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| 1 | Insulin and heparin in treatment of hypertriglyceridemia-induced pancreatitis显示文摘TO THE EDITOR We read with great interest the case report, 'Hypertriglyceridemia -induced pancreatitis: A case-based review' by Gan et al[1] in the November 2006 issue of World Journal of Gastroenterology. | Pankaj Jain Ramesh Roop Rai Harsh Udawat Sandeep Nijhawan Amit Mathur | 2007 | World Journal of Gastroenterology2007，13，18： | 23 |
| 2 | Role of bisphosphonates in the management of acute Charcot foot显示文摘Diabetes mellitus is the most common cause of Charcot neuropathy affecting foot and ankle. Acute Charcot foot(CF) presents with a red and swollen foot in co-ntrast to the painless deformed one of chronic CF. En-hanced osteoclastogenesis plays a central role in the pathogenesis of acute CF. Many studies have shown elevated levels of bone turnover markers in patients with acute CF confirming it. These findings have led cl-inicians to use anti-resorptive agents [bisphosphonates(BP), calcitonin, and denosumab] along with immobi-lization and offloading in acute CF patients. The ma-ximum evidence among all anti-resorptive agents is available for BPs, although its quality is low. Pamidronate has been shown to reduce the markers of activity of CF like raised skin temperature, pain, edema, and bone turnover markers in the majority of studies. Intravenous BPs are known to cause acute phase reactions leading to flu-like illness following their first infusion, which can be ameliorated by oral acetaminophen. Alendronate is the only oral BP used in these patients. It needs to be taken on an empty stomach with a full glass of water to avoid esophagitis. The side-effects and contraindications to BPs should be kept in mind while treating acute CF patients with them. | Harsh Durgia Jayaprakash Sahoo Sadishkumar Kam-alanathan Rajan Palui Kalyani Sridharan Henith Raj | 2018 | World Journal of Diabetes2018，9，7： | 9 |
| 3 | SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common comorbidity with type 2 diabetes.The existing therapeutic options for NAFLD are not adequate.Hypocaloric diet and exercise is the cornerstone of therapy in NAFLD.Pioglitazone is the only drug recommended in diabetes patients with biopsy proven non-alcoholic steatohepatitis.The frequent coexistence of NAFLD and type 2 diabetes with their combined adverse health consequences and inadequate therapeutic options makes it necessary to search for newer alternatives.AIM To assess the effect of sodium glucose cotransporter-2(SGLT-2)inhibitors on liver enzymes in type 2 diabetes patients with NAFLD.METHODS We searched PubMed/MEDLINE,Cochrane library,Google scholar,and Clinicaltrials.gov for the relevant articles to be included in this systematic review.Human studies done in type 2 diabetes patients with NAFLD treated with SGLT-2 inhibitors for at least 12 wk were included.Data from eight studies(four randomised controlled trials and four observational studies)were extracted and a narrative synthesis was done.A total of 214 patients were treated with SGLT-2 inhibitors in these studies(94 in randomised controlled trials and 120 in observational studies).RESULTS The primary outcome measure was change in serum alanine aminotransferase level.Out of eight studies,seven studies showed a significant decrease in serum alanine aminotransferase level.Most of the studies revealed reduction in serum level of other liver enzymes like aspartate aminotransferase and gamma glutamyl transferase.Five studies that reported a change in hepatic fat exhibited a significant reduction in hepatic fat content in those treated with SGLT-2 inhibitors.Likewise,among the three studies that evaluated a change in indices of hepatic fibrosis,two studies revealed a significant improvement in liver fibrosis.Moreover,there was an improvement in obesity,insulin resistance,glycaemia,and lipid parameters in those subjects taking SGLT-2 inhibitors.The studies disclosed that about 17%(30/176)of the subjects taking SGLT-2 inhibitors developed adverse events and more than 40%(10/23)of them had genitourinary tract infections.CONCLUSION Based on low to moderate quality of evidence,SGLT-2 inhibitors improve the serum level of liver enzymes,decrease liver fat,and fibrosis with additional beneficial effects on various metabolic parameters in type 2 diabetes patients with NAFLD. | Henith Raj Harsh Durgia Rajan Palui Sadishkumar Kamalanathan Sandhiya Selvarajan Sitanshu Sekhar Kar Jayaprakash Sahoo | 2019 | World Journal of Diabetes2019，10，2： | 9 |
| 4 | Aluminium tolerance in barley (Hordeum vulgare L.): physiological mechanisms, genetics and screening methods显示文摘Aluminium (Al) toxicity is one of the major limiting factors for barley production on acid soils. It inhibits root cell division and elongation, thus reducing water and nutrient uptake, consequently resulting in poor plant growth and yield. Plants tolerate Al either through external resistance mechanisms, by which Al is excluded from plant tissues or internal tolerance mechanisms, conferring the ability of plants to tolerate Al ion in the plant symplasm where Al that has permeated the plas- malemma is sequestered or converted into an innocuous form. Barley is considered to be most sensitive to Al toxicity among cereal species. Al tolerance in barley has been assessed by several methods, such as nutrient solution culture, soil bioassay and field screening. Genetic and molecular mapping research has shown that Al tolerance in barley is controlled by a single locus which is located on chromosome 4H. Molecular markers linked with Al tolerance loci have been identified and validated in a range of diverse populations. This paper reviews the (1) screening methods for evaluating Al tolerance, (2) genetics and (3) mechanisms underlying Al tolerance in barley. | WANG Jun-ping RAMAN Harsh ZHANG Guo-ping MENDHAM Neville ZHOU Mei-xue | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 7 |
| 5 | Differential Sensitivity of Macrocarpa and Microcarpa Types of Chickpea (Cicer arietinum L.) to Water Stress: Association of Contrasting Stress Response with Oxidative Injury显示文摘Chickpea (Cicer arietinum L.) 是特别地敏感的在它的繁殖阶段浇应力并且在水应力的条件下面,将放弃花和豆荚,因此减少收益潜力。有 chickpea 的二种类型:(i) Macrocarpa (Kabuli ) 它有大,击打塑造头的、轻棕色的种子;并且(ii ) Microcarpa (Desi ) 它有小、尖、黑暗褐的种子。相对说, Kabuli 被报导了更敏感比 Desi 浇应力。与对比敏感流水联系的内在的机制在新陈代谢的水平强调井没被理解。我们假设了一个原因因为在 chickpea 的二种类型的形成对照的水压力敏感可以是在氧化损害的一个变化。在现在的学习,两种类型的植物是为 14 d 在繁殖舞台强调的水。由于压力, Kabuli 类型与为 Desi 类型观察的 64% 减小相比在控制上在种子产量展出了 80% 减小。在叶水潜力(w) 的减少与 Desi 类型相比在 Kabuli 是更快的。在水压力时期的结束, w 被归结为 ? 2.9 并且 ? 分别地,没有他们之间的任何重要差别,在 Desi 和 Kabuli 的 3.1 MPa 打字。在应力的最后一天, Kabuli 比 Desi 经历了 20% 更多的膜损害。叶绿素内容和光合的率与 Kabuli 相比在 Desi 是显著地更大的。malondialdehyde 和 H2O2 内容与 Desi 相比在在 Kabuli 的水压力的结束是显著地更高的,显示在前者的更大的氧化应力。抗氧化剂的层次例如维生素酸和谷胱甘肽,比 Kabuli 在 Desi 是显著地更高的。, Superoxide dismutase 和过氧化氢酶活动没在第 10 天, ascorbate peroxidase 的活动, dehydroascorbate reductase,和谷胱甘肽 reductase 在 chickpea 的二种类型之间显著地不同在 Desi 是更高的。这些调查结果显示在 Desi 类型的更大的应力公差可以被归功于到它维持更好的水地位的优异能力,它导致更少的氧化损坏。另外,实验室研究由使 chickpea 的两种类型遭到到聚乙烯的类似的层次进行了导致乙二醇的水应力并且到 10 .mol/L abscisic,酸显示了 Desi 类型的一个更大的能力比 Kabuli 类型处理氧化应力。 | Harsh Nayyar Smita Singh Satwinder Kaur Sanjeev Kumar Hari D. Upadhyaya | 2006 | Journal of Integrative Plant Biology2006，48，11： | 6 |
| 6 | Aerobic vs anaerobic exercise training effects on the cardiovascular system显示文摘Physical exercise is one of the most effective methods to help prevent cardiovascular(CV) disease and to promote CV health. Aerobic and anaerobic exercises are two types of exercise that differ based on the intensity, interval and types of muscle fibers incorporated. In this article, we aim to further elaborate on these two categories of physical exercise and to help decipher which provides the most effective means of promoting CV health. | Harsh Patel Hassan Alkhawam Raef Madanieh Niel Shah Constantine E Kosmas Timothy J Vittorio | 2017 | World Journal of Cardiology2017，9，2： | 2 |
| 7 | De novo design of future rapeseed crops:Challenges and opportunities显示文摘To address the global demand for rapeseed while considering farmers’profit,we face the challenges of making a quantum leap in seed yield and,at the same time,reducing yield loss due to biotic and abiotic stresses.We also face the challenge of efficiently applying new transformative biotechnology tools such as gene editing and breeding by genome design to increase rapeseed productivity and profitability.In this Perspective,we review advances in research on the physiological and genetic bases of both stress factorsaffected yield stability and seed yield potential,focusing on source–sink relationships and allocation of photosynthetic assimilates to vegetative growth and seed development.We propose research directions and highlight the role of plant architecture in the relative contributions of the root system,leaves,and pods to seed yield.We call for de novo design of new rapeseed crops.We review trait variation in existing germplasm and biotechnologies available for crop design.Finally,we discuss opportunities to apply fundamental knowledge and key germplasm to rapeseed production and propose an ideotype for de novo design of future rapeseed cultivars. | Shengyi Liu Harsh Raman Yang Xiang Chuanji Zhao Junyan Huang Yuanyuan Zhang | 2022 | The Crop Journal2022，10，3： | 2 |
| 8 | 战争与和平 绝望与希望——“九一一”后亚洲知识分子的再定位显示文摘“亚洲交流(ARENA)”在二○○二年五月召开座谈会,邀请亚洲十五名学者参加,座谈内容包括:“九一一”的现实与象征涵义,趋势与挑战,希望的声音,面向未来。以下座谈摘要由刘健芝编译。 | 刘健芝 Chandra Muzaffar 武藤一羊 Abdul Nayyar Joseph Gerson Conrad de Quiros Max de Mesa Aditya Nigam 许兆麟 李贞玉 Chandra Muzaffar Harsh Sethi Jeannie Manipon 梁兰周 | 2002 | 读书2002，，9： | 2 |
| 9 | How plants communicate using the underground information superhighway显示文摘 | Harsh Pal Bais Sang-Wook Park Tiffany L Weir Ragan M Callaway Jorge M Vivanco | 2003 | Trends in Plant Science2003，，1： | 2 |
| 10 | A robust soc-MOF platform exhibiting high gravimetric uptake and volumetric deliverable capacity for on-board methane storage显示文摘Emerging as an outperformed class of metal-organic frameworks(MOFs),square-octahedron(soc)topology MOFs(soc-MOFs)feature superior properties of high porosity,large gas storage capacity,and excellent thermal/chemical stability.We report here an iron based soc-MOF,denoted as Fe-pbpta(H4pbpta=4,4',4'',4'''-(1,4-phenylenbis(pyridine-4,2-6-triyl))-tetrabenzoic acid)possessing a very high Brunauer,Emmett and Teller(BET)surface area of 4,937 m2/g and a large pore volume of 2.15 cm3/g.The MOF demonstrates by far the highest gravimetric uptake of 369 cm3(STP)/g under the DOE operational storage conditions(35 bar and 298 K)and a high volumetric deliverable capacity of 192 cc/cc at 298 K and 65 bar.Furthermore,Fe-pbpta exhibits high thermal and aqueous stability making it a promising candidate for on-board methane storage. | Gaurav Verma Sanjay Kumar Harsh Vardhan Junyu Ren Zheng Niu Tony Pham Lukasz Wojtas Sydney Butikofer Jose C Echeverria Garcia Yu-Sheng Chen Brian Space and Shengqian Ma | 2021 | Nano Research2021，14，2： | 2 |
| 11 | lntracranial arachnoid cysts in children显示文摘 | Cilicillo SF Cogen PH Harsh GR | 1991 | J Neurosurg1991，74，： | 1 |
| 12 | Internal Business and Relationship Marketing: A Conceptual Study 显示文摘 | HARSH ARORA | 2008 | Industrial Marketing Management2008，5，1： | 1 |
| 13 | Allelopathy and exotic plant invasion: from molecules and genes to species interactions 显示文摘 | HARSH P B VEPACLEDU R GILORY S | 2003 | Science2003，301，： | 1 |
| 14 | The role of root exudates in rhizosphere interactions with plants and other organisms显示文摘 | Harsh P B Tiffany L W Laura G P | 2006 | Plant Biology2006，57，： | 1 |
| 15 | Intraspecific and interspecific interactions mediated by a phytotoxin,(-)-catechin,secreted by the roots of Centaurea maculosa显示文摘 | Tiffany L Weir Harsh Pal Bais Jorge M Vivanco | 2003 | Journal of Chemical Ecology2003，29，11： | 1 |
| 16 | Human gliomas with wild-type P53 express bcl-2显示文摘 | Alderson L M Castleberg R L Harsh G R 4th | 1995 | Cancer Res1995，55，5： | 1 |
| 17 | Prostacyclin and Thromboxane levels in pleural space fluid during cardiopulmonary bypass显示文摘 | Harsh P Hoahn L Lzumos | 1995 | Ann Thorac Surg1995，59，： | 1 |
| 18 | Fine needle aspiration cytology of pilomatrixoma显示文摘 | CHERRY BANSAL UMA HANDA HARSH MOHAN | 2011 | Journal of Cytology2011，28，1： | 1 |
| 19 | Intracranial arachnoid cysts in children显示文摘 | CIRICILLO SF COGEN PH HARSH GR | 1991 | J Neurosurg1991，20，74： | 1 |
| 20 | Accumulation of osmotytes and osmotic adjustment in water-stressed wheat and maize as affected by calcium and its antagonists 显示文摘 | Harsh N | 2003 | Environ Exp Bot2003，50，3： | 1 |
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