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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | The effects of psychological contract breach and organizational cynicism: not all social exchange violations are created equal显示文摘 | Jonathan L.Johnson Anne M.O’Leary‐Kelly | 2003 | J Organiz Behav2003，，5： | 2 |
| 4 | Eosinophilic Esophagitis: A 10-Year Experience in 381 Children显示文摘 | Chris A. Liacouras Jonathan M. Spergel Eduardo Ruchelli Ritu Verma Maria Mascarenhas Edisio Semeao Jonathan Flick Janice Kelly Terry Brown–Whitehorn Petar Mamula Jonathan E. Markowitz | 2005 | Clinical Gastroenterology and Hepatology2005，，： | 2 |
| 5 | Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery显示文摘 | Jaya Mishra Catherine Dent Ridwan Tarabishi Mark M Mitsnefes Qing Ma Caitlin Kelly Stacey M Ruff Kamyar Zahedi Mingyuan Shao Judy Bean Kiyoshi Mori Jonathan Barasch Prasad Devarajan | 2005 | The Lancet . 2005 (9466)2005，，： | 2 |
| 6 | Cognitive load selectively interferes with utilitarian moral judgment显示文摘 | Joshua D. Greene Sylvia A. Morelli Kelly Lowenberg Leigh E. Nystrom Jonathan D. Cohen | 2007 | Cognition2007，，3： | 2 |
| 7 | Learning Bayesian networks from data: an information theory based approach显示文摘 | Cheng Jie Greiner Russell Kelly Jonathan | 2002 | Artificial Intelligence2002，37，2： | 1 |
| 8 | Use of thoracodorsal artery perforator flaps to enhance outcomes in alloplastic breast reconstruction 显示文摘 | Jonathan S Kelly B | 2014 | Plast Reconstr Surg2014，2，5： | 1 |
| 9 | National Healthcare Safety Network(NHSN)report:Data summary for 2006through2008显示文摘 | Jonathan R Kelly D Yi Mu | 2009 | Am J Infect Control2009，37，12： | 1 |
| 10 | National Healthcare Safety Network (NHSN) report, data summary for 2009, device-associated module显示文摘 | Margaret A. Dudeck Teresa C. Horan Kelly D. Peterson Katherine Allen-Bridson Gloria C. Morrell Daniel A. Pollock Jonathan R. Edwards | 2011 | AJIC: American Journal of Infection Control2011，，： | 1 |
| 11 | The un-predictable nature of internal tides on continental shelves显示文摘 | Nash Jonathan D Kelly Samuel M Shroyer Emily L | | 0，，： | 1 |
| 12 | Short-term outcomes in heart failure patients with chronic obstructive pulmonary disease in the community显示文摘AIM:To establish the short term outcomes of heart failure(HF)patients in the community who have concurrent chronic obstructive pulmonary disease(COPD).METHODS:We evaluated 783 patients(27.2%)with left ventricular systolic dysfunction under the care of a regional nurse-led community HF team between June 2007 and June 2010 through a database analysis.RESULTS:One hundred and one patients(12.9%)also had a diagnosis of COPD;94% of patients were treated with loop diuretics,83% with angiotensin converting enzyme inhibitors,74% with β-blockers;10.6% with bronchodilators;and 42% with aldosterone an-tagonists.The mean age of the patients was 77.9 ± 5.7 years;43% were female and mean New York Heart Association class was 2.3 ± 0.6.The mean follow-up was 28.2 ± 2.9 mo.β-blocker utilization was markedly lower in patients receiving bronchodilators compared with those not taking bronchodilators(overall 21.7% vs 81%,P < 0.001).The 24-mo survival was 93% in patients with HF alone and 89% in those with both comorbidities(P = not significant).The presence of COPD was associated with increased risk of HF hospitalization [hazard ratio(HR):1.56;95% CI:1.4-2.1;P < 0.001] and major adverse cardiovascular events(HR:1.23;95% CI:1.03-1.75;P < 0.001).CONCLUSION:COPD is a common comorbidity in ambulatory HF patients in the community and is a powerful predictor of worsening HF.It does not however appear to affect short-term mortality in ambulatory HF patients. | Noel O'Kelly William Robertson Jude Smith Jonathan Dexter Collette Carroll-Hawkins Sudip Ghosh | 2012 | World Journal of Cardiology2012，4，3： | 1 |
| 13 | Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis 显示文摘 | Kelly ED Tania Tang Jonathan EG | 2009 | Am J Trop Med Hyg2009，80，4： | 1 |
| 14 | National healthcare Safety Network(NHSN)report,data summary for 2006,through 2007,issued November 2008显示文摘 | Jonathan RE Kelly DP Mary LA | 2007 | AJIC2007，35，5： | 1 |
| 15 | Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease显示文摘 | Joelle M. van der Walt Kristin K. Nicodemus Eden R. Martin William K. Scott Martha A. Nance Ray L. Watts Jean P. Hubble Jonathan L. Haines William C. Koller Kelly Lyons Rajesh Pahwa Matthew B. Stern Amy Colcher Bradley C. Hiner Joseph Jankovic William G. | 2003 | The American Journal of Human Genetics2003，，4： | 1 |
| 16 | National Healthcare Safety Network (NHSN) report: Data summary for 2006 through 2008, issued December 2009显示文摘 | Jonathan R. Edwards Kelly D. Peterson Yi Mu Shailendra Banerjee Katherine Allen-Bridson Gloria Morrell Margaret A. Dudeck Daniel A. Pollock Teresa C. Horan | 2009 | AJIC: American Journal of Infection Control2009，，： | 1 |
| 17 | Learning Bayesian networks from data: An information-theory based approach显示文摘 | Jie Cheng Russell Greiner Jonathan Kelly | 2002 | Artificial Intelligence2002，137，12： | 1 |
| 18 | Pushing moral buttons: The interaction between personal force and intention in moral judgment显示文摘 | Joshua D. Greene Fiery A. Cushman Lisa E. Stewart Kelly Lowenberg Leigh E. Nystrom Jonathan D. Cohen | 2009 | Cognition2009，，3： | 1 |
| 19 | National Heahhcare Safety Network (NHSN) report, data summary for 2006 through 2007 显示文摘 | JONATHAN R MSTAT KELLY D | 2008 | Am J Infect Control2008，36，9： | 1 |
| 20 | Prospective Validation of the Computed Tomographic Angiography Spot Sign Score for Intracerebral Hemorrhage显示文摘 | Javier M. Romero H. Bart Brouwers JingJing Lu Josser E. Delgado Almandoz Hillary Kelly Jeremy Heit Joshua Goldstein Jonathan Rosand R. Gilberto Gonzalez | 2013 | Stroke2013，，： | 1 |
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