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| 1 | Rescue associating liver partition and portal vein ligation for staged hepatectomy after portal embolization: Our experience and literature review显示文摘AIM To report a single-center experience in rescue associating liver partition and portal vein ligation for staged hepatectomy(ALPPS), after failure of previous portal embolization. We also performed a literature review.METHODS Between January 2014 and December 2015, every patient who underwent a rescue ALPPS procedure in Toulouse Rangueil University Hospital, France, was included. Every patient included had a project of major hepatectomy and a previous portal vein embolization(PVE) with insufficient future liver remnant to body weight ratio after the procedure. The ALPPS procedure was performed in two steps(ALPPS-1 and ALPPS-2), separated by an interval phase. ALPPS-2 was done within 7 to 9 d after ALPPS-1. To estimate the FLR, a computed tomography scan examination was performed 3 to 6 wk after the PVE procedure and 6 to 8 d after ALPPS-1. A transcystic stent was placed during ALPPS-1 and remained opened duringthe interval phase, in order to avoid biliary complications. Postoperative liver failure was defined using the 50-50 criteria. Postoperative complications were assessed according to the Dindo-Clavien Classification.RESULTS From January 2014 to December 2015, 7 patients underwent a rescue ALPPS procedure. Median FLR before PVE, ALPPS-1 and ALPPS-2 were respectively 263 cc(221-380), 450 cc(372-506), and 660 cc(575-776). Median FLR/BWR before PVE, ALPPS-1 and ALPPS-2 were respectively 0.4%(0.3-0.5), 0.6%(0.5-0.8), and 1%(0.8-1.2). Median volume growth of FLR was 69%(18-92) after PVE, and 45%(36-82) after ALPPS-1. The combination of PVE and ALPPS induced a growth of median initial FLR of +408 cc(254-513), leading to an increase of +149%(68-199). After ALPPS-2, 4 patients had stage Ⅰ-Ⅱ complications. Three patients had more severe complications(one stage Ⅲ, one stage Ⅳ and one death due to bowel perforation). Two patients suffered from postoperative liver failure according to the 50/50 criteria. None of our patients developed any biliary complication during the ALPPS procedure.CONCLUSION Rescue ALPPS may be an alternative after unsuccessful PVE and could allow previously unresectable patients to reach surgery. Biliary drainage seems to reduce biliary complications. | Charlotte Maulat Antoine Philis Bérénice Charriere Fatima-Zohra Mokrane Rosine Guimbaud Philippe Otal Bertrand Suc Fabrice Muscari | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 3 | Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy显示文摘BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological criteria.More recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor cells.AIM To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after NAC.METHODSFrom January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt TRG.Based on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were performed.RESULTS Seventy-four patients were classified as responders and 76 as non-responders.The postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological response.Three were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P <0.005). Two were predictive of a good response: A rectal origin of the primary tumor and a liver-first strategy(P < 0.005). The overall survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 yr.The factors contributing to a poor prognosis for disease-free survival were: No histological response after NAC, largest metastasis > 3 cm, more than three preoperative metastases, R1 resection, and the use of a targeted therapy with NAC(P < 0.005).CONCLUSION A non-radiological response and a number of NAC sessions > 7 are the two most pertinent predictive factors of non-histological response(TRG 4 or 5). | Chloé Serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane Janick Selves Rosine Guimbaud Philippe Otal Bertrand Suc Emilie Berard Fabrice Muscari | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 4 |
| 4 | Dihydropyrimidine dehydrogenase activity in normal,inflammatory and tumour tissues of colon and liver in humans 显示文摘 | Guimbaud R Guichard S Dusseau C | 2000 | Cancer Chemother Pharmacol2000，45，： | 1 |
| 5 | Network of inflammatory cytokines and correlation with disease activity in ulcerative colitis显示文摘 | GUIMBAUD R BERTRAND V Chauvelot-Moachon L | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 6 | Annexin 1 is secreted in situ during ulcerative colitis in humans显示文摘 | Vergnolle N Pages P Guimbaud R | 2004 | Inflamm Bowel Dis2004，10，5： | 1 |
| 7 | Network of inflammatory cytokines and correlation with disease activity in ulcerative colitis显示文摘 | Guimbaud R Bertrand V Chauvelot-Moachon L | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 8 | Population pharmacokinetics of oxaliplatin 显示文摘 | Delord JP Umlil A Guimbaud R | 2003 | Cancer Chemother Pharmacol2003，51，2： | 1 |
| 9 | Dihydropyrimidine dehydrogenase activity innormal, inflammatory and tumour tissues ofcolon and liver in humans显示文摘 | GUIMBAUD R GUICHARD S DUSSEAU C | 2000 | Cancer ChemotherPharmacol2000，45，6： | 1 |
| 10 | Prospective, randomized, muhicenter, phase m study of fluorouraeil, leueovorin, and iri- notecan versus epirubicin, eisplatin, and capeeitabine in ad- vanced gastric adenoeareinoma: a French intergroup (Federation Franeophone de Cancerologie Digestive, Federation Nationale des Centres de Lutte Contre le Cancer, and Groupe Cooperateur Multidiseiplinaire en Oncologie) study显示文摘 | Guimbaud R Louvet C Ries P | 2014 | J Clin Oncol2014，32，31： | 1 |
| 11 | Simplified identification of Lynch syndrome: A prospective, multicenter study显示文摘 | Delphine Bonnet Janick Selves Christine Toulas Marie Danjoux Jean Pierre Duffas Guillaume Portier Sylvain Kirzin Laurent Ghouti Nicolas Carrère Bertrand Suc Laurent Alric Karl Barange Louis Buscail Thierry Chaubard Kamran Imani Rosine Guimbaud | 2012 | Digestive and Liver Disease2012，，6： | 1 |
| 12 | Net work of inflammatory cytokines and correlation with disease activity in ulcerative colitis 显示文摘 | GUIMBAUD R BERTRAND V CHAUVELOT MOACHON L | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 13 | Inducible nitric oxide synthase activity in colon biopsies from inflammatory areas:correlation with inflammation intensity in patients with ulcerative colitis but not with Crohn's disease显示文摘 | Guimbaud R Bertrand V | 2000 | Amino Acids2000，18，3： | 1 |
| 14 | A quantum cascade laser infrared spectrometer for CO_2 stable isotope analysis:Field implementation at a hydrocarbon contaminated site under bio-remediation显示文摘Real-time methods to monitor stable isotope ratios of CO_2 are needed to identify biogeochemical origins of CO_2 emissions from the soil–air interface. An isotope ratio infra-red spectrometer(IRIS) has been developed to measure CO_2 mixing ratio with δ~13C isotopic signature, in addition to mixing ratios of other greenhouse gases(CH_4, N2_O). The original aspects of the instrument as well as its precision and accuracy for the determination of the isotopic signature δ~13C of CO_2 are discussed. A first application to biodegradation of hydrocarbons is presented, tested on a hydrocarbon contaminated site under aerobic bio-treatment. CO_2 flux measurements using closed chamber method is combined with the determination of the isotopic signature δ~13C of the CO_2 emission to propose a non-intrusive method to monitor in situ biodegradation of hydrocarbons. In the contaminated area, high CO_2 emissions have been measured with an isotopic signature δ~13C suggesting that CO_2 comes from petroleum hydrocarbon biodegradation.This first field implementation shows that rapid and accurate measurement of isotopic signature of CO_2 emissions is particularly useful in assessing the contribution of contaminant degradation to the measured CO_2 efflux and is promising as a monitoring tool for aerobic bio-treatment. | Christophe Guimbaud Cécile Noel Michel Chartier Valéry Catoire Michaela Blessing Jean Christophe Gourry Claude Robert | 2016 | Journal of Environmental Sciences2016，28，2： | 1 |
| 15 | Prospective,randomized,multicenter,phaseⅢstudy of fluorouracil,leucovorin,and irinotecan versus epirubicin,cisplatin,and capecitabine in advanced gastric adenocarcinoma:a French intergroup(Federation Francophone de Cancerologie Digestive,Federation Nationale des Centres de Lutte Contre le Cancer,and Groupe Cooperateur Multidisciplinaire en Oncologie)Study显示文摘 | Guimbaud R Louvet C Ries P | 2014 | J Clin Oncol2014，32，31： | 1 |
| 16 | A Randomized Phase II Trial of Three Intensified Chemotherapy Regimens in First-Line Treatment of Colorectal Cancer Patients with Initially Unresectable or Not Optimally Resectable Liver Metastases. The METHEP Trial显示文摘 | Marc Ychou Michel Rivoire Simon Thezenas Fran?ois Quenet Jean-Robert Delpero Christine Rebischung Christian Letoublon Rosine Guimbaud Eric Francois Michel Ducreux Fran?oise Desseigne Jean-Michel Fabre Eric Assenat | 2013 | Annals of Surgical Oncology2013，，13： | 1 |
| 17 | Prospective, randomized, multi- center, phase m study of fluorouracil, leucovorin, and irinotecan versus epirubicin, cisplatin, and capecitabine in advanced gastric adenocarcinoma: a French intergroup (Federation Francophone de Cancerologie Digestive, Federation Nationale des Centres de Lutte Contre le Cancer, and Groupe Cooperateur Multidisciplinaire en Oncologie) study显示文摘 | Guimbaud R Louvet C Ries P | | J Clin Oncol0，32，31： | 1 |
| 18 | Network of inflammatory cytokinesand correlation with disease activity in ulcerative colitis 显示文摘 | Guimbaud R Bertrand V Chauvelot-MoachonL | 1998 | Am J Gastroenterol1998，93，12： | 1 |
| 19 | Inducible nitric oxide synthase activity in colon biopsies from inflammatory areas: correlation with inflammation intensity in patients with ulcerative colitis but not with Crohn’s disease显示文摘 | G. Guihot R. Guimbaud V. Bertrand B. Narcy-Lambare D. Couturier P. H. Duée S. Chaussade F. Blachier | 2000 | Amino Acids2000，，3： | 1 |
| 20 | Inducible nitric oxide synthase activity in colon biopsies from inflammatory areas: correlation with inflammation intensity in patients with ulcerative colitis but not with Crohn’s disease显示文摘 | G. Guihot R. Guimbaud V. Bertrand B. Narcy-Lambare D. Couturier P. H. Duée S. Chaussade F. Blachier | 2000 | Amino Acids2000，，3： | 1 |
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