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| 1 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 2 | Inter-observer agreement for Crohn’s disease sub-phenotypes using the Montreal Classification: How good are we? A multi-centre Australasian study显示文摘 | Krupa Krishnaprasad Jane M. Andrews Ian C. Lawrance Timothy Florin Richard B. Gearry Rupert W.L. Leong Gillian Mahy Peter Bampton Ruth Prosser Peta Leach Laurie Chitti Charles Cock Rachel Grafton Anthony R. Croft Sharon Cooke James D. Doecke Graham L. Rad | 2011 | Journal of Crohn’s and Colitis2011，，3： | 2 |
| 3 | Analysis and synthesis of feed for- ward and neural networks using discrete affine wavelet 显示文摘 | PATI Y C KRISHNAPRASAD P S | 1993 | IEEE Trans on Neural Networks1993，4，1： | 1 |
| 4 | An information extraction approach to reorganizing and summarizing specifications显示文摘 | Krishnaprasad Thirunarayan Aaron Berkovich Dan Z. Sokol | 2004 | Information and Software Technology2004，，4： | 1 |
| 5 | Analysis aad synthesis of feedforward neural networks using discrete affine wavelet transformations 显示文摘 | Pati YC Krishnaprasad PS | 1993 | IEEE Trans Neural Netw1993，4，1： | 1 |
| 6 | The dynamics of mutual motion camouflage 显示文摘 | Mischiati M Krishnaprasad P S | 2012 | System & Control Letters2012，61，9： | 1 |
| 7 | Dissipation Induced Instabilities显示文摘 | Bloch A M Krishnaprasad P S Marsden J E | 1994 | Ann Inst H Poincaré Analyse Nonlineare1994，11，： | 1 |
| 8 | Steering laws for motion camouflage 显示文摘 | Justh E W Krishnaprasad P S | 2006 | Proceeding of the Royal Society A: Mathematical Physical and Engineering Science2006，462，： | 1 |
| 9 | Nonholonomic mechanical systems with symmetry 显示文摘 | Bloch A M Krishnaprasad P S Marsden J E | 1996 | Archive for Rational Mechanics and Analysis1996，136，1： | 1 |
| 10 | A novel algorithm for the invention of the preisach operator显示文摘 | Venkataraman R Krishnaprasad P S | 2000 | SPIE2000，3984，： | 1 |
| 11 | Motion control of drift-free,left-invariant systems on lie groups显示文摘 | Leonard N E Krishnaprasad P S | 1995 | IEEE Transactions on Automatics Control1995，40，9： | 1 |
| 12 | Analysis and synthesis of feedforward neural networks using discrete affine wavelet transformations显示文摘 | PATI Y C KRISHNAPRASAD P S | 1993 | IEEE Trans on Neural Networks1993，4，1： | 1 |
| 13 | On a low-dimensional model for ferromagnetism显示文摘 | IYER R V KRISHNAPRASAD P S | 2005 | Nonlinear Analysis2005，61，： | 1 |
| 14 | Identification of Pea Genotypes with Enhanced Thermotoleranee Using Temperature Induction Response Technique (TIR) 显示文摘 | Srikanthbabu V Ganeshkumar Krishnaprasad B T | 2002 | Journal of Plant Physiology2002，159，5： | 1 |
| 15 | Control of hysteresis in smart actuators with application to micro-positioning 显示文摘 | TAN X B BARAS J S KRISHNAPRASAD P S | 2005 | Systems and Control Letters2005，54，5： | 1 |
| 16 | Analysis and synthesis of feed forward and neural networks using discrete affine wavelet显示文摘 | PATI Y C KRISHNAPRASAD P S | 1993 | IEEE Trans on Neural Networks1993，4，1： | 1 |
| 17 | Motion control of drift-free, left-invariant systems on Lie groups 显示文摘 | Leonard N E Krishnaprasad P S | 1995 | IEEE Transactions on Automatic Control1995，40，9： | 1 |
| 18 | Approximate nonlinear filtering and its application in navigation 显示文摘 | B Azimi-Sadjadi P S Krishnaprasad | 2005 | Automatica (S0005-1098)2005，41，6： | 1 |
| 19 | 查看详情显示文摘 | Babak A S Krishnaprasad P S | | 0，，： | 1 |
| 20 | Steering laws for motion camouflage显示文摘 | Justh E W Krishnaprasad P S | | 0，，： | 1 |
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