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| 1 | Study on the creep permeability of mining-cracked N2 laterite as the key aquifuge for preserving water resources in Northwestern China显示文摘 | Wenping Li Qiqing Wang Shiliang Liu Yabing Pei | 2018 | International Journal of Coal Science & Technology2018，5，3： | 22 |
| 2 | Recanalization of extracranial internal carotid artery occlusion A 12-year retrospective study显示文摘This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterec-tomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extrac-ranial internal carotid artery occlusion. The study included 65 patients with extracranial internal ca-rotid artery occlusion who underwent carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, or hybrid surgery in the Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China between January 2006 and December 2012. Prior to surgery, all patients underwent perfusion CT or xenon CT to evaluate the occlusion. The procedure for each patient was chosen according to digital subtraction angiography data. The carotid artery was successfully recanalized in 46 of 51 patients who underwent carotid endarterectomy, 9 of 10 patients who underwent carotid endarterectomy combined with Fogarty catheter embolectomy, and 3 of 4 patients who underwent hybrid surgery. In patients with symptomatic carotid artery occlusion, the carotid artery can be recanalized by choosing a treatment procedure based on imaging ex-amination findings. | Liqun Jiao Gang Song Yang Hua Yan Ma Yanfei Chen Yabing Wang Feng Ling | 2013 | Neural Regeneration Research2013，8，23： | 19 |
| 3 | Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese显示文摘Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95% CI 1.08-1.55). None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population. | Yabing Wang Di Zhang Yun Liu Yifeng Yang Teng Zhao Jie Xu Sheng Li Zuofeng Zhang Guoyin Feng Lin He He Xu | 2009 | Journal of Genetics and Genomics2009，36，7： | 7 |
| 4 | Genomic insights into the fast growth of paulownias and the formation of Paulownia witches' broom显示文摘Paulownias are among the fastest growing trees in the world,but they often suffer tremendous loss of wood production due to infection by Paulownia witches'broom(PaWB)phytoplasmas.In this study,we have sequenced and assembled a high-quality nuclear genome of Paulownia fortunei,a commonly cultivated paulownia species.The assembled genome of P.fortunei is 511.6 Mb in size,with 93.2%of its sequences anchored to 20 pseudo-chromosomes,and it contains 31985 protein-coding genes.Phylogenomic analyses show that the family Paulowniaceae is sister to a clade composed of Phrymaceae and Orobanchaceae.Higher photosynthetic efficiency is achieved by integrating C3 photosynthesis and the crassulacean acid metabolism pathway,which may contribute to the extremely fast growth habit of paulownia trees.Comparative transcriptome analyses reveal modules related to cambial growth and development,photosynthesis,and defense responses.Additional genome sequencing of PaWB phytoplasma,combined with functional analyses,indicates that the effector PaWB-SAP54 interacts directly with Paulownia PfSPLa,which in turn causes the degradation of PfSPLa by the ubiquitin-mediated pathway and leads to the formation of witches'broom.Taken together,these results provide significant insights into the biology of paulownias and the regulatory mechanism for the formation of PaWB. | Yabing Cao Guiling Sun Xiaoqiao Zhai Pingluo Xu Liming Ma Minjie Deng Zhenli Zhao Haibo Yang Yanpeng Dong Zhonghai Shang Yujie Lv Lijun Yan Haifang Liu Xibing Cao Bingbing Li Zhe Wang Xiaogai Zhao Haiyan Yu Fan Wang Wen Ma Jinling Huang Guoqiang Fan | 2021 | Molecular Plant2021，14，10： | 7 |
| 5 | Is new American Thyroid Association risk classification for hereditary medullary thyroid carcinoma applicable to Chinese patients? A single-center study显示文摘Objective: The American Thyroid Association(ATA) proposed a new risk classification for hereditary medullary thyroid carcinoma(MTC) in 2015. This study aimed to assess whether the new guidelines are suitable for the Chinese population, and reported our experience on prophylactic thyroidectomy.Methods: A total of 73 patients from 22 families were screened as rearranged during transfection(RET) mutation carriers from 2010 to 2016 in Cancer Hospital, Chinese Academy of Medical Science; the medical history for each patient was collected. Based on the initial treatment, we identified the risk factors for poor prognosis by univariate and multivariate logistic regression. Then, 4 RET mutation carriers were enrolled for prophylactic thyroidectomy,and their pathological data and follow-up outcomes were recorded.Results: In univariate and multivariate logistic regression analyses, age at initial surgery and risk classification were significant risk factors for stage Ⅲ/Ⅳ hereditary MTC at initial diagnosis. The likelihood was increased by 11.6% per year of age at initial surgery [95% confidence interval(95% CI), 1.040–1.198; P=0.002). It was 7.888 times more likely to have Ⅲ/Ⅳ stage disease for ATA highest risk patients, compared to ATA moderate risk individuals(95% CI, 1.607–38.717; P=0.003). Postoperative pathological results showed all 4 multiple endocrine neoplasia type 2A(MEN2A) patients had C-cell hyperplasia(CCH); multifocal malignancies were detected in 3 of them. All 4 patients were cured biochemically, and none developed permanent hypoparathyroidism.Conclusions: In Chinese individuals, hereditary MTC aggressiveness is in line with the new ATA risk classification. Germline RET gene mutation carriers should undergo prophylactic thyroidectomy according to basal serum calcitonin levels. | Xiwei Zhang Dangui Yan Junyi Wang Hanfeng Wan Yongxia Zhang Yabing Zhang Yuqin He Wensheng Liu Bin Zhang | 2017 | Chinese Journal of Cancer Research2017，29，3： | 5 |
| 6 | PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer显示文摘Objective:As a member of the peptidyl arginine deiminase(PAD)family,PADI3 is weakly expressed in colon cancer tissues and highly expressed in adjacent colon cancer tissues.However,the role of PADI3 in colon cancer is unclear.In this study,we investigated the function and molecular mechanism of PADI3 in colon cancer tumorigenesis.Methods:Western blot and real-time PCR were used to detect the expression levels of several genes.CCK-8,flow cytometry(FCM)and colony formation assays were used to examine cell proliferation,the cell cycle and colony formation ability.RNAsequencing analysis was used to study the molecular mechanism of PADI3 in tumorigenesis.A truncation mutation experiment was performed to determine the key functional domain of PADI3.Results:PADI3 overexpression inhibited cell proliferation and colony formation and led to G1 phase arrest in both HCT116(originating from primary colon cancer)and LoVo(originating from metastatic tumor nodules of colon cancer)cells.PADI3-expressing HCT116 cells had a lower tumor formation rate and produced smaller tumors than control cells.PADI3 significantly decreased Sirtuin2(Sirt2)and Snail expression and AKT phosphorylation and increased p21 expression,and Sirt2 overexpression partly reversed the effects induced by PADI3 overexpression.Immunocytochemistry showed that PADI3 is mainly localized in the cytoplasm.Truncation mutation experiments showed that the C-domain is the key domain involved in the antitumor activity of PADI3.Conclusions:PADI3 suppresses Snail expression and AKT phosphorylation and promotes p21 expression by downregulating Sirt2 expression in the cytoplasm,and the C-domain is the key domain for its antitumor activity. | Xiaotian Chang Zhengbin Chai Jiaorui Zou Hongxing Wang Yao Wang Yabing Zheng Hui Wu Chunyan Liu | 2019 | Cancer Biology & Medicine2019，16，4： | 4 |
| 7 | miR-573 is a negative regulator in the pathogenesis of rheumatoid arthritis显示文摘风湿性关节炎(RA ) 是反常发炎, angiogenesis,和软骨破坏描绘的长期的自体免疫的疾病。我们的以前的学习在 RA 的 synovial 纸巾表明了包含 5 的 thioredoxin 领域(TXNDC5 ) 的增加的表情,并且它的 overexpression 在 RA 病理被含有。尽管 TXNDC5 变化被连接到基因危险性到 RA,它的反常表示的规定一直不是明确的。这里,我们证明 TXNDC5 被 microRNA (米尔) 直接指向接着, -573, 和 TXNDC5 调停 RA (RASF ) 的 synovial 成纤维细胞的侵略上的 miR-573 的镇压效果。miR-573 overexpression 压制了 interleukin 的表示 6 (IL-6 ) 并且 cyclooxygenase 2 在由响应 lipopolysaccharide (LPS ) 的激活的 THP-1 房间的肿瘤坏死 factor-alpha 和 interleukin-1 贝它的 RASF,以及生产刺激。而且,有有 miR-573 的 RASF transfected 的调节媒介的处理模仿禁止了人的脐的静脉 endothelial 房间(HUVEC ) 的 angiogenic 能力。笔记,表皮的生长因素受体和像使用费的受体, 2 作为 miR-573 的新直接目标被验证,并且调停象 HUVEC 的 angiogenesis 一样的 IL-6 生产上的 miR-573 的规定。另外,外长的 miR-573 表示压制了激活 mitogen 的蛋白质的激活 kinase (MAPK ) ,信号变换器和抄写 3 的使活跃之物,和在响应 LPS 的 RASF 的 phosphatidylinositol-3 kinase/activate 蛋白质 kinase B。确实, MAPK 发信号是必要的保证 miR-573 的功能。一起拿,我们的学习在 RA 的病理学的过程向 miR-573 的保护的角色指并且在 RA 的处理建议一个潜在的目标。 | Lin Wang Guanhua Song Yabing Zheng Dan Wang Hongyan Dong Jihong Pan Xiaotian Chang | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 8 | Design and Analysis of the Gemini Chain System in Dual Clutch Transmission of Automobile显示文摘Chain drive system is widely used in the conditions of high-speed, overload, variable speed and load. Many studies are focused on the meshing theory and wear characteristics of chain drive system, but system design, analysis, and noise characteristics of the chain drive system are weak. System design and noise characteristic are studied for a new type Gemini chain of dual-clutch automatic transmission. Based on the meshing theory of silent chain, the design parameters of the Gemini chain system are calculated and the mathematical models and dynamic analysis models of the Gemini chain system are established. Dynamic characteristics of the Gemini chain system is simulated and the contact force of plate and pin, plate and sprockets, the chain tension forces, the transmission error and the stress of plates and pins are analyzed. According to the simulation results of the Gemini chain system, the noise experiment about system is carried out. The noise values are tested at different speed and load and spectral characteristics are analyzed. The results of simulation and experimental show that the contact forces of plate and pin, plate and sprockets are smaller than the allowable stress values, the chain tension force is less than ultimate tension and transmission error is limited in 1.2%. The noise values can meet the requirements of industrial design, and it is proved that the design and analysis method of the Gemini chain system is scientific and feasible. The design and test system is built from analysis to test of Gemini chain system. This research presented will provide a corresponding theoretical guidance for the design and dynamic characteristics and noise characteristics of chain drive system. | CHENG Yabing GUO Haitao FU Zhenming WAN Nen LI Lei WANG Yang | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 3 |
| 9 | 2D materials for conducting holes from grain boundaries in perovskite solar cells显示文摘Grain boundaries in organic-inorganic halide perovskite solar cells(PSCs)have been found to be detrimental to the photovoltaic performance of devices.Here,we develop a unique approach to overcome this problem by modifying the edges of perovskite grain boundaries with flakes of high-mobility two-dimensional(2D)materials via a convenient solution process.A synergistic effect between the 2D flakes and perovskite grain boundaries is observed for the first time,which can significantly enhance the performance of PSCs.We find that the 2D flakes can conduct holes from the grain boundaries to the hole transport layers in PSCs,thereby making hole channels in the grain boundaries of the devices.Hence,2D flakes with high carrier mobilities and short distances to grain boundaries can induce a more pronounced performance enhancement of the devices.This work presents a cost-effective strategy for improving the performance of PSCs by using high-mobility 2D materials. | Peng You Guanqi Tang Jiupeng Cao Dong Shen Tsz-Wai Ng Zafer Hawash Naixiang Wang Chun-Ki Liu Wei Lu Qidong Tai Yabing Qi Chun-Sing Lee Feng Yan | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 10 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 11 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 12 | The Main Progress of Perovskite Solar Cells in 2020-2021显示文摘Perovskite solar cells(PSCs)emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the world.Both the efficiency and stability of PSCs have increased steadily in recent years,and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by step.This review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency,stability,perovskite-based tandem devices,and lead-free PSCs.Moreover,a brief discussion on the development of PSC modules and its challenges toward practical application is provided. | Tianhao Wu Zhenzhen Qin Yanbo Wang Yongzhen Wu Wei Chen Shufang Zhang Molang Cai Songyuan Dai Jing Zhang Jian Liu Zhongmin Zhou Xiao Liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding Zhijun Ning Yabing Qi Yiqiang Zhang Liyuan Han | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 13 | Distribution and origin of high magnetic anomalies at Luobusa Ophiolite in Southern Tibet显示文摘The Luobusa Ophiolite,Southern Tibet,lies in the eastern portion of Indus–Yarlung Zangbo suture zone that separates Eurasia from the Indian continent.An aeromagnetic reconnaissance survey has revealed an EWtrending Yarlung Zangbo River aeromagnetic anomaly zone,and it is considered to be caused mainly by the Indus–Yarlung Zangbo Ophiolite.The Luobusa Ophiolite reflects the eastern portion of the Yarlung Zangbo River aeromagnetic anomaly zone.Conventionally,the ultramafic rock in the Luobusa Ophiolite is considered as the origin of the high magnetic anomalies.However,results from the surface magnetic survey and the magnetic susceptibility measurements from drill cores indicate that the high magnetic anomalies are distributed inhomogeneously in the Luobusa Ophiolite.In some cases,the susceptibility exhibits more than 30 times difference between two sides of the same sample.A fact emerged that the susceptibility of dunite with serpentinization is higher than that of fresh dunite,harzburgite and chromite when we analyzed the measurement results.In order to understand the origin of the high magnetic anomalies,we measured the density and susceptibility of 17 samples,microscopic and electron probe analyses have been performed as well.The result indicates the presence of dunite with serpentinization containing an abundant of micro-fissures filled with magnetite.Olivine has a susceptibility of about 2.7–351(910-5SI),pyroxene about 16–320,and chromite about200–800.All these units feature relatively low susceptibility in ultramafic rock,and only the magnetite is characterized by a high susceptibility of about 200,000(910-5SI).Based on these observations,we conclude that the precipitation of magnetite in the process of serpentinization of the olivine caused by the geological process in the Luobusa Ophiolite is the origin of high magnetic anomalies. | Lanfang He Xiumian Hu Yabing Zha Ligui Xu Yaohui Wang | 2014 | Chinese Science Bulletin2014，59，23： | 2 |
| 14 | Transarterial infusion chemotherapy with FOLFOX for advanced hepatocellular carcinoma:a multi-center propensity score matched analysis of real-world practice显示文摘Background:To compare the treatment effectiveness and safety among transarterial infusion chemotherapy(TAI)with FOLFOX regimen,transarterial chemoembolization(TACE),and sorafenib in patients with BCLC stage C hepatocellular carcinoma(HCC).Methods:The data of consecutive patients with BCLC stage C HCC treated with TAI,TACE,or sorafenib from January 2015 to December 2018 at three centers were retrospectively analyzed.Propensity-score matched(PSM)analysis was pairwise performed to reduce selection bias.Treatment effectiveness and safety were evaluated and compared using the Kaplan-Meier method,log-rank test,Cox regression models,andχ2 test.Results:The median overall survival(OS)in the matched TAI cohort was significantly longer than the sorafenib cohort(19.6 vs.7.5 months,P=0.009),and the TACE cohort(estimated 27.8 vs.6.6 months,P<0.001).The difference in median progression-free survival(PFS)between the matched TAI and sorafenib cohorts was not significant(5.8 vs.2.3 months,P=0.219).The median PFS in the matched TAI cohort was significantly longer than the TACE cohort(6.5 vs.2.8 months,P<0.001).The objective response rate(ORR)in the matched TAI cohort was significantly higher than the sorafenib cohort(36.4%vs.0.0%,P<0.001)and the TACE cohort(48.7%vs.4.7%,P<0.001).The incidences of adverse events(AEs)were similar among these three cohorts.Conclusions:TAI with FOLFOX regimen was an effective and safe therapy that improved survival of patients with BCLC stage C HCC. | Shaohua Li Jie Mei Qiaoxuan Wang Feng Shi Hongyan Liu Ming Zhao Lianghe Lu Yihong Ling Zhixing Guo Yabing Guo Xiaoming Chen Ming Shi Wan Yee Lau Wei Wei Rongping Guo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 2 |
| 15 | Immunoinhibitory effect of soluble HLA-G1 on the cytotoxicity of NK92 cells显示文摘HLA-G (human leukocyte antigen-G) is a non-classical HLA class I molecule, playing an important immuno-modulatory role in maintaining maternal immune tolerance of the semiallogenic fetus and organ transplantation. In this study, the cDNA sequence of extracellular domain of HLA-G1 was subcloned into the pET28a vector and a soluble 35 kD fusion protein (His-sHLA-G1) with six histine residues was obtained. In the 4 h 51Cr-release assay the fusion protein obviously inhibited the cytotoxicity of NK92 cells in a dose-dependent manner. These results indicated that sHLA-G1, as an activated immunoinhibitor, may provide an effective approach to overcoming the immune rejection of transplantation. | TIAN Xinghui, LI Zhiwei, LIU Yabing, WANG Yun, TANG Haiyang and FENG Meifu(The National Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China) | 2003 | Progress in Natural Science:Materials International2003，13，3： | 1 |
| 16 | Selec- tive accumulation of the high molecular weight neurofilament subunit within the distal region of growing axonal neurites显示文摘 | Yabe J T Wang F S Chylinski T Katchmar T Shea T B | 2001 | Cell Motil Cytoskeleton2001，5，： | 1 |
| 17 | Etching of transparent materials by laser ablation of an organic solution显示文摘 | Wang J Niino H Yabe A | 2001 | RIKEN Review2001，，32： | 1 |
| 18 | Selective accumulation of the high molecular weight neurofilament subunit within the distal region of growing axonal neurites显示文摘 | Yabe J T Wang F S Chylinski T | 2001 | Cell Motil Cytoskeleton2001，50，1： | 1 |
| 19 | Selective accumu- lation of the high molecular weight neurofilament subunit within the distal region of growing axonal neurites显示文摘 | Yabe JT Wang FS Chylinski T | 2001 | Cell Motil Cytoskeleton2001，50，1： | 1 |
| 20 | Differentiated cells derived from fetal neural stem cells improve motor deficits in a rat model of Parkinson's disease显示文摘Objective: Parkinson's disease(PD), which is one of the most common neuro‐degenerative disorders, is characterized by the loss of dopamine(DA) neurons in the substantia nigra in the midbrain. Experimental and clinical studies have shown that fetal neural stem cells(NSCs) have therapeutic effects in neurological disorders. The aim of this study was to examine whether cells that were differentiated from NSCs had therapeutic effects in a rat model of PD. Methods: NSCs were isolated from 14‐week‐old embryos and induced to differentiate into neurons, DA neurons, and glial cells, and these cells were characterized by their expression of the following markers: βⅢ‐tubulin and microtubule‐associated protein 2(neurons), tyrosine hydroxylase(DA neurons), and glial fibrillary acidic protein(glial cells). After a 6‐hydroxydopamine(6‐OHDA)‐lesioned rat model of PD was generated, the differentiated cells were transplanted into the striata of the 6‐OHDA‐lesioned PD rats. Results: The motor behaviors of the PD rats were assessed by the number of apomorphine‐induced rotation turns. The results showed that the NSCs differentiated in vitro into neurons and DA neurons with high efficiencies. After transplantation into the striata of the PD rats, the differentiated cells significantly improved the motor deficits of the transplanted PD rats compared to those of the control nontransplanted PD rats by decreasing the apomorphine‐induced turn cycles as early as 4 weeks after transplantation. Immunofluorescence analyses showed that the differentiated DA neurons survived more than 16 weeks. Conclusions: Our results showed that cells that were differentiated from NSCs had therapeutic effects in a rat PD model, which suggests that differentiated cells may be an effective treatment for patients with PD. | Wei Wang Hao Song Aifang Shen Chao Chen Yanming Liu Yabing Dong Fabin Han | 2015 | Translational Neuroscience and Clinics2015，1，2： | 1 |
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