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| 1 | High tacrolimus intra-patient variability is associated with graft rejection,and de novo donor-specific antibodies occurrence after liver transplantation显示文摘AIM To investigate the role of tacrolimus intra-patient variability(IPV) in adult liver-transplant recipients.METHODS We retrospectively assessed tacrolimus variability in a cohort of liver-transplant recipients and analyzed its effect on the occurrence of graft rejection and de novo donor-specific antibodies(dn DSAs), as well as graft survival during the first 2 years posttransplantation. Between 02/08 and 06/2015, 116 patients that received tacrolimus plus mycophenolate mofetil(with or without steroids) were included. RESULTS Twenty-two patients(18.5%) experienced at least one acute-rejection episode(BPAR). Predictive factors for a BPAR were a tacrolimus IPV of > 35% [OR = 3.07 95%CI(1.14-8.24), P = 0.03] or > 40% [OR = 4.16(1.38-12.50), P = 0.01), and a tacrolimus trough level of < 5 ng/mL [OR=3.68(1.3-10.4), P =0.014]. Thirteen patients(11.2%) developed at least one dn DSA during the follow-up. Tacrolimus IPV [coded as a continuous variable: OR = 1.1, 95%CI(1.0-1.12), P = 0.006] of > 35% [OR = 4.83, 95%CI(1.39-16.72), P = 0.01] and > 40% [OR = 9.73, 95%CI(2.65-35.76), P = 0.001] were identified as predictors to detect dn DSAs. IPV did not impact on patient-or graft-survival rates during the follow-up. CONCLUSION Tacrolimus-IPV could be a useful tool to identify patients with a greater risk of graft rejection and of developing a de novo DSA after liver | Arnaud Del Bello Nicolas Congy-Jolivet Marie Danjoux Fabrice Muscari Laurence Lavayssière Laure Esposito Anne-Laure Hebral Julie Bellière Nassim Kamar | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 2 | Prospective assessment of gastrointestinal and genitourinary toxicity of salvage radiotherapy for patients with prostate-specific antigen relapse or local recurrence after radical prostatectomy 显示文摘 | Pearse M Choo R Danjoux C | 2008 | Int J Radiat Oncol Biol Phys2008，72，3： | 1 |
| 3 | Computed tomographic simulation of craniospinal fields in pediatric patients:improved treatment accuracy and patient comfort显示文摘 | Mah K Danjoux CE Manship S | 1998 | Int J Radiat Oncol Biol Phys1998，41，5： | 1 |
| 4 | Mueosa-associated lymphoid tissue of the thymus hyperplasia vs lymphoma显示文摘 | Parrens M Dubus P Danjoux M | 2002 | Am J Clin Patho12002，117，1： | 1 |
| 5 | The pro -inflammatory actionof tumour necrosis factor-ot in non-alcoholic steatohepatitis in in-dependent of the NSMAF gene product 显示文摘 | Mas E Danjoux M Gracia V | 2013 | Dig Liver Dis2013，45，2： | 1 |
| 6 | Review of telephone follow-up experience at the Rapid Response Radiotherapy Program显示文摘 | Edward Chow Kin-Wah Fung Nicole Bradley Lori Davis Lori Holden Cyril Danjoux | 2005 | Supportive Care in Cancer2005，，7： | 1 |
| 7 | IL- 6 deficiency attenuates murine diet - induced non - alcoholic steatohepatitis 显示文摘 | Mas E Danjoux M Garcia V | 2009 | PLoS One2009，4，11： | 1 |
| 8 | Wearable performance 显示文摘 | Birringer J Danjoux M | 2009 | Digital Creativity2009，20，12： | 1 |
| 9 | Palliation of bone metastases : a survey of patterns of practice among Canadian radiation oncolo- gist显示文摘 | Chow E Danjoux C Wong R | 2000 | Radiol Onco12000，56，： | 1 |
| 10 | Quality of Life in Patients With Brain Metastases Using the EORTC QLQ-BN20+2 and QLQ-C15-PAL显示文摘 | Amanda Caissie Janet Nguyen Emily Chen Liying Zhang Arjun Sahgal Mark Clemons Marc Kerba Palmira Foro Arnalot Cyril Danjoux May Tsao Elizabeth Barnes Lori Holden Brita Danielson Edward Chow | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 11 | Efficacy of salvage radiotherapy plus 2-Year androgen suppression for postradical prostatectomy patients with PSA relapse显示文摘 | Choo R Danjoux C Gardner S | 2009 | Int J Radiat Oncol Biol Phys2009，75，4： | 1 |
| 12 | Simplified identification of Lynch syndrome: A prospective, multicenter study显示文摘 | Delphine Bonnet Janick Selves Christine Toulas Marie Danjoux Jean Pierre Duffas Guillaume Portier Sylvain Kirzin Laurent Ghouti Nicolas Carrère Bertrand Suc Laurent Alric Karl Barange Louis Buscail Thierry Chaubard Kamran Imani Rosine Guimbaud | 2012 | Digestive and Liver Disease2012，，6： | 1 |
| 13 | Efficacy of salvage radiotherapy plus 2-year androgen suppression for postradical prostatectomy patients with PSA relapse 显示文摘 | Choor Danjoux C Gardner S | 2009 | Int J Radiat Onco Biol Phys2009，75，4： | 1 |
| 14 | Mucosa-associated lymphoid tissue of the thymus hyperplasia vs lymphoma显示文摘 | Parrens M Dubus P Danjoux M | | 0，，： | 1 |
| 15 | Successful salvage using percutaneous vertebroplasty in cancer patients with painful spinal metastases or osteoporotic compression fractures显示文摘 | Chow E Holden L Danjoux C | 2004 | Radiother Oncol2004，70，3： | 1 |
| 16 | Mucosa-associated lymphoid tissue of the thymus hyperplasia vs lymphoma显示文摘 | Parreus M Dubus P Danjoux M | 2002 | Am J Clin Pathol2002，117，1： | 1 |
| 17 | Hepatitis E virus and chronic hepatitis in organtransplant recipients显示文摘 | Kamar N Selves J Mansuy J M Ouezzani L Peron J M Guitard J Cointault O Esposito L Abravanel F Danjoux M Durand D Vinel J P Izopet J Rostaing L | 2008 | N Engl J Med2008，358，8： | 1 |
| 18 | 肱动脉内径,而不是血流介导的血管舒张,与睡眠呼吸暂停相关:动脉粥样硬化的多种族研究显示文摘肱动脉血流介导的血管舒张率(the percentage flow-mediated dilation,FMD%)被认为是动脉粥样硬化的早期预测因子,有研究报道其在阻塞性睡眠呼吸暂停患者中降低。 | 刘莉 叶鹏 Atkinson G Danjoux G Ells L Suri S Batterham AM | 2016 | 中华高血压杂志2016，24，1： | 1 |
| 19 | Childhood medullob-lastoma in Ontario,1977-1987:population-based results显示文摘 | Danjoux CE Jenkin RD McLaughlin J | 1996 | MedPediatr Oncol1996，26，： | 1 |
| 20 | Feasibility Study: Watchful Waiting For Localized Low To Intermediate Grade Prostate Carcinoma With Selective Delayed Intervention Based On Prostate Specific Antigen, Histological And/Or Clinical Progression显示文摘 | Richard Choo Laurence Klotz Cyril Danjoux Gerard C. Morton Gerrit DeBoer Ewa Szumacher Neil Fleshner Peter Bunting George Hruby | 2002 | The Journal of Urology2002，，： | 1 |
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