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| 1 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 2 | 16 × 16 silicon Mach–Zehnder interferometer switch actuated with waveguide microheaters显示文摘We experimentally demonstrate a 16 × 16 reconfigurably nonblocking optical switch fabric using a Benes architecture. The switch fabric consists of 56 2 × 2 Mach–Zehnder interferometer based elementary switches, with each integrated with a pair of waveguide microheaters. The average on-chip insertion loss is ~5.2 dB for both of the 'all-cross' and the 'all-bar' states, with a loss variation of 1 dB over all routing paths. The cross talk for all switching states is better than -30 d B. The switching time of the switch element is about 22 μs. The switching functionality is verified by transmission of a 40 Gb∕s quadrature phase-shift keying optical signal. | Shuoyi Zhao Liangjun Lu Linjie Zhou Dong Li Zhanzhi Guo Jianping Chen | 2016 | Photonics Research2016，4，5： | 7 |
| 3 | Identification and Functional Analysis of Three MAX2 Orthologs in Chrysanthemum显示文摘MORE AXILLARY BRANCHING 2 (MAX2), initially identified in Arabidopsis thaliana, is a key regulatory gene in strigolactone signal transduction. Three orthologs of MAX2 were cloned from Dendranthema grandiflorum (DgMAX2a, b, and c). Each of the genes has an open reading frame of 2,049 bp and encodes 682 amino acid proteins. The predicted amino acid sequences of the three DgMAX2s are most closely related to the MAX2 orthologs identified in petunia (PhMAX2A and PhMAX2B), and display the highest amino acid sequence similarity with PhMAX2A compared to other MAX2s. Expression analysis revealed that DgMAX2s are predominantly expressed in the stem and axillary buds. On a cellular level, we localized the DgMAX2a::GFP fusion protein to the nucleus in onion epidermal cells, which is consistent with the nuclear localization of MAX2 in Arabidopsis. The chrysanthemum DgMAX2a is able to restore the max2-1 mutant branching to wild-type (WT) Arabidopsis, suggesting that it is a functional MAX2 ortholog. These results suggest that DgMAX2s may be candidate genes for reducing the shoot branching of chrysanthemum. | Lili Dong Abdurazak Ishak Jing Yu Ruiyan Zhao Liangjun Zhao | 2013 | Journal of Integrative Plant Biology2013，55，5： | 6 |
| 4 | 4×4 nonblocking optical switch fabric based on cascaded multimode interferometers显示文摘We experimentally demonstrate a 4 × 4 nonblocking silicon thermo-optic(TO) switch fabric consisting of three stages of tunable generalized Mach–Zehnder interferometers. All 24 routing states for nonblocking switching are characterized. The device's footprint is 4.6 mm × 1.0 mm. Measurements show that the worst cross talk of all switching states is-7.2 dB. The on-chip insertion loss is in the range of 3.7–13.1 dB. The average TO switching power consumption is 104.8 mW. | Zuxiang Li Linjie Zhou Liangjun Lu Shuoyi Zhao Dong Li Jianping Chen | 2016 | Photonics Research2016，4，1： | 2 |
| 5 | Plant regeneration through protocorm-like bodies induced from rhizoids using leaf explants of Rosa spp.显示文摘 | Chuanwei Tian Ying Chen Xiaolan Zhao Liangjun Zhao | 2008 | Plant Cell Reports2008，，5： | 2 |
| 6 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 7 | Simultaneous detection of porcine circovirus type 2, classical swine fever virus, porcine parvovirus and porcine reproductive and respiratory syndrome virus in pigs by multiplex polymerase chain reaction显示文摘 | Yonghou Jiang Hanwu Shang Hui Xu Liangjun Zhu Weijie Chen Lingyan Zhao Li Fang | 2008 | The Veterinary Journal2008，，2： | 1 |
| 8 | Agrobacterium tumefaciens-mediated transformation of modern rose(Rosa hybrida)using leaf-derived embryogenic callus显示文摘Rose(Rosa hybrida)is widely used for cut flowers and as garden plants.Stable and efficient transformation system is required for functional genomics of rose.Here,we established an efficient transformation method for rose using Agrobacterium tumefaciens-mediated transformation of embryogenic callus.Expanding rose leaves were used as explants to induce somatic embryos,which were subjected to transformation with A.tumefaciens strain GV3101 using Green Fluorescence Protein(GFP)as a marker gene.It took about 8 months to generate transgenic shoots from embryogenic callus.PCR,RT-PCR,Southern and Western blotting,as well as stereoscopic fluorescence microscopy analysis demonstrated that GFP transgenes integrated stably into the rose genome.According to our data,a transformation efficiency of up to 6%can be achieved by following this optimized protocol. | Guoqin Liu Yuan Yuan Hui Jiang Ying Bao Guogui Ning Liangjun Zhao Xiaofeng Zhou Hougao Zhou Junping Gao Nan Ma | 2021 | Horticultural Plant Journal2021，7，4： | 1 |
| 9 | Characterization of CIbl gene promoter from silkworm, Bombyx mori 显示文摘 | Zhao Qiaoling Shen Xingjia Zhu Liangjun | 2007 | Zeitschrift fur Natuforschung2007，62，： | 1 |
| 10 | Geology of the Grove Mountains in East Antarctica显示文摘 | Xiaohan Liu Yue Zhao Xiaochun Liu Liangjun Yu | 2003 | Science in China Series D: Earth Sciences2003，，4： | 1 |
| 11 | Geology of the Grove Mountains in East Antarctica显示文摘 | Xiaohan Liu Yue Zhao Xiaochun Liu Liangjun Yu | 2003 | Science in China Series D: Earth Sciences2003，，4： | 1 |
| 12 | Constructing ultrastable electrode/electrolyte interface for rapid potassium ion storage capability via salt chemistry and interfacial engineering显示文摘Conversion/alloying anode materials exhibiting high K storage capacities suffer from large volume variations and unstable electrode/electrolyte interfaces upon cycling.Herein,taking SnS/reduced graphene oxide(SnS/rGO)anodes as an example,the electrochemical performance of SnS/rGO could significantly be improved via employing potassium bis(fluorosulfonyl)imide(KFSI)salt in electrolytes and ultrathin TiO_(2) coating.KF-rich inorganic layer was demonstrated to help form robust SEI layer,which could suppress the side reactions to increase the Coulombic efficiency.The formed potassiated K_(x)TiO_(2) coating layer was constructed to boost charge transfer capability and K-ion diffusion kinetics.The as-prepared SnS/rGO@TiO_(2)-20 electrode in KFSI electrolyte delivers the high CE of 99.1%and 424 mAh·g^(−1) after 200 cycles with an ultrahigh capacity retention of 98.5%. | Sheng Wen Xin Gu Xiangwei Ding Li Zhang Pengcheng Dai Liangjun Li Dandan Liu Wenchao Zhang Xuebo Zhao Zaiping Guo | 2022 | Nano Research2022，15，3： | 0 |
| 13 | Chromosome-scale genome assembly of marigold (Tagetes erecta L.):An ornamental plant and feedstock for industrial lutein production显示文摘Marigold(Tagetes erecta L., African marigold) is a widely grown ornamental plant and a main source of the carotenoid lutein for the industrial production of pharmaceuticals, food coloring, and feed additives. To gain a deeper understanding of the genetic mechanism of lutein in marigold, a chromosome-scale assembly of the marigold(T. erecta V-01) genome was completed based on Illumina, PacBio, and Hi-C reads. The707.21-Mb assembled genome consisted of 35 834 annotated protein-coding genes, with 97.7% genomic integrity. We anchored 87.8% of the contigs(covering 621.20 Mb) to 12 pseudochromosomes, bringing the scaffold N50 length to 54.15 Mb. Phylogenetic analysis showed that marigold was closely related to the Asteraceae species bitter vine(Mikania micrantha) and sunflower(Helianthus annuus), all three of which originated in the Americas. Marigold diverged from the sunflower clade 23.57 million years ago(MYA) and from M. micrantha 19.59 MYA.Marigold has undergone three whole-genome duplication events, as well as a recent whole-genome duplication event(WGD-2) common to H.annuus and M. micrantha. Marigold gene families were significantly less expanded than those of M. micrantha or H. annuus, and the marigold genome contained significantly fewer interspersed repeats, which might account for its smaller genome. In addition, a range of candidate genes involved in the lutein biosynthetic pathway were identified. The high-quality reference genome obtained in this study provided a valuable genomic resource for studying the evolution of the Asteraceae family and for improving marigold breeding strategies. | Haibo Xin Fangfang Ji Jie Wu Shiya Zhang Caijie Yi Shiwei Zhao Richen Cong Liangjun Zhao Hua Zhang Zhao Zhang | 2023 | Horticultural Plant Journal2023，9，6： | 0 |
| 14 | Current perspectives on shoot branching regulation显示文摘Shoot branching is regulated by the complex interactions among hormones, development, and environmental factors. Recent studies into the regulatory mechanisms of shoot branching have focused on strigolactones,which is a new area of investigation in shoot branching regulation. Elucidation of the function of the D53 gene has allowed exploration of detailed mechanisms of action of strigolactones in regulating shoot branching. In addition,the recent discovery that sucrose is key for axillary bud release has challenged the established auxin theory, in which auxin is the principal agent in the control of apical dominance. These developments increase our understanding of branching control and indicate that regulation of shoot branching involves a complex network. Here, we first summarize advances in the systematic regulatory network of plant shoot branching based on current information. Then we describe recent developments in the synthesis and signal transduction of strigolactones.Based on these considerations, we further summarize the plant shoot branching regulatory network, including long distance systemic signals and local gene activity mediated by strigolactones following perception of external environmental signals, such as shading, in order to provide a comprehensive overview of plant shoot branching. | Cunquan YUAN Lin XI Yaping KOU Yu ZHAO Liangjun ZHAO | 2015 | Frontiers of Agricultural Science and Engineering2015，2，1： | 0 |
| 15 | Guangdong Dapeng LNG cold energy utilization-C_2++ extraction process integration显示文摘This paper makes a study of some technical and engineering aspects by using C2+ hydrocarbon separation facility at Guangdong Dapeng liquefied natural gas (GDLNG) terminal. In the C2+ hydrocarbon extraction process,the cold energy contained in LNG will be utilized. In order to ensure the optimum operating conditions of the terminal and C2+ hydrocarbon extraction facility by optimizing the current operating processes of the terminal,the C2+ hydrocarbon extraction facility construction plan is proposed. We conducted numerous calculations and simulations using such specific analysis software as PRO II. Additionally available flow data are used to verify the cyclic send-out rates from the terminal,thus establishing the current and future projected load factors. This study is intended to make sure that GDLNG can continue to supply gas via the pipeline system safely without interruptions and most significantly solves the effects of flow fluctuations at the terminal gasification send-out facility on the hydrocarbons extraction,ensuring optimum pipeline operations and ensuring safe and effective means for such C2+ hydrocarbons extraction process as well. At the same time,the terminal is also in the optimum operation condition. This is very significant to the terminal safety operation and the energy conservation and emission reduction. | Wang liangjun Liu Yang Andrew C. Potocki Zhao Xueliang Dong Shaohua | 2010 | Engineering Sciences2010，8，2： | 0 |
| 16 | The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants显示文摘Coronavirus disease 2019(COVID-19),the disease caused by infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Since the first SARS-CoV-2 genome was released[1],thousands of genetic variants have been identified in SARS-CoV-2 strains isolated from worldwide patients. | Ben Hu Ran Liu Xiaolu Tang Yuchen Pan Ming Wang Yongqing Tong Guangming Ye Gaigai Shen Ruochen Ying Aisi Fu Di Li Wanxu Zhao Jing Peng Jie Guo Dong Men Xinmin Yao Yirong Wang Hong Zhang Zhihui Feng Junping Yu Liangjun Chen Zixin Deng Xuemei Lu Ya-Ping Zhang Yirong Li Bende Liu Lilei Yu Yan Li Jian Lu Tiangang Liu | 2021 | National Science Review2021，8，8： | 0 |
| 17 | Numerical Investigation of the Superimposed Effects on Stator Wake Oscillation in an Axial-radial Combined Compressor显示文摘The superimposed influences of the blade rows in a multistage compressor are important because different matches of upstream and downstream blades can result in significant differences in the stator wake oscillation. Numerical investigation of the axial stator wake oscillation, which is affected upstream by the axial rotor and downstream by the radial rotor, was performed in an axial-radial combined compressor. Many configurations with different blade numbers and locations, which influence axial stator wake oscillation were investigated. When rotors have equal blade numbers, the axial stator wake oscillates periodically versus time within time T(moving blade passing 1/3 revolution). In contrast, stator wake oscillates irregularly within T when rotors have different blade numbers. A model-split subtraction method is presented in order to separate the influences of the individual blade rows on the wake oscillation of the axial stator. Analysis from the rotor-stator configuration showed that the unsteady flow angle fluctuation response is caused by the upstream rotor. For the rotor-stator-rotor configuration, the unsteady flow angle fluctuations are influenced by upand downstream blade rows. With the model-split subtraction method, the upand downstream influences on the flow angle fluctuation could be clearly separated and quantified. Low amplitudes could be observed when the influences from upand downstream moving rows were superimposed with the 'positive peaknegative peak' type wave. Clocking investigations were carried out to change the relative superimposed phase of influences from the surrounding blade rows in order to modulate the amplitudes of the axial stator wake oscillation. However, the amplitudes did not reach the maximum when they were superimposed with 'positive peak-positive peak' type wave due to the impact of the interaction between the two moving blade rows. | ZHAO Ben YANG Ce HU Liangjun ZHOU Mi ZHANG Jizhong | 2014 | Journal of Thermal Science2014，23，1： | 0 |
| 18 | Continuous synthesis for zirconium metal-organic frameworks with high quality and productivity via microdroplet flow reaction显示文摘Zirconium metal-organic frameworks(Zr-MOFs) represent the most promising candidates among MOFs for industrial utilizations owing to their high porosity and excellent stability. However, the efficient synthesis of Zr-MOFs combining with continuous production, high productivity and good product quality still remains a critical issue for practical applications. Herein, we report an efficient method of synthesizing a series of Zr-MOFs through a microdroplet flow reaction, which is more accommodate the requirements of industrial production. Four types of Zr-based MOFs with different ligands and topologies(MOF-801, MOF-804, DUT-67 and MOF-808) were produced as a pure phase of high quality crystalline with uniform morphologies. Furthermore, this series of Zr-MOFs were obtained in a continuous way and at a space-time yield(STY) highly up to 367.2 kg m^(-3) d^(-1). These MOFs exhibit the similar pore structure and thermal stability with that prepared from conventional solvothermal synthesis. CO_2 sorption studies on these MOFs demonstrate that the hydroxyl groups on ligand can render MOFs with high CO_2/N_2 selectivity. | Ying Wang Liangjun Li Liting Yan Lei Cao Pengcheng Dai Xin Gu Xuebo Zhao | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
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