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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Reduced Systemic Arterial Compliance Impacts Significantly on Left Ventricular Afterload and Function in Aortic Stenosis显示文摘 | Martin Briand Jean G. Dumesnil Lyes Kadem Antonio G. Tongue Régis Rieu Damien Garcia Philippe Pibarot | 2005 | Journal of the American College of Cardiology2005，，2： | 2 |
| 3 | MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions 显示文摘 | du Rieu MC Torrisani J Selves J | 2010 | Clin Chem2010，56，4： | 1 |
| 4 | Direct mechanical force measurements during the migration of dictyostelium slugs using flexible substrata显示文摘 | Rieu J P Barentin C Maeda Y Sawada Y | 2005 | Biophysical Journal2005，89，5： | 1 |
| 5 | Fractal Fragmentation, Soil Porosity, and Soil Water Properties显示文摘 | Rieu M Sposito G | 1991 | Soil Sci Soc Am J1991，，55： | 1 |
| 6 | An iterative method to calculate forces exerted by single cells and multicellular assemblies from the detection of deformations of flexible substrates 显示文摘 | Barentin C Sawada Y Rieu J P | 2006 | European Biophysics Journal with Biophysics Letters2006，35，4： | 1 |
| 7 | An experimental investigation of flow characterstics in bifurcation models显示文摘 | Rieu R Pelissier R Farahifor D | 1989 | Eur J Mech1989，8，1： | 1 |
| 8 | Neutrophils: molecules, functions and pathophysiological aspects 显示文摘 | Witko-Sarsat V Rieu P Descamps-Latscha B | 2000 | Lab Invest2000，80，5： | 1 |
| 9 | Neutrophils:molecules, functions and pathophysiological aspects 显示文摘 | Witko - Sarsat V Rieu P Descamps - Latscha B | 2000 | Lab Invest2000，80，2： | 1 |
| 10 | The gibberellinsbiosynthetic genes AtGA20oxl and AtGA20oxl act, partiallyredundantly, to promote growth and development throughout theArabidopsis life cycle 显示文摘 | Rieu I Ruiz-Rivero 0 Femandez-Garcia N | 2008 | Plant J2008，53，3： | 1 |
| 11 | let-7MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression显示文摘 | Torrisani J Bournet B du Rieu MC | 2009 | Hum Gene Ther2009，20，8： | 1 |
| 12 | A convenient one-step synthesis of glyeidyl ethers显示文摘 | Mouzin G Cousse H Rieu J P | 1983 | Synthesis1983，，2： | 1 |
| 13 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 14 | Diffusion tensor imaging in early Alzheime's disease显示文摘 | Naggara O Oppenheim C Rieu D | 2006 | Psychiatry Res2006，146，： | 1 |
| 15 | Nervonic acid in red blood cell sphingomyelin in premature infants: An index of myelin maturation?显示文摘 | F. Babin P. Sarda B. Limasset B. Descomps D. Rieu F. Mendy A. Crastes de Paulet | 1993 | Lipids1993，，7： | 1 |
| 16 | Let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progressin显示文摘 | Torrisani J Bournet B du Rieu MC | | 0，，： | 1 |
| 17 | Neutrophils: molecules, functions and pathophysiological aspects显示文摘 | WitkoSarsat V Rieu P Descamps2Latscha B | 2000 | Lab Invest2000，80，5： | 1 |
| 18 | Fractal Fragmentation, Soil Porosity, and Soil Water Properties显示文摘 | Rieu M Sposito G | 1991 | Soil SciAm J1991，55，： | 1 |
| 19 | 显示文摘 | Rieu P | 2003 | Nephrologie2003，24，7： | 1 |
| 20 | Genetic a- nalysis reveals that C19-GA 2-oxidation is a major gib- berellin inactivation pathway in Arabidopsis 显示文摘 | RIEU I ERIKSSON S POWERS S J | 2008 | Plant Cell2008，20，9： | 1 |
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