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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial显示文摘 | Leon A. Adams Darrell H. Crawford Katherine Stuart Michael J. House Timothy G. St. Pierre Malcolm Webb Helena L.I. Ching Jenny Kava Michael Bynevelt Gerry C. MacQuillan George Garas Oyekoya T. Ayonrinde Trevor A. Mori Kevin D. Croft Xianwa Niu Gary P. Jef | 2015 | Hepatology2015，，5： | 2 |
| 3 | Antioxidant inhibition of oxygen radicals for measurement of total antioxidant capacity in biological samples显示文摘 | Simon Y L Ching Jon Hall Kevin Croft | 2006 | Analytical Biochemistry2006，353，2： | 1 |
| 4 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 5 | Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle显示文摘 | Natalie C Ward Jonathan M Hodgson Ian B Puddey Trevor A Mori Lawrence J Beilin Kevin D Croft | 2003 | Free Radical Biology and Medicine2003，，2： | 1 |
| 6 | Vitamin E Supplementation and Hepatic Drug Metabolism in Humans显示文摘 | Michael W Clarke John R Burnett Jason H Y Wu Jonathan M Hodgson Thomas Ledowski Ian B Puddey Kevin D Croft | 2009 | Journal of Cardiovascular Pharmacology2009，，： | 1 |
| 7 | Crohn’s disease and smoking: Is it ever too late to quit?显示文摘 | Ian C. Lawrance Kevin Murray Birol Batman Richard B. Gearry Rachel Grafton Krupa Krishnaprasad Jane M. Andrews Ruth Prosser Peter A. Bampton Sharon E. Cooke Gillian Mahy Graham Radford-Smith Anthony Croft Katherine Hanigan | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 8 | Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines显示文摘 | Christoph Bock Evangelos Kiskinis Griet Verstappen Hongcang Gu Gabriella Boulting Zachary D. Smith Michael Ziller Gist F. Croft Mackenzie W. Amoroso Derek H. Oakley Andreas Gnirke Kevin Eggan Alexander Meissner | 2011 | Cell2011，，3： | 1 |
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