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| 1 | BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity显示文摘基础编辑() ,包含 cytidine 脱氨基酶和催化地有缺点的 Cas9,广泛地被用来执行基础编辑。然而,狭窄的编辑窗口是限制它的实用程序。这里,我们开发了依照到由熔化 10 的 U (T) 范围(加) 的更大的 C 为招募 GCN4 肽拷贝到 nCas9 (D10A ) 的编程作为基础编辑命名的一种新编辑技术 scFv-APOBEC-UGI-GB1 到目标地点。新系统完成与一扇拓宽的窗户的基础编辑,导致一个增加的指向染色体的范围。有趣地,新系统很产出更少讨厌的 indels 和 non-C-to-T 变换。我们也通过站 codons (iSTOP ) 的正式就职越过整个染色体在基因混乱表明了它的潜在的使用。一起拿,加系统与编辑窗口和提高的忠实增加提供一个新编辑工具。 | Wen Jiang Songjie Feng Shisheng Huang Wenxia Yu Guanglei Li Guang Yang Yajing Liu Yu Zhang Lei Zhang Yu Hou Jia Chen Jieping Chen Xingxu Huang | 2018 | Cell Research2018，28，8： | 20 |
| 2 | An 8.1Ma calcite record of Asian summer monsoon evolution on the Chinese central Loess Plateau显示文摘Carbonates in loess-red clay sequences consist mainly of calcite and dolomite. The EDTA analysis of carbonates in different size fractions and magnetic susceptibility reveal that calcite is a sensitive index of summer monsoon. The chemical analysis of carbonates and calcite from an 8.1 Ma loess-red clay sequence at Chaona on the Chinese central Loess Plateau shows that the evolution of the Asian summer monsoon experienced four stages, namely 8.1―5.5 Ma, 5.5―2.8 Ma, 2.8―1.5 Ma and 1.5―0 Ma, with increasing intensification and fluctuation, suggesting a possible combining impacts of uplift of the Tibetan Plateau and global changes on the Asian summer monsoon. | CHEN XiuLing FANG XiaoMin AN ZhiSheng HAN WenXia WANG Xin BAI Yan HONG Ye | 2007 | Science China Earth Sciences2007，50，3： | 16 |
| 3 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 4 | In vivo evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria显示文摘这个工作试图估计散开的价值加权的成像(DWI ) 和在有希望地与 normoalbuminuria (NAU ) 对 microalbuminuria (MAU ) 在类型 2 糖尿病的病人检测早阶段的肾损害的散开张肌成像(DTI ) 。有正常的肾功能的 30 个 T2DM 病人的一个总数被招募并且分到 NAU 组(n = 14 ) 或 MAU 组(n = 16 ) 根据 8 h,一夜间尿的蛋白尿排泄率(AER ) 结果。健康检查接受者的一个当代的队作为控制被包括(n = 12 ) 。DWI 和 DTI 扫描用 SE 单个射击的 EPI,和明显的散开系数(模数转换器) 在双边的肾上被执行,肾的实质的部分 anisotropy (FA ) 从模数转换器和三个组的 FA 地图是坚定的。模数转换器和 FA 价值在三个组之中被比较。根据有 400 s/mm 的 b 价值的 DWI <啜class=“ a-plus-plus ”> MAU 和 NAU 组显著地显示出的 2 ,与健康控制相比降低了吝啬的模数转换器价值( P 3 公里<啜class=“ a-plus-plus ”> 2 /s]比的稍微低 NAU 组[( 2.31 b >水平枌?枌?? | Xiaoyan Chen Wenxia Xiao Xinchun Li Jianxun He Xiaochun Huang Yuyu Tan | 2014 | Frontiers of Medicine2014，8，4： | 10 |
| 5 | Late Eocene pollen records and palaeoenvironmental changes in northern Tibetan Plateau显示文摘The Eocene palaeovegetation landscape and palaeoclimate reconstructed from the pollen records in the Jiuquan Basin, northwest China provide some important information on the early uplift of the Tibetan Plateau and the origin and evolution of the aridification in northwest China. The records show the arid-semiarid scrubs with open forest palynofloras controlled by the subtropical high existed in northwest China during the 40.2-33.4 Ma. Four pollen assemblages are found: Nitrariadites-Cheno-podipollis-Pinaceae assemblage (40.2-37.9 Ma) is followed by Chenopodipollis-Nitrariadites assemblage (37.9-34.6 Ma), Pinuspollenites & Abietineaepollenites-Chenopodipollis assemblage (34.6-33.9 Ma), and Chenopodipollis-Nitrariadites assemblage (33.9-33.4 Ma). The percentage of thermophilic types is in anti-correlation with that of the dry types, which means the palaeoclimate is relatively warmwet or cold-dry during most of that time. Such aridity may be related to the water vapor reduction and the planetary wind system movement northward in response to the cooling caused by small-ephemeral icesheets. | MIAO YunFa FANG XiaoMin SONG ZhiChen WU FuLi HAN WenXia DAI Shuang SONG ChunHui | 2008 | Science China Earth Sciences2008，51，8： | 10 |
| 6 | Fouling in offshore areas southeast of the Zhujiang(Pearl)River Delta,the northern South China Sea显示文摘In order to understand the type and extent of marine fouling in offshore areas southeast of the Zhujiang (Pearl) River delta, within the period form May 1986 to June 1987, two biological buoys were deployed at water depths of 95 m and 113 m located in 114 km and 160 km off the coast of Hong Kong, respectively. Moreover, the fouling community of a Marex hydrological buoy located in 115 m depth water 172 km off Hong Kong was also surveyed. The results show that a total of 78 species were collected and identified. The panels exposed for 3 months were mainly dominated by stalked barnacles Conchoderma hunteri and Lepas anatifera and hydroids Orthopyxis sp. As for the buoys, including the subsurface buoy, and their mooring systems exposed for 6 and 12 months, respectively, some hard foulers such as common oysters, pearl oysters, acorn barnacles and bryozoans were also found. The compositions of fouling communities also varied greatly with depth. | Yan Tao, Yan Wenxia, Dong Yu, Liang Guanhe, Yan Yan, Wang Huajie South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China. | 2003 | Acta Oceanologica Sinica2003，22，2： | 9 |
| 7 | Pd/AlF3 Catalysts for Catalytic Dehydrofluorination of 1,1,1,3,3-Pentafluoropropane显示文摘 | WANG Fang ZHANG Wenxia LIANG Yan WANG Yuejuan LU Jiqing LUO Mengfei | 2015 | Chemical Research in Chinese Universities2015，31，6： | 8 |
| 8 | CONSTRUCTION OF FREQUENCY HOPPING SEQUENCES WITH NO HIT ZONE显示文摘In this paper,a property of Frequency Hopping (FH) sequence set with No Hit Zone (NHZ) is analyzed. Based on matrix transform and mapping methods,respectively,two classes of NHZ FH sequences are presented. These NHZ FH sequences have good Hamming auto-correlation and Hamming cross-correlation properties. FH Code-Division Multiple Access (FH-CDMA) communication systems employing such NHZ FH sequences will eliminate multiple-access interference if the maximum time delay is shorter than the length of the NHZ. | Ye Wenxia Fan Pingzhi | 2007 | Journal of Electronics(China)2007，24，3： | 8 |
| 9 | Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice显示文摘The oral microbiota is associated with oral diseases and digestive systemic diseases.Nevertheless,the causal relationship between them has not been completely elucidated,and colonisation of the gut by oral bacteria is not clear due to the limitations of existing research models.The aim of this study was to develop a human oral microbiota-associated (HOMA) mouse model and to investigate the ecological invasion into the gut.By transplanting human saliva into germ-free (GF) mice,a HOMA mouse model was first constructed.16S rRNA gene sequencing was used to reveal the biogeography of oral bacteria along the cephalocaudal axis of the digestive tract.In the HOMA mice,84.78% of the detected genus-level taxa were specific to the donor.Principal component analysis (PCA) revealed that the donor oral microbiota clustered with those of the HOMA mice and were distinct from those of specific pathogen-free (SPF) mice.In HOMA mice,OTU counts decreased from the stomach and small intestine to the distal gut.The distal gut was dominated by Streptococcus,Veillonella,Haemophilus,Fusobacterium,Trichococcus and Actinomyces.HOMA mice and human microbiota-associated (HMA) mice along with the GF mice were then cohoused.Microbial communities of cohoused mice clustered together and were significantly separated from those of HOMA mice and HMA mice.The Source Tracker analysis and network analysis revealed more significant ecological invasion from oral bacteria in the small intestines,compared to the distal gut,of cohoused mice.In conclusion,a HOMA mouse model was successfully established.By overcoming the physical and microbial barrier,oral bacteria colonised the gut and profiled the gut microbiota,especially in the small intestine. | Bolei Li Yang Ge Lei Cheng Benhua Zeng Jinzhao Yu Xian Peng Jianhua Zhao Wenxia Li Biao Ren Mingyun Li Hong Wei Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 7 |
| 10 | The dynamic and thermodynamic processes dominating the reduction of global land monsoon precipitation driven by anthropogenic aerosols emission显示文摘Changes in monsoon precipitation have profound social and economic impacts as more than two-thirds of the world’s population lives in monsoon regions.Observations show a significant reduction in global land monsoon precipitation during the second half of the 20 th century.Understanding the cause of this change,especially possible anthropogenic origins,is important.Here,we compare observed changes in global land monsoon precipitation during 1948–2005 with those simulated by 5 global climate models participating in the Coupled Model Inter-comparison Project-phase 5(CMIP5)under different external forcings.We show that the observed drying trend is consistent with the model simulated response to anthropogenic forcing and to anthropogenic aerosol forcing in particular.We apply the optimal fingerprinting method to quantify anthropogenic influences on precipitation and find that anthropogenic aerosols may have contributed to 102%(62–144%for the 5–95%confidence interval)of the observed decrease in global land monsoon precipitation.A moisture budget analysis indicates that the reduction in precipitation results from reduced vertical moisture advection in response to aerosol forcing.Since much of the monsoon regions,such as India and China,have been experiencing rapid developments with increasing aerosol emissions in the past decedes,our results imply a further reduction in monsoon precipitation in these regions in the future if effective mitigations to reduce aerosol emissions are not deployed.The observed decline of aerosol emission in China since 2006 helps to alleviate the reducing trend of monsoon precipiptaion. | Tianjun ZHOU Wenxia ZHANG Lixia ZHANG Xuebin ZHANG Yun QIAN Dongdong PENG Shuangmei MA Buwen DONG | 2020 | Science China Earth Sciences2020，63，7： | 7 |
| 11 | Multistage Deformation in the Northeastern Segment of the Jiangshao Fault (Suture) Belt: Constraints for the Relationship between the Yangtze Plate and the Cathaysia Old Land显示文摘Multistage deformation events have occurred in the northeastern Jiangshao Fault (Suture) Belt. The earliest two are ductile deformation events. The first is the ca. 820 Ma top-to-the-northwest ductile thrusting, which directly resulted from the collision between the Cathaysia Old Land and the Chencai Arc (?) during the Late Neoproterozoic, and the Jiangnan Orogenic Belt that formed as the ocean closed between the Yangtze Plate and the jointed Cathaysia Old Land and the Chencai Arc due to continuous compression. The second is the ductile left-lateral strike-slipping that occurred in the latest Early Paleozoic. Since the Jinning period, all deformation events represent the reactivation or inversion of intraplate structures due to the collisions between the North China and Yangtze plates during the Triassic and between the Philippine Sea and Eurasian plates during the Cenozoic. In the Triassic, brittle right-lateral strike-slipping and subsequent top-to-the south thrusting occurred along the whole northeastern Jiangshao Fault Zone because of the collision between the North China and Yangtze plates. In the Late Mesozoic, regional extension took place across southeastern China. In the Cenozoic, the collision between the Philippine Sea and Eurasian plates resulted in brittle thrusts along the whole Jiangnan Old land in the Miocene. The Jiangshao Fault Belt is a weak zone in the crust with long history, and its reactivation is one of important characteristics of the deformation in South China; however, late-stage deformation events did not occur beyond the Jiangnan Old Land and most of them are parallel to the strike of the Old Land, which is similar to the Cenozoic deformation in Central Asia. In addition, the Jiangnan old Land is not a collisional boundary between the Yangtze Plate and Cathaysia Old Land in the Triassic. | ZHANG Jin LI Jinyi XIAO Wenxia FENG Qianwen MA Zongjin | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 7 |
| 12 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 13 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 14 | Multi-Residual Module Stacked Hourglass Networks for Human Pose Estimation显示文摘A multi-residual module stacked hourglass network(MRSH)was proposed to improve the accuracy and robustness of human body pose estimation.The network uses multiple hourglass sub-networks and three new residual modules.In the hourglass sub-network,the large receptive field residual module(LRFRM)and the multi-scale residual module(MSRM)are first used to learn the spatial relationship between features and body parts at various scales.Only the improved residual module(IRM)is used when the resolution is minimized.The final network uses four stacked hourglass sub-networks,with intermediate supervision at the end of each hourglass,repeating high-low(from high resolution to low resolution)and low-high(from low resolution to high resolution)learning.The network was tested on the public datasets of Leeds sports poses(LSP)and MPII human pose.The experimental results show that the proposed network has better performance in human pose estimation. | Wenxia Bao Yaping Yang Dong Liang Ming Zhu | 2020 | Journal of Beijing Institute of Technology2020，29，1： | 6 |
| 15 | MEF2C mediates the activation induced cell death(AICD)of macrophages显示文摘有免疫力的房间的导致激活的房间死亡(AICD ) 广泛地被相信为有免疫力的回答的规定关键。尽管巨噬细胞 apoptosis 在许多病理学的条件下面被观察了,是否并且怎么有巨噬细胞的 AICD 的问题巨噬细胞寿命被调整很好没被探讨。在巨噬细胞的 AICD 要求二个信号。一个人是 LPS 或另外的细菌的部件触发的房间激活。其它是存在在的一个事件 AICD 易受影响(告知) 然而并非 unsusceptible (休息) 巨噬细胞。这里,我们证明当它与沙门氏菌 typhimurium,类型 5 侵入人体气管粘膜的病菌(Ad5 ) 或 IFN-gamma 被告知时,那个 RAW264.7 房间产生 LPS 刺激。我们发现抄写因素 MEF2C 的稳定性在告知的 RAW264.7 房间被增加。MEF2C 的一种主导的否定形式的 Transfection 保护告知的巨噬细胞免受 LPS 触发的房间死亡的伤害。我们的数据证明 MEF2C 蛋白质稳定性的增加是在巨噬细胞的 AICD 的一个关键因素。 | Wenxia Fu Jinxue Wei Jun Gu | 2006 | Cell Research2006，16，6： | 5 |
| 16 | Differentiation degree combination weighting method for investment decision-making risk assessment in power grid construction projects显示文摘Power grid construction projects are distinguished by their wide variety,high investment,long payback period,and close relation to national development and human welfare.To improve the investment accuracy in such projects and effectively prevent investment risks,this paper proposes an investment optimization decision-making method for multiple power grid construction projects under a certain investment scale.Firstly,an in-depth analysis of the characteristics and development requirements of China’s power grid projects was performed.Thereafter,the time sequence and holographic method was adopted to conduct multi-dimensional,multi-perspective risk assessment of different parts of power grid projects,and a holographic risk assessment index system was developed.Moreover,an investment decision model considering the comprehensive risk based on combination weighting was developed according to the output and input of power grid construction projects.A new combination weighting optimization method that takes into account the investment willingness of enterprises was designed to improve the current weighting evaluation methods.Finally,the validity and applicability of the proposed evaluation method were verified by case examples. | Yuan Chang Chenmiao Liu Minghua Liu Wenxia Liu Zongqi Liu Heng Zhang Yan Zheng | 2019 | Global Energy Interconnection2019，2，5： | 5 |
| 17 | Expert consensus on regenerative endodontic procedures显示文摘Regenerative endodontic procedures(REPs)is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis.The ultimate objective of REPs is to regenerate the pulp-dentin complex,extend the tooth longevity and restore the normal function.Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports,case series,cohort studies,and randomized controlled studies.However,variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics.The heterogeneity in protocols may cause confusion among dental practitioners,thus guidelines and considerations of REPs should be explicated.This expert consensus mainly discusses the biological foundation,the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis,as well as the main complications of this treatment,aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies,suggesting REPs may become a more consistently evidence-based option in dental treatment. | Xi Wei Maobin Yang Lin Yue Dingming Huang Xuedong Zhou Xiaoyan Wang Qi Zhang Lihong Qiu Zhengwei Huang Hanguo Wang Liuyan Meng Hong Li Wenxia Chen Xiaoying Zou Junqi Ling | 2022 | International Journal of Oral Science2022，14，4： | 5 |
| 18 | 2021:A Year of Unprecedented Climate Extremes in Eastern Asia,North America,and Europe显示文摘The year 2021 was recorded as the 6th warmest since 1880.In addition to large-scale warming,2021 will be remembered for its unprecedented climate extremes.Here,a review of selected high-impact climate extremes in 2021,with a focus on China,along with an extension to extreme events in North America and Europe is presented.Nine extreme events that occurred in 2021 in China are highlighted,including a rapid transition from cold to warm extremes and sandstorms in spring,consecutive drought in South China and severe thunderstorms in eastern China in the first half of the year,extremely heavy rainfall over Henan Province and Hubei Province during summer,as well as heatwaves,persistent heavy rainfall,and a cold surge during fall.Potential links of extremes in China to four global-scale climate extremes and the underlying physical mechanisms are discussed here,providing insights to understand climate extremes from a global perspective.This serves as a reference for climate event attribution,process understanding,and high-resolution modeling of extreme events. | Tianjun ZHOU Wenxia ZHANG Lixia ZHANG Robin CLARK Cheng QIAN Qinghong ZHANG Hui QIU Jie JIANG Xing ZHANG | 2022 | Advances in Atmospheric Sciences2022，39，10： | 5 |
| 19 | Analysis on Phase Arrangement and Transposition Modes for UHV DC and Double-circuit EHV AC Transmission Line Built on the Same Tower显示文摘 | SIMA Wenxia ZHOU Yuan YUAN Tao YANG Qing SUN Shujie Gilles Tremouille | 2012 | 高电压技术2012，38，12： | 5 |
| 20 | Wind farm polymerization influences on security and economic operation in power system based on Copula function显示文摘Wind speed dependences on different areas in a wind farm have influences on security and economic operation in power system.In order to simulate the correlation of wind speed series between different positions,this paper applies Copula function and rank correlation matrix methods to measure the coherence of wind speed in a wind farm.The correlated wind sample space is established.According to active power output characteristics of wind turbines,the polymerization model in a wind farm can be achieved.Monte Carlo optimal power flow is applied to IEEE-30 and IEEE-300 bus systems based on the principle of energy saving dispatching.The study shows that the accuracy of outputs is improved,thus reducing the fluctuation ranges in unit generating costs and power flow in branches while considering wind speed polymerization.This approach provides a new method to improve the effectiveness of energy saving dispatching and system operation arrangement.Results have been tested to be effective. | Xiong PAN Zhuo LIU Wenxia LIU Yanqing LI | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 4 |
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