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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | E-cadherin in gastric cancer显示文摘Cadherin 是一个粘附分子和调停钙的膜 glycoproteins 的一个总科。E-cadherin 是连接到 catenins 形成细胞骨架的班 E-cadherin 的原型。最近的证据显示出那 E-cadherin 不仅充当粘合剂,而且在生长开发和致癌作用起重要作用。它最近被看作了侵略以及生长压制或基因。这评论在胃的癌症在 E-cadherin 和它的角色上总结最近的发现。特别地,包括它有 Helicobacter pylori 和临床的应用的关系,我们在胃的癌症的 E-cadherin 上的工作详细被描述。 | Annie On On Chan | 2006 | World Journal of Gastroenterology2006，12，2： | 27 |
| 3 | Androgen and bone mass in men显示文摘Androgens have multiple actions on the skeleton throughout life. Androgens promote skeletal growth and accumulation of minerals during puberty and adolescence and stimulate osteoblast but suppress osteoclast function,activity and lifespan through complex mechanisms. Also androgens increase periosteal bone apposition, resulting in larger bone size and thicker cortical bone in men. There is convincing evidence to show that aromatization to estrogens was an important pathway for mediating the action of testosterone on bone physiology. Estrogen is probably the dominant sex steroid regulating bone resorption in men, but both testosterone and estrogen are important in maintaining bone formation. ( Asian J Androl 2003 Jun; 5: 148-154) | Annie W.C.Kung | 2003 | Asian Journal of Andrology2003，5，2： | 18 |
| 4 | Evolutionary Lineages and Functional Diversification of Plant Hexokinases显示文摘从 10 种类表演定序数据一个植物 hexokinase (HXK ) 家庭包含 511 基因。机能上地,一个给定的家庭能包括新陈代谢的催化剂,葡萄糖发信号蛋白质,和非催化的、明显的规章的酶相当或相同的事物。这研究有二个目标。第一个目的是开发一个预兆的方法决定在种以内的蛋白质有哪个 HXK 功能打字。第二个目的是决定 HXK 依赖的葡萄糖发信号蛋白质是否发生在更原始的植物之中,以及在被子植物之中。用一条分子的发展史途径,与选择试验性的测试结合了,我们发现非催化的 HXK 相当或相同的事物可能发生在所有植物,包括相对原始的 Selaginella moellendorffi。我们也发现被子植物 HXK 的不同的系为催化活动并且为指向的亚 cellular 有明显的保存特征。最高植物的 HXK 在线粒体主要被表示,与发生在发生在 cytosol 的一个 monocot 系的质体,和 HXK 的一个系的 HXK。用原物短暂表示试金,我们发现 HXK 葡萄糖发信号蛋白质在所有更高的植物并且在 S 多半发生。moellendorffi 也。因此,由在新陈代谢或作为规章的代谢物的植物 HXK isoforms 的葡萄糖的使用作为普遍、保存过程发生。 | Rucha Karve Michael Lauria Annie Virnig Xiaoxia Xia Bradley L. Rauh Brandon d. Moore | 2010 | Molecular Plant2010，3，2： | 15 |
| 5 | Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells显示文摘AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cay pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro.METHODS: A cytotoxic wild-type H pylori strain (TN2),its three isogenic mutants (TN2△cag, TN2△cagA and TN2△cagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45,were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter.RESULTS: The wild-type strain and the isogenic mutants,TN2△cagA and TN2△cagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2△cag did not increase the release of MIF at any of the four ratios.3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2△cagA and TN2△cagE, but not from the mutant TN2△cag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared.CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric epithelial cell proliferation. | Harry Hua-Xiang Xia Shiu Kum Lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg Benjamin Chun-Yu Wong | 2005 | World Journal of Gastroenterology2005，11，13： | 12 |
| 6 | 二阶线性中立时滞方程非振动解的存在性显示文摘考虑具有正负系数的中立时滞微分方程这里P∈R和τ∈(0,∞),σ1,σ2∈[0,∞)且Q1,Q2∈C([t0,∞),R+).对于上面方程非振动解的存在性,得到一个用,∫sQids <∞,i=1,2,来表达的充分条件。这个结果去掉了M.R.S.Kulenovic和S.Hadziomerspahic文中一个相当强的假设,改进了其中的相关定理. | 程金发 Annie Z. | 2004 | 系统科学与数学2004，24，3： | 11 |
| 7 | Increasing dietary fiber intake in terms of kiwifruit improves constipation in Chinese patients显示文摘瞄准:如果以弥猴桃,增加的饮食的纤维在中国便秘的病人是有效的,调查。方法:33 个便秘的病人和 20 个健康志愿者每天为弥猴桃的 4-wk 治疗被招募两次。反应在 wk 1-4 期间被定义为完全的自发的碗的增加,运动(CSBM )>= 1/wk。第二等的功效在肠习惯和便秘的 wk 1-4,单个症状和分数期间包括了反应。回答与基线 run-in 时期相比。结肠的运输时间和肛门直肠的测压法在治疗前后被执行。结果:应答者率在便秘的组是 54.5% 。吝啬的 CSBM 增加了术后疗法(2.2 +/- 2.6 对 4.4 +/- 4.6, P = 0.013 ) 。也在为便秘的麻烦海角的分数有改进(P = 0.02 ) ,并且肠习惯的满足(P = 0.001 ) ,并且在使用的 laxative 的天内减少了(P = 0.003 ) 。也在运输时间有改进(P = 0.003 ) 并且直肠的感觉(P <
0.05 ) 。然而,在健康题目在肠症状或肛门直肠的生理学没有变化。结论:增加饮食的纤维吸入在在中国人口减轻长期的便秘是有效的。 | Annie On On Chan Gigi Leung Teresa Tong Nina YH Wong | 2007 | World Journal of Gastroenterology2007，13，35： | 10 |
| 8 | 通过改进TFT-LCD生产工艺提高光透过率降低生产成本和能耗显示文摘很多人都把注意力集中在TFT液晶显示器的面板技术上,例如LED背光源、120/240Hz帧频、宽视角以及其它一些能提高显示性能的技术。在这个背景下,通过不断改进TFT液晶显示器的制造工艺,提高了生产效率,降低了成本,同时亦提高了能源利用率。最新的技术进展涉及滤光片、液晶配向、TFT设计等方面。 | Charles Annis Paul Semenza 尹春健(译) 熊绍珍(校对) | 2011 | 现代显示2011，，1： | 9 |
| 9 | Kinesin-4 Functions in Vesicular Transport on Cortical Microtubules and Regulates Cell Wall Mechanics during Cell Elongation in Plants显示文摘在植物,各向异性的房间扩大取决于作为轨道服务哪个大分子和泡被未知身份的马达 kinesins 搬运的外皮的微导管。我们使用了经历了柔韧的延伸发现涉及房间延伸并且发现 Gh KINESIN-4A 的 kinesins 的纤维富有地表示了的棉花(Gossypium hirsutum ) 。马达被 immunofluorescence 在与外皮的微导管被联系的像泡的结构上检测。在 Arabidopsis thaliana,在 KINESIN-4A/FRA1 的 orthologous 马达,以前在纤维细胞在第二等的生长期间在纤维素免职含有,被实时房间的成像在表示荧光灯地标注的功能的蛋白质的细胞检验。马达装饰了与 0.89m/min 的平均速度沿着外皮的微导管展出一个线性运动的像泡的粒子,它与连接到纤维素生合成的那些显著地不同。我们也在 KINESIN-4A/FRA1 发现了那并且在细胞墙力学,细胞延伸,和各种各样的植物、繁殖的器官的轴的生长在 KINESIN-4C 玩联系了冗余的角色,,损失在极大地提高的 KINESIN-4C,缺点在 KINESIN-4A/FRA1 地点由一个空变化引起了。双异种显示了房间墙在快速的房间延伸的正常阶段弄软的缺乏。而且,提高了包含 arabinose 的免职糖类在 kinesin-4 异种被检测。我们的调查结果建立了在在 flowering 植物沿着外皮的微导管和房间墙力学和房间延伸包含非有纤维质的部件的货物的 Kinesin-4-based 运输之间的一个连接。 | Zhaosheng Kong Motohide Ioki Siobhan Braybrook Shundai Li Zheng-Hua Ye Yuh-Ru Julie Lee Takashi Hotta Anny Chang Juan Tian Guangda Wang Bo Liu | 2015 | Molecular Plant2015，8，7： | 8 |
| 10 | One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy显示文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery. | Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 11 | Comparable Characterization of Nanocellulose Extracted from BleachedSoftwood and Hardwood Pulps显示文摘In this study, the characteristics of nanocellulose extracted from bleached softwood and hardwood pulps by formic acid hydrolysis followed by TEMPO-mediated oxidation were compared using transmission electron microscopy(TEM), atomic force microscopy(AFM), Fourier transform infrared analysis(FT-IR), X-ray diffraction(XRD), and thermal gravimetric analysis(TGA). The experimental results showed that the nanocellulose products derived from spruce pulp exhibited a relatively larger particle size, higher crystallinity, and higher thermal stability, compared with the corresponding products obtained from aspen pulp under the same conditions.Furthermore, the study helped establish that the properties of the nanocellulose products were highly dependent on the nature of the starting materials under identical processing conditions. | Bin Li WenYang Xu Dennis Kronlund Jan-Erik Eriksson Anni Maattanen Stefan Willfor ChunLin Xu | 2018 | Paper And Biomaterials2018，3，4： | 7 |
| 12 | Hepatocellular carcinoma in the elderly:Meta-analysis and systematic literature review显示文摘AIM: To conduct a meta-analysis to investigate theclinical outcomes of surgical resection and locoregional treatments for hepatocellular carcinoma(HCC) in elderly patients defined as aged 70 years or more. METHODS: Literature documenting a comparison of clinical outcomes for elderly and non elderly patients with hepatocellular carcinoma was identified by searching Pub Med, Ovid, Cochrane Library, and Web of Science databases, for those from inception to March 2015 with no limits. Dichotomous outcomes and standard meta-analysis techniques were used. Heterogeneity was tested by the Cochrane Q statistic. Pooled estimates were measured using the fixed or random effect model.RESULTS: Twenty three studies were included with a total of 12482 patients. Of these patients, 6341 were treated with surgical resection, 3138 were treated with radiofrequency ablation(RFA), and 3003 were treated with transarterial chemoembolization(TACE). Of the patients who underwent surgical resection, the elderly had significantly more respiratory co-morbidities than the younger group, with both groups having a similar proportion of cardiovascular co-morbidities and diabetes. After 1 year, the elderly group had significantly increased survival rates after surgical resection compared to the younger group(OR = 0.762, 95%CI: 0.583-0.994, P = 0.045). However, the 3-year and 5-year survival outcomes with surgical resection between the two groups were similar(OR = 0.947, 95%CI: 0.777-1.154, P = 0.67 for the third year; and OR = 1.131, 95%CI: 0.895-1.430, P = 0.304 for the fifth year). Postoperative treatment complications were similar between the elderly and younger group. The elderly group and younger group had similar survival outcomes for the first and third year after RFA(OR = 1.5, 95%CI: 0.788-2.885, P = 0.217 and OR = 1.352, 95%CI: 0.940-1.944, P = 0.104). For the fifth year, the elderly group had significantly worse survival rates compared to the younger group after RFA(OR = 1.379, 95%CI: 1.079-1.763, P = 0.01). For patients who underwent TACE, the elderly group had significantlyincreased survival compared to the younger group for the first and third year(OR = 0.664, 95%CI: 0.548-0.805, P = 0.00 and OR = 0.795, 95%CI: 0.663-0.953, P = 0.013). At the fifth year, there were no significant differences in overall survival between the elderly group and younger group(OR = 1.256, 95%CI: 0.806-1.957, P = 0.313). CONCLUSION: The optimal management strategy for elderly patients with HCC is dependent on patient and tumor characteristics. Compared to patients less than 70, elderly patients have similar three year survival after resection and ablation and an improved three year survival after TACE. At five years, elderly patients had a lower survival after ablation but similar survival with resection and TACE as compared to younger patients. Heterogeneity of patient populations and selection bias can explain some of these findings. Overall, elderly patients have similar success, if not better, with these treatments and should be considered for all treatments after assessment of their clinical status and cancer burden. | Annie K Hung Jennifer Guy | 2015 | World Journal of Gastroenterology2015，21，42： | 7 |
| 13 | Piperine,an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice显示文摘Objective:To explore the hepatoprotective and antioxidant effects of piperine against acetaminophen-induced hepatotoxicity in mice.Methods:In mice,hepatotoxicity was induced by a single dose of acetaminophen(900 mg/kg b.w.i.p.).Piperine(25 mg/kg b.w.i.p.) and standard drug silymarin(25 mg/kg b.w.i.p.) were given to mice,30 min after the single injection of acetaminophen.After 4 h,the mice were decapitated.Activities of liver marker enzymes [(aspartate transaminase(AST),alanine transaminase(ALT),and alkaline phosphatase(ALP)]and inflammatory mediator tumour necrosis factor-alpha(TNF-α) were estimated in serum,while lipid peroxidation and antioxidant status(superoxide dismutase,catalase,glutathione peroxidase, glutathione reductase,glutathione-s-transferase and glutathione) were determined in liver homogenate of control and experimental mice.Results:Acetaminophen induction(900 mg/kg b.w.i.p.) significantly increased the levels of liver marker enzymes,TNF-α,and lipid peroxidation,and caused the depletion of antioxidant status.Piperine and silymarin treatment to acetaminophen challenged mice resulted in decreased liver marker enzymes activity,TNF-αand lipid peroxidation levels with increase in antioxidant status.Conclusions:The results clearly demonstrate that piperine shows promising hepatoprotective effect as comparable to standard drug silymarin. | Evan Prince Sabina Annie Deborah Harris Souriyan Deborah Jackline Mahaboob Khan Rasool | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 7 |
| 14 | Towards single-molecule optoelectronic devices显示文摘Benefiting from the development of molecular electronics and molecular plasmonics, the interplay of light and electronic transport in molecular junctions has attracted growing interest among researchers in both fields, leading to a new research direction of 'single-molecule optoelectronics'. Here, we review the latest developments of photo-modulated charge transport,electroluminescence and Raman spectroscopy from single-molecule junctions, and suggest future directions for single-molecule optoelectronics. | Lijue Chen Anni Feng Maoning Wang Junyang Liu Wenjing Hong Xuefeng Guo Dong Xiang | 2018 | Science China Chemistry2018，61，11： | 7 |
| 15 | Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients显示文摘Our previous work showed that the cartilage proteoglycan aggrecan could induce an erosive polyarthritis and spondylitis in BALB/c mice and the GI globular domain of the aggrecan (GI) contained the arthritogenic region. To elucidate whether autoreactive T cells to G1 are expressed in rheumatoid arthritis patients, we analyzed the frequency of human G1-specific T cells in the peripheral blood of five rheumatoid arthritis patients and tried to establish G1-reactive T cell lines from these rheumatoid arthritis patients. The results showed that the G1-specific T cells in PBL were detectable at the range of 4.97 ±0.5 ×10-6 in peripheral blood lymphocytes. We have also generated 15 G1-specific T lymphocyte lines from these pateints with a standard split-well method. All these cells expressed fine specificity to human recombinant G1, but not to unrelated antigen. All the 15 lines expressed a panT cell marker and 13 of them selectively used the αβ T cell receptor. Two of them used rye T cell receptor. The 13 of these T cell lines was CD4 positive. One line expressed CD8. One line expressed both CD4 and CD8. Moreover, 14 out of 15 lines expressed the Th-1 cytokine profile, characterized by interferon-γpositivity and IL-4 negativity. No Th-2 type cell line was generated. These data provide strong evidence in favor of the presence of autoreactive T cells in the rheumatoid arthritis pateints. What is the mechanism(s) that these autoreactive T cells attack self-target and whether these G1-specific, Th-1 type T cell lines can induce arthritis in immune deficiency mice are currently under investigation. | LI NING LI DONG QING ZHANG KUANG YAN ZHOU ANNIE CARTMAN JEAN YVES LEROUX A ROBIN POOLE YI PING ZHANG ( Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China)(Joint Diseases Laboratory, Shriners Hospital, Dep | 2000 | Cell Research2000，10，1： | 7 |
| 16 | Assessment of liver ablation using cone beam computed tomography显示文摘AIM: To investigate the feasibility and accuracy of cone beam computed tomography(CBCT) in assessing the ablation zone after liver tumor ablation.METHODS: Twenty-three patients(17 men and 6 women, range: 45-85 years old, mean age 65 years) with malignant liver tumors underwent ultrasoundguided percutaneous tumor ablation [radiofrequency(n = 14), microwave(n = 9)] followed by intravenous contrast-enhanced CBCT. Baseline multidetector computed tomography(MDCT) and peri-procedural CBCT images were compared. CBCT image quality was assessed as poor, good, or excellent. Image fusion was performed to assess tumor coverage, and quality of fusion was rated as bad, good, or excellent. Ablation zone volumes on peri-procedural CBCT and post-procedural MDCT were compared using the nonparametric paired Wilcoxon t-test.RESULTS: Rate of primary ablation effectiveness was 100%. There were no complications related to ablation. Local tumor recurrence and new liver tumors were found 3 mo after initial treatment in one patient(4%). The ablation zone was identified in 21/23(91.3%) patients on CBCT. The fusion of baseline MDCT and peri-procedural CBCT images was feasible in all patients and showed satisfactory tumor coverage(at least 5-mm margin). CBCT image quality was poor, good, and excellent in 2(9%), 8(35%), and 13(56%), patients respectively. Registration quality between periprocedural CBCT and post-procedural MDCT images was good to excellent in 17/23(74%) patients. The median ablation volume on peri-procedural CBCT and post-procedural MDCT was 30 cm3(range: 4-95 cm3) and 30 cm3(range: 4-124 cm3), respectively(P-value > 0.2). There was a good correlation(r = 0.79) between the volumes of the two techniques. CONCLUSION: Contrast-enhanced CBCT after tumor ablation of the liver allows early assessment of the ablation zone. | Mohamed Abdel-Rehim Maxime Ronot Annie Sibert Valérie Vilgrain | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 17 | 铅胁迫对黄瓜幼苗叶片蛋白质的影响显示文摘黄瓜幼苗经不同质量浓度铅处理后,叶片中可溶性蛋白质含量均发生了明显的变化.100 mg/L铅处理时,黄瓜幼苗叶片中可溶性蛋白质含量高于对照值,且随处理时间的延长,与对照比增加的值逐渐减少;500 mg/L和900 mg/L铅处理的叶片中可溶性蛋白质含量随着处理时间的延长表现为下降趋势,并且铅质量浓度越高,随着处理时间的延长,蛋白质含量下降量增加.不同质量浓度铅处理不同时期黄瓜幼苗叶片可溶性蛋白质组分的变化在谱带数和表达量上有明显的差异. | 刘素纯 萧浪涛 廖柏寒 Annie Zhu jiang Connie Lo | 2006 | 湖南农业大学学报(自然科学版)2006，32，2： | 6 |
| 18 | Combination Therapy With Infliximab and Azathioprine Is Superior to Monotherapy With Either Agent in Ulcerative Colitis显示文摘 | Remo Panaccione Subrata Ghosh Stephen Middleton Juan R. Márquez Boyd B. Scott Laurence Flint Hubert JF. van Hoogstraten Annie C. Chen Hanzhe Zheng Silvio Danese Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 19 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 5 |
| 20 | Polymeric foams for flexible and highly sensitive low-pressure capacitive sensors显示文摘Flexible low-pressure sensors(<10 kPa)are required in areas as diverse as blood-pressure monitoring,human–computer interactions,robotics,and object detection.For applications,it is essential that these sensors combine flexibility,high sensitivity,robustness,and low production costs.Previous works involve surface micro-patterning,electronic amplification(OFET),and hydrogels.However,these solutions are limited as they involve complex processes,large bias voltages,large energy consumption,or are sensitive to evaporation.Here,we report a major advance to solve the challenge of scalable,efficient and robust e-skin.We present an unconventional capacitive sensor based on composite foam materials filled with conductive carbon black particles.Owing to the elastic buckling of the foam pores,the sensitivity exceeds 35 kPa^(−1) for pressure<0.2 kPa.These performances are one order of magnitude higher than the ones previously reported.These materials are low-cost,easy to prepare,and display high capacitance values,which are easy to measure using low-cost electronics.These materials pave the road for the implementation of e-skin in commercialized applications. | Mickaël Pruvost Wilbert J.Smit Cécile Monteux Philippe Poulin Annie Colin | 2019 | npj Flexible Electronics2019，3，1： | 5 |
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