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| 1 | DMP1 prevents osteocyte alterations,FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease显示文摘During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone mineralization,but its effects in CKD are unknown.We tested the hypothesis that DMP1 supplementation in CKD would improve bone health,prevent FGF23 elevations and minimize consequent adverse cardiovascular outcomes.We investigated DMP1 regulation and effects in wild-type (WT) mice and the Col4a3^-/- mouse model of CKD.Col4a3^-/- mice demonstrated impaired kidney function,reduced bone DMP1 expression,reduced bone mass,altered osteocyte morphology and connectivity,increased osteocyte apoptosis,increased serum FGF23,hyperphosphatemia,left ventricular hypertrophy (LVH),and reduced survival.Genetic or pharmacological supplementation of DMP1 in Col4a3^-/- mice prevented osteocyte apoptosis,preserved osteocyte networks,corrected bone mass,partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription,and further increased serum phosphate.Despite impaired kidney function and worsened hyperphosphatemia,DMP1 prevented development of LVH and improved Col4a3^-/- survival.Our data suggest that CKD reduces DMP1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and improve bone and cardiac health in CKD. | Corey Dussold Claire Gerber Samantha White Xueyan Wang Lixin Qi Connor Francis Maralee Capella Guillaume Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tamara Isakova Myles Wolf Valentin David Aline Martin | 2019 | Bone Research2019，7，2： | 4 |
| 2 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 3 | High temperature tribological behaviour of PVD coated tool steel and aluminium under dry and lubricated conditions显示文摘Aluminium alloys are commonly used as lightweight materials in the automotive industry.This non-ferrous family of metallic alloys offers a high versatility of properties and designs.To reduce weight and improve safety,high strength-to-weight ratio alloys(e.g.6XXX and 7XXX),are increasingly implemented in vehicles.However,these alloys exhibit low formability and experience considerable springback during cold forming,and are therefore hot formed.During forming,severe adhesion(i.e.galling)of aluminium onto the die surface takes place.This phenomenon has a detrimental effect on the surface properties,geometrical tolerances of the formed parts and maintenance of the dies.The effect of surface engineering as well as lubricant chemistry on galling has not been sufficiently investigated.Diamond-like carbon(DLC)and CrN physical vapour deposition(PVD)coated steel have been studied to reduce aluminium transfer.However,the interaction between lubricants and PVD coatings during hot forming of aluminium alloys is not yet fully understood.The present study thus aims to characterise the high temperature tribological behaviour of selected PVD coatings and lubricants during sliding against aluminium alloy.The objectives are to first select promising lubricant-coating combinations and then to study their tribological response in a high-temperature reciprocating friction and wear tester.Dry and lubricated tests were carried out at 300℃ using a commercial polymer lubricant.Tests using DLC,CrN,CrTiN,and CrAIN coated tool steel were compared to uncoated tool steel reference tests.The initial and worn test specimen surfaces were analysed with a 3-dimensional(3D)optical profiler,scanning electron microscope(SEM)and energy dispersive X-ray spectroscope(EDS)as to understand the wear mechanisms.The results showed formation of tribolayers in the contact zone,reducing both friction and wear.The stability of these layers highly depends on both the coatings'roughness and chemical affinity towards aluminium.The DLC and CrN coatings combined with the polymer lubricant were the most effective in reducing aluminium transfer. | Justine DECROZANT-TRIQUENAUX Leonardo PELCASTRE Cedric COURBON Braham PRAKASH Jens HARDELL | 2021 | Friction2021，9，4： | 3 |
| 4 | Vision -based navigation of unmanned aerial vehicles 显示文摘 | Jonathan Courbon Youcef Mezouar Nicolas Guehard | 2010 | Control engineering practice2010，18，7： | 1 |
| 5 | Cross-comparison of macroscopic fundamental diagram estimation meth- ods 显示文摘 | COURBON T LECLERCQ L | 2011 | Procedia-Social and Behavioral Sciences2011，20，： | 1 |
| 6 | Alcohol consumption and carotid artery structure in older french adults the Three-City Study显示文摘 | Zureik M Gariepy J Courbon D | 2004 | Stroke2004，35，12： | 1 |
| 7 | Distribution of plasma angiotensin I-converting enzyme levels in healthmer:relationship to environmental and hormonal parameters显示文摘 | Alhence GF Richard J Courbon D | 1991 | J Lab Clin Med1991，117，1： | 1 |
| 8 | Distibution of plasma and angiotensin converting enzyme levels in healthy men:relationship to environmental and hormonal parameters显示文摘 | Alhenee Gelas F Richard J Courbon D | 1991 | J Lab Clin Med1991，117，： | 1 |
| 9 | Genes enco- ding endothelin - converting enzyme - 1 and endothelin - 1 interact to influence blood pressure in women: the EVA study显示文摘 | FUNALOT B COURBON D BROUSSEAU T | 2004 | J Hy- pertens2004，22，4： | 1 |
| 10 | Lung function impairment and metabolic syndrome: the critical role of abdominal obesity显示文摘 | Leone N Courbon D Thomas F etal | 2009 | Am J Respir Crit Care Meal2009，179，6： | 1 |
| 11 | Effect of training programs and exercise in adult stroke patients: literature review 显示文摘 | Ramas J Courbon A Roche F | 2007 | Ann Readapt Med Phys2007，50，6： | 1 |
| 12 | Training programs in stroke patients:literature review显示文摘 | Ramas J Courbon A Fayolle-Minon I | 2007 | Ann Readapt Med Phys2007，50，1： | 1 |
| 13 | Distribution of plasma argiotensin I-converting enzyme levels in healthy men and its relationship to environmental and hormonal parameters显示文摘 | Alhene GF Richard J Courbon D | 1991 | J Lab Clin Med1991，117，： | 1 |
| 14 | Heart rate Profile during exercise as a Predictor of sudden death 显示文摘 | Empana JP Desnos M Courbon D | 2005 | N Engl J Med2005，252，19： | 1 |
| 15 | Alcohol consumption and carotid artery structure in older French sdults:the Three-City Study显示文摘 | Zureik M Gariepy J Courbon D Dartigues JF Ritchie K Tzouriio C | 2004 | Stoke2004，35，12： | 1 |
| 16 | Genes encoding endothelin-converting enzyme-1 and endothelin-1 interact to influence blood pressure in women:the EVA study显示文摘 | Funalot B Courbon D Brousseau T Poirier O Berr C Cambien F | 2004 | J Hypertens2004，22，： | 1 |
| 17 | Vision-based navigationof unmanned aerial vehicles 显示文摘 | Courbon J Mezouar Y Gurnard N | 2010 | Control Engineering Practice2010，18，7： | 1 |
| 18 | Vacuum-ultraviolet refractive index of LiF and MgF2 in the temperature range 80-300 K显示文摘 | Laporte P Subtil J L Courbon M | 1983 | Op tical Society of America1983，73，8： | 1 |
| 19 | Vacuum-ultraviolet refractive index of LiF and MgF2 in the temperature range 80-300 K显示文摘 | Laporte P Subtil J L Courbon M | 1983 | Optical Society of America1983，73，8： | 1 |
| 20 | Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness-the ECTIM,AXA,EVA and GENIC Studies显示文摘 | Poirier O Nicaud V Gariepy J Courbon D Elbaz A Morrison C | 2004 | Eur J Hum Genet2004，12，： | 1 |
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