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| 1 | Design of a new dynamical core for global atmospheric models based on some efficient numerical methods显示文摘A careful study on the integral properties of the primitive hydrostatic balance equations for baroclinic atmosphere is carried out, and a new scheme todesign the global adiabatic model of atmospheric dynamics ispresented. This scheme includes a method of weighted equal-areamesh and a fully discrete finite difference method with quadraticand linear conservations for solving the primitive equationsystem. Using this scheme, we established a new dynamical corewith adjustable high resolution acceptable to the availablecomputer capability, which can be very stable without anyfiltering and smoothing. Especially, some important integralproperties are kept unchanged, such as the anti-symmetries of thehorizontal advection operators and the vertical convectionoperator, the mass conservation, the effective energy conservationunder the standard stratification approximation, and so on. Somenumerical tests on the new dynamical core, respectively regardingits global conservations and its integrated performances inclimatic modeling, incorporated with the physical packagesfrom the Community Atmospheric Model Version 2 (CAM2) of NationalCenter for Atmospheric Research (NCAR), are included. | WANG Bin, WAN Hui, Jl Zhongzhen, ZHANG Xin, YU Rucong, YU Yongqiang & LIU HongtaoState Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Computational Mathematics, Academy of Mathematics and System Sciences, Peking University, Beijing 100871, China | 2004 | Science China Mathematics2004，47，z1： | 92 |
| 2 | Western North Pacific Tropical Cyclone Database Created by the China Meteorological Administration显示文摘This paper describes the access to, and the content, characteristics, and potential applications of the tropical cyclone(TC) database that is maintained and actively developed by the China Meteorological Administration, with the aim of facilitating its use in scientific research and operational services. This database records data relating to all TCs that have passed through the western North Pacific(WNP) and South China Sea(SCS) since 1949. TC data collection has expanded over recent decades via continuous TC monitoring using remote sensing and specialized field detection techniques,allowing collation of a multi-source TC database for the WNP and SCS that covers a long period, with wide coverage and many observational elements. This database now comprises a wide variety of information related to TCs, such as historical or real-time locations(i.e., best track and landfall), intensity, dynamic and thermal structures, wind strengths, precipitation amounts, and frequency. This database will support ongoing research into the processes and patterns associated with TC climatic activity and TC forecasting. | Xiaoqin LU Hui YU Ming YING Bingke ZHAO Shuai ZHANG Limin LIN Lina BAI Rijin WAN | 2021 | Advances in Atmospheric Sciences2021，38，4： | 96 |
| 3 | Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study显示文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a safe and effective treatment for acute cerebral infarction patients,especially for moderate stroke patients.This study was approved by the Ethical Committee of Peking University Third Hospital,China(approval No.2013-068-2)on May 20,2013,and registered in the Chinese Clinical Trial Registry(registration No.ChiCTR1800017937). | Hui Zhang Chuan-Ling Li Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan | 2020 | Neural Regeneration Research2020，15，7： | 54 |
| 4 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 5 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 6 | Safety threshold of high-speed railway pier settlement based on train-track-bridge dynamic interaction显示文摘This paper presents a method to determine the safety threshold of bridge pier settlement in high-speed railways.An analytical expression of the mapping relationship between the pier settlement and the rail deformation is derived theoretically for the double block ballastless track-bridge system.By adopting the superposition of the track random irregularity and the rail deformation caused by the pier settlement as the excitation inputs,the variations of vehicle dynamics indices with pier settlement are comparatively analyzed.Then,the safety threshold of the bridge pier settlement is obtained according to the limit of vehicle running safety and ride comfort indices of the high-speed trains.Results show that the dynamics indices of different trains have different sensitivities to the pier settlement,and the train CRH2C is the most sensitive one among all the types of Chinese high-speed trains.When passing through the bridges in common span with pier settlement at the speed of 250–350 km/h,the trains suffer the low-frequency excitations,and the vertical acceleration of car body is most sensitive to the pier settlement of all the dynamics indices.When the car body vertical acceleration just exceeds the allowable limit,the critical settlement value is 23.4 mm,which is much bigger than the pier differential settlement limit in the current code for Chinese high-speed railways. | CHEN Zhao Wei ZHAI Wan Ming CAI Cheng Biao SUN Yu | 2015 | Science China(Technological Sciences)2015，58，2： | 26 |
| 7 | Biodegradable Materials for Bone Repairs:A Review显示文摘With attractive research and development of biomaterials,more and more opportunities have been brought to the treatments of human tissue repairs.The implant is usually no need to exist in the body accompanied with the recovery or regeneration of the tissue lesions,and the long-term effect of exotic substance to human body should be reduced as lower as possible.For this purpose,biodegradable materials,including polymers, magnesium alloys and ceramics,have attracted much attention for medical applications due to their biodegradable characters in body environment.This paper in turn introduces these three different types of widely studied biodegradable materials as well as their advantages as implants in applications for bone repairs.Relevant history and research progresses are summarized. | Lili Tan Xiaoming Yu Peng Wan Ke Yang | 2013 | Journal of Materials Science & Technology2013，29，6： | 24 |
| 8 | Preliminary molecular epidemiology of the Staphylococcus aureus in lower respiratory tract infections: a multicenter study in China显示文摘 | LI De-zhi CHEN Yu-sheng YANG Jing-ping ZHANG Wei HU Cheng-ping LI Jia-shu MU Lan HU Ying-hui GENG Rong HU Ke CAI Shao-xi WAN Huan-ying WANG Qiu-yue WEI Li-ping DU Juan YU Qin ZHONG Xiao-ning WANG Rui-qin MA Jian-jun TIAN Gui-zhen WANG Si-qin GAO Zhan-cheng | 2011 | Chinese Medical Journal2011，，5： | 21 |
| 9 | Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia:A systematic review and network meta-analysis显示文摘Background:Exercise is a promising nonpharmacological therapy for cognitive dysfunction,but it is unclear which type of exercise is most effective.The objective of this study was to compare and rank the effectiveness of various exercise interventions on cognitive function in patients with mild cognitive impairment(MCI)or dementia and to examine the effects of exercise on the symptoms relevant to cognitive impairment.Methods:We searched PubMed,Web of Science,Embase,Cochrane Central Register of Controlled Trials,SPORTDiscus,and PsycInfo through September 2019 and included randomized controlled trials that examined the effectiveness of exercise interventions in patients with MCI or dementia.Primary outcomes included global cognition,executive cognition,and memory cognition.Secondary outcomes included activities of daily living,neuropsychiatric symptoms,and quality of life.Pairwise analyses and network meta-analyses were performed using a random effects model.Results:A total of 73 articles from 71 trials with 5606 participants were included.All types of exercise were effective in increasing or maintaining global cognition,and resistance exercise had the highest probability of being the most effective intervention in slowing the decrease in global cognition(standard mean difference(SMD)=1.05,95%confidence interval(95%CI):0.56-1.54),executive function(SMD=0.85,95%CI:0.21-1.49),and memory function(SMD=0.32,95%CI:0.01-0.63)in patients with cognitive dysfunction.Subgroup analyses for patients with MCI revealed different effects,and multicomponent exercise was most likely to be the optimal exercise therapy for preventing the decline of global cognition(SMD=0.99,95%CI:0.44-1.54)and executive function(SMD=0.72,95%CI:0.06-1.38).However,only resistance exercise showed significant effects on memory function for patients with MCI(SMD=0.35,95%CI:0.01-0.69).Exercise interventions also showed various effects on the secondary outcomes.Conclusion:Resistance exercise has the highest probability of being the optimal exercise type for slowing cognitive declin e in patients withcognitive dysfunction,especially in patients with dementia.Multicomponent exercise tends to be most effective in protecting global cognition and executive function in patients with MCI. | Xiuxiu Huang Xiaoyan Zhao Bei Li Ying Cai Shifang Zhang Qiaoqin Wan Fang Yu | 2022 | Journal of Sport and Health Science2022，11，2： | 19 |
| 10 | Characteristics of coastline changes in China's Mainland since the early 1940s显示文摘Based on multi-temporal topographic maps, remote sensing images and field surveys covering the entire coastal zone of China's Mainland, the coastlines of six periods since the early 1940 s were extracted. Coastline changes over the last 70 years were then analyzed in terms of coastline structure, coastline fractals, coastline change rates, land-sea patterns, and bay areas. The results showed that mainland coastline structure changed dramatically, and due to the significant coastline artificialization mainly driven by sea reclamation and coastal engineering, the remaining natural coastline merely accounts for less than one third at present. Coastline fractal dimension represented an overall spatial pattern of 'north < entirety < south'; however, the discrepancy between the north and south coast was apparently narrowed due to dramatic coastline artificialization of northern China which in turn altered the whole pattern. Patterns and processes of land-sea interchange along the mainland coast were complex and varied spatially and temporally, with over 68% advancing toward sea and 22% retreating toward land. The net growth of land area was nearly 14.2 ×103 km2 with an average growth rate of 202.82 km2 a??; and coast retreat was characterized by area decrease of 93 bays with a magnitude of 10.1 ×103 km2 and an average shrinking rate up to 18.19% or an average shrinking speed up to 144.20 km2 a??, among which the total area of Bohai shrunk by 7.06%, with an average annual loss amounting to 82 km2. The dramatic coastline changes along China's Mainland have brought about kinds of challenges to the coastal environment, therefore the integrated management, effective environment protection and sustainable utilization of coastlines is urgent. | HOU XiYong WU Ting HOU Wan CHEN Qing WANG YuanDong YU LiangJu | 2016 | Science China Earth Sciences2016，59，9： | 18 |
| 11 | Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism显示文摘Background:Cervical cancer has the fourth highest incidence and mortality rate of all cancers in women worldwide;让seriously harms their physical and mental health.The aim of this study was to observe the roles and preliminary mechanism of Taurine(Tau)-induced apoptosis in cervical cancer cells.Methods:Cells from the human cervical cancer cell line SiHa were transfected with the recombinant plasmid pEGFP-N1-MST1(mammalian sterile 20-like kinase 1);then,the cell proliferation activity was analyzed by the MTT assay,cell apoptosis by flow cytometry,and the related protein levels by Western blotting.Results:Tau inhibited the proliferation of SiHa cells and induced apoptosis in these cells(the apoptotic rate was 21.95%in the Tau 160 mmol/L group and 30%in the Tau 320 mmol/L group),upregulated the expression of the MST1(control,0.53;Tau 40-320 mmol/L groups,0.84-1.45)and Bax(control,0.45;Tau 40-320 mmol/L groups,0.64-1.51)proteins(P<0.01),and downregulated the expression of Bcl-2(control,1.28,Tau 40-320 mmol/L groups,0.93-0.47)(P<0.01).The overexpression of MST1 promoted the apoptosis of SiHa cells,enhanced the apoptosis-inductive effects of Tau(P<0.01),upregulated the expression of the proapoptotic proteins p73,p53,PUMA(p53 upregulated modulator of apoptosis),and caspase-3,and promoted the phosphorylation of YAP(Yes-associated protein).Conclusions:Tau inhibited the proliferation and induced the apoptosis of cervical cancer SiHa cells.The MST1 protein plays an important role in the Tau-induced apoptosis of cervical cancer cells. | Hua Li Wen-Jing Ruan Li-Qiao Liu Hui-Fang Wan Xiao-Hong Yang Wei-Feng Zhu Le-Han Yu Xia-Li Zhang Fu-Sheng Wan | 2019 | Chinese Medical Journal2019，，8： | 18 |
| 12 | Coping as a Mechanism Linking Stressful Life Events and Mental Health Problems in Adolescents显示文摘Objective Although stressful life events represent an etiologic factor of mental health problems in adolescents,few studies have been conducted to address mechanisms linking the stress‐psychopathology relation.The present study was designed to examine coping as a mediate factor on the relationship between stressful life events and symptoms of anxiety and depression.Methods The participants were 13 512 students from eight cities of China,who participated in a school‐based survey.Data were collected by a questionnaire comprising coping,stressful life events,anxiety,and depressive symptoms.As a model,a series of regression equations were used to examine whether coping mediated the association between stressful life events and symptoms of anxiety and depression.Results Each dimension of stressful life events showed significant correlation with anxiety,depression and coping (all P<0.001).In the model to analyze mediate effects,all standardized coefficients (β) were significant (all P<0.01),indicating marked mediator effects.Furthermore,negative coping might account for more mediate effects than positive coping on this relationship.Conclusion Coping partially mediated the relationship between stressful life events and mental health during adolescence.This study highlighted an important public health priority for preventive interventions targeting stress‐related psychopathology,and for further promoting adolescents'mental health. | MENG Xiu Hong TAO Fang Biao WAN Yu Hui HU Yan WANG Ren Xi | 2011 | Biomedical and Environmental Sciences2011，24，6： | 16 |
| 13 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 14 | Influence of whole peptidoglycan of bifidobacterium on cytotoxic effectors produced by mouse peritoneal macrophages显示文摘INTRODUCTIONBifidobacteria are physiologically beneficial bacteria which are perdominant in human intestine ,and possess the most important functions .They play an important role in maintaining microbial balance of the intestine .Furthermore , their presence is thought to be an important indication of health of the body [1-4].Whole peptidoglycan ( WPG) is the major component in the cell wall of bifidobacterium ,which is also a biological responsemodifier with nontoxic side dffcets. | Li Sheng Wang~1 Hui Ming Zhu~1 Dian Yuan Zhou~2 Yu Lin Wang~1 Wan Dai Zhang~2 ~1Departrnent of Gastroenterology,Shenzhen Municipal People’s Hospital,Jinan University of Medical Sciences,Shenzhen 518020,Guangdong Province,China ~2Chinese PLA Institute of Digestion,the First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaLi Sheng Wang graduated and obtained Ph.D,from the First Military Medical University in 1998,now working at Department of Gastroenterology,Shenzhen Municipal People’s Hospital.Jinan University of Medical Sciences.having 35 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 15 |
| 15 | Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats显示文摘在糖尿病的可勃起的机能障碍(编辑) 的高发生为有效处理策略加亮需要。Resveratrol,沉默信息管理者 2-related 酶的使活跃之物 1 (sirtuin1, SIRT1 ) ,在癌症, neurodegenerative 疾病,长寿和心血管的疾病为它的珍贵效果收到了注意。在导致糖尿病的编辑探索 resveratrol 的效果, resveratrol 与 streptozocin 予老鼠被以(65 mg kg −1)-induced 糖尿病。可勃起的功能,多孔的结构,沉默信息管理者 2-related 酶的织物蛋白质表示 1 (sirtuin1, SIRT1 ) , p53 和 O 3a (FOXO3a )(MDA ) , superoxide dismutase (草皮) 活动和 malondialdehyde 在阴茎海绵体铺平的 forkhead 抄写因素被学习。我们发现 SIRT1 在 cavernosal 组织被表示,并且它是在糖尿病的老鼠的宫体的 downregulated。resveratrol upregulated 的管理 SIRT1 和恢复可勃起的功能的表示。相反, resveratrol downregulated p53 和 FOXO3a 的表示,调整 apoptosis 和氧化应力。而且,对待 resveratrol 的组在光滑的肌肉内容,草皮活动和 MDA 层次看了改进什么时候与糖尿病患者相比组织。因此, resveratrol 的能力改进导致糖尿病的编辑与它 SIRT1 表示的激活有关是可能的,因此向氧化应力引起 apoptosis 和抵抗的抑制。 | Wen Yu Zan Wan Xue-Feng Qiu Yun Chen Yu-Tian Dai | 2013 | Asian Journal of Andrology2013，15，5： | 15 |
| 16 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 17 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 18 | Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways显示文摘BACKGROUND Allyl isothiocyanate(AITC),a classic anti-inflammatory and antitumorigenic agent,was recently identified as a potential treatment for obesity and insulin resistance.However,little is known about its direct impact on the liver.AIM To investigate the effect and underlying mechanism of AITC in nonalcoholic fatty liver disease(commonly referred to as NAFLD).METHODS To establish a mouse and cellular model of NAFLD,C57BL/6 mice were fed a high fat diet(HFD)for 8 wk,and AML-12 cells were treated with 200μM palmitate acid for 24 h.For AITC treatment,mice were administered AITC(100 mg/kg/d)orally and AML-12 cells were treated with AITC(20μmol/L).RESULTS AITC significantly ameliorated HFD-induced weight gain,hepatic lipid accumulation and inflammation in vivo.Furthermore,serum alanine aminotransferase and aspartate aminotransferase levels were markedly reduced in AITC-treated mice.Mechanistically,AITC significantly downregulated the protein levels of sterol regulatory elementbinding protein 1(SREBP1)and its lipogenesis target genes and upregulated the levels of proteins involved in fatty acidβ-oxidation,as well as the upstream mediators Sirtuin 1(Sirt1)and AMPactivated protein kinaseα(AMPKα),in the livers of HFD-fed mice.AITC also attenuated the nuclear factor kappa B(NF-κB)signaling pathway.Consistently,AITC relieved palmitate acid-induced lipid accumulation and inflammation in AML-12 cells in vitro through the Sirt1/AMPK and NF-κB signaling pathways.Importantly,further studies showed that the curative effect of AITC on lipid accumulation was abolished by siRNA-mediated knockdown of either Sirt1 or AMPKαin AML-12 cells.CONCLUSION AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-κB pathway.Therefore,AITC is a potential therapeutic agent for NAFLD. | Chun-Xiao Li Jian-Guo Gao Xing-Yong Wan Yi Chen Cheng-Fu Xu Ze-Min Feng Hang Zeng Yi-Ming Lin Han Ma Ping Xu Chao-Hui Yu You-Ming Li | 2019 | World Journal of Gastroenterology2019，25，34： | 14 |
| 19 | What Drove Housing Wealth Inequality in China?显示文摘Although China is experiencing a deterioration in wealth distribution where housing is playing a dominant role,this issue has received scant research attention despite its importance.Combining four rounds of the China Household Finance Survey(CHFS)data,this paper measures and discusses wealth inequality in China,with a special emphasis on the contribution of housing.Our analysis reveals that housing is the largest contributor to wealth inequality,responsible for around 70 percent of total wealth inequality,and its contribution has been increasing over time.Our research ejforts have focused on the housing wealth disparity,exploring its composition from alternative perspectives.The results show that housing wealth inequality has also been rising over time and an absolute majority of housing wealth inequality is due to within-group gaps.Finally,we employ Wan's(2004)regression-based decomposition methodology to quantify the contributions of dijferent determinants to housing wealth disparity in China,and to demonstrate serious biases in the conventional approach that is often used to analyze housing wealth inequality. | Guanghua Wan Chen Wang Yu Wu | 2021 | China & World Economy2021，29，1： | 14 |
| 20 | Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B_1-induced hepatotumorigenesis in mice显示文摘瞄准:估计黄麴毒素的结合的角色 B1 (AFB1 ) , cyanobacterial 毒素(cyanotoxins ) ,和肝炎 B (HBV ) 在 hepatotumorigenicity 的 x 基因。方法:( ip )带 HBV x 基因和他们的野类型的同窝出生的人的 One-week-old 动物 intraperitoneally 与也被注射单个剂量的 AFB1 [ 6 mg/kg 体重( bw )],重复剂量 cyanotoxins ( microcystin-LR 或在榴状, 10 microg/kg bw 每周一次为 15 wk ), DMSO (车辆控制)独自一个,或 AFB1 一个星期以后由 cyanotoxins 列在后面,并且在 24 和 52 wk 被牺牲处理以后。结果:AFB1 在 29 中的 13 个导致了肝肿瘤(44.8%) 在 52 wk 的转基因的老鼠处理以后,显著地比在野类型的老鼠(13.3%) 更经常。这有效差量没在 24-wk 学习被显示出。与 AFB1 暴露相比独自一个, MC-LR 并且在榴状在导致的 AFB (1 ) 的发生产出近似 3 褶层和 6 褶层增加在在 24 wk 的野类型的动物的肝肿瘤分别地。HBV x 基因进一步没提高与合作暴露联系到 AFB1 和 cyanotoxins 的风险。与一个 MC-LR-dosed 野类型的鼠标的异常,没有肝肿瘤在在 24 wk 独自与 cyanotoxins 对待的鼠标被观察。既不对待 DMSO 的转基因的老鼠也不他们的野类型的同窝出生的人在甚至多达 52 wk 有与 hepatotumorigenesis 相关的病理学的改变。结论:HBV x 基因并且在榴状支持导致的 AFB (1 ) 的发展肝肿瘤。到 AFB1 和 MC-LR 的合作暴露趋于相对暴露在 24 wk 提高肝肿瘤的风险到他们之一。hepatotumorigenesis 上的 AFB1, cyanotoxins 和 HBVx 的结合的效果在 24 wk 是弱的。 | Min Lian Ying Liu Shun-Zhang Yu Geng-Sun Qian Shu-Guang Wan Kenneth R Dixon | 2006 | World Journal of Gastroenterology2006，12，19： | 14 |
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