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| 1 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 2 | Chemical Constituents from Roots of Flemingia philippinensis显示文摘Objective To study the chemical constituents from the roots of Flemingia philippinensis. Methods The chemical constituents were isolated and purified by combination of silica gel column, Sephadex LH-20, polyamide, and ODS column chromatography. The structures of the isolated compounds were identified by means of spectral data. Results Ten compounds were isolated from F. philippinensis and identified as isoderrone (1), dalparvin A (2), prunetin (3), 7,3′-dihydroxy-5,4′,5′-trimethoxyisoflavone (4), pratensein-7-O-β-D-glucoside (5), sissotrin (6), sophororicoside (7), formononetin (8), orobol (9), and biochanin A (10). Conclusion Compounds 1-6 are obtained from this plant for the first time. | Man-qin FU Dun DENG Shi-xiu FENG Ri-ming HUANG Shuai TIAN Sheng-xiang QIU | 2012 | Chinese Herbal Medicines2012，4，1： | 7 |
| 3 | Three Super Active Regions in the Descending Phase of Solar Cycle 23显示文摘We analyze the magnetic configurations of three super active regions,NOAA 10484, 10486 and 10488, observed by the Huairou Multi-Channel Solar Telescope (MCST) from 2003 October 18 to November 4. Many energetic phenomena,such as flares (including a X-28 flare) and coronal mass ejections (CMEs), occurred during this period. We think that strong shear and fast emergence of magnetic flux are the main causes of these events. The question is also of great interest why these dramatic eruptions occurred so close together in the descending phase of the solar cycle. | Hong-Qi Zhang, Xing-Ming Bao, Yin Zhang, Ji-Hong Liu, Shu-Dong Bao, Yuan-Yong Deng, Wei Li, Jie Chen, Jin-Ping Dun, Jiang-Tao Su, Juan Guo, Xiao-Fan Wang, Ke-Liang Hu, Gang-Hua Lin and Dong-Guang WangNational Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 | 2003 | Chinese Journal of Astronomy and Astrophysics2003，3，6： | 2 |
| 4 | The mobilization of rat’s mesenchymal stem cells into peripheral blood by LiCL and its potency differentiation显示文摘Mesenchymal stem cells (MSCs) are multipotent cells, which can differentiate into different tissues. It is still controversial whether MSCs can be isolated from adult peripheral blood (PB) under normal conditions and whether they can be mobilized in a way similar to that of hematopoietic stem cells (HSCs). In this study, rat MSCs circulating in the PB under normal conditions can be isolated and cultured, and MSCs from PB and BM can be mobilized by LiCL. The mobilized MSCs can be induced to differentiate into neuron by such factors as β-mercaptoethanol and supernatants of nerve cell cultures. The present study provides a broader perspective on the repair of neural trauma. | DENG dun ZOU ZhongMin ZHOU TaoLi AI GuoPing WANG JunPing DONG ShiWu SU YongPing | 2008 | Chinese Science Bulletin2008，53，17： | 2 |
| 5 | Morphological and proteomic analysis of early stage of osteoblast differentiation in osteoblastic progenitor cells显示文摘 | Dun Hong Hai-Xiao Chen Hai-Qiang Yu Yong Liang Carrie Wang Qing-Quan Lian Hai-Teng Deng Ren-Shan Ge | 2010 | Experimental Cell Research2010，，14： | 1 |
| 6 | Tauroursodeoxycholic acid(TUDCA)improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets显示文摘Background:Tauroursodeoxycholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary diseases.Meanwhile,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in mice.However,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely unclear.Methods:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying mechanisms.In vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,respectively.Three female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were collected.In vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to explore the possible underlying mechanisms.Results:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and immunity.In addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier function.Furthermore,the in-vitro results showed that TUDCA improved the E.coli-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGR5)protein expression.However,knockdown of TGR5 and inhibition of myosin light chain kinase(MLCK)pathway abolished the TUDCA-improved epithelial barrier impairment in E.coli-treated IPEC-J2 cells,indicating the involvement of TGR5-MLCK in this process.Conclusions:These findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets,suggesting the potential application of TUDCA in improving gut health in piglet production. | Min Song Fenglin Zhang Yiming Fu Xin Yi Shengchun Feng Zhichang Liu Dun Deng Qiang Yang Miao Yu Canjun Zhu Xiaotong Zhu Lina Wang Ping Gao Gang Shu Xianyong Ma Qingyan Jiang Songbo Wang | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 7 | Supplementing l-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs显示文摘 | Yulong Yin Kang Yao Zhaojin Liu Min Gong Zheng Ruan Dun Deng Bie Tan Zhiqiang Liu Guoyao Wu | 2010 | Amino Acids2010，，5： | 1 |
| 8 | 猪Enho基因的分子克隆及其仔猪的组织分布(英文)显示文摘目的:通过pEnho基因的克隆,分析p Enho基因在仔猪相关组织的分布情况,增加仔猪糖脂代谢方面相关的知识,为通过调控adropin来促进仔猪的健康和生长提供理论基础。创新点:首次克隆了猪Enho基因,命名为p Enho,其基因序列提交至美国国立生物技术信息中心(NCBI)(No.GQ414763)。方法:通过实时荧光定量逆转录聚合酶链式反应(real-time RT-PCR)方法获得猪Enho基因序列,并应用BLAST、Clustal W、PHYLIP、TMHMM、Helixturnhelix等生物信息学软件对其基因序列进行分析;通过荧光定量PCR方法检测了不同日龄(出生后1、7、14和21天)猪Enho基因的组织分布(肝脏、肌肉、空肠前端、空肠后端和回肠)。结论:克隆得到p Enho基因序列;发现随着仔猪日龄的增加,其表达量有下降;在组织分布上,产后7天内p Enho在肠道(特别是回肠)的表达量较高,在第14天和第21天,各被检组织的表达量无显著差异。 | Sheng-ping WANG Yun-ling GAO Gang LIU Dun DENG Rong-jun CHEN Yu-zhe ZHANG Li-li LI Qing-qi WEN Yong-qing HOU Ze-meng FENG Zhao-hui GUO | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，6： | 0 |
| 9 | Irregular Spatial Distributions of Spectral Line Parameters in the Middle Solar Chromosphere Revealed from Analysis of Solar Flash MgⅠb_(2)Spectra显示文摘This paper presents the analytical results of solar MgⅠb_(2)flash spectra,obtained by the prototype Fiber Arrayed Solar Optic Telescope in process of the 2013 Gabon total solar eclipse.The analysis reveals irregular distributions of the spectral line parameters like ratio of line source function to continuum oneβ,ratio of line emissivity to continuum emissivityζ,ratio of the continuum opacity to the line opacity r_(0),line center optical depthτ_(0)、,the line widthΔλ_(D),and the line-of-sight velocity v_(los),while the approximately spherical symmetry can be found in the maps of integrated line intensity and continuum intensity.These irregular distributions originate from those of line profile features like the maximum intensity,the line width and line center wavelength.It is also found from the recovered line center optical depthτ_(0) that in the middle chromosphere,the optical depth is not small due to nonignorable absorption and the long light path along the line-of-sight.Finally,we show that the excessive broadening of spectral lines can be due to co-existence of multiple radiative sources with different line-of-sight velocities unresolved in one detector pixel. | Yuhang Jin Zhongquan Qu Zhi Xu Guangtao Dun Liang Chang Xiangming Cheng Xiaoyu Zhang Linhua Deng Yang Peng | 2022 | Research in Astronomy and Astrophysics2022，22，8： | 0 |
| 10 | A New Post-hoc Flat Field Measurement Method for the Solar X-Ray and Extreme Ultraviolet Imager Onboard the FengYun-3E Satellite显示文摘Extreme ultraviolet(EUV)observations are widely used in solar activity research and space weather forecasting since they can observe both the solar eruptions and the source regions of the solar wind.Flat field processing is indispensable to remove the instrumental non-uniformity of a solar EUV imager in producing high-quality scientific data from original observed data.FengYun-3E(FY-3E)is a meteorological satellite operated in a Sunsynchronous orbit,and the routine EUV imaging data from the Solar X-ray and Extreme Ultraviolet Imager(X-EUVI)onboard FY-3E has the characteristic of concentric rotation.Taking advantage of the concentric rotation,we propose a post-hoc flat field measurement method for its EUV 195A channel in this paper.This method removes the small-scale and time-varying component of coronal activities by taking the median value for each pixel along the time axis of a concentric rotation data cube,and then derives the large-scale and invariable component of the quiet coronal radiation,and finally generates a flat field image.The flat field can be generated with cadences from hundreds of minutes(one orbit)to several days.Higher flat field accuracy can be achieved by employing more data.Further analysis shows that our method is able to measure the instrumental spot-like nonuniformity possibly caused by contamination on the detector,which mostly disappears after the in-orbit selfcleaning process.It can also measure the quasi-periodic grid-like non-uniformity,possibly from the obscuration of the support mesh on the rear filter.After flat field correction,these instrumental non-uniformities from the original data are effectively removed.Moreover,the X-EUVI 195A data after dark and flat field corrections are consistent with the 193A imaging data from the Atmospheric Imaging Assembly onboard the Solar Dynamics Observatory,verifying the suitability of the method.The post-hoc method does not occupy observation time,which is advantageous for space weather operations.Our method is not only suitable for FY-3E/X-EUVI but also a candidate method for the flat field measurement of future solar EUV telescopes. | Qiao Song Xianyong Bai Bo Chen Xiuqing Hu Yajie Chen Zhenyong Hou Xiaofan Zhang Lingping He Kefei Song Peng Zhang Jing-Song Wang Xiaoxin Zhang Weiguo Zong Jinping Dun Hui Tian Yuanyong Deng | 2022 | Research in Astronomy and Astrophysics2022，22，10： | 0 |
| 11 | Analysis of Overall Popularization of Low-Protein Diet显示文摘The shortage of protein feed resources and environmental pollution restrict the healthy and sustainable development of breeding industry,so it is imperative to promote low protein diet. Based on the current industry trends and national policies, this paper analyzes the background con-ditions, significance and specific measures of popularizing low-protein diets, in order to provide policy, theoretical and technical support for the im-plementation of low-protein diets throughout the year. | Ma Xianyong Tian Zhimei Deng Dun Li Zhenming Cui Yiyan Rong Ting Liu Zhichang Lu Huijie Wang Gang Chen Weidong | 2019 | Animal Husbandry and Feed Science2019，11，1： | 0 |
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