIM:To present a dedicated series of transjugular intrahepatic porto-systemic shunts(TIPS) in the elderly since data is sparse on this population group.METHODS:A retrospective review was performed of patients at least 65 years of age who underwent TIPS at our institutions between 1997 and 2010.Twentyfive patients were referred for TIPS.We deemed that 2 patients were not considered appropriate candidates due to their markedly advanced liver disease.Of the 23 patients suitable for TIPS,the indications for TIPS placement was portal hypertension complicated by refractory ascites alone(n = 9),hepatic hydrothorax alone(n = 2),refractory ascites and hydrothorax(n = 1),gastrointestinal bleeding alone(n = 8),gastrointestinal bleeding and ascites(n = 3).RESULTS:Of these 23 attempted TIPS procedure patients,21 patients had technically successful TIPS procedures.A total of 29 out of 32 TIPS procedures including revisions were successful in 21 patients with a mean age of 72.1 years(range 65-82 years).Three of the procedures were unsuccessful attempts at TIPS and 8 procedures were successful revisions of our existing TIPS.Sixteen of 21 patients who underwent successful TIPS(excluding 5 patients lost to follow-up) were followed for a mean of 14.7 mo.Ascites and/or hydrothorax was controlled following technically successful procedures in 12 of 13 patients.Bleeding was controlled following technically successful procedures in 10 out of 11 patients.CONCLUSION:We have demonstrated that TIPS is an effective procedure to control refractory complications of portal hypertension in elderly patients. | Mubin I Syed Hetal Karsan Hector Ferral Azim Shaikh Uzma Waheed Talal Akhter Alan Gabbard Kamal Morar Robert Tyrrell | 2012 | World Journal of Hepatology2012，4，2： | 4 |
| 5 | Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia显示文摘Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%—60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases. In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS. Five patients had no underlying medical illnesses, and three patients were asymptomatic. Of the seven cases, four (57%) patients sought medical advice within 1-7 days from the onset of symptoms. The three other patients (43%) were asymptomatic and were in contact with patients with confirmed diagnosis of MERS-CoV. The most common presenting symptoms were fever (57%), cough (14%), shortness of breath (14%), vomiting (28%), and diarrhea (28%). Two (28.6%) patients had platelet counts of < 150 ×10^9/L, and one patient had an underlying end-stage renal disease. The remaining patients presented with normal blood count, liver function, and urea and creatinine levels. The documented MERS-CoV Ct values were 32 38 for four of the seven cases. Two patients (28.6%) had abnormal chest radiographic findings of bilateral infiltration. One patient (14.3%) required ventilator support, and two patients (28.6%) required oxygen supplementation. All the seven patients were discharged without complications. | Sarah H. Alfaraj Jaffar A. Al-Tawfiq Talal A. Altuwaijri Ziad A. Memish | 2019 | Frontiers of Medicine2019，13，1： | 3 |
| 6 | Experimental investigation of the effects of various parameters on viscosity reduction of heavy crude by oil-water emulsion显示文摘The effects of water content, shear rate, temperature, and solid particle concentration on viscosity reduction(VR) caused by forming stable emulsions were investigated using Omani heavy crude oil. The viscosity of the crude oil was initially measured with respect to shear rates at different temperatures from 20 to 70 C. The crude oil exhibited a shear thinning behavior at all the temperatures. The strongest shear thinning was observed at 20 C. A non-ionic water soluble surfactant(Triton X-100) was used to form and stabilize crude oil emulsions. The emulsification process has significantly reduced the crude oil viscosity. The degree of VR was found to increase with an increase in water content and reach its maximum value at 50 % water content.The phase inversion from oil-in-water emulsion to water-inoil emulsion occurred at 30 % water content. The results indicated that the VR was inversely proportional to temperature and concentration of silica nanoparticles. For water-in-oil emulsions, VR increased with shear rate and eventually reached a plateau at a shear rate of around350 s-1. This was attributed to the thinning behavior of the continuous phase. The VR of oil-in-water emulsions remained almost constant as the shear rate increased due to the Newtonian behavior of water, the continuous phase. | Talal Al-Wahaibi Yahya Al-Wahaibi Abdul-Aziz R.Al-Hashmi Farouq S.Mjalli Safiya Al-Hatmi | 2015 | Petroleum Science2015，12，1： | 3 |
| 7 | 金融服务与环境:会计专业显示文摘本文调查了“环境审计”的发展 ,尤其涉及会计专业对服务于公共利益的责任——和对服务于公共利益的反应性 .本文描述了联合国贸发会议 ( UNCTAD)发起国际会计学标准工作组 ( ISAR)为制订环境会计学指导准则而开展的工作 .引进环境会计学的内在含义 ,包括需要进行教育和培训变革、与其它国际标准制定实体一道工作、和重新考察该专业的一些基础概念和标准 . | Talal Abu-Ghazaleh | 2000 | 产业与环境2000，22，1： | 2 |
| 8 | The new paradigm of hepatitis C therapy: integration of oral therapies into best practices显示文摘 | N. H. Afdhal S. Zeuzem R. T. Schooley D. L. Thomas J. W. Ward A. H. Litwin H. Razavi L. Castera T. Poynard A. Muir S. H. Mehta L. Dee C. Graham D. R. Church A. H. Talal M. S. Sulkowski I. M. Jacobson | 2013 | J Viral Hepat2013，，11： | 2 |
| 9 | Absolute and relative contraindications to pegylated‐interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV ‐infected, evaluated patients显示文摘 | A. H. Talal J. LaFleur R. Hoop P. Pandya P. Martin I. Jacobson J. Han E. J. Korner | 2013 | Aliment Pharmacol Ther2013，，4： | 2 |
| 10 | Evaluation of anti-resistant activity of Auklandia(Saussurea lappa) root against some human pathogens显示文摘Objective:The antimicrobial activity of the ethanol extract of the Auklandia(Saussurea lappa)root plant was investigated to verify its medicinal use in the treatment of microbial infections.Methods:The antimicrobial activity of the ethanol extract was tested against clinical isolates ofsome multidrug-resistant bacteria using the agar well diffusion method.Commercial antibioticswere used as positive reference standards to determine the sensitivity of the clinical isolates.Results:The extracts showed significant inhibitory activity against clinical isolates of methicillinresistantStaphylococcus aureus,Pseudomonas aeruginosa,Escherichia coli,Klebsiella pneumonia,Extended Spectrum Beta-Lactemase,Acinetobacter baumannii.The minimum inhibitory concentration values obtained using the agar dilution test ranged from 2.0μg/μL-12.0μg/μL.In the contrary the water extract showed no activity at all against the tested isolates.Furthermore,theresults obtained by examining anti-resistant activity of the plant ethanolic extract showed thatat higher concentration of the plant extract(12μg)all tested bacteria isolates were inhibited with variable inhibition zones similar to those obtained when we applied lower extract concentrationusing the well diffusion assay.Conclusion:The results demonstrated that the crude ethanolicextract of the Auklandia(Saussurea lappa)root plant has a wide spectrum of activity suggestingthat it may be useful in the treatment of infections caused by the above clinical isolates(humanpathogens). | Sidgi Syed Anwer Hasson Mohammed Saeed Al-Balushi KhazinaAlharthy JumaZaidAl-Busaidi MunaSulimanAldaihani Mohammed Shafeeq Othman Elias Antony Said Omar Habal Talal Abdullah Sallam Ali Abdullah Aljabri Mohamed AhmedIdris | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，7： | 2 |
| 11 | Retroviruse, apoptosis and autogenes显示文摘 | Mountz J D Talal N | | 0，，： | 1 |
| 12 | Delayed androgen treatment prolongs survival in murine lupus显示文摘 | Roubinian JR Talal N Greespan JS | | 0，，05： | 1 |
| 13 | Use of novel autoantibody and cancer-related protein arrays for the detection of esophageal adenocarcinoma in serum显示文摘 | Arman Kilic Matthew J. Schuchert James D. Luketich Rodney J. Landreneau Anna E. Lokshin William L. Bigbee Talal El-Hefnawy | 2008 | The Journal of Thoracic and Cardiovascular Surgery2008，，1： | 1 |
| 14 | Novel functional polycarbonate by lipase-eatalyzed ring-opening polymerization of 5-methyl-5- benzyloxyearbonyl-1,3-dioxan-2-one显示文摘 | Al-Azemi Talal F Bisht Kirpal S | 1999 | Macromolecules1999，32，20： | 1 |
| 15 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 16 | Amblyopia screening for first and second-grade children in Jordan显示文摘AIM:To share the results of a national screening program for amblyopia in school children in the north of Jordan.METHODS:This is a prospective national screening study for amblyopia.The program rolls first and second-grade children(6 to 7 years old) in the north of Jordan.The eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic retinoscopy.Monocular visual acuity was tested using an ETDRS visual acuity chart without correction.Moreover,children were tested with full cycloplegic refraction when the test criteria were met.Unilateral amblyopia was defined as a best-corrected visual acuity difference of 2 or more lines.In comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best eye.RESULTS:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with amblyopia.In their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population. | Khalil M.Al-Salem Mohammad S.Saleem Ismat Ereifej Hamzeh M.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-Momani Layal Mohammed Hammad Omar Ahmad al-Habahbeh Yaqeen M.Assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al Maaitah Deya'-Aldin Muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah Mahmoud Mohammad Murad Amany Jehad Faleh AL-Zurqan Enas Jamal Mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a Majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.Matar | 2022 | International Journal of Ophthalmology(English edition)2022，15，2： | 1 |
| 17 | The Formation of Water Droplets in an Air-breathing PEMFC 显示文摘 | TALAL O ARCOUMANIS C | 2009 | International Journal of Hydrogen Energy2009，34，8： | 1 |
| 18 | The histopathol- ogy of Sjgren's syndrome in labial salivary gland biopsies 显示文摘 | Greenspan JS Daniels TE Talal N | 1974 | Oral Surg Oral Med Oral Pathol1974，37，2： | 1 |
| 19 | Secure Spread Spectrum Watermarking for Multimedia显示文摘 | Ingemar J Cox Joe Kilian F Thomson Leighton Talal Shamoon | 1997 | IEEE Transaction on Image Processing1997，6，12： | 1 |
| 20 | Delayed androgen treatment prolongs survival in murine lupus显示文摘 | Roubinian JR Talal N Greespan JS | 1979 | J Clin Invest1979，63，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员