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| 1 | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation显示文摘The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. | Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe | 2015 | Journal of Molecular Cell Biology2015，7，4： | 8 |
| 2 | Hydrodynamic Links between Shallow and Deep Mineralization Systems and Implications for Deep Mineral Exploration显示文摘Deep mineral exploration is increasingly important for finding new mineral resources but there are many uncertainties.Understanding the factors controlling the localization of mineralization at depth can reduce the risk in deep mineral exploration.One of the relatively poorly constrained but important factors is the hydrodynamics of mineralization.This paper reviews the principles of hydrodynamics of mineralization,especially the nature of relationships between mineralization and structures,and their applications to various types of mineralization systems in the context of hydrodynamic linkage between shallow and deep parts of the systems.Three categories of mineralization systems were examined,i.e.,magmatic-hydrothermal systems,structurally controlled hydrothermal systems with uncertain fluid sources,and hydrothermal systems associated with sedimentary basins.The implications for deep mineral exploration,including potentials for new mineral resources at depth,favorable locations for mineralization,as well as uncertainties,are discussed. | CHI Guoxiang XU Deru XUE Chunji LI Zenghua Patrick LEDRU DENG Teng WANG Yumeng SONG Hao | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 5 |
| 3 | New diagnostic criteria for diabetes and coronary artery disease:insights from an angiographic study显示文摘 | Ledru F Ducimetière P Battaglia S | 2001 | J Am Coll Cardiol2001，37，6： | 1 |
| 4 | New diagnostic criteria for diabetes and coronary disease:insights from an angiographie study显示文摘 | Ledru F Ducimetiere P Battaglia S | 2001 | J AM Coll Cardiol2001，37，6： | 1 |
| 5 | Genetic Polymorphisms of the rennin-angiotensin system and angiographic extent and severity of coronary artery disease:the CORGENE study显示文摘 | Jeunemaitre X Ledru F Battaglia S | 1997 | Hum Genet1997，99，1： | 1 |
| 6 | Acytofluorometric method for the simultaneous detection of both intracellular and surface antigens of apoptotic peripheral lymphocytes显示文摘 | Lecoeur H Ledru E Gougeon ML | 1998 | Jlmmunol methods1998，217，12： | 1 |
| 7 | Holocene palaeo environmen- tal reconstruction in northeastern Brazi inferred from pole charcoal and carbon isotope records显示文摘 | Pessenda L Ledru M Gouveia S E | 2005 | The Holocene2005，15，6： | 1 |
| 8 | Validity of beck depression inventory for the assessment of depressive mood in chronic heart failure patients 显示文摘 | Lahlou-Laforet K Ledru F Niarra R | 2015 | Journal of Affective Disorders2015，184，： | 1 |
| 9 | New diagnostic criteria for diabetes and coronary artery disease:Insights from an angiographic study显示文摘 | Ledru F Ducimetiere P Battaglia S | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 10 | Relation between severity of coronary artery dis- ease, left ventricular function and myocardial infarction, and influence of the ACE I,/D gene polymorphism 显示文摘 | Ledru F | 1998 | Am J Cardiol1998，82，16： | 1 |
| 11 | New di- agnostic criteria for diabetes and coronary artery disease:in- sights from an angiographic study 显示文摘 | LEDRU F DUCIMETIER E P BATTAGLIA S | 2001 | J Am Coll Cardiol2001，37，6： | 1 |
| 12 | Role of previous treatment with sulfonylureas in diabetic patients with acute myocardial infarction:results from a nationwide French registry显示文摘 | Danchin N Charpentier G Ledru F | 2005 | Diabetes Metab Res Rev2005，21，2： | 1 |
| 13 | The Variscan French Massif Central-a new addition to the ultra-high pressure metamorphic 'club':exhumation processes and geodynamic consequences显示文摘 | Lardeaux J M Ledru P Daniel I Duchene S | | 0，，： | 1 |
| 14 | One- step Screen -printed Elec- trode Modified in Its Bulk With HRP Based On Direct Electron Transfer For Hydrogen Peroxide Detection In Flow Injection mode 显示文摘 | Sophie Ledru Nadine Ruille | 2006 | Biosensors and Bioelectronics2006，21，8： | 1 |
| 15 | New diagnostic criteria for diabetes and coronary artery disease: ilasights from an angiographic study显示文摘 | Ledru F Ducimetibre P Battaglia S | 2001 | J Am Coil Cardiol2001，37，6： | 1 |
| 16 | One-step screen-printed electrode modified in its bulk with HRP based on direct electron transfer for hydrogen peroxide detection in flow injection mode 显示文摘 | Sophie Ledru Nadine Ruille | 2006 | Biosensors and Bioelectronics2006，21，8： | 1 |
| 17 | Regulation of extracellular signal- regulated kinase by homocysteine in hippocampus 显示文摘 | Robert K Pages C Ledru A | 2005 | Neuroscience2005，133，4： | 1 |
| 18 | Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus显示文摘 | Robert K Pages C Ledru A | 2005 | Neuscience2005，133，4： | 1 |
| 19 | New diagnostic criteria for diabetes and coronary artery disease : insights from an angiographic study显示文摘 | Ducimetiere P Battaglia S | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 20 | Regulation of extracellular sig- nal regulated kinase by homoeysteine in hippoeampus显示文摘 | Robert K Pages C Ledru A | 2005 | Neuro- science2005，133，： | 1 |
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