|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS显示文摘Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within China's Mainland is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both. | ZHOU ShanShi CAO YueLing ZHOU JianHua HU XiaoGong TANG ChengPan LIU Li GUO Rui HE Feng CHEN JunPing WU Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 31 |
| 2 | High-accuracy primary and transfer standards for radiometric calibration显示文摘The first research and experimental results obtained in China of high-accuracy radiometric calibration based on cryogenic radiometer are reported. Uncertainties of cryogenic radiometer and trap detectors at 7 wavelengths in the visible spectrum (488-786 nm) were less than 0.023% and 0.035% respectively, which proved the reasonability and possibility of establishing and transferring high-accuracy radiometric standards based on detectors. | Xiaobing Zheng Haoyu Wu Junping Zhang Yucheng Liu Wei Zhou Leyi Wang Yanli Qiao | 2000 | Chinese Science Bulletin2000，45，21： | 12 |
| 3 | Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer worldwide.Although many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully clarified.Methods:A total of 165 HCC patients,including 146 males and 19 females,were enrolled.The median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene sequencing.Genomic alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were analyzed.Tumor mutational burden(TMB)was measured by an algorithm developed in-house.The top quartile of HCC was classified as TMB high.Results:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC tissues.TMB values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/Mb.The most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and FGF19.SNV was the most common mutation type and C:G>T:A and guanine transformation were the most common SNVs.Compared to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TERT was independently correlated with tumor invasion of the liver capsule(P=0.001,OR=3.030),and the mutation of CTNNB1 was independently correlated with AFP(<25μmg/L)(P=0.009,OR=3.414).Conclusions:The most frequently mutated genes of HCC patients in China were TP53,TERT,and CTNNB1,which mainly lead to the occurrence and development of HCC by regulating the P53 pathway,Wnt pathway,and telomere repair pathway.There were more patients with microvascular invasion and Edmondson III-IV grade in TP53 mutated patients and more patients with hepatic capsule invasion in TERT mutated patients,while in CTNNB1 mutated patients,there were more patients with Edmondson I-II grade,AFP<25μmg/L,and a non-hepatitis B background.Also,the TMB values were significantly higher in CTNNB1 mutated patients than in wild type patients. | Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi Yunjin Zang Jingyu Cao Liqun Wu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 8 |
| 4 | Danggui-shaoyao-san, a traditional Chinese medicine prescription, alleviates the orthodontic pain and inhibits neuronal and microglia activation显示文摘 | Li Hongshi Gu Zexu Wu Li'an Xia Liang Zhou Kecheng E Lingling Wang Dongsheng Kou Junping Liu Hongchen | 2014 | Chinese Medical Journal2014，，20： | 4 |
| 5 | GNSS clock corrections densification at SHAO:from 5 min to 30 s显示文摘High frequency multi-GNSS zero-difference applications like Precise Orbit Determination(POD)for Low Earth Orbiters(LEO)and high frequency kinematic positioning require corresponding high-rate GNSS clock corrections.The determination of the GNSS clocks in the orbit determination process is time consuming,especially in the combined GPS/GLONASS processing.At present,a large number of IGS Analysis Centers(AC)provide clock corrections in 5-min sampling and only a few ACs provide clocks in 30-s sampling for both GPS and GLONASS.In this paper,an efficient epoch-difference GNSS clock determination algorithm is adopted based on the algorithm used by the Center for Orbit Determination in Europe(CODE).The clock determination procedure of the GNSS Analysis Center at Shanghai Astronomical Observatory(SHAO)and the algorithm is described in detail.It is shown that the approach greatly speeds up the processing,and the densified 30-s clocks have the same quality as the 5-min clocks estimated based on a zero-difference solution.Comparing the densified 30-s GNSS clocks provided by SHAO with that of IGS and its ACs,results show that our 30-s GNSS clocks are of the same quality as that of IGS.Allan deviation also gives the same conclusion.Further validation of the SHAO 30-s clock product is performed in kinematic PPP and LEO POD.Results indicate that the positions have the same accuracy when using SHAO 30-s GNSS clocks or IGS(and its AC)finals.The robustness of the algorithm and processing approach ensure its extension to provide clocks in 5-s or even higher frequencies.The implementation of the new approach is simple and it could be delivered as a black-box to the current scientific software packages. | CHEN JunPing ZHANG YiZe ZHOU XuHua PEI Xiao WANG JieXian WU Bin | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，1： | 4 |
| 6 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 7 | Cross-media Hot Topic Auto-tracking Model Based on Semantics and Temporal Context显示文摘As the Internet multimedia information grows explosively, seeking an automatic technology to realize the effective organization and management of crossmedia emergency information is significantly necessary. A novel cross-media hot topic auto-tracking model based on semantics and temporal context is proposed in this paper. According to the semantic correlations of cross-media information, we learn the image visual semantics by the text semantics based on the Latent Dirichlet Allocation probability model, and establish the unified cross-media information description on the same semantic level. Also a semantics-based two-step feature dimension-reduction scheme is proposed to establish the efficient semantic feature space. The self-adaptive learning of topic model is realized to track the dynamic changes in the topic. Experimental results demonstrate that the proposed method outperforms the existing methods, which further improves the effect of hot topic auto-tracking. | LIANG Meiyu DU Junping ZHOU Yipeng | 2015 | Chinese Journal of Electronics2015，24，3： | 3 |
| 8 | Targeted thrombolysis strategies for neuroprotective effect显示文摘Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with adverse effects such as fibrinogenolysis and bleeding. In an attempt to increase the efficacy, safety, and specificity of thrombolytic therapy, a number of targeted thrombolytic agents have been studied in recent years. This review focuses on the concepts underlying targeted thrombolytic therapy and describes recent drug developments in this field. | Junping Zhang Guoxing Ma Zhimin Lv Yu Zhou Chunguang Wen Yaqing Wu Ruian Xu | 2014 | Neural Regeneration Research2014，9，13： | 2 |
| 9 | The mobilization of rat’s mesenchymal stem cells into peripheral blood by LiCL and its potency differentiation显示文摘Mesenchymal stem cells (MSCs) are multipotent cells, which can differentiate into different tissues. It is still controversial whether MSCs can be isolated from adult peripheral blood (PB) under normal conditions and whether they can be mobilized in a way similar to that of hematopoietic stem cells (HSCs). In this study, rat MSCs circulating in the PB under normal conditions can be isolated and cultured, and MSCs from PB and BM can be mobilized by LiCL. The mobilized MSCs can be induced to differentiate into neuron by such factors as β-mercaptoethanol and supernatants of nerve cell cultures. The present study provides a broader perspective on the repair of neural trauma. | DENG dun ZOU ZhongMin ZHOU TaoLi AI GuoPing WANG JunPing DONG ShiWu SU YongPing | 2008 | Chinese Science Bulletin2008，53，17： | 2 |
| 10 | Immune activities comparison of polysaccharide and polysaccharide-protein complex from Lycium barbarum L.显示文摘 | Xiaorui Zhang Yingjie Li Junping Cheng Gang Liu Chunhui Qi Wenxia Zhou Yongxiang Zhang | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 11 | An efficient CRISPR/Cas9 platform for targeted genome editing in rose(Rosa hybrida)显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-related nuclease 9(Cas9)system enables precise,simple editing of genes in many animals and plants.However,this system has not been applied to rose(Rosa hybrida)due to the genomic complexity and lack of an efficient transformation technology for this plant.Here,we established a platform for screening single-guide RNAs(sgRNAs)with high editing efficiency for CRISPR/Cas9-mediated gene editing in rose using suspension cells.We used the Arabidopsis thaliana U6-29 promoter,which showed high activity for driving sgRNA expression,to modify the CRISPR/Cas9 system.We used our highly efficient optimized CRISPR/Cas9 system to successfully edit RhEIN2,encoding an indispensable component of the ethylene signaling pathway,resulting in ethylene insensitivity in rose.Our optimized CRISPR/Cas9 system provides a powerful toolbox for functional genomics,molecular breeding,and synthetic biology in rose. | Chengpeng Wang Yang Li Na Wang Qin Yu Yonghong Li Junping Gao Xiaofeng Zhou Nan Ma | 2023 | Journal of Integrative Plant Biology2023，65，4： | 1 |
| 12 | Study of the influence of the electric field on membrane flux of a new type of membrane bioreactor 显示文摘 | Chen Junping Yang Changzhu Zhou Jiahua | 2007 | Chemical Engineering Journal2007，128，23： | 1 |
| 13 | LDTS: A lightweight and dependable trust system for clustered wireless sensor networks显示文摘 | Li Xiaoyong Zhou Feng Du Junping | 2013 | IEEE Translnformation Forensics and Security2013，8，6： | 1 |
| 14 | Agrobacterium tumefaciens-mediated transformation of modern rose(Rosa hybrida)using leaf-derived embryogenic callus显示文摘Rose(Rosa hybrida)is widely used for cut flowers and as garden plants.Stable and efficient transformation system is required for functional genomics of rose.Here,we established an efficient transformation method for rose using Agrobacterium tumefaciens-mediated transformation of embryogenic callus.Expanding rose leaves were used as explants to induce somatic embryos,which were subjected to transformation with A.tumefaciens strain GV3101 using Green Fluorescence Protein(GFP)as a marker gene.It took about 8 months to generate transgenic shoots from embryogenic callus.PCR,RT-PCR,Southern and Western blotting,as well as stereoscopic fluorescence microscopy analysis demonstrated that GFP transgenes integrated stably into the rose genome.According to our data,a transformation efficiency of up to 6%can be achieved by following this optimized protocol. | Guoqin Liu Yuan Yuan Hui Jiang Ying Bao Guogui Ning Liangjun Zhao Xiaofeng Zhou Hougao Zhou Junping Gao Nan Ma | 2021 | Horticultural Plant Journal2021，7，4： | 1 |
| 15 | Coordinating ordering,pricing and advertising policies for a supply chain with random demand and two production modes显示文摘 | Wang Shengdong Zhou Yongwu Wang JunPing | | 0，，02： | 1 |
| 16 | In vivo characterization of a novel GnRH (gonadotropin-releasing hormone) antagonist,LXT-101 ,in normal male rats显示文摘 | CHI Xiaoli ZHOU Wenxia CHENG Junping | 2006 | Regul Pept2006，136，13： | 1 |
| 17 | Mechanical properties, water-swelling behavior, and morphology of water-swellable rubber prepared using erosslinked sodium polyacrylate显示文摘 | Changsheng Liu Junping Ding Lang Zhou | 2006 | Journal of Applied Polymer Science2006，，102： | 1 |
| 18 | Ultrasound- assisted ionic liquid dispersive liquid-phase a novel approach for the sensitive determination of aromatic amines in water samples显示文摘 | ZHOU Qingxiang ZHANG Xiaoguo XIAO Junping | 2009 | Journal of Chromatography A2009，1216，20： | 1 |
| 19 | Type2d Iabetesandsyndromecharacter Ist Icsof显示文摘 | Wei Junp Ing Zhou LIbo LIu Fang Zhong Zhen LIu Ya jun Cao A Im ei Wang XIu zhi Zhu Yan Yu Bo LIu XIa Zhang Yanni To ng XIaol In | | 0，，12： | 1 |
| 20 | High-resolution mapping of the Alp locus and identification of a candidate gene HvMATE controlling aluminium tolerance in barley (Hordeum vulgare L.)显示文摘 | Junping Wang Harsh Raman Meixue Zhou Peter R. Ryan Emmanuel Delhaize Diane M. Hebb Neil Coombes Neville Mendham | 2007 | Theoretical and Applied Genetics2007，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员