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| 1 | Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey显示文摘AIM: To investigate and compare frequencies of serum positive cagA in patients from two separate regions of Turkey who were grouped according to the presence of peptic ulcer disease or non-ulcer dyspepsia.METHODS: One hundred and eighty Helicobacter pyloripositive patients with peptic ulcer disease or non-ulcer dyspepsia were included in the study. One hundred and fourteen patients had non-ulcer dyspepsia and 66 had peptic ulcer disease (32 with gastric ulcers and/or erosions and 34with duodenal ulcers). Each patient was tested for serum antibody to H. pylori cagA protein by enzyme immunoassay.RESULTS: The total frequency of serum positive cagA in the study group was 97.2 %. The rates in the patients with peptic ulcers and in those with non-ulcer dyspepsia were 100% and 95.6%, respectively. These results were similar to those reported in Asian studies, but higher than those that have been noted in other studies from Turkey and Western countries.CONCLUSION: The high rates of serum positive cagA in these patients with peptic ulcer disease and non-ulcer dyspepsia were similar to results reported in Asia. The fact that there was high seroum prevalence regardless of ulcer status suggests that factors other than cagA might be responsible for ulceration or other types of severe pathology in H. pylori-positive individuals. | Ender Serin Uur Yilmaz Ganiye Künefeci Birol zer Yüksel Gümürdülü Mustafa Gülü Fazilet Kayaseluk Sedat Boyaciolu | 2003 | World Journal of Gastroenterology2003，9，4： | 10 |
| 2 | 普瑞巴林治疗糖尿病周围神经痛的疗效、安全性和耐受性显示文摘目的:通过分析7项普瑞巴林治疗糖尿病周围神经病(DPN)的临床研究,评估普瑞巴林在其有效剂量范围内的疗效、安全性和耐受性;评估每日两次给药(BID)和每日三次给药(TID)的疗效差异; | Roy Freeman Edith Durso-Decruz Birol Emir | 2011 | 中国新药杂志2011，20，6： | 10 |
| 3 | 采用冷却倾斜板铸造方法生产悬架零部件用EN Aw 6082铝合金锻坯(英文)显示文摘对采用冷却倾斜板铸造方法生产EN AW 6082铝合金锻坯用于制备悬架零部件的可行性进行研究。采用冷却倾斜板铸造方法生产的EN AW 6082铝合金坯料具有细小的均匀组织,可直接用于锻造生产而不需要另外的均匀化处理。这可能是因为铸造开始时采用较小的过热和冷却倾斜板上发生较多的凝固所致。对采用冷却倾斜板铸造和均匀化处理的含或者不含Cr的EN AW 6082铝合金坯料,通过锻造生产的悬架零部件均具有均匀的组织,经过标准的人工时效处理后硬度可达到HV110。 | Yucel BIROL Seracettin AKDI | 2014 | Transactions of Nonferrous Metals Society of China2014，24，6： | 9 |
| 4 | 铝含量对AZ系列镁合金机械加工性能的影响(英文)显示文摘研究铝含量对AZ系列铸造铝合金机械加工性能的影响。为评价该合金的机械加工性能,测量切削操作过程中的切削力以及表面粗糙度,以及研究显微组织和拉伸性能。结果表明:添加2%铝含量的镁合金具有最佳的拉伸性能。随着铝含量增加到2%以上,由于晶界上析出金属间化合物β-Mg17Al12,切削力会随延展性的降低而降低。切削力也会随着切削速度的增加而增大,这是由于在加工过程中切削工具的尖端有侧面生成。 | Birol AKYUZ | 2013 | Transactions of Nonferrous Metals Society of China2013，23，8： | 5 |
| 5 | Recurrent ischemic stroke as an initial manifestation of an concealed pancreatic adenocarcinoma: Trousseau's syndrome显示文摘在稀罕例子,摸可以 preceed 癌症的诊断并且是 malignancy.Cerebral 梗塞主要复杂化淋巴瘤,癌,和稳固的肿瘤的位于 \O 下面的第一条临床的证据。恶意相关的 thromboembolism 能介绍同样尖锐的服的梗塞, nonbacterial thrombotic 心内膜炎和迁移的 thrombophlebitis。它通常被归因于一个癌症相关的 hypercoagulable 时期,长期的 dissemiated intravascular coagulopathy (DIC ) ,或肿瘤栓塞。我们从 undiagnosed 报导了 malignancy-releated thromboembolism 的一个案例在由于长期的 DIC 与周期性的 ischemic 击介绍了的一个 54 岁的人的胰腺的腺癌。尽管有 anticoagulation therapy.This 大小写的适当机构,他死于内在的恶意强调服的梗塞可以是 undiagnosed 癌症的第一表明。如果有实验室或临床的证据,与 DIC 联系,有未知病原学的服的梗塞的病人应该为一个恶意的过程被调查。在有 thromboembolic 疾病的癌症病人的 anticoagulation 的最佳的方法(晒) 仍然保持不清楚。 | Semih Giray Feyzi Birol Sarica Zulfikar Arlier Nebil Bal | 2011 | Chinese Medical Journal2011，，4： | 4 |
| 6 | 铝合金半固态浆料中球形颗粒的演变(英文)显示文摘用AlSi7Mg0.6半固态浆料进行实验,研究球形颗粒的演变机理。在略高于液相线温度下水淬的样品中结晶相主要为枝晶,而采用旋转圆筒的方式来搅拌熔体使其冷却到半固态温度范围内时样品的结晶相完全球化。在铸造前进行较长时间的内冷却和搅拌,可以得到较高的固相分数。不同大小的枝晶碎片的存在表明,在搅拌过程中,初始的固相分数形成后不再受冷却的影响。 | Yucel BIROL | 2013 | Transactions of Nonferrous Metals Society of China2013，23，1： | 4 |
| 7 | Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey显示文摘AIM:The eradication rate of Helicobacter pylori (H pylon) shows variation among countries and regimens of treatment.We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication.METHODS:One hundred and sixty-four Hpylori positivepatients (68 males, 96 females; mean age:48±12 years)with duodenal or gastric ulcer without a smoking history were included in the study. The patients were divided into three groups according to the treatment regimens. Omeprazole 20mg, clarithromycin 500mg, amoxicillin 1g were given twice daily for 1 week (Group I) and 2 weeks (Group Ⅱ).Patients in Group Ⅲ received bismuth subsitrate 300mg,tetracyline 500 mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice daily.Two biopsies each before and after treatment were obtained from antrum and corpus, and histopathologically evaluated.Eradication was assumed to be successful if no Hpylorus was detected from four biopsy specimens taken after treatment. The effects of factors like age, sex, Hpyloridensity on antrum and corpus before treatment, the total Hpylori density, and the inflammation scores on the rate of Hpylori eradication were evaluated.RESULTS:The overall eradication rate was 42%. The rates in groups Ⅱ and Ⅲ were statistically higher than that in group I (P<0.05). The rates of eradication were 24.5%,40.7% and 61.5% in groups Ⅰ, Ⅱ and Ⅲ, respectively. The eradication rate was negatively related to either corpus Hpylori density or total Hpyloridensity (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55yr vs 39yr, P<0.001). No correlation between sex and Hpylori eradication was found.CONCLUSION: Our rates of eradication were significantly lower when compared to those reported in literature.We believe that advanced age and high Hpyloridensity are negative predictive factors for the rate of Hpylorieradication. | Yuksel Gumurdulu Ender Serin Birol zer Fazilet Kayaselcuk Kursat Ozsahin Arif Mansur Cosar Murat Gursoy Gurden Gur Ugur Yilmaz Sedat Boyacioglu | 2004 | World Journal of Gastroenterology2004，10，5： | 4 |
| 8 | Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy显示文摘AIM: To determine whether Helicobacter pylori ( H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B12, serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level.METHODS: The study involved 73 dyspeptic H pylori-positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of Hpylori4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B12, folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after Hpylorieradication therapy were compared.RESULTS: The group with a successful eradication of Hpylori had significantly higher serum vitamin B12 and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210±97 pg/mL vs237±94pg/mL, P<0.O01 and 442±212 ng/mL vs 539±304 ng/mL,P = 0.024, respectively), but showed no significant change in serum folate levels (5.6±2.6 ng/mL vs 6.0±2.4 ng/mL,P= 0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1±5.2 μmol/L vs 11.9±6.2 μmol/L, P = 0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P = 0.01) and negatively with serum folate level before therapy (P = 0.003).CONCLUSION: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B12, serum folate and erythrocyte folate levels. | Birol Ozer Ender Serin Yuksel Gumurdulu Fazilet Kayaselcuk Ruksan Anarat Gurden Gur Kemal Kul Mustafa Guclu Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 9 | A modular simulation package for fed-batch fermentation: penicillin production显示文摘 | Gülnur Birol Cenk ündey Ali ?inar | 2002 | Computers and Chemical Engineering2002，，11： | 3 |
| 10 | Nociceptin effect on intestinal motility depends on opioidreceptor like-1 receptors and nitric oxide synthase colocalization显示文摘AIM: To study the effect of the opioid-receptor like-1(ORL1) agonist nociceptin on gastrointestinal(GI)myenteric neurotransmission and motility. METHODS: Reverse transcriptase- polymerase chain reaction and immunohistochemistry were used to localize nociceptin and ORL1 in mouse tissues. Intracellular electrophysiological recordings of excitatory and inhibitory junction potentials(EJP, IJP) were made in a chambered organ bath. Intestinal motility was measured in vivo. RESULTS: Nociceptin accelerated whole and upper GI transit, but slowed colonic expulsion in vivo in an ORL1-dependent manner, as shown using [Nphe1]NOC and AS ODN pretreatment. ORL1 and nociceptin immunoreactivity were found on enteric neurons. Nociceptin reduced the EJP and the nitric oxide-sensitive slow IJP in an ORL1-dependent manner, whereas the fast IJP was unchanged. Nociceptin further reduced the spatial spreading of the EJP up to 2 cm. CONCLUSION: Compounds acting at ORL1 are good candidates for the future treatment of disorders associated with increased colonic transit, such as diarrhea or diarrhea-predominant irritable bowel syndrome. | Andrei Sibaev Jakub Fichna Dieter Saur Birol Yuece Jean-Pierre Timmermans Martin Storr | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3： | 2 |
| 11 | Pre-aging to improve bake hardening in a twin-roll cast Al–Mg–Si alloy显示文摘 | Yucel Birol | 2004 | Materials Science & Engineering A2004，，1： | 2 |
| 12 | Comparison of three sequential extraction procedures for partitioning of heavy metals in car park dusts显示文摘 | TOKALIOGLU S KARTAL S BIROL G | 2003 | J Environ Moni2003，5，3： | 1 |
| 13 | A modular simulation package for fed-batch fermentation: Penicillin produetion显示文摘 | Birol G Undey C Cinar A | 2002 | Computers and Chemical En- gineering2002，26，11： | 1 |
| 14 | A case of porokeratotic eccrine ostial and dermal duct naevus of late onset显示文摘 | Birol A Erkek E Bozdoethan O | 2004 | J Eur Acad Dermatol Venereol2004，18，5： | 1 |
| 15 | Components of Innovation Ecosystems:A Cross-Country Study显示文摘 | BIROL M DENIZ G | 2011 | International Research Journal of Finance and Economics2011，，76： | 1 |
| 16 | Impact of grain size on mechanical properties of AlSiTMg03 alloy显示文摘 | Yucel Birol | 2013 | Materials Science and Engineering: A2013，559，1： | 1 |
| 17 | A modular simulation package for fed-batch fermentation: penicillin production显示文摘 | BIROL G UNDEY C CINAR A | 2002 | Computer and Chemical Engineering2002，26，： | 1 |
| 18 | Using a choice experiment to account for preference heterogeneity in wetland attributes: The case of Cheimaditida wetland in Greece 显示文摘 | Ekin Birol Katia Karousakis Phoebe Koundouri | 2006 | Ecological Economics2006，60，： | 1 |
| 19 | A1B3 master alloy to refine A1Sil0Mg and A1Sil2Cu aluminium foundry alloys 显示文摘 | Yucel Birol | 2012 | Journal of Alloys and Compounds2012，513，： | 1 |
| 20 | Ethanol production and fermentation characteristics of recombinant Saccharomyces cerevisiae strains grown on starch 显示文摘 | Birol G Onsan Z I Kirdar B | 1998 | Enzyme and Microbial Technology1998，22，8： | 1 |
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