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| 1 | Molecular therapy for hepatic injury and fibrosis:Where are we?显示文摘肝的纤维变性是弯屈的愈合的回答,包含发炎和纤维发生的小径。响应各种各样的侮辱,例如酒精,局部缺血,病毒的代理人,和药或肝毒素, hepatocyte 损坏将在肝由 Kupffer 房间和另外的房间类型引起 cytokines 和另外的可溶的因素的版本。这些因素导致肝的星形细胞的激活,它综合大量细胞外的矩阵部件。与长期的损害和纤维变性,肝建筑学和新陈代谢被破坏,最后作为肝硬化和它的复杂并发症表明。除了消除病原学,例如抗病毒的治疗和药理学干预,新奇策略正在被开发直接在细胞的潜水艇和分子的层次探讨肝的损害和纤维变性,这令人鼓舞。与在理解这些机制和小径的改进,在损害给步调音,发信号,激活,和基因表示被分子的形式和分子的其它或基因治疗途径正在指向。这篇文章打算为肝的损害和纤维变性以分子的治疗的当前的地位提供更改并且我们多远从这些新治疗学的形式的临床的利用。 | Colette C Prosser Roy D Yen Jan Wu | 2006 | World Journal of Gastroenterology2006，12，4： | 41 |
| 2 | The practice of mine ventilation engineering显示文摘The practice of ventilation is continually evolving with new technological advances developed in the mining industry.In recent years the advances in diesel engine technologies,ventilation modeling software,and ventilation management capacities have redefined the historical methods used to evaluate systems.The advances re-evaluate previous methods used to calculate the airflow requirements for the dilution of diesel exhaust fumes.Modeling software has become an integral part of planning and developing ventilation systems in partnership with graphical mine design software packages to generate realistic representations of the mine.Significant advances in ventilation control strategies through remote sensors and monitoring capabilities have been developed to results in cost savings.Though there has been much advancement in mine ventilation technology,the practices and basic ventilation principals enacted through the ventilation engineer cannot be placated with technological advances only. | Wallace Keith Prosser Brian Stinnette J.Daniel | 2015 | International Journal of Mining Science and Technology2015，25，2： | 17 |
| 3 | Dietary stimulation of the endogenous somatotropic axis in weaner and growerfinisher pigs using medium chain triglycerides and cysteamine hydrochloride显示文摘Background: Three experiments were conducted to examine the overall hypothesis that addition of medium chain triglycerides(MCT) and cysteamine hydrochloride(CSH) into the diets of young and growing pigs would stimulate the endogenous somatotropic axis to improve growth and performance.Results: In Experiment 1, weaner pigs were given either a 5 d dietary supplement of 5 % MCT(n = 8) or a control diet(n = 8). MCT increased the plasma concentration of growth hormone(GH; P < 0.05) and the GH secretagogue,ghrelin(P < 0.05). Additionally, the MCT treatment reduced scouring(P < 0.05), maintained villous height in the small intestine(P < 0.05) and stabilised daily weight gain(P < 0.05), compared to the controls. Experiment 2compared the effects of 4 levels(0, 1, 3 and 6 % v/v) of MCT supplementation in grower-finisher male pigs, of approximately 35 kg live weight(n = 15 per treatment). Blood samples taken after 7 wk of treatment showed that the MCT supplementation increased circulating ghrelin(P < 0.001), GH(P < 0.01) and insulin(P < 0.05)concentrations in a dose-dependent manner. Daily weight gain, feed intake and feed conversion ratio were not affected by the MCT diets. In Experiment 3, 64 female pigs of approximately 60 kg live weight were allocated to one of three dietary treatments: control(n = 20); 6 % MCT(n = 21); and 70 mg/kg CSH(n = 21). After 3 wk of supplementation, the MCT treated pigs had a higher plasma concentration of ghrelin compared to the control and CSH pigs(P < 0.05). Plasma concentrations of GH and weight were not affected by any of the dietary treatments.Conclusions: Evidence is provided in Experiment 1 to support the use of dietary MCT supplements, perhaps acting via stimulation of somatotropic endocrine pathways, to minimise weaning-associated disorders such as slowing of growth and diarrhoea. In Experiments 2 and 3, although there was no effect on weight gain or feed conversion ratio in either experiment, MCT and CSH increased endocrine components of the somatotropic axis. | David W.Miller Zoe Prosser Edward Y.W.Chee Christian F.Hansen Frank R.Dunshea Bruce P.Mullan John R.Pluske | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 3 |
| 4 | Tracking domestic ducks:A novel approach for documenting poultry market chains in the context of avian influenza transmission显示文摘Agro-ecological conditions associated with the spread and persistence of highly pathogenic avian influenza(HPAI) are not well understood, but the trade of live poultry is suspected to be a major pathway. Although market chains of live bird trade have been studied through indirect means including interviews and questionnaires, direct methods have not been used to identify movements of individual poultry. To bridge the knowledge gap on quantitative movement and transportation of poultry, we introduced a novel approach for applying telemetry to document domestic duck movements from source farms at Poyang Lake, China. We deployed recently developed transmitters that record Global Positioning System(GPS) locations and send them through the Groupe Spécial Mobile(GSM) cellular telephone system. For the first time, we were able to track individually marked ducks from 3 to 396 km from their origin to other farms, distribution facilities, or live bird markets. Our proof of concept test showed that the use of GPS-GSM transmitters may provide direct, quantitative information to document the movement of poultry and reveal their market chains. Our findings provide an initial indication of the complexity of source-market network connectivity and highlight the great potential for futuretelemetry studies in poultry network analyses. | Chang-Yong Choi John Y Takekawa XIONG Yue LIU Ying Martin Wikelski George Heine Diann J Prosser Scott H Newman John Edwards Fusheng Guo Xiangming Xiao | 2016 | Journal of Integrative Agriculture2016，15，7： | 3 |
| 5 | Predicting the spatial patterns of hillslope sediment delivery to river channels in the Murrumbidgee catchment, Australia显示文摘 | Gert Verstraeten Ian P. Prosser Peter Fogarty | 2006 | Journal of Hydrology2006，，3： | 2 |
| 6 | Increased secretion of insulin- like growth factor I into milk of cows treated with recombinantly derived bovine growth hormone显示文摘 | PROSSER C G | 1989 | J Dairy Res1989，56，： | 2 |
| 7 | Inter-observer agreement for Crohn’s disease sub-phenotypes using the Montreal Classification: How good are we? A multi-centre Australasian study显示文摘 | Krupa Krishnaprasad Jane M. Andrews Ian C. Lawrance Timothy Florin Richard B. Gearry Rupert W.L. Leong Gillian Mahy Peter Bampton Ruth Prosser Peta Leach Laurie Chitti Charles Cock Rachel Grafton Anthony R. Croft Sharon Cooke James D. Doecke Graham L. Rad | 2011 | Journal of Crohn’s and Colitis2011，，3： | 2 |
| 8 | A Comparison of Soil Acidscation and Aluminium under Eucalyptus Forest and Unim- proved Pasture显示文摘 | PROSSER IP HAILES KJ MELVILLE MD | 1993 | Australian Journal of Soil Research1993，31，： | 1 |
| 9 | Mosaiccomplementation demonstrates a regulatory role for myo-sin VIIa in actin dynamics of stereocilia显示文摘 | Prosser H M Rzadzinska A K Steel K P | 2008 | Mol CellBiol2008，28，5： | 1 |
| 10 | Alteration of medical records submitted for medicalegal review显示文摘 | Robert L Prosser Jr | 1992 | JAMA1992，267，19： | 1 |
| 11 | Improving the Quality of Student Learning: The Influence of Learning Context and Student Approaches to Learning on Learning Outcomes 显示文摘 | Trigwell K Prosser M | 1991 | Higher Education1991，22，3： | 1 |
| 12 | Reliability and Validity of the PAS-ADD Checklist for Detecting Psychiatric Disorders in Adults with Intellectual Disability 显示文摘 | MOSS S PROSSER H COSTELLO H | 1998 | Journal of Intellectual Disability Research1998，42，2： | 1 |
| 13 | Infertility in the modem world:presentand fu--ture prospects显示文摘 | Patricia D Prosser | 2001 | Fam Practice2001，18，4： | 1 |
| 14 | Molecular and functional diversity in soil microorganisms显示文摘 | PROSSER J I | | 0，，： | 1 |
| 15 | Comparison of constrained sparse spike and stochastic inversion for porosity prediction at Kristin field显示文摘 | Helgesen J Magnus I Prosser S | | 0，，04： | 1 |
| 16 | Molecular analysis of bacterial community structure and diversity in unimproved and improved upland grass pastures 显示文摘 | Mccaig A E Glover L A Prosser J I | 1999 | Applied and Enviromental Microbiology1999，65，4： | 1 |
| 17 | The use of caprylic acid for the extraction of the immunoglobulin fraction from egg yolk of chickens immunised with ovine alpha - lactalbumind 显示文摘 | MCLAREN R D PROSSER C G GRIEVE R C | 1994 | J Immunol Met1994，177，12： | 1 |
| 18 | Anaphylactic shock due to cefu-roxime in a patient taking penicillin prophylaxis显示文摘 | Prosser DP Gompels M | 2002 | Paed-iatr Anaesth2002，12，1： | 1 |
| 19 | Clinical-Diffusion Mismatch Predicts the Putative Penumbra With High Specificity 显示文摘 | Prosser J Butcher K Allport L | 2005 | Stroke2005，36，： | 1 |
| 20 | Conversion of Hydrogenie Materials to Hydrogen for Isotopic Analysis 显示文摘 | Bigeleisen J Perlman M L Prosser H C | 1952 | Analytical Chemistry1952，24，8： | 1 |
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